EE03826B1 - Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode - Google Patents

Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode

Info

Publication number: EE03826B1
Authority: EE; Estonia
Prior art keywords: preparation; compound; combination; pharmaceutical composition; product containing
Prior art date: 1996-10-01

Application number

EE9700253A

Other languages

English (en)

Estonian (et)

Other versions

EE9700253A (et

Inventor

Joseph Kukla Michael

Adriaan Jan Janssen Paul

Emiel Lodewijk Moereels Henri

William Ludovici Donald

Heeres Jan

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-09-26

Publication date

2002-08-15

1997-09-26 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1998-04-15 Publication of EE9700253A publication Critical patent/EE9700253A/xx

2002-08-15 Publication of EE03826B1 publication Critical patent/EE03826B1/xx

Links

VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical class NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Plural Heterocyclic Compounds (AREA)

EE9700253A 1996-10-01 1997-09-26 Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode EE03826B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2726096P	1996-10-01	1996-10-01

Publications (2)

Publication Number	Publication Date
EE9700253A EE9700253A (et)	1998-04-15
EE03826B1 true EE03826B1 (et)	2002-08-15

Family

ID=21836641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700253A EE03826B1 (et)	1996-10-01	1997-09-26	Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode

Country Status (33)

Country	Link
US (4)	US6380194B1 (id)
EP (1)	EP0834507B1 (id)
JP (1)	JP4127882B2 (id)
KR (1)	KR100478846B1 (id)
CN (1)	CN1083438C (id)
AP (1)	AP914A (id)
AR (1)	AR008864A1 (id)
AT (1)	ATE267179T1 (id)
AU (1)	AU740809B2 (id)
BR (1)	BR9704937A (id)
CA (1)	CA2216486A1 (id)
CZ (1)	CZ297333B6 (id)
DE (1)	DE69729153T2 (id)
DK (1)	DK0834507T3 (id)
EE (1)	EE03826B1 (id)
ES (1)	ES2221679T3 (id)
HR (1)	HRP970526B1 (id)
HU (1)	HU225270B1 (id)
ID (1)	ID19599A (id)
IL (1)	IL121849A (id)
MY (1)	MY123803A (id)
NO (1)	NO311614B1 (id)
NZ (1)	NZ328854A (id)
OA (1)	OA10620A (id)
PL (1)	PL190155B1 (id)
PT (1)	PT834507E (id)
RU (1)	RU2186774C2 (id)
SG (1)	SG53075A1 (id)
SI (1)	SI0834507T1 (id)
SK (1)	SK285241B6 (id)
TR (1)	TR199701070A2 (id)
TW (1)	TW411335B (id)
ZA (1)	ZA978766B (id)

