ECSP993005A - SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS - Google Patents
SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTSInfo
- Publication number
- ECSP993005A ECSP993005A ECSP993005A ECSP993005A EC SP993005 A ECSP993005 A EC SP993005A EC SP993005 A ECSP993005 A EC SP993005A EC SP993005 A ECSP993005 A EC SP993005A
- Authority
- EC
- Ecuador
- Prior art keywords
- 4alkyl
- halo
- substituted
- unsaturated
- inflammatory
- Prior art date
Links
- VTILWYBQQRECER-UHFFFAOYSA-N 5-sulfonylcyclohexa-1,3-diene Chemical class O=S(=O)=C1CC=CC=C1 VTILWYBQQRECER-UHFFFAOYSA-N 0.000 title 1
- 239000000730 antalgic agent Substances 0.000 title 1
- 239000002260 anti-inflammatory agent Substances 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 6
- -1 4- (sulfonyl) phenyl Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000229 (C1-C4)alkoxy group Chemical class 0.000 abstract 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000006413 ring segment Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención proporciona un compuesto de la siguiente fórmula: (gráfico), o una sal farmacéuticamente aceptable del mismo, en la que A es un heterociclo de cinco eslabones, parcialmente insaturado o insaturado, o un grupo carbociclico de cinco miembros parcialmente insaturado o insaturado, donde el 4-(sulfonil) fenilo y el fenilo 4-sustituido presentes en la fórmula (I) estan unidos a átomos de aniillo del anillo A adyacentes entre si; R1 es arilo o heteroarilo opcionalmente sustituido, con la condición de que cuando A es pirazol, R1 es heteroarilo; R2 es alquilo C1-4, alquilo C1-4 halo-sustituido, alquilamino C1-4, dialquilamino C1-4 o amino; R3, R4 y R5 son, independientemente hidrógeno, halo, alquilo C1-4, alquilo C1-4 halo-sustituido o similares; o dos de R3, R4 y R5 se toman conjuntamente con átomos a los que están unidos y forman un anillo de 4-7 eslabones; R6 y R7 son, independientemente, hidrógeno, halo, alquilo C1-4, alquilo C1-4 halo-sustituido, alcoxi C1-4, alquiltio C1-4, alquilamino C1-4 o N,N di-alquilamino C1-4; y m y n son independientemente 1, 2, 3 ó 4.The present invention provides a compound of the following formula: (graphic), or a pharmaceutically acceptable salt thereof, wherein A is a five-membered heterocycle, partially unsaturated or unsaturated, or a five-membered carboxylic group partially unsaturated or unsaturated , where the 4- (sulfonyl) phenyl and 4-substituted phenyl present in formula (I) are attached to adjacent ring A ring atoms; R1 is optionally substituted aryl or heteroaryl, with the proviso that when A is pyrazole, R1 is heteroaryl; R2 is C1-4alkyl, halo-substituted C1-4alkyl, C1-4alkylamino, C1-4 dialkylamino or amino; R3, R4 and R5 are independently hydrogen, halo, C1-4alkyl, halo-substituted C1-4alkyl or the like; or two of R3, R4 and R5 are taken together with atoms to which they are attached and form a 4-7 membered ring; R6 and R7 are independently hydrogen, halo, C1-4alkyl, halo-substituted C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4alkylamino or N, N-di-C1-4alkylamino; and m and n are independently 1, 2, 3 or 4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993005 ECSP993005A (en) | 1999-06-11 | 1999-06-11 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993005 ECSP993005A (en) | 1999-06-11 | 1999-06-11 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993005A true ECSP993005A (en) | 1999-10-29 |
Family
ID=42043994
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993005 ECSP993005A (en) | 1999-06-11 | 1999-06-11 | SULFONYLBENZENE COMPOUNDS AS ANTI-INFLAMMATORY / ANALGESIC AGENTS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993005A (en) |
-
1999
- 1999-06-11 EC ECSP993005 patent/ECSP993005A/en unknown
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