ECSP993159A - MONONITRATE DERIVATIVES OF ISOSORBIDE AND ITS USE AS VASODILATOR AGENTS WITH DECREASED TOLERANCE - Google Patents
MONONITRATE DERIVATIVES OF ISOSORBIDE AND ITS USE AS VASODILATOR AGENTS WITH DECREASED TOLERANCEInfo
- Publication number
- ECSP993159A ECSP993159A ECSP993159A ECSP993159A EC SP993159 A ECSP993159 A EC SP993159A EC SP993159 A ECSP993159 A EC SP993159A EC SP993159 A ECSP993159 A EC SP993159A
- Authority
- EC
- Ecuador
- Prior art keywords
- group
- aryl
- graph
- aralkyl
- alkyl
- Prior art date
Links
- 206010052805 Drug tolerance decreased Diseases 0.000 title abstract 2
- 239000003071 vasodilator agent Substances 0.000 title abstract 2
- KLDXJTOLSGUMSJ-JGWLITMVSA-N Isosorbide Chemical class O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 KLDXJTOLSGUMSJ-JGWLITMVSA-N 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 229910004679 ONO2 Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical class [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen nuevos derivados de mononitrato de isosorbida y sus sales farmacéuticamente aceptables, que poseen actividad vasodilatadora con un efecto de tolerancia disminuido, de fórmula general I (gráfico), en la que A y B representan indistintamente cualquiera de los grupos -ONO; y -Z-CO-R, siendo Z un átomo de oxígeno o de azufre, y R un grupo alquilo C1-C4, arilo o aralquilo, eventualmente substituido, o el grupo (gráfico), en el que R1 es hidrógeno o un grupo alquilo C1-C4, arilo o aralquilo, eventualmente susbstituido, de manera que siempre uno de A o B es -ONO2, pero nunca los dos a la vez, cuando Z es un átomo de azufre R es un grupo alquilo C1-C4, arilo o aralquilo, eventualmente substituido, y cuando Z es un átomo de oxígeno R es el grupo (gráfico).Novel isosorbide mononitrate derivatives and their pharmaceutically acceptable salts are described, which have vasodilator activity with a decreased tolerance effect, of general formula I (graph), in which A and B represent indistinctly any of the -ONO groups; and -Z-CO-R, where Z is an oxygen or sulfur atom, and R is an optionally substituted C1-C4 alkyl, aryl or aralkyl group, or the group (graph), in which R1 is hydrogen or a group C1-C4 alkyl, aryl or aralkyl, possibly substituted, so that always one of A or B is -ONO2, but never both at the same time, when Z is a sulfur atom R is a C1-C4 alkyl group, aryl or aralkyl, optionally substituted, and when Z is an oxygen atom R is the group (graph).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993159 ECSP993159A (en) | 1999-09-29 | 1999-09-29 | MONONITRATE DERIVATIVES OF ISOSORBIDE AND ITS USE AS VASODILATOR AGENTS WITH DECREASED TOLERANCE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993159 ECSP993159A (en) | 1999-09-29 | 1999-09-29 | MONONITRATE DERIVATIVES OF ISOSORBIDE AND ITS USE AS VASODILATOR AGENTS WITH DECREASED TOLERANCE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993159A true ECSP993159A (en) | 2000-01-27 |
Family
ID=42044147
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993159 ECSP993159A (en) | 1999-09-29 | 1999-09-29 | MONONITRATE DERIVATIVES OF ISOSORBIDE AND ITS USE AS VASODILATOR AGENTS WITH DECREASED TOLERANCE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993159A (en) |
-
1999
- 1999-09-29 EC ECSP993159 patent/ECSP993159A/en unknown
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| ECSP993159A (en) | MONONITRATE DERIVATIVES OF ISOSORBIDE AND ITS USE AS VASODILATOR AGENTS WITH DECREASED TOLERANCE |