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NO311614B1 (no) *	1996-10-01	2001-12-17	Janssen Pharmaceutica Nv	Substituerte diamino-1,3,5-triazinderivater
JP3635238B2 (ja)	1998-11-10	2005-04-06	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｈｉｖの複製を阻害するピリミジン類
AP1636A (en) *	1998-11-10	2006-07-17	Janssen Pharmaceutica Nv	2.4-disubstituted triazine derivatives.
DE60025837T2 (de) *	1999-09-24	2006-11-02	Janssen Pharmaceutica N.V.	Antivirale feste dispersionen
DE19945982A1 (de) *	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
ATE449764T1 (de) *	1999-12-28	2009-12-15	Pharmacopeia Inc	Cytokine, insbesondere tnf-alpha, hemmer
US6906067B2 (en)	1999-12-28	2005-06-14	Bristol-Myers Squibb Company	N-heterocyclic inhibitors of TNF-α expression
US7276510B2 (en)	2000-05-08	2007-10-02	Janssen Pharmaceutica, Inc.	HIV replication inhibitors
US7034019B2 (en)	2000-05-08	2006-04-25	Janssen Pharmaceutica N.V.	Prodrugs of HIV replication inhibiting pyrimidines
JP2004525109A (ja)	2001-02-15	2004-08-19	キング・ファーマシューティカルズ・インコーポレイティッド	安定化された甲状腺ホルモン医薬組成物、及びその製法
DE60235470D1 (de) *	2001-06-26	2010-04-08	Pharmacopeia Inc	N-heterocyclische inhibitoren der expression von tnf-alpha
US6958211B2 (en)	2001-08-08	2005-10-25	Tibotech Bvba	Methods of assessing HIV integrase inhibitor therapy
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
CN1582277A (zh)	2001-11-01	2005-02-16	詹森药业有限公司	用作糖原合酶激酶3β抑制剂的酰胺衍生物
MXPA04004178A (es)	2001-11-01	2004-09-06	Janssen Pharmaceutica Nv	Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta.
WO2003096982A2 (en) *	2002-05-16	2003-11-27	Cytovia, Inc.	Substituted 4h-chromenes, 2h-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
WO2003097806A2 (en)	2002-05-16	2003-11-27	Cytovia, Inc.	Substituted 4-aryl-4h-pyrrolo[2,3-h]chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
AU2002350719A1 (en)	2002-11-29	2004-06-23	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
CN102503903A (zh) *	2003-02-07	2012-06-20	詹森药业有限公司	抑制hiv的1,2,4-三嗪
CL2004000303A1 (es) *	2003-02-20	2005-04-08	Tibotec Pharm Ltd	Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
WO2005003103A2 (en) *	2003-06-30	2005-01-13	Astrazeneca Ab	2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases
RU2401833C2 (ru)	2004-08-10	2010-10-20	Янссен Фармацевтика Н.В.	Производные 1, 2, 4-триазин-6-она, ингибирующие вич
CA2578995A1 (en) *	2004-09-03	2006-03-09	Prometic Biosciences Inc.	2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use
CA2577467C (en)	2004-09-30	2013-05-28	Tibotec Pharmaceuticals Ltd.	Hiv inhibiting 5-heterocyclyl pyrimidines
US7531548B2 (en)	2004-09-30	2009-05-12	Tibotec Pharmaceuticals Ltd	HIV inhibiting 5-carbo- or heterocyclic substituted pyrimidines
RU2410379C2 (ru)	2004-09-30	2011-01-27	Тиботек Фармасьютикалз Лтд.	5-замещенные пиримидины, ингибирующие вич
US8153640B2 (en)	2004-10-29	2012-04-10	Tibotec Pharmaceuticals Ltd.	HIV inhibiting bicyclic pyrimdine derivatives
US8193206B2 (en)	2005-06-14	2012-06-05	Taigen Biotechnology Co., Ltd.	Pyrimidine compounds
US20060281712A1 (en)	2005-06-14	2006-12-14	Chi-Feng Yen	Pyrimidine compounds
EP2004632B1 (en)	2006-03-30	2014-03-12	Janssen R&D Ireland	Hiv inhibiting 5-amido substituted pyrimidines
US9006243B2 (en)	2006-12-29	2015-04-14	Janssen R&D Ireland	HIV inhibiting 6-substituted pyrimidines
CN106045965A (zh) *	2006-12-29	2016-10-26	爱尔兰詹森科学公司	抑制hiv的5,6‑取代的嘧啶类化合物
EP2152676B1 (en) *	2007-04-30	2013-04-03	ProMetic BioSciences Inc.	"triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives"
EP2268635B1 (en)	2008-04-21	2015-06-10	Taigen Biotechnology Co., Ltd.	Heterocyclic compounds
TW201021855A (en)	2008-11-13	2010-06-16	Taigen Biotechnology Co Ltd	Lyophilization formulation
US9058223B2 (en) *	2011-04-22	2015-06-16	Microsoft Technology Licensing Llc	Parallel entropy encoding on GPU
CA2888413C (en) *	2012-10-24	2021-11-16	Basf Se	Herbicidal azines
US10941122B2 (en) *	2014-04-11	2021-03-09	Basf Se	Diaminotriazine derivatives as herbicides
WO2016059647A2 (en) *	2014-10-13	2016-04-21	SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India)	Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1
CN105837525B (zh) *	2016-03-25	2019-05-28	浙江工业大学	2,4-二胺-1,3,5-三嗪类化合物及其制备方法与应用

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NO311614B1 (no) *	1996-10-01	2001-12-17	Janssen Pharmaceutica Nv	Substituerte diamino-1,3,5-triazinderivater

