ECSP993025A - NON-PEPTIDILIC INHIBITORS OF THE UNION TO VLA -4 DEPENDENT CELLS USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASES - Google Patents
NON-PEPTIDILIC INHIBITORS OF THE UNION TO VLA -4 DEPENDENT CELLS USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASESInfo
- Publication number
- ECSP993025A ECSP993025A ECSP993025A ECSP993025A EC SP993025 A ECSP993025 A EC SP993025A EC SP993025 A ECSP993025 A EC SP993025A EC SP993025 A ECSP993025 A EC SP993025A
- Authority
- EC
- Ecuador
- Prior art keywords
- vla
- autoimmune
- inflammatory
- peptidilic
- union
- Prior art date
Links
- 230000001363 autoimmune Effects 0.000 title abstract 2
- 230000002757 inflammatory effect Effects 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 230000000241 respiratory effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 108010008212 Integrin alpha4beta1 Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000021164 cell adhesion Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 208000023504 respiratory system disease Diseases 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Se describen compuestos de fórmula (1.0.0) (gráfico), (1.0.0), en los que A es, por ejemplo, arilo, heteroarilo o heterociclilo, y es preferiblemente -C(=0) -; B se selecciona independientemente de un grupo de radicales, siendo los más preferidos de los cuales los de fórmulas parciales (1.1.2) y (1.1.6): (gráficos), y E es un enlace sencillo; oxigeno: 1,1 -ciclopropilo; C(CH3)2; CF2; o un radical puente de fórmula parcial (gráfico), Donde R1a es hidrógeno cuando R1 tiene el significado de un sustituyente monovalente; y R1a es un enlace sencillo cuando R1 tiene el significado de un sustituyente divalente. Dichos compuestos son útiles en procedimientos para tratar o prevenir una enfermedad inflamatoria, autoinmune o respiratoria inhibiendo la adhesión celular y los procesos patógenos consecuentes o asociados mediados posteriormente por VLA-4.Compounds of formula (1.0.0) (graph), (1.0.0) are described, in which A is, for example, aryl, heteroaryl or heterocyclyl, and is preferably -C (= 0) -; B is independently selected from a group of radicals, the most preferred of which are those of partial formulas (1.1.2) and (1.1.6): (graphs), and E is a single bond; oxygen: 1,1-cyclopropyl; C (CH3) 2; CF2; or a bridge radical of partial formula (graph), where R1a is hydrogen when R1 has the meaning of a monovalent substituent; and R1a is a single bond when R1 has the meaning of a divalent substituent. Such compounds are useful in methods of treating or preventing inflammatory, autoimmune, or respiratory disease by inhibiting cell adhesion and consequent or associated pathogenic processes subsequently mediated by VLA-4.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993025 ECSP993025A (en) | 1999-06-17 | 1999-06-17 | NON-PEPTIDILIC INHIBITORS OF THE UNION TO VLA -4 DEPENDENT CELLS USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993025 ECSP993025A (en) | 1999-06-17 | 1999-06-17 | NON-PEPTIDILIC INHIBITORS OF THE UNION TO VLA -4 DEPENDENT CELLS USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993025A true ECSP993025A (en) | 1999-08-12 |
Family
ID=42044014
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993025 ECSP993025A (en) | 1999-06-17 | 1999-06-17 | NON-PEPTIDILIC INHIBITORS OF THE UNION TO VLA -4 DEPENDENT CELLS USEFUL IN THE TREATMENT OF INFLAMMATORY, AUTOIMMUNE AND RESPIRATORY DISEASES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993025A (en) |
-
1999
- 1999-06-17 EC ECSP993025 patent/ECSP993025A/en unknown
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