ECSP993133A - NEW COMPACT ORAL COMPOSITION INCLUDING CATECOL DERIVATIVES - Google Patents
NEW COMPACT ORAL COMPOSITION INCLUDING CATECOL DERIVATIVESInfo
- Publication number
- ECSP993133A ECSP993133A ECSP993133A ECSP993133A EC SP993133 A ECSP993133 A EC SP993133A EC SP993133 A ECSP993133 A EC SP993133A EC SP993133 A ECSP993133 A EC SP993133A
- Authority
- EC
- Ecuador
- Prior art keywords
- oral composition
- catecol
- derivatives
- composition including
- new compact
- Prior art date
Links
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 3
- 229910052708 sodium Inorganic materials 0.000 abstract 3
- 239000011734 sodium Substances 0.000 abstract 3
- UPMRZALMHVUCIN-UHFFFAOYSA-N Nitecapone Chemical compound CC(=O)C(C(C)=O)=CC1=CC(O)=C(O)C([N+]([O-])=O)=C1 UPMRZALMHVUCIN-UHFFFAOYSA-N 0.000 abstract 2
- JRURYQJSLYLRLN-BJMVGYQFSA-N entacapone Chemical compound CCN(CC)C(=O)C(\C#N)=C\C1=CC(O)=C(O)C([N+]([O-])=O)=C1 JRURYQJSLYLRLN-BJMVGYQFSA-N 0.000 abstract 2
- 229960003337 entacapone Drugs 0.000 abstract 2
- 229950008980 nitecapone Drugs 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
La presente invención se relaciona con una composición oral compactada que comprende entacapona, nitecapona o una sal farmacéuticamente aceptable de las mismas y croscamelosa de sodio. La composición se fundamente en el descubrimiento de que la croscamelosa de sodio aumenta la velocidad de liberación de la entacapona o de la nitecapona de una composición oral compactada. de preferencia, la cantidad de crocarmelosa de sodio en la composición es el de al menos 6% en peso, preferentemente, de aproximadamente 8% a proximadamente 16% en peso y, especialemente de aproximadamente 10% a paroximadamente 14% en peso.The present invention relates to a compacted oral composition comprising entacapone, nitecapone, or a pharmaceutically acceptable salt thereof and croscamellose sodium. The composition is based on the discovery that croscamellose sodium increases the rate of release of entacapone or nitecapone from a compacted oral composition. Preferably, the amount of crocarmellose sodium in the composition is at least 6% by weight, preferably from about 8% to about 16% by weight, and especially from about 10% to about 14% by weight.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993133 ECSP993133A (en) | 1999-09-10 | 1999-09-10 | NEW COMPACT ORAL COMPOSITION INCLUDING CATECOL DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993133 ECSP993133A (en) | 1999-09-10 | 1999-09-10 | NEW COMPACT ORAL COMPOSITION INCLUDING CATECOL DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993133A true ECSP993133A (en) | 1999-12-23 |
Family
ID=42044121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993133 ECSP993133A (en) | 1999-09-10 | 1999-09-10 | NEW COMPACT ORAL COMPOSITION INCLUDING CATECOL DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993133A (en) |
-
1999
- 1999-09-10 EC ECSP993133 patent/ECSP993133A/en unknown
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