EE03048B1 - Method for the preparation of lovastatin - Google Patents

Method for the preparation of lovastatin

Info

Publication number
EE03048B1
EE03048B1 EE9400129A EE9400129A EE03048B1 EE 03048 B1 EE03048 B1 EE 03048B1 EE 9400129 A EE9400129 A EE 9400129A EE 9400129 A EE9400129 A EE 9400129A EE 03048 B1 EE03048 B1 EE 03048B1
Authority
EE
Estonia
Prior art keywords
lovastatin
preparation
Prior art date
Application number
EE9400129A
Other languages
Estonian (et)
Inventor
S. Dahiya Jagroop
Original Assignee
Novopharm Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002062023A external-priority patent/CA2062023A1/en
Application filed by Novopharm Limited filed Critical Novopharm Limited
Publication of EE03048B1 publication Critical patent/EE03048B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/40Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42Hydroxy-carboxylic acids
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A20/00Water conservation; Efficient water supply; Efficient water use
    • Y02A20/40Protecting water resources
    • Y02A20/402River restoration

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
EE9400129A 1992-02-10 1994-11-14 Method for the preparation of lovastatin EE03048B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83349692A 1992-02-10 1992-02-10
CA002062023A CA2062023A1 (en) 1992-02-10 1992-02-27 Novel fungal strains and use thereof in antibiotic production

Publications (1)

Publication Number Publication Date
EE03048B1 true EE03048B1 (en) 1997-10-15

Family

ID=25674996

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9400129A EE03048B1 (en) 1992-02-10 1994-11-14 Method for the preparation of lovastatin

Country Status (18)

Country Link
EP (1) EP0556699A1 (en)
JP (1) JPH0622780A (en)
CN (1) CN1076965A (en)
AU (1) AU667498B2 (en)
BG (1) BG61180B1 (en)
BR (1) BR9300467A (en)
CZ (1) CZ17293A3 (en)
EE (1) EE03048B1 (en)
FI (1) FI930561A7 (en)
HR (1) HRP930134A2 (en)
HU (1) HUT67061A (en)
IL (1) IL104481A0 (en)
LV (1) LV10502B (en)
NO (1) NO930446L (en)
NZ (1) NZ245713A (en)
PL (1) PL297691A1 (en)
SI (1) SI9300068A (en)
SK (1) SK5593A3 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6100054A (en) * 1989-05-05 2000-08-08 Baylor College Of Medicine Production for recombinant lactoferrin and lactoferrin polypeptides using DNA sequences in various organisms
US5849881A (en) * 1989-05-05 1998-12-15 Baylor College Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using cDNA sequences in various organisms
IL94183A (en) 1989-05-05 2003-09-17 Baylor College Medicine cDNA SEQUENCE CODING FOR HUMAN LACTOFERRIN PROTEIN OR PORTION THEREOF AND LACTOFERRIN PROTEIN PRODUCED FROM SAID SEQUENCE
US5766939A (en) * 1989-05-05 1998-06-16 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
US5571691A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Production of recombinant lactoferrin and lactoferrin polypeptides using CDNA sequences in various organisms
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
JPH09504436A (en) * 1993-11-02 1997-05-06 メルク エンド カンパニー インコーポレーテッド DNA encoding triol polyketide synthase
US6221637B1 (en) 1996-03-05 2001-04-24 Takeda Chemical Industries, Ltd. Xanthene derivatives, their production and use
US6111081A (en) * 1996-05-31 2000-08-29 Baylor College Of Medicine Lactoferrin variants and uses thereof
PL335227A1 (en) * 1997-02-20 2000-04-10 Dsm Nv Industrial-scale production of valuable compounds by fermentation in a chemically defined medium
NZ500870A (en) * 1998-03-20 2002-03-01 Biogal Gyogyszergyar Metabolic controlled fermentation process for preparing mevinolin (lovastatin)
US6391583B1 (en) 1998-12-18 2002-05-21 Wisconsin Alumni Research Foundation Method of producing antihypercholesterolemic agents
EP1176208A1 (en) * 2000-07-28 2002-01-30 Société des Produits Nestlé S.A. Koji molds and use thereof for preparing cholesterol-lowering products
EP1358343A2 (en) * 2001-02-09 2003-11-05 Unilever N.V. Process for the preparation of one or more statins by fermentation
KR100423892B1 (en) * 2001-12-03 2004-03-22 씨제이 주식회사 A new process of lactonization in the preparation of statins
WO2006035295A1 (en) * 2004-09-27 2006-04-06 Ranbaxy Laboratories Limited Process for the purification of lovastatin
CN102533893A (en) * 2010-12-09 2012-07-04 浙江海正药业股份有限公司 A kind of method for preparing monacolin J
CN104277980B (en) * 2013-07-09 2020-04-21 丰益(上海)生物技术研发中心有限公司 Method for separating and purifying aspergillus oryzae transformant
CN105602856B (en) * 2015-12-16 2019-04-16 浙江师范大学 Aspergillus niger (Aspergillus niger) An-19 bacterial strain and its purposes and fermentation process of the production for Lovastatin
CN108118042B (en) * 2016-11-30 2021-01-15 中国科学院青岛生物能源与过程研究所 2-methylbutyrate side chain hydrolase, Monacolin J-producing aspergillus strain, and construction method and application thereof
CN111117894B (en) * 2019-11-26 2023-11-10 漳州大北农农牧科技有限公司 Aspergillus oryzae strain and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL60219A (en) * 1979-06-15 1985-05-31 Merck & Co Inc Hypocholesteremic fermentation products of the hmg-coa reductase inhibitor type,their preparation and pharmaceutical compositions containing them
JPS63502636A (en) * 1985-12-17 1988-10-06 ルブリゾル ジエネテイクス,インコ−ポレイテツド Isolation of genes for polyketide antibiotic biosynthesis
FI104984B (en) * 1988-08-11 2000-05-15 Dsm Nv Process for the identification of biosynthetic or regulatory genes and their use to improve the production of secondary metabolites

Also Published As

Publication number Publication date
FI930561L (en) 1993-08-11
HUT67061A (en) 1995-01-30
CN1076965A (en) 1993-10-06
NZ245713A (en) 1994-12-22
LV10502B (en) 1995-08-20
BR9300467A (en) 1993-08-17
SK5593A3 (en) 1993-12-08
CZ17293A3 (en) 1993-12-15
IL104481A0 (en) 1993-05-13
HU9300330D0 (en) 1993-04-28
AU3212193A (en) 1993-08-12
PL297691A1 (en) 1994-01-24
FI930561A7 (en) 1993-08-11
HRP930134A2 (en) 1995-10-31
SI9300068A (en) 1993-09-30
FI930561A0 (en) 1993-02-09
JPH0622780A (en) 1994-02-01
NO930446D0 (en) 1993-02-09
BG61180B1 (en) 1997-02-28
LV10502A (en) 1995-02-20
AU667498B2 (en) 1996-03-28
NO930446L (en) 1993-08-11
BG97421A (en) 1994-03-24
EP0556699A1 (en) 1993-08-25

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