ECSP993105A - THE USE OF ARYL- CYCLLOHEXYLAMINE DERIVATIVES AGAINST DISORDERS OF THE CENTRAL NERVOUS SYSTEM - Google Patents

THE USE OF ARYL- CYCLLOHEXYLAMINE DERIVATIVES AGAINST DISORDERS OF THE CENTRAL NERVOUS SYSTEM

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Publication number
ECSP993105A
ECSP993105A ECSP993105A ECSP993105A EC SP993105 A ECSP993105 A EC SP993105A EC SP993105 A ECSP993105 A EC SP993105A EC SP993105 A ECSP993105 A EC SP993105A
Authority
EC
Ecuador
Prior art keywords
alkyl
cycllohexylamine
aryl
nervous system
central nervous
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Bernd Buettelmann
Emmanuel Pinard
Alexander Alanine
Neidhart Marie Paule Heitz
Rene Wyler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP993105 priority Critical patent/ECSP993105A/en
Publication of ECSP993105A publication Critical patent/ECSP993105A/en

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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere al uso de compuestos de la fórmula general (gráfico), en donde Ar1 representa fenilo, naftilo o tetarhidronaftilo, opcionalmente sustituidos por hidroxi, alcoxi-inferior, nitro, amino o matanosulfonamida; Ar2 representa fenilo, naftilo o tetrahidronaftilo, opcionalmente sustituidos por alquil-inferior o halógeno; X representa C, CH, C(OH) o N; Y representa -CH2-, CH u O Z -CH2-, -CH(CH3)- o -C(CH3)2-; R1 representa hidrógeno, alquil-inferior o acetilo; A representa C=0 o -(CHR2)n, en donde R2 representa hidrógeno, alquil-inferior o alquil-inferior-hidroxi; B representa -(CH2)n-, o, -CH(OH) (CH2)n, CH(CH2OH) (CH2)n-, -(CH2)n CH(OH)- o -CH(CH2OH)-; puede representar un enlace y n representa 0-4 y las sales de adición de ácido aceptables farmacéuticamente para la elaboración de medicamentos que representen indicaciones terapéuticas para bloqueadores específicos de subtipos de receptores NMDA.The present invention relates to the use of compounds of the general formula (graph), wherein Ar1 represents phenyl, naphthyl, or tetarhydronaphthyl, optionally substituted by hydroxy, lower alkoxy, nitro, amino, or matanosulfonamide; Ar2 represents phenyl, naphthyl, or tetrahydronaphthyl, optionally substituted by lower-alkyl or halogen; X represents C, CH, C (OH) or N; Y represents -CH2-, CH or O Z -CH2-, -CH (CH3) - or -C (CH3) 2-; R1 represents hydrogen, lower-alkyl or acetyl; A represents C = 0 or - (CHR2) n, where R2 represents hydrogen, lower-alkyl or lower-alkyl-hydroxy; B represents - (CH2) n-, or, -CH (OH) (CH2) n, CH (CH2OH) (CH2) n-, - (CH2) n CH (OH) - or -CH (CH2OH) -; may represent a bond and n represents 0-4 and pharmaceutically acceptable acid addition salts for the manufacture of medicinal products that represent therapeutic indications for specific blockers of NMDA receptor subtypes.

ECSP993105 1999-08-18 1999-08-18 THE USE OF ARYL- CYCLLOHEXYLAMINE DERIVATIVES AGAINST DISORDERS OF THE CENTRAL NERVOUS SYSTEM ECSP993105A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP993105 ECSP993105A (en) 1999-08-18 1999-08-18 THE USE OF ARYL- CYCLLOHEXYLAMINE DERIVATIVES AGAINST DISORDERS OF THE CENTRAL NERVOUS SYSTEM

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP993105 ECSP993105A (en) 1999-08-18 1999-08-18 THE USE OF ARYL- CYCLLOHEXYLAMINE DERIVATIVES AGAINST DISORDERS OF THE CENTRAL NERVOUS SYSTEM

Publications (1)

Publication Number Publication Date
ECSP993105A true ECSP993105A (en) 2000-03-22

Family

ID=42044092

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP993105 ECSP993105A (en) 1999-08-18 1999-08-18 THE USE OF ARYL- CYCLLOHEXYLAMINE DERIVATIVES AGAINST DISORDERS OF THE CENTRAL NERVOUS SYSTEM

Country Status (1)

Country Link
EC (1) ECSP993105A (en)

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