ECSP993008A - DERIVATIVES OF DIAZA- ESPIRO [3,5] NONANO - Google Patents
DERIVATIVES OF DIAZA- ESPIRO [3,5] NONANOInfo
- Publication number
- ECSP993008A ECSP993008A ECSP993008A ECSP993008A EC SP993008 A ECSP993008 A EC SP993008A EC SP993008 A ECSP993008 A EC SP993008A EC SP993008 A ECSP993008 A EC SP993008A
- Authority
- EC
- Ecuador
- Prior art keywords
- lower alkyl
- naphthalen
- hydrogen
- decahydro
- optionally substituted
- Prior art date
Links
- -1 bicyclo [3.3.1] non-9-yl Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000004129 indan-1-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])([H])C2([H])* 0.000 abstract 1
- 125000004130 indan-2-yl group Chemical group [H]C1=C([H])C([H])=C2C(=C1[H])C([H])([H])C([H])(*)C2([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención se refiere a compuestos de fórmula general (gráfico), en donde R1 es cicloalquilo de 6 a 12 átomos de acrbono, opcionalmente substituido con laquilo inferior o C(O)O alquilo inferior; indan 1-ilo ó indan-2-ilo, opcionalmente substituido con alquilo inferior; acenaften-1-ilo; biciclo [3.3.1]non-9-ilo; octahidro-inden-2-ilo; 2,3-dihidro-1H-fenalen-1-ilo; 2,3,3a,4,5,6-hexahidro-1H-fenalen-1-ilo; decahidro-azulen-2-ilo; biciclo [6.2.0] dec-9-il; decahidro-naftalen-1-ilo; decahidro-naftalen-2-ilo; tetrahidro-naftalen-1-ilo; tetrahidro-naftalen-2-ilo ó 2-oxo-1,2-difenil-etilo; R2 es =O ó hidrógeno; R3 es hidrógeno, isoindolil-1,3-diona, alcoxilo, inferior, alquilo inferior, amino, benciloxilo, -CH2OR5 ó -CH2N(R5)2; R4 es hidrógeno o -CH2OR5; R5 es hidrógeno o alquilo inferior; A es ciclohexilo o fenilo, opcionalmente substituido con alquilo inferior, halógeno o alcoxilo, a las ,mezclas racémicas y a sus correspondinetes enantiómeros y/o las sales de adición ácida farmacéuticamente aceptables de los mismos. Los compuestos de la presente invención son agonistas y/o anrtagonistas del receptor de la orfanina FQ (OFQ) y por lo tanto son de utilidad para el tratamiento de enfermedades relacionadas con este receptor.The invention relates to compounds of the general formula (graph), wherein R1 is cycloalkyl of 6 to 12 acbon atoms, optionally substituted with lower lakyl or C (O) O lower alkyl; indan 1-yl or indan-2-yl, optionally substituted with lower alkyl; acenaphten-1-yl; bicyclo [3.3.1] non-9-yl; octahydro-inden-2-yl; 2,3-dihydro-1H-phenalen-1-yl; 2,3,3a, 4,5,6-hexahydro-1H-phenalen-1-yl; decahydro-azulen-2-yl; bicycle [6.2.0] dec-9-yl; decahydro-naphthalen-1-yl; decahydro-naphthalen-2-yl; tetrahydro-naphthalen-1-yl; tetrahydro-naphthalen-2-yl or 2-oxo-1,2-diphenyl-ethyl; R2 is = O or hydrogen; R3 is hydrogen, isoindolyl-1,3-dione, lower alkoxy, lower alkyl, amino, benzyloxy, -CH2OR5 or -CH2N (R5) 2; R4 is hydrogen or -CH2OR5; R5 is hydrogen or lower alkyl; A is cyclohexyl or phenyl, optionally substituted by lower alkyl, halogen, or alkoxy, to the racemic mixtures and their corresponding enantiomeric and / or pharmaceutically acceptable acid addition salts thereof. The compounds of the present invention are CF orphanin receptor (OFQ) agonists and / or anrtagonists and are therefore useful for the treatment of diseases related to this receptor.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993008 ECSP993008A (en) | 1999-06-11 | 1999-06-11 | DERIVATIVES OF DIAZA- ESPIRO [3,5] NONANO |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993008 ECSP993008A (en) | 1999-06-11 | 1999-06-11 | DERIVATIVES OF DIAZA- ESPIRO [3,5] NONANO |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993008A true ECSP993008A (en) | 2000-01-27 |
Family
ID=42043997
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993008 ECSP993008A (en) | 1999-06-11 | 1999-06-11 | DERIVATIVES OF DIAZA- ESPIRO [3,5] NONANO |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993008A (en) |
-
1999
- 1999-06-11 EC ECSP993008 patent/ECSP993008A/en unknown
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