ECSP993163A - NEW BIS - BENZIMIDAZOLES - Google Patents

NEW BIS - BENZIMIDAZOLES

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Publication number
ECSP993163A
ECSP993163A ECSP993163A ECSP993163A EC SP993163 A ECSP993163 A EC SP993163A EC SP993163 A ECSP993163 A EC SP993163A EC SP993163 A ECSP993163 A EC SP993163A
Authority
EC
Ecuador
Prior art keywords
hydrogen
halogen
carbon atoms
benzimidazoles
hydroxy
Prior art date
Application number
Other languages
Spanish (es)
Inventor
Mitsuyuki Shimada
Karl Heinz Schlemmer
Toshiki Murata
Siegfried Raddatz
Joachim Mittendorf
Rolf Henning
Makiko Hiraoka
Hiroshi Kadono
Muneto Mogi
Toshiya Moriwaki
Sachiko Sakakibara
Nagahiro Yoshida
Takashi Yoshino
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to ECSP993163 priority Critical patent/ECSP993163A/en
Publication of ECSP993163A publication Critical patent/ECSP993163A/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos bis-benzimidazoles de la fórmula general (I): (gráfico), en la cual: R1, R2, R3 y R4 son hidrógeno, hidroxi o halógeno; R5 y R6 son hidrógeno, o alquilo de 1 a 4 átomos de carbono; R6 y R7 son hidrógeno, o alquilo de 1 a 6 átomos de carbono, hidroxi, halógeno, o alcoxi de 1 a 6 átomos de carbono; R9, R10 y R11 son hidrógeno, halógeno, nitro, ciano o trifluormetilo, y A es un heterociclo no aromático, de 5 a 7 miembros, etc; proceso para preparación y su utilización para tratar enfermedades asociadas con la actividad de la triptasa, tales como el asma y la rinitis alérgica.Bis-benzimidazole compounds of the general formula (I): (graph), in which: R1, R2, R3 and R4 are hydrogen, hydroxy or halogen; R5 and R6 are hydrogen, or alkyl of 1 to 4 carbon atoms; R6 and R7 are hydrogen, or alkyl of 1 to 6 carbon atoms, hydroxy, halogen, or alkoxy of 1 to 6 carbon atoms; R9, R10 and R11 are hydrogen, halogen, nitro, cyano or trifluoromethyl, and A is a 5- to 7-membered non-aromatic heterocycle, etc; process for preparation and its use to treat diseases associated with tryptase activity, such as asthma and allergic rhinitis.

ECSP993163 1999-10-01 1999-10-01 NEW BIS - BENZIMIDAZOLES ECSP993163A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ECSP993163 ECSP993163A (en) 1999-10-01 1999-10-01 NEW BIS - BENZIMIDAZOLES

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ECSP993163 ECSP993163A (en) 1999-10-01 1999-10-01 NEW BIS - BENZIMIDAZOLES

Publications (1)

Publication Number Publication Date
ECSP993163A true ECSP993163A (en) 1999-11-29

Family

ID=42044151

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP993163 ECSP993163A (en) 1999-10-01 1999-10-01 NEW BIS - BENZIMIDAZOLES

Country Status (1)

Country Link
EC (1) ECSP993163A (en)

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