EE03746B1 - Farmatseutiline kompositsioon tsüklooksügenaas-2 vahendatud haiguste raviks, 3-fenüül-4-(4-(metüülsulfonüül) fenüül)-2-(5H)-furanooni kasutamine ja ühikuline oraalne doseerimisvorm - Google Patents

Farmatseutiline kompositsioon tsüklooksügenaas-2 vahendatud haiguste raviks, 3-fenüül-4-(4-(metüülsulfonüül) fenüül)-2-(5H)-furanooni kasutamine ja ühikuline oraalne doseerimisvorm

Info

Publication number
EE03746B1
EE03746B1 EE9800393A EE9800393A EE03746B1 EE 03746 B1 EE03746 B1 EE 03746B1 EE 9800393 A EE9800393 A EE 9800393A EE 9800393 A EE9800393 A EE 9800393A EE 03746 B1 EE03746 B1 EE 03746B1
Authority
EE
Estonia
Prior art keywords
phenyl
furanone
cyclooxygenase
methylsulfonyl
treatment
Prior art date
Application number
EE9800393A
Other languages
English (en)
Estonian (et)
Other versions
EE9800393A (et
Inventor
Hancock Bruno
Winters Conrad
Gertz Barry
Ehrich Elliot
Original Assignee
Merck & Co., Inc.
Merck Frosst Canada & Co. / Merck Frosst Canada &Cie.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26309472&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03746(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9612063.9A external-priority patent/GB9612063D0/en
Application filed by Merck & Co., Inc., Merck Frosst Canada & Co. / Merck Frosst Canada &Cie. filed Critical Merck & Co., Inc.
Publication of EE9800393A publication Critical patent/EE9800393A/xx
Publication of EE03746B1 publication Critical patent/EE03746B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
EE9800393A 1996-05-17 1997-05-13 Farmatseutiline kompositsioon tsüklooksügenaas-2 vahendatud haiguste raviks, 3-fenüül-4-(4-(metüülsulfonüül) fenüül)-2-(5H)-furanooni kasutamine ja ühikuline oraalne doseerimisvorm EE03746B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1787896P 1996-05-17 1996-05-17
GBGB9612063.9A GB9612063D0 (en) 1996-06-10 1996-06-10 Compositions for a once a day treatment of cyclooxygenase-2 mediated diseases
PCT/US1997/008041 WO1997044028A1 (fr) 1996-05-17 1997-05-13 Compositions pour traitement journalier monodose de maladies a mediateur cyclooxygenase-2

Publications (2)

Publication Number Publication Date
EE9800393A EE9800393A (et) 1999-06-15
EE03746B1 true EE03746B1 (et) 2002-06-17

Family

ID=26309472

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800393A EE03746B1 (et) 1996-05-17 1997-05-13 Farmatseutiline kompositsioon tsüklooksügenaas-2 vahendatud haiguste raviks, 3-fenüül-4-(4-(metüülsulfonüül) fenüül)-2-(5H)-furanooni kasutamine ja ühikuline oraalne doseerimisvorm

Country Status (28)

