EE03447B1 - Meetod muskariinset aktiivsust omavate stereokeemiliselt puhaste oksiimide valmistamiseks - Google Patents

Meetod muskariinset aktiivsust omavate stereokeemiliselt puhaste oksiimide valmistamiseks

Info

Publication number: EE03447B1
Authority: EE; Estonia
Prior art keywords: muscarinic activity; stereochemically pure; oximes; preparing stereochemically; heptan
Prior art date: 1994-06-10

Application number

EE9600176A

Other languages

English (en)

Estonian (et)

Other versions

EE9600176A (et

Inventor

Carlos Jaen Juan

Jerome Thomas Anthony

Bucsh Ruth

Laborde Edgardo

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-10

Filing date

1995-04-18

Publication date

2001-06-15

1995-04-18 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

1997-06-16 Publication of EE9600176A publication Critical patent/EE9600176A/xx

2001-06-15 Publication of EE03447B1 publication Critical patent/EE03447B1/xx

Links

238000000034 method Methods 0.000 title abstract 2
230000003551 muscarinic effect Effects 0.000 title abstract 2
150000002923 oximes Chemical class 0.000 title 1
VZPRMKOCTSUHCR-UHFFFAOYSA-N 1-azabicyclo[2.2.1]heptan-3-one Chemical compound C1CC2C(=O)CN1C2 VZPRMKOCTSUHCR-UHFFFAOYSA-N 0.000 abstract 1
238000010934 O-alkylation reaction Methods 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
NGAZZOYFWWSOGK-UHFFFAOYSA-N ethyl-n-butyl-ketone Natural products CCCCC(=O)CC NGAZZOYFWWSOGK-UHFFFAOYSA-N 0.000 abstract 1
-1 heptan-3-one oximes Chemical class 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
238000013341 scale-up Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

EE9600176A 1994-06-10 1995-04-18 Meetod muskariinset aktiivsust omavate stereokeemiliselt puhaste oksiimide valmistamiseks EE03447B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/257,858 US5514812A (en)	1994-06-10	1994-06-10	Preparation of stereochemically pure oximes with muscarinic activity
PCT/US1995/005033 WO1995034562A1 (en)	1994-06-10	1995-04-18	Preparation of stereochemically pure oximes with muscarinic activity

Publications (2)

Publication Number	Publication Date
EE9600176A EE9600176A (et)	1997-06-16
EE03447B1 true EE03447B1 (et)	2001-06-15

Family

ID=22978073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9600176A EE03447B1 (et)	1994-06-10	1995-04-18	Meetod muskariinset aktiivsust omavate stereokeemiliselt puhaste oksiimide valmistamiseks

Country Status (11)

Country	Link
US (1)	US5514812A (da)
EP (1)	EP0764165B1 (da)
AT (1)	ATE208391T1 (da)
AU (1)	AU2297295A (da)
DE (1)	DE69523753T2 (da)
DK (1)	DK0764165T3 (da)
EE (1)	EE03447B1 (da)
ES (1)	ES2167430T3 (da)
PT (1)	PT764165E (da)
WO (1)	WO1995034562A1 (da)
ZA (1)	ZA954794B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ335784A (en) *	1997-01-27	2000-12-22	Warner Lambert Co	Process for isolation of (z)-azabicyclo oxime ethers by reacting an O-substituted hydroxylamine with an azabicycloketone
AU1753301A (en) *	1999-10-28	2001-05-08	3M Innovative Properties Company	Transdermal drug delivery devices

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3004979A (en) *		1961-10-17		Oximes of certain tetrahydropyridine
DE2019536A1 (de) *	1970-04-23	1971-11-11	Basf Ag	Oximcarbamate
US4158015A (en) *	1978-08-16	1979-06-12	Mobil Oil Corporation	Process for the stereoselective synthesis of the E isomer of aryl alkyl oximes
US4710508A (en) *	1986-12-08	1987-12-01	Warner-Lambert Company	O-substituted tetrahydropyridine oxime cholinergic agents
US5306718A (en) *	1990-03-06	1994-04-26	Warner-Lambert Company	Oxime and amine substituted azabicyclo and azocyclo muscarinic agonists and methods of treatment
IL97266A0 (en) *	1990-03-06	1992-05-25	Warner Lambert Co	Azabicyclo and azacyclo oximes and amines,their preparation and pharmaceutical compositions containing them
GB2258652A (en) *	1991-08-15	1993-02-17	Merck Sharp & Dohme	Pharmaceutically useful azabicyclic oxime ethers
WO1993008191A1 (en) *	1991-10-15	1993-04-29	Warner-Lambert Company	Azabicyclo oxime and amine cholinergic agents and methods of treatment

1994
- 1994-06-10 US US08/257,858 patent/US5514812A/en not_active Expired - Fee Related
1995
- 1995-04-18 DK DK95916486T patent/DK0764165T3/da active
- 1995-04-18 EE EE9600176A patent/EE03447B1/xx not_active IP Right Cessation
- 1995-04-18 WO PCT/US1995/005033 patent/WO1995034562A1/en not_active Ceased
- 1995-04-18 AT AT95916486T patent/ATE208391T1/de not_active IP Right Cessation
- 1995-04-18 PT PT95916486T patent/PT764165E/pt unknown
- 1995-04-18 EP EP95916486A patent/EP0764165B1/en not_active Expired - Lifetime
- 1995-04-18 AU AU22972/95A patent/AU2297295A/en not_active Abandoned
- 1995-04-18 DE DE69523753T patent/DE69523753T2/de not_active Expired - Fee Related
- 1995-04-18 ES ES95916486T patent/ES2167430T3/es not_active Expired - Lifetime
- 1995-06-09 ZA ZA954794A patent/ZA954794B/xx unknown

Also Published As

Publication number	Publication date
AU2297295A (en)	1996-01-05
EP0764165B1 (en)	2001-11-07
WO1995034562A1 (en)	1995-12-21
DE69523753T2 (de)	2002-08-01
DK0764165T3 (da)	2002-02-18
ZA954794B (en)	1996-04-22
ES2167430T3 (es)	2002-05-16
EP0764165A1 (en)	1997-03-26
DE69523753D1 (de)	2001-12-13
PT764165E (pt)	2002-04-29
ATE208391T1 (de)	2001-11-15
US5514812A (en)	1996-05-07
EE9600176A (et)	1997-06-16

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Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2004-12-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20040418