ECSP993274A - NK1 RECEPTOR ANTAGONISTS - Google Patents
NK1 RECEPTOR ANTAGONISTSInfo
- Publication number
- ECSP993274A ECSP993274A ECSP993274A ECSP993274A EC SP993274 A ECSP993274 A EC SP993274A EC SP993274 A ECSP993274 A EC SP993274A EC SP993274 A ECSP993274 A EC SP993274A
- Authority
- EC
- Ecuador
- Prior art keywords
- alkyl
- receptor antagonists
- aryl
- antagonists
- nhconh
- Prior art date
Links
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 title 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 150000003869 acetamides Chemical class 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Los derivados de acetamida que no contiene péptido de la fórmula I son antagonistas de NK, especificos (gráfico), donde R es arilo, R1 y R2 son H o alquilo m, n y q son números enteros de 0 a 4, X es NR6 o NHCONH, R3 y R9 son H o alquilo, R4 es naftilo o indolilo, R5 y R2 son H o alquilo, y R6 es arilo. Los compuestos son agentes útiles para el tratamiento de trastornos inflamatorios y alérgicos, dolor, ansiedad, depresión, esquizofrenia y émesis.Non-peptide-containing acetamide derivatives of formula I are specific NK antagonists (graph), where R is aryl, R1 and R2 are H or m-alkyl, n and q are integers from 0 to 4, X is NR6 or NHCONH , R3 and R9 are H or alkyl, R4 is naphthyl or indolyl, R5 and R2 are H or alkyl, and R6 is aryl. The compounds are useful agents for the treatment of inflammatory and allergic disorders, pain, anxiety, depression, schizophrenia, and emesis.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993274 ECSP993274A (en) | 1999-12-17 | 1999-12-17 | NK1 RECEPTOR ANTAGONISTS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993274 ECSP993274A (en) | 1999-12-17 | 1999-12-17 | NK1 RECEPTOR ANTAGONISTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993274A true ECSP993274A (en) | 2000-03-22 |
Family
ID=42044263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993274 ECSP993274A (en) | 1999-12-17 | 1999-12-17 | NK1 RECEPTOR ANTAGONISTS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993274A (en) |
-
1999
- 1999-12-17 EC ECSP993274 patent/ECSP993274A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR004516A1 (en) | DERIVATIVES OF PYRIMIDINE, ITS USE, PROCEDURES TO PREPARE THEM AND MEDICINES THAT CONTAIN THEM | |
| ATE161821T1 (en) | AZYCLIC ETHYLENEDIAMINE DERIVATIVES AS 'SUBSTANCE P RECEPTOR' ANTAGONISTS | |
| DE69328975D1 (en) | AMINOMETHYLENE SUBSTITUTED HETEROCYCLIC COMPOUNDS AND THEIR USE AS ALSO SUBSTANCE P ANTAGONISTS | |
| PE20040512A1 (en) | PYRAZOLE-PYRIMIDINE ANILINE COMPOUND | |
| MX9100308A (en) | QUINUCLIDINE DERIVATIVES | |
| ATE188472T1 (en) | 4-ARYLMETHYLOXYMETHYL PIPERIDINE AS TACHYKININ ANTAGONISTS | |
| NO981496D0 (en) | Imidazole derivatives with affinity for <alfa> 2 receptor activity | |
| PE46899A1 (en) | N-PHENYL-SULFONAMIDE DERIVATIVES | |
| EP0945445A4 (en) | 1,5-BENZODIAZEPINE DERIVATIVES | |
| BG101110A (en) | SUBSTITUTED PIRIMIDINE COMPOUNDS AND THEIR USE | |
| DE69805781D1 (en) | SUBSTITUTED 4-ARYLMETHYLENE-2-IMINO-2,3-DIHYDROTHIAZOLES, THEIR DERIVATIVES, AND THEIR PHARMACEUTICAL USE | |
| MXPA02011417A (en) | Substituted 1 aminoalkyl lactams and their use as muscarinic receptor antagonists. | |
| DE69115297D1 (en) | LEUKOTRIA B4 ANTAGONISTS. | |
| MXPA02011418A (en) | Substituted 1 aminoalkyl lactams and their use as muscarinic receptor antagonists. | |
| MX9302178A (en) | PEPTIDE COMPOUNDS. | |
| BR9306221A (en) | Acylaminoindole derivatives as 5-htl agonists | |
| DK0902018T3 (en) | 2- (arylpheny) amino-imidazoline derivatives | |
| PE20001384A1 (en) | NON-PEPTIDIC ACETAMIDE DERIVATIVES AS NK1 RECEPTOR ANTAGONISTS | |
| ES2167617T3 (en) | DERIVATIVES OF 1-BENCENOSULFONILPIRROLIDINA AS ANTAGONISTS OF THE BRADIQUININE RECEPTOR. | |
| CY1108837T1 (en) | New aminopyridine derivatives as mGluR5 antagonists | |
| MXPA02011464A (en) | 1,4 diazepan 2,5 dione derivatives and their use as nk 1 receptor antagonists. | |
| ECSP993274A (en) | NK1 RECEPTOR ANTAGONISTS | |
| AR021094A1 (en) | INHIBITING HETEROCICLICAL COMPOUNDS OF PHOSPHODIESTERASE IV AND ITS USE FOR THE TREATMENT OF INFLAMMATORY DISEASES | |
| DE69616357D1 (en) | BENZOCYCLOALKEN COMPOUNDS WITH BINDING SFFINITY TO THE MELATONIN RECEPTOR, THEIR PRODUCTION AND USE | |
| DE69925160D1 (en) | ARYLPIPERIDINE AND ARYL 1,2,5,6-TETRAHYDROPYRIDINAMIDE DERIVATIVES WITH 5HT1A RECEPTOR ACTIVITY |