ECSP993184A - PYRAZOLOPYRIMIDINONES INHIBITORS OF cGMP PDE5 FOR THE TREATMENT OF SEXUAL DYSFUNCTION - Google Patents
PYRAZOLOPYRIMIDINONES INHIBITORS OF cGMP PDE5 FOR THE TREATMENT OF SEXUAL DYSFUNCTIONInfo
- Publication number
- ECSP993184A ECSP993184A ECSP993184A ECSP993184A EC SP993184 A ECSP993184 A EC SP993184A EC SP993184 A ECSP993184 A EC SP993184A EC SP993184 A ECSP993184 A EC SP993184A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- optionally substituted
- treatment
- sexual dysfunction
- inhibitors
- Prior art date
Links
- ZOOGRGPOEVQQDX-UUOKFMHZSA-N 3',5'-cyclic GMP Chemical compound C([C@H]1O2)OP(O)(=O)O[C@H]1[C@@H](O)[C@@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-UUOKFMHZSA-N 0.000 title abstract 2
- 101100189582 Dictyostelium discoideum pdeD gene Proteins 0.000 title abstract 2
- 101150098694 PDE5A gene Proteins 0.000 title abstract 2
- 201000001880 Sexual dysfunction Diseases 0.000 title abstract 2
- 102100029175 cGMP-specific 3',5'-cyclic phosphodiesterase Human genes 0.000 title abstract 2
- 231100000872 sexual dysfunction Toxicity 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- NYHBQMYGNKIUIF-UUOKFMHZSA-N Guanosine Chemical compound C1=NC=2C(=O)NC(N)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O NYHBQMYGNKIUIF-UUOKFMHZSA-N 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- MIKUYHXYGGJMLM-GIMIYPNGSA-N Crotonoside Natural products C1=NC2=C(N)NC(=O)N=C2N1[C@H]1O[C@@H](CO)[C@H](O)[C@@H]1O MIKUYHXYGGJMLM-GIMIYPNGSA-N 0.000 abstract 1
- NYHBQMYGNKIUIF-UHFFFAOYSA-N D-guanosine Natural products C1=2NC(N)=NC(=O)C=2N=CN1C1OC(CO)C(O)C1O NYHBQMYGNKIUIF-UHFFFAOYSA-N 0.000 abstract 1
- 208000010228 Erectile Dysfunction Diseases 0.000 abstract 1
- 229940124639 Selective inhibitor Drugs 0.000 abstract 1
- 102000011016 Type 5 Cyclic Nucleotide Phosphodiesterases Human genes 0.000 abstract 1
- 108010037581 Type 5 Cyclic Nucleotide Phosphodiesterases Proteins 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclic monophosphate Chemical class 0.000 abstract 1
- 229940029575 guanosine Drugs 0.000 abstract 1
- 125000004438 haloalkoxy group Chemical group 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 201000001881 impotence Diseases 0.000 abstract 1
- 125000002757 morpholinyl group Chemical group 0.000 abstract 1
- 125000003386 piperidinyl group Chemical group 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de las formulas IA o IB: en las que R''es alquilo C1 a C3 opcionalmente sustituido con fenilo, Het o un grupo heterociclico unido a N seleccionado entre piperidinilo y morfolinilo;en donde dicho grupo fenilo esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre alcoxi C1 a C4;halo;CN;CF3, OCF3 0 alquilo C1 a C4, en donde dicho grupo alquilo C1 a C4 esta opcionalmente sustituido con haloalquilo o haloalcoxi C1 a C4, estando cualquiera de ellos sustituido con o mas atomos de halo;R2 es alquilo C1 a C6 y R13 es OR3 0 NR5R6, o las sales farmaceutica o veterinariamente aceptables de los mismos, o los solvatos farmaceutica o veterinariamente aceptables de cualquier entidad, son inhibidores potentes y selectivos de la guanosina 3'', 5'' monofosfato ciclica fosfodiesterasa de tipo 5, (GMPc PDE5), y tienen utilidad en el tratamiento de, entre otros, la disfuncion erectil en machos, MED, y la disfuncion sexual en hembras, FSD.Compounds of formulas IA or IB: wherein R''is C1 to C3 alkyl optionally substituted with phenyl, Het or an N-linked heterocyclic group selected from piperidinyl and morpholinyl; wherein said phenyl group is optionally substituted with one or more substituents selected from C1 to C4 alkoxy; halo; CN; CF3, OCF3 or C1 to C4 alkyl, wherein said C1 to C4 alkyl group is optionally substituted with haloalkyl or C1 to C4 haloalkoxy, any of them being substituted with or more atoms halo; R2 is C1 to C6 alkyl and R13 is OR3 0 NR5R6, or the pharmaceutically or veterinarily acceptable salts thereof, or the pharmaceutically or veterinarily acceptable solvates of any entity, are potent and selective inhibitors of guanosine 3 '', 5 '' cyclic monophosphate phosphodiesterase type 5, (cGMP PDE5), and have utility in the treatment of, inter alia, erectile dysfunction in males, MED, and sexual dysfunction in females, FSD.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993184 ECSP993184A (en) | 1999-10-20 | 1999-10-20 | PYRAZOLOPYRIMIDINONES INHIBITORS OF cGMP PDE5 FOR THE TREATMENT OF SEXUAL DYSFUNCTION |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993184 ECSP993184A (en) | 1999-10-20 | 1999-10-20 | PYRAZOLOPYRIMIDINONES INHIBITORS OF cGMP PDE5 FOR THE TREATMENT OF SEXUAL DYSFUNCTION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993184A true ECSP993184A (en) | 2000-06-19 |
Family
ID=42044173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993184 ECSP993184A (en) | 1999-10-20 | 1999-10-20 | PYRAZOLOPYRIMIDINONES INHIBITORS OF cGMP PDE5 FOR THE TREATMENT OF SEXUAL DYSFUNCTION |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993184A (en) |
-
1999
- 1999-10-20 EC ECSP993184 patent/ECSP993184A/en unknown
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