ECSP993170A - NEW METHOD FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH A GSK-3 INHIBITION NEED - Google Patents
NEW METHOD FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH A GSK-3 INHIBITION NEEDInfo
- Publication number
- ECSP993170A ECSP993170A ECSP993170A ECSP993170A EC SP993170 A ECSP993170 A EC SP993170A EC SP993170 A ECSP993170 A EC SP993170A EC SP993170 A ECSP993170 A EC SP993170A
- Authority
- EC
- Ecuador
- Prior art keywords
- substituted
- unsubstituted
- phenyl
- hydrogen
- alkyl
- Prior art date
Links
- FHCSBLWRGCOVPT-UHFFFAOYSA-N AZD2858 Chemical compound C1CN(C)CCN1S(=O)(=O)C1=CC=C(C=2N=C(C(N)=NC=2)C(=O)NC=2C=NC=CC=2)C=C1 FHCSBLWRGCOVPT-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 4
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 3
- -1 diabetes Chemical compound 0.000 abstract 3
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 208000028683 bipolar I disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Un método para el tratamiento de condiciones asociadas con una necesidad de inhibición de la GSK-3, tales como diabetes, demencias tales como la enfermedad de Alzheimer y la depresión maniaca, cuyo método comprende la administración de una cantidad no tóxica, farmacéuticamente eficaz, de un compuesto de fórmula I: (gráfico), o un derivado farmacéuticamente aceptable de este en que: R es hidrógeno, alquilo, arilo o arialquilo; R1 es hidrógeno, alquilo, arialquilo, hidroxialquilo o alcoxialquilo; R2 es arilo sustituido o sin sustituir o heterociclilo sustituido o sin sustituir; R3 es hidrógeno, alquilo sustituido o sin sustituir, ciclo9alquilo, alcoxialquilo, arilo sustituido o sin sustituir, heterociclilo sustituido o sin sustituir o arilalquilo en que el resto arilo está sustituido o sin sustituir; o R1 y R3 conjuntamente con el nitrógeno al que estan unidos forman un anillo heterociclico saturado o insaturado, opcionalmente sustituido, único o condensado; a un mamífero humano o no humano con necesidad de ello. en la que R y R1 son como se han definido en relación con la fórmula I; R2 es fenilo, sustituido o indolilo; R3 es hidrógeno, alquilo, cicloalquilo, fenilo, fenilo sustituido, alquil C1-6-fenilo, en que el grupo fenilo está opcionalemnte sustituido alcoxialquilo, heterociclilo sustituido o sin sustituir.A method for treating conditions associated with a need for GSK-3 inhibition, such as diabetes, dementias such as Alzheimer's disease, and manic depression, the method of which comprises the administration of a non-toxic, pharmaceutically effective amount of a compound of formula I: (graph), or a pharmaceutically acceptable derivative thereof where: R is hydrogen, alkyl, aryl, or aryalkyl; R1 is hydrogen, alkyl, arialkyl, hydroxyalkyl, or alkoxyalkyl; R2 is substituted or unsubstituted aryl or substituted or unsubstituted heterocyclyl; R3 is hydrogen, substituted or unsubstituted alkyl, cyclo9alkyl, alkoxyalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or arylalkyl in which the aryl moiety is substituted or unsubstituted; or R1 and R3 together with the nitrogen to which they are attached form an optionally substituted, single or fused saturated or unsaturated heterocyclic ring; to a human or non-human mammal in need of it. wherein R and R1 are as defined in relation to formula I; R2 is phenyl, substituted or indolyl; R3 is hydrogen, alkyl, cycloalkyl, phenyl, substituted phenyl, C1-6alkyl-phenyl, in which the phenyl group is optionally substituted alkoxyalkyl, substituted or unsubstituted heterocyclyl.