ECSP993282A - 4 - ARYLOXINDOLES - Google Patents
4 - ARYLOXINDOLESInfo
- Publication number
- ECSP993282A ECSP993282A ECSP993282A ECSP993282A EC SP993282 A ECSP993282 A EC SP993282A EC SP993282 A ECSP993282 A EC SP993282A EC SP993282 A ECSP993282 A EC SP993282A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- pharmaceutically acceptable
- formula
- treatment
- acceptable salts
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 5
- 108091007914 CDKs Proteins 0.000 abstract 2
- 102000003903 Cyclin-dependent kinases Human genes 0.000 abstract 2
- 108090000266 Cyclin-dependent kinases Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 102000015792 Cyclin-Dependent Kinase 2 Human genes 0.000 abstract 1
- 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Este invento se refiere alkenyl-4-y 4-alkynyl oxindoles tener la formulaand las sales farmacéuticamente aceptable del mismo, donde R1, R2, R3, a, b, y X son definidos aquí. Estos compuestos inhiben quinasas dependientes de ciclina (CDKs), en particular CDK2. Estos compuestos y sus sales farmacéuticamente aceptable, y dijo prodrugs de compuestos, son anti-proliferativa agentes útiles en el tratamiento o control de proliferación de células de los trastornos, en particular el cáncer, más en particular, el tratamiento o control de los tumores de mama y colon. Reveló también son composiciones farmacéuticas que contienen los compuestos de fórmula I y II, así como intermediarios útiles en la preparación de los compuestos de fórmula I y II.This invention relates to alkenyl-4-and 4-alkynyl oxindoles having the formuland the pharmaceutically acceptable salts thereof, where R1, R2, R3, a, b, and X are defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and said prodrugs of compounds, are anti-proliferative agents useful in the treatment or control of cell proliferation of disorders, in particular cancer, more particularly, the treatment or control of tumors of breast and colon. It also disclosed are pharmaceutical compositions containing the compounds of formula I and II, as well as intermediates useful in the preparation of the compounds of formula I and II.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993282 ECSP993282A (en) | 1999-12-17 | 1999-12-17 | 4 - ARYLOXINDOLES |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP993282 ECSP993282A (en) | 1999-12-17 | 1999-12-17 | 4 - ARYLOXINDOLES |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP993282A true ECSP993282A (en) | 2000-07-21 |
Family
ID=42044272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP993282 ECSP993282A (en) | 1999-12-17 | 1999-12-17 | 4 - ARYLOXINDOLES |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP993282A (en) |
-
1999
- 1999-12-17 EC ECSP993282 patent/ECSP993282A/en unknown
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