ECSP993099A - TACE INHIBITORS - Google Patents
TACE INHIBITORSInfo
- Publication number
- ECSP993099A ECSP993099A ECSP993099A ECSP993099A EC SP993099 A ECSP993099 A EC SP993099A EC SP993099 A ECSP993099 A EC SP993099A EC SP993099 A ECSP993099 A EC SP993099A
- Authority
- EC
- Ecuador
- Prior art keywords
- cancer
- treatment
- inhibitors
- combination
- tace inhibitors
- Prior art date
Links
- 239000002447 tumor necrosis factor alpha converting enzyme inhibitor Substances 0.000 title 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 abstract 2
- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 abstract 1
- WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 229940009456 adriamycin Drugs 0.000 abstract 1
- 229930013930 alkaloid Natural products 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- 229960004316 cisplatin Drugs 0.000 abstract 1
- 238000002648 combination therapy Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 abstract 1
- 229960005420 etoposide Drugs 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 229940124641 pain reliever Drugs 0.000 abstract 1
- -1 taxate Natural products 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 abstract 1
- 229960004528 vincristine Drugs 0.000 abstract 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
(gráfico), en la que R1, R2, R3, R4, R5, R6, y Q son como se han definido antes, útil en el tratamiento de artritis, cáncer y otras enfermedades que implican una producción / liberación no regulada de reprolisinas como TNF y otras enfermedades caracterizadas por actividad de metaloproteinasas de la matriz. Además, los compuestos de la presente invención se pueden usar en terapia de combinación con fármacos antiinflamatorios no esteroides (AINE), inhibidores de la COX-2 y analgésicos convencionales, y en el tratamiento de cáncer, en combinación con fármacos citotóxicos como adriamicina, daunomicina, cisplatino, etopósido, taxol, taxótero y otros alcaloides como vincristina.(graph), in which R1, R2, R3, R4, R5, R6, and Q are as defined above, useful in the treatment of arthritis, cancer, and other diseases involving an unregulated production / release of reprolysins such as TNF and other diseases characterized by activity of matrix metalloproteinases. Furthermore, the compounds of the present invention can be used in combination therapy with non-steroidal anti-inflammatory drugs (NSAIDs), COX-2 inhibitors and conventional pain relievers, and in the treatment of cancer, in combination with cytotoxic drugs such as adriamycin, daunomycin , cisplatin, etoposide, taxol, taxate, and other alkaloids such as vincristine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993099 ECSP993099A (en) | 1999-08-12 | 1999-08-12 | TACE INHIBITORS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993099 ECSP993099A (en) | 1999-08-12 | 1999-08-12 | TACE INHIBITORS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993099A true ECSP993099A (en) | 1999-10-06 |
Family
ID=42044086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993099 ECSP993099A (en) | 1999-08-12 | 1999-08-12 | TACE INHIBITORS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993099A (en) |
-
1999
- 1999-08-12 EC ECSP993099 patent/ECSP993099A/en unknown
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