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993170 ECSP993170A (en) | 1999-10-07 | 1999-10-07 | NEW METHOD FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH A GSK-3 INHIBITION NEED |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993170 ECSP993170A (en) | 1999-10-07 | 1999-10-07 | NEW METHOD FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH A GSK-3 INHIBITION NEED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993170A true ECSP993170A (en) | 2000-01-27 |
Family
ID=42044158
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993170 ECSP993170A (en) | 1999-10-07 | 1999-10-07 | NEW METHOD FOR THE TREATMENT OF CONDITIONS ASSOCIATED WITH A GSK-3 INHIBITION NEED |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993170A (en) |
-
1999
- 1999-10-07 EC ECSP993170 patent/ECSP993170A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2000021927A3 (en) | Pyrrole-2,5-diones as gsk-3 inhibitors | |
| NO20072115L (en) | Pharmaceutical compounds | |
| CO5080780A1 (en) | AMIDA DERIVATIVE AND NOCICEPTINE ANTAGONIST | |
| BRPI0413233A (en) | new compounds | |
| DK1323710T3 (en) | Nitrogen-containing five-membered ring compounds | |
| AR047076A1 (en) | PIRROLOTRIAZINE COMPOUNDS AS THYROSINE KINASE INHIBITORS, PHARMACEUTICAL COMPOSITIONS | |
| IL164487A0 (en) | 3-Heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides | |
| PE20081679A1 (en) | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | |
| TW200800938A (en) | Indole carboxylic acid derivatives exhibiting PGD2 receptor antagonism | |
| AR035716A1 (en) | BETA3-ADRENERGIC RECEIVER AGONIST COMPOUNDS, USE OF THE SAME IN THE MANUFACTURE OF PHARMACEUTICAL MEDICINES AND COMPOSITIONS CONTAINING THE SAME | |
| PE20090276A1 (en) | COMPOUNDS DERIVED FROM IMIDAZOQUINOLINE AS MODULATORS OF TLR7 | |
| PE20071100A1 (en) | DERIVATIVES OF AZEPINOINDOL AS PHARMACEUTICAL AGENTS | |
| DE69835877D1 (en) | TRICYCLIC CONNECTIONS | |
| CO5590957A2 (en) | AMINO-1,3,5-TRIAZINES REPLACED IN N WITH CHIRAL BICYCLE RADICALS, PROCEDURE FOR PREPARATION, COMPOSITIONS OF THE SAME AND ITS USE AS HERBICIDES AND REGULATORS OF GROWTH OF PLANTS | |
| AR065811A1 (en) | DERIVATIVES OF 2-AMINO-4H-IMIDAZOL-4-ONA, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS. | |
| TW200744587A (en) | Azaindole derivatives exhibiting PGD2 receptor antagonism | |
| ATE173256T1 (en) | AZOLIDINDONE DERIVATIVES AND THEIR USE AS ANTIHYPERGLYCEMICS | |
| ES2476422T3 (en) | 3,5-substituted piperidine compounds as renin inhibitors | |
| RU2011102396A (en) | AMINO COMPOUNDS AND THEIR MEDICAL USE | |
| AR045791A1 (en) | TRIAZOL DERIVATIVES REPLACED AS AN OXITOCINE ANTAGONISTS | |
| BG94282A (en) | 2,9-DISUBSTITUTED-4H-PYRIDO/1,2,-A/PYRIMIDIN-4-ONES | |
| AR094123A1 (en) | TRICYCLE COMPOUND | |
| PE20050442A1 (en) | DERIVATIVES OF 8-AZONIABICICLO [3.2.1] OCTANE AS ANTAGONISTS OF MUSCARINE ACETYLCHOLINE RECEPTORS | |
| PE20070212A1 (en) | 1,4-DIHYDROPYRIDINE-CONDENSED HETEROCYCLES, PROCESSES TO PREPARE THE SAME, USE AND COMPOSITIONS CONTAINING THEM | |
| MXPA02011464A (en) | 1,4 diazepan 2,5 dione derivatives and their use as nk 1 receptor antagonists. |