ECSP993092A - HEPATITIS C INHIBITING TRIPEPTIDES - Google Patents
HEPATITIS C INHIBITING TRIPEPTIDESInfo
- Publication number
- ECSP993092A ECSP993092A ECSP993092A ECSP993092A EC SP993092 A ECSP993092 A EC SP993092A EC SP993092 A ECSP993092 A EC SP993092A EC SP993092 A ECSP993092 A EC SP993092A
- Authority
- EC
- Ecuador
- Prior art keywords
- formula
- amido
- alkyl
- optionally substituted
- lower alkyl
- Prior art date
Links
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 125000003368 amide group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 230000002425 cardiocirculatory effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Racematos, diastereoisómeros e isómeros ópticos de un compuesto de fórmula (I), (gráfico), en que B es H, un arilo C6 ó C10, arilalquilo C7-16; Het o (alquil inferior)-Het, todos ellos opcionalmente sustituidos con alquilo C1-6; alcoxi C1-6; alcanoilo C1-6; hidroxi, hidroxialquilo; halo; haloalquilo; nitro; ciano; cianoalquilo; amino opcionalmente sustituido con alquilo C1-6; amido; o (alquil inferior) amido; o B es un derivado de acilo de fórmula R4-C(O); un carboxilo de fórmula R4-O-C(O); un amido de fórmula R4-NH-C(O); un tioamido de fórmula R4-N(R5)-, C(S); o un sulfonilo de fórmula R4-SO2; R5 es H o alquilo C1-6; e Y es H o alquilo C1-6; R3 es alquilo C1-8 cicloalquilo C3-7 o alquilcicloalquilo C4-10, todos ellos opcionalmente sustituidos con hidroxi, alcoxi C1-6, tioalquilo C1-6, amido, (alquil Inferior) amido, arilo C6 ó C10 o arilalquilo C7-16; R2 es CH2-R20, NH-R20, O-R20 ó S-R20, en que R20 es un cicloalquilo C3-7 o (alquilcicloalquilo) C4-10 saturado o insaturado, estando todos ellos opcionalmente mono-, di o tri-sustituidos con R21, en la que los subtituyentes R1, R2, R3, A, X e Y tienen el significado indicativo, asi como a procedimientos para su preparación y a su uso como medicamentos, en especial como medicamentos para el taratmiento de enfermedades cardiocirulatorias.Racemates, diastereoisomers and optical isomers of a compound of formula (I), (graph), wherein B is H, a C6 or C10 aryl, C7-16 arylalkyl; Het or (lower alkyl) -Het, all optionally substituted with C1-6alkyl; C1-6 alkoxy; C1-6 alkanoyl; hydroxy, hydroxyalkyl; halo; haloalkyl; nitro; cyano; cyanoalkyl; amino optionally substituted with C1-6alkyl; amido; or (lower alkyl) amido; or B is an acyl derivative of formula R4-C (O); a carboxyl of formula R4-O-C (O); an amido of formula R4-NH-C (O); a thioamido of formula R4-N (R5) -, C (S); or a sulfonyl of formula R4-SO2; R5 is H or C1-6 alkyl; and Y is H or C1-6 alkyl; R3 is C1-8 alkyl C3-7 cycloalkyl or C4-10 alkylcycloalkyl, all optionally substituted with hydroxy, C1-6 alkoxy, thioalkyl C1-6, amido, (lower alkyl) amido, C6 or C10 aryl or C7-16 arylalkyl ; R2 is CH2-R20, NH-R20, O-R20 or S-R20, where R20 is a C3-7 cycloalkyl or C4-10 (alkylcycloalkyl) saturated or unsaturated, all of which are optionally mono-, di or tri-substituted with R21, in which the substituents R1, R2, R3, A, X and Y have the indicative meaning, as well as procedures for their preparation and their use as drugs, especially as drugs for the treatment of cardio-circulatory diseases.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993092 ECSP993092A (en) | 1999-08-10 | 1999-08-10 | HEPATITIS C INHIBITING TRIPEPTIDES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993092 ECSP993092A (en) | 1999-08-10 | 1999-08-10 | HEPATITIS C INHIBITING TRIPEPTIDES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993092A true ECSP993092A (en) | 1999-10-29 |
Family
ID=42044079
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993092 ECSP993092A (en) | 1999-08-10 | 1999-08-10 | HEPATITIS C INHIBITING TRIPEPTIDES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993092A (en) |
-
1999
- 1999-08-10 EC ECSP993092 patent/ECSP993092A/en unknown
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