ECSP993046A - COMPOUND OF 1 -PIPERIDIL BENZOIMIDAZOLE 2 - REPLACED AS ORL1 RECEPTOR AGONISTS - Google Patents

COMPOUND OF 1 -PIPERIDIL BENZOIMIDAZOLE 2 - REPLACED AS ORL1 RECEPTOR AGONISTS

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Publication number
ECSP993046A
ECSP993046A ECSP993046A ECSP993046A EC SP993046 A ECSP993046 A EC SP993046A EC SP993046 A ECSP993046 A EC SP993046A EC SP993046 A ECSP993046 A EC SP993046A
Authority
EC
Ecuador
Prior art keywords
alkyl
compound
aromatic
piperidil
benzoimidazole
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Fumitaka Ito
Hiroshi Kondo
Hirohide Noguchi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP993046 priority Critical patent/ECSP993046A/en
Publication of ECSP993046A publication Critical patent/ECSP993046A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Un compuesto de la fórmula: (gráfico), o una sal farmacéuticamente aceptable del mismo, en la que R es cicloalquilo (C3-C11) o cicloalquenilo (C3-C11) mono-di- o tri-sustituidos, o similares, A es alquilo (C1-C7) o alquenilo (C2-C5) no sustituido, o arilo mono-, di- o tri- sustituido, heterociclos aromáticos o similares, Y es hidrógeno, halo, amino o mercapto, o alquil (C1-C10)-M- mono-, di- o tri-sustituido, cicloalquil (C3-C7)-M-, alquenil (C2-C6) -M-, alquil (C1-C4) -NH- (alquil(C1-C4)) -M-, di-alquil (C1-C4) -N- (alquil (C1-C4)) -M, aril-M, heterociclo aromátco o no aromático -M, aril-alquil (C1-C5) -M- o heterociclo aromático o no aromático-alquilo (C1-C5) -M-, donde M es un enlace covalente, O, S, NH o similares; Z1, Z2, Z3 y Z4 son hidrógenos o similares; tiene actividad agonista del receptor ORL1, y el útil como analgésico o similar en mamíferos.A compound of the formula: (graph), or a pharmaceutically acceptable salt thereof, wherein R is mono-di- or tri-substituted cycloalkyl (C3-C11) or cycloalkenyl (C3-C11), or the like, A is unsubstituted (C1-C7) alkyl or (C2-C5) alkenyl, or mono-, di- or tri- substituted aryl, aromatic heterocycles or the like, Y is hydrogen, halo, amino or mercapto, or (C1-C10) alkyl -M- mono-, di- or tri-substituted, (C3-C7) cycloalkyl -M-, (C2-C6) alkenyl -M-, (C1-C4) -alkyl-NH- (C1-C4-alkyl)) -M-, di-C1-C4-alkyl-N- (C1-C4-alkyl) -M, aryl-M, aromatic or non-aromatic heterocycle -M, aryl-C1-C5-alkyl-M- or aromatic or non-aromatic heterocycle-C1-C5 alkyl-M-, where M is a covalent bond, O, S, NH or the like; Z1, Z2, Z3 and Z4 are hydrogens or the like; it has ORL1 receptor agonist activity, and useful as an analgesic or the like in mammals.

ECSP993046 1999-06-28 1999-06-28 COMPOUND OF 1 -PIPERIDIL BENZOIMIDAZOLE 2 - REPLACED AS ORL1 RECEPTOR AGONISTS ECSP993046A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP993046 ECSP993046A (en) 1999-06-28 1999-06-28 COMPOUND OF 1 -PIPERIDIL BENZOIMIDAZOLE 2 - REPLACED AS ORL1 RECEPTOR AGONISTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP993046 ECSP993046A (en) 1999-06-28 1999-06-28 COMPOUND OF 1 -PIPERIDIL BENZOIMIDAZOLE 2 - REPLACED AS ORL1 RECEPTOR AGONISTS

Publications (1)

Publication Number Publication Date
ECSP993046A true ECSP993046A (en) 1999-09-09

Family

ID=42044033

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP993046 ECSP993046A (en) 1999-06-28 1999-06-28 COMPOUND OF 1 -PIPERIDIL BENZOIMIDAZOLE 2 - REPLACED AS ORL1 RECEPTOR AGONISTS

Country Status (1)

Country Link
EC (1) ECSP993046A (en)

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