ECSP993203A - PIRAZOLOPIRIDINE DERIVATIVES - Google Patents
PIRAZOLOPIRIDINE DERIVATIVESInfo
- Publication number
- ECSP993203A ECSP993203A ECSP993203A ECSP993203A EC SP993203 A ECSP993203 A EC SP993203A EC SP993203 A ECSP993203 A EC SP993203A EC SP993203 A ECSP993203 A EC SP993203A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- alkoxy
- fluorine atoms
- derivatives
- pirazolopiridine
- Prior art date
Links
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000001153 fluoro group Chemical group F* 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010037660 Pyrexia Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229940111134 coxibs Drugs 0.000 abstract 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La invención proporciona los compuestos de fórmula (I) y derivados del mismo, farmacéuticamente aceptables en los cuales: R0 y R1 se seleccionan independientemente de Hidrógeno, halógeno, alquilo C1-6, alcoxi C1-6 , o alcoxi C1-6 substituido por uno o más átomos de flúor; R2 es hidrógeno, alquilo C1-6, alquilo C1-6 substituido por uno o mas átomos de flúor, alcoxi C1-6, hidroxialquilo C1-6, alquilo SC1-6, C(O)H, alquilo C(O)C1-6, alquilsulfonilo C1-6, alcoxi C1-6 substituido por uno o más átomos de flúor; y R3 es alquilo C1-6 o NH2. Compuestos de fórmula (I) son inhibidores potentes y selectivos de COX-2 y son de uso en el tratamiento del dolor, fiebre, inflamación de una variedad de condiciones y padecimientos.The invention provides the compounds of formula (I) and pharmaceutically acceptable derivatives thereof in which: R0 and R1 are independently selected from Hydrogen, halogen, C1-6 alkyl, C1-6 alkoxy, or C1-6 alkoxy substituted by one or more fluorine atoms; R2 is hydrogen, C1-6 alkyl, C1-6 alkyl substituted by one or more fluorine atoms, C1-6 alkoxy, C1-6 hydroxyalkyl, SC1-6 alkyl, C (O) H, C (O) C1- alkyl 6, C1-6 alkylsulfonyl, C1-6 alkoxy substituted by one or more fluorine atoms; and R3 is C1-6 alkyl or NH2. Compounds of formula (I) are potent and selective COX-2 inhibitors and are of use in the treatment of pain, fever, inflammation of a variety of conditions and conditions.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993203 ECSP993203A (en) | 1999-11-03 | 1999-11-03 | PIRAZOLOPIRIDINE DERIVATIVES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993203 ECSP993203A (en) | 1999-11-03 | 1999-11-03 | PIRAZOLOPIRIDINE DERIVATIVES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993203A true ECSP993203A (en) | 2001-06-22 |
Family
ID=42044191
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993203 ECSP993203A (en) | 1999-11-03 | 1999-11-03 | PIRAZOLOPIRIDINE DERIVATIVES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993203A (en) |
-
1999
- 1999-11-03 EC ECSP993203 patent/ECSP993203A/en unknown
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