ECSP993021A - THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY - Google Patents
THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITYInfo
- Publication number
- ECSP993021A ECSP993021A ECSP993021A ECSP993021A EC SP993021 A ECSP993021 A EC SP993021A EC SP993021 A ECSP993021 A EC SP993021A EC SP993021 A ECSP993021 A EC SP993021A
- Authority
- EC
- Ecuador
- Prior art keywords
- compositions
- fragility
- pyridin
- oxo
- phenyl
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- -1 2,4-difluoro-benzyloxymethyl Chemical group 0.000 abstract 2
- WFKAJVHLWXSISD-UHFFFAOYSA-N isobutyramide Chemical compound CC(C)C(N)=O WFKAJVHLWXSISD-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WRASVFOICVIUGY-UHFFFAOYSA-N 1-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol Chemical compound OC1=CC=C2CCCCC2=C1C(C=C1)=CC=C1OCCN1CCCC1 WRASVFOICVIUGY-UHFFFAOYSA-N 0.000 abstract 1
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000001164 Osteoporotic Fractures Diseases 0.000 abstract 1
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere a composiciones farmacéuticas de combinación y a procedimientos que comprenden (-) -cis-6-fenil-5-(4-(2-pirrolidin-1-il-etoxi)-fenil-5,6,7,8-tetrahidronaftalen-2-ol, o una sal farmacéuticamente aceptables del mismo y 2-amino-N-(1(R)-(2,4-difluoro-benciloximetil)2-oxo-2-(3-oxo-3a(R) - piridin - 2-ilmetil)-2-(2,2,2 -trifluoro-etil)-2,3,3a,4,6,7, -hexahidro-pirazolo (4,3 -C(piridin -5-il)-etil)2-metil- propionamida o una sal farmacéuticamente aceptable de la misma, a procedimientos de uso de tales composiciones y a estuches que contiene tales composiciones. Las composiciones son útiles para el tratamiento de la fragilidad musculoesquelética; incluyendo la osteoporosis, fracturas osteoporóticas, reducción de masa ósea, fragilidad y reducción de masa muscular.This invention relates to combination pharmaceutical compositions and processes comprising (-) -cis-6-phenyl-5- (4- (2-pyrrolidin-1-yl-ethoxy) -phenyl-5,6,7,8- tetrahydronaphthalen-2-ol, or a pharmaceutically acceptable salt thereof and 2-amino-N- (1 (R) - (2,4-difluoro-benzyloxymethyl) 2-oxo-2- (3-oxo-3a (R) - pyridin-2-ylmethyl) -2- (2,2,2 -trifluoro-ethyl) -2,3,3a, 4,6,7, -hexahydro-pyrazolo (4,3 -C (pyridin -5-yl ) -ethyl) 2-methyl-propionamide or a pharmaceutically acceptable salt thereof, to methods of using such compositions and to kits containing such compositions The compositions are useful for the treatment of musculoskeletal fragility, including osteoporosis, osteoporotic fractures , reduction of bone mass, fragility and reduction of muscle mass.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993021 ECSP993021A (en) | 1999-06-16 | 1999-06-16 | THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993021 ECSP993021A (en) | 1999-06-16 | 1999-06-16 | THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993021A true ECSP993021A (en) | 1999-08-12 |
Family
ID=42044010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993021 ECSP993021A (en) | 1999-06-16 | 1999-06-16 | THERAPEUTIC COMBINATIONS FOR MUSCULOSKELETAL FRAGILITY |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993021A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11723902B2 (en) | 2014-09-04 | 2023-08-15 | Helsinn Healthcare Sa | Medical treatments based on anamorelin |
-
1999
- 1999-06-16 EC ECSP993021 patent/ECSP993021A/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11723902B2 (en) | 2014-09-04 | 2023-08-15 | Helsinn Healthcare Sa | Medical treatments based on anamorelin |
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