ECSP993024A - ANTITHROMBOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
ANTITHROMBOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- ECSP993024A ECSP993024A ECSP993024A ECSP993024A EC SP993024 A ECSP993024 A EC SP993024A EC SP993024 A ECSP993024 A EC SP993024A EC SP993024 A ECSP993024 A EC SP993024A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- compounds
- quinolinyl
- iso
- formula
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000002785 anti-thrombosis Effects 0.000 title abstract 2
- 239000003146 anticoagulant agent Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 1,2,3,4-tetrahydronaphthyl Chemical group 0.000 abstract 2
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical group C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 abstract 1
- 108090000190 Thrombin Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001483 monosaccharide substituent group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000006574 non-aromatic ring group Chemical group 0.000 abstract 1
- 150000002482 oligosaccharides Polymers 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000006850 spacer group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229960004072 thrombin Drugs 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se refiere aq los compuestos de la fórmula (T) (gráfico), donde R1 es fenilo, naftilo, 1,2,3,4-tetrahidronaftilo, (iso) quinolinilo, tetrahidro (iso) quinolinilo, 3,4-dihidro-1H-isoquinolinilo, cromanilo o el grupo alcanfor, cuyos grupos pueden estar opcionalmente sustituidos con uno o más sustituyentes seleccionados entre (1-8C) alquilo ó (1-8C)alcoxi; R2 y R3 son independientemente H ó (1-8C) alquilo; R4 es (1-8C)alquilo ó (3-8C) alquilo; o R3 y R4 junto con el átomo de nitrógeno el cual están unidos, forman un anillo no aromático de 4-8 miembros que opcionalmente contiene otro heteroátomo, estando al anillo opcionalmente sustituido con (1-8C) alquilo ó SO2- (1-8C)alquilo]; Q es un espaciador que tiene una longitud de cadena de 10m a 70 átomos; y Z es un residuo de oligosacárido cargado negativamente que comprende de dos a seis unidades monosacáridos estando la carga compensada por contraiones cargados positivamente; O una sal farmacéuticamente aceptable del mismo o una prodroga del mismo. Los compuestos de la invención tienen actividad antitrombótica y pueden usarse para tratar o prevenir enfermedades relacionadas con la trombina. La presente invención se refiere a los compuestos de la fórmula (T)The present invention relates to q compounds of formula (T) (graph), where R1 is phenyl, naphthyl, 1,2,3,4-tetrahydronaphthyl, (iso) quinolinyl, tetrahydro (iso) quinolinyl, 3,4- dihydro-1H-isoquinolinyl, chromanyl or the camphor group, the groups of which may optionally be substituted with one or more substituents selected from (1-8C) alkyl or (1-8C) alkoxy; R2 and R3 are independently H or (1-8C) alkyl; R4 is (1-8C) alkyl or (3-8C) alkyl; or R3 and R4 together with the nitrogen atom to which they are attached, form a 4-8 membered non-aromatic ring optionally containing another heteroatom, the ring being optionally substituted with (1-8C) alkyl or SO2- (1-8C )I rent]; Q is a spacer having a chain length of 10m to 70 atoms; and Z is a negatively charged oligosaccharide residue comprising from two to six monosaccharide units with the charge being offset by positively charged counterions; Either a pharmaceutically acceptable salt thereof or a prodrug thereof. The compounds of the invention have antithrombotic activity and can be used to treat or prevent thrombin related diseases. The present invention relates to compounds of formula (T)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993024 ECSP993024A (en) | 1999-06-17 | 1999-06-17 | ANTITHROMBOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993024 ECSP993024A (en) | 1999-06-17 | 1999-06-17 | ANTITHROMBOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993024A true ECSP993024A (en) | 1999-09-09 |
Family
ID=42044013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993024 ECSP993024A (en) | 1999-06-17 | 1999-06-17 | ANTITHROMBOTIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993024A (en) |
-
1999
- 1999-06-17 EC ECSP993024 patent/ECSP993024A/en unknown
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