Country Link
US (1) US6063811A (fr)
EP (1) EP0910368A1 (fr)
JP (1) JPH11512754A (fr)
KR (1) KR100373622B1 (fr)
CN (1) CN1140267C (fr)
AR (1) AR012014A1 (fr)
AU (1) AU3004997A (fr)
BG (1) BG103000A (fr)
BR (1) BR9709097A (fr)
CA (1) CA2254061C (fr)
CO (1) CO5050370A1 (fr)
CZ (1) CZ291463B6 (fr)
DZ (1) DZ2200A1 (fr)
EA (1) EA001596B1 (fr)
EE (1) EE03746B1 (fr)
HR (1) HRP970262A2 (fr)
HU (1) HUP9902889A3 (fr)
ID (1) ID16921A (fr)
IL (1) IL126899A (fr)
IS (1) IS4891A (fr)
MY (1) MY116201A (fr)
NO (1) NO985342L (fr)
NZ (1) NZ332670A (fr)
PE (1) PE66998A1 (fr)
PL (1) PL188649B1 (fr)
SK (1) SK284330B6 (fr)
TR (1) TR199802345T2 (fr)
WO (1) WO1997044028A1 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136804A (en) * 1998-03-13 2000-10-24 Merck & Co., Inc. Combination therapy for treating, preventing, or reducing the risks associated with acute coronary ischemic syndrome and related conditions
WO1999045913A1 (fr) * 1998-03-13 1999-09-16 Merck & Co., Inc. Therapie associee destinee au syndrome ischemique coronarien aigu ainsi qu'a des troubles connexes
SA99191255B1 (ar) * 1998-11-30 2006-11-25 جي دي سيرل اند كو مركبات سيليكوكسيب celecoxib
CO5190664A1 (es) 1999-06-30 2002-08-29 Pfizer Prod Inc Terapia de combinacion para el tratamiento de migrana administracion de un receptor 5ht, cafeina y un inhibidor de ciclooxigenasa-2
GB9920558D0 (en) * 1999-08-31 1999-11-03 Bradford Particle Design Ltd Methods for particle formation and their products
CN1434713A (zh) * 1999-12-22 2003-08-06 法马西亚公司 环加氧酶－2抑制剂的缓释制剂
MXPA02012344A (es) 2000-06-13 2004-02-26 Wyeth Corp Composiciones y anti-inflamatorias que contienen inhibidores cox-2.
DK1309315T3 (da) * 2000-08-18 2006-10-09 Pharmacia Corp Hurtigt disintegrerende oral valdecoxib-formulering
CN1638739A (zh) * 2000-08-18 2005-07-13 法玛西雅厄普约翰美国公司 治疗成瘾性障碍的化合物
AU2001285334A1 (en) * 2000-08-29 2002-03-13 Peter Van Patten Combination for the treatment of migraine comprising a cyclooxygenase-2 inhibitor and acetylsalicylic acid
AR030630A1 (es) * 2000-09-11 2003-08-27 Novartis Ag Composiciones farmaceuticas
US7115565B2 (en) * 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
US20040132780A1 (en) * 2001-05-04 2004-07-08 Allen Christopher P. Method and compositions for treating migraines
AR036312A1 (es) * 2001-08-31 2004-08-25 Novartis Ag Composicion farmaceutica
EP1429736A2 (fr) * 2001-09-26 2004-06-23 Pharmacia Corporation Compositions a desintegration orale, acceptables sur le plan organoleptique
HUP0401776A2 (hu) * 2001-10-10 2004-12-28 Pharmacia Corporation Intraorálisan széteső valdekoxib készítmények porlasztásos szárítási eljárással előállítva
US20050123604A1 (en) * 2002-03-07 2005-06-09 Karnachi Anees A. Pharmaceutical compositions
ES2213485B1 (es) 2003-02-13 2005-12-16 Almirall Prodesfarma, S.A. Derivados de la 2-fenilpiran-4-ona.
ES2214129B1 (es) * 2003-02-13 2005-12-01 Almirall Prodesfarma, S.A. 3-fenilfuran-2-onas.
ES2275218T3 (es) 2003-05-07 2007-06-01 Osteologix A/S Sales de estroncio hidrosolubles para el tratamiento de afecciones de cartilagos y/o huesos.
TR200301552A1 (tr) * 2003-09-18 2005-10-21 Nobel İlaç Sanayi̇ Ve Ti̇caret A. Ş. Rofekoksib' in yeni oral farmakolojik formülasyonları.
EP2114461A2 (fr) * 2007-01-19 2009-11-11 Mallinckrodt Inc. Ligands de liaison à la cycloxygénase-2 diagnostiques et thérapeutiques
JP7291220B2 (ja) 2018-11-21 2023-06-14 トレモ― ファーマシューティカルズ，インコーポレーテッド ロフェコキシブの精製形態、製造方法および使用
US20200323813A1 (en) * 2019-04-09 2020-10-15 Tremeau Pharmaceuticals, Inc. Treatment of viral hemorrhagic fevers with cox-2 selective non-steroidal anti-inflammatory drugs
US10945992B1 (en) 2019-11-13 2021-03-16 Tremeau Pharmaceuticals, Inc. Dosage forms of rofecoxib and related methods
US11161833B1 (en) 2021-04-09 2021-11-02 Tremeau Pharmaceuticals, Inc. Deuterated etoricoxib, methods of manufacture, and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5474995A (en) * 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
CA2180651A1 (fr) * 1994-01-10 1995-07-13 Yves Ducharme Heterocycles phenyliques utilises comme inhibiteurs de cox-2

Also Published As

Publication number Publication date
SK156798A3 (en) 2000-01-18
AU3004997A (en) 1997-12-09
EE9800393A (et) 1999-06-15
KR20000011082A (ko) 2000-02-25
CN1140267C (zh) 2004-03-03
IL126899A (en) 2004-03-28
CA2254061A1 (fr) 1997-11-27
EA001596B1 (ru) 2001-06-25
BG103000A (en) 1999-09-30
NO985342D0 (no) 1998-11-16
US6063811A (en) 2000-05-16
PL188649B1 (pl) 2005-03-31
SK284330B6 (sk) 2005-01-03
DZ2200A1 (fr) 2004-06-20
MY116201A (en) 2003-11-28
CO5050370A1 (es) 2001-06-27
JPH11512754A (ja) 1999-11-02
PE66998A1 (es) 1998-10-24
EP0910368A1 (fr) 1999-04-28
TR199802345T2 (xx) 1999-03-22
HUP9902889A2 (hu) 2002-01-28
WO1997044028A1 (fr) 1997-11-27
HRP970262A2 (en) 1998-06-30
NO985342L (no) 1998-11-16
HUP9902889A3 (en) 2002-04-29
CA2254061C (fr) 2003-12-02
CZ291463B6 (cs) 2003-03-12
ID16921A (id) 1997-11-20
BR9709097A (pt) 1999-08-03
CN1225010A (zh) 1999-08-04
HK1021623A1 (en) 2000-06-23
CZ373898A3 (cs) 1999-06-16
IS4891A (is) 1998-11-10
EA199801017A1 (ru) 1999-04-29
NZ332670A (en) 2000-07-28
AR012014A1 (es) 2000-09-27
PL329940A1 (en) 1999-04-26
IL126899A0 (en) 1999-09-22
KR100373622B1 (ko) 2003-07-12

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