1997
- 1997-09-22 NO NO19974368A patent/NO311614B1/no unknown
- 1997-09-23 SG SG1997003520A patent/SG53075A1/en unknown
- 1997-09-23 CZ CZ0299397A patent/CZ297333B6/cs not_active IP Right Cessation
- 1997-09-24 DE DE69729153T patent/DE69729153T2/de not_active Expired - Fee Related
- 1997-09-24 EP EP97202917A patent/EP0834507B1/en not_active Expired - Lifetime
- 1997-09-24 SI SI9730663T patent/SI0834507T1/xx unknown
- 1997-09-24 PT PT97202917T patent/PT834507E/pt unknown
- 1997-09-24 AT AT97202917T patent/ATE267179T1/de not_active IP Right Cessation
- 1997-09-24 ES ES97202917T patent/ES2221679T3/es not_active Expired - Lifetime
- 1997-09-24 DK DK97202917T patent/DK0834507T3/da active
- 1997-09-25 CA CA002216486A patent/CA2216486A1/en not_active Abandoned
- 1997-09-26 EE EE9700253A patent/EE03826B1/xx not_active IP Right Cessation
- 1997-09-26 US US08/938,602 patent/US6380194B1/en not_active Expired - Fee Related
- 1997-09-26 AU AU39266/97A patent/AU740809B2/en not_active Ceased
- 1997-09-26 NZ NZ328854A patent/NZ328854A/xx unknown
- 1997-09-29 SK SK1319-97A patent/SK285241B6/sk unknown
- 1997-09-29 ID IDP973312A patent/ID19599A/id unknown
- 1997-09-29 AP APAP/P/1997/001109A patent/AP914A/en active
- 1997-09-29 JP JP27938797A patent/JP4127882B2/ja not_active Expired - Fee Related
- 1997-09-29 MY MYPI97004540A patent/MY123803A/en unknown
- 1997-09-29 KR KR1019970049662A patent/KR100478846B1/ko not_active Expired - Fee Related
- 1997-09-29 IL IL12184997A patent/IL121849A/xx not_active IP Right Cessation
- 1997-09-30 RU RU97116200/04A patent/RU2186774C2/ru not_active IP Right Cessation
- 1997-09-30 TR TR97/01070A patent/TR199701070A2/xx unknown
- 1997-09-30 CN CN97121454A patent/CN1083438C/zh not_active Expired - Fee Related
- 1997-09-30 AR ARP970104503A patent/AR008864A1/es active IP Right Grant
- 1997-09-30 BR BR9704937-9A patent/BR9704937A/pt not_active Application Discontinuation
- 1997-09-30 TW TW086114172A patent/TW411335B/zh not_active IP Right Cessation
- 1997-09-30 PL PL97322369A patent/PL190155B1/pl not_active IP Right Cessation
- 1997-09-30 ZA ZA978766A patent/ZA978766B/xx unknown
- 1997-09-30 HR HR970526A patent/HRP970526B1/xx not_active IP Right Cessation
- 1997-09-30 HU HU9701596A patent/HU225270B1/hu not_active IP Right Cessation
- 1997-10-01 OA OA70094A patent/OA10620A/en unknown
2001
- 2001-11-15 US US10/002,456 patent/US6858609B2/en not_active Expired - Fee Related
2003
- 2003-03-26 US US10/397,760 patent/US6962916B2/en not_active Expired - Fee Related
2005
- 2005-08-12 US US11/203,325 patent/US7449575B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9704937A (pt)	2000-06-06
SK285241B6 (sk)	2006-09-07
SI0834507T1 (en)	2004-10-31
NO974368D0 (no)	1997-09-22
PL322369A1 (en)	1998-04-14
HUP9701596A3 (en)	2000-04-28
HUP9701596A2 (hu)	1999-06-28
ID19599A (id)	1998-07-23
CZ297333B6 (cs)	2006-11-15
TW411335B (en)	2000-11-11
AR008864A1 (es)	2000-02-23
CZ299397A3 (cs)	1998-11-11
NZ328854A (en)	2000-10-27
DK0834507T3 (da)	2004-09-06
OA10620A (en)	2002-09-03
KR19980032428A (ko)	1998-07-25
AU740809B2 (en)	2001-11-15
MY123803A (en)	2006-06-30
US6380194B1 (en)	2002-04-30
US6962916B2 (en)	2005-11-08
AU3926697A (en)	1998-04-09
EE9700253A (et)	1998-04-15
AP914A (en)	2000-12-18
SK131997A3 (en)	1999-06-11
CN1083438C (zh)	2002-04-24
US6858609B2 (en)	2005-02-22
ATE267179T1 (de)	2004-06-15
IL121849A (en)	2001-08-26
DE69729153D1 (de)	2004-06-24
SG53075A1 (en)	1998-09-28
US20060189614A1 (en)	2006-08-24
HRP970526B1 (en)	2002-10-31
TR199701070A2 (xx)	1998-04-21
HU9701596D0 (en)	1997-11-28
EP0834507B1 (en)	2004-05-19
HK1009676A1 (en)	1999-06-04
DE69729153T2 (de)	2005-01-27
KR100478846B1 (ko)	2006-06-13
PT834507E (pt)	2004-10-29
IL121849A0 (en)	1998-02-22
NO974368L (no)	1998-04-02
ES2221679T3 (es)	2005-01-01
HU225270B1 (en)	2006-08-28
US20030199473A1 (en)	2003-10-23
US7449575B2 (en)	2008-11-11
PL190155B1 (pl)	2005-11-30
ZA978766B (en)	1999-03-30
US20020147181A1 (en)	2002-10-10
EP0834507A1 (en)	1998-04-08
JPH10114759A (ja)	1998-05-06
HRP970526A2 (en)	1998-10-31
NO311614B1 (no)	2001-12-17
CA2216486A1 (en)	1998-04-01
JP4127882B2 (ja)	2008-07-30
CN1180698A (zh)	1998-05-06
RU2186774C2 (ru)	2002-08-10
MX9707511A (es)	1998-06-30
AP9701109A0 (en)	1997-10-31

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20070926

Publication	Publication Date	Title
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HUP9601712A3 (en)	1999-03-29	Substituted benzothiazine derivatives, intermediates of them, process for their preparation and pharmaceutical compositions containing the same
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