EE03826B1 - Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode - Google Patents

Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode

Info

Publication number: EE03826B1
Authority: EE; Estonia
Prior art keywords: preparation; compound; combination; pharmaceutical composition; product containing
Prior art date: 1996-10-01

Application number

EE9700253A

Other languages

English (en)

Estonian (et)

Other versions

EE9700253A (et

Inventor

Joseph Kukla Michael

Adriaan Jan Janssen Paul

Emiel Lodewijk Moereels Henri

William Ludovici Donald

Heeres Jan

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-01

Filing date

1997-09-26

Publication date

2002-08-15

1997-09-26 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

1998-04-15 Publication of EE9700253A publication Critical patent/EE9700253A/xx

2002-08-15 Publication of EE03826B1 publication Critical patent/EE03826B1/xx

Links

VZXTWGWHSMCWGA-UHFFFAOYSA-N 1,3,5-triazine-2,4-diamine Chemical class NC1=NC=NC(N)=N1 VZXTWGWHSMCWGA-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
238000000034 method Methods 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Immunology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

EE9700253A 1996-10-01 1997-09-26 Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode EE03826B1 (et)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US2726096P	1996-10-01	1996-10-01

Publications (2)

Publication Number	Publication Date
EE9700253A EE9700253A (et)	1998-04-15
EE03826B1 true EE03826B1 (et)	2002-08-15

Family

ID=21836641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9700253A EE03826B1 (et)	1996-10-01	1997-09-26	Asendatud diamino-1,3,5-triasiini derivaat , selle valmistamismeetod ja kasutamine, farmatseutilinekompositsioon ja selle valmistamismeetod ning ühendi kombinatsioon ja seda sisaldav toode

Country Status (33)

Country	Link
US (4)	US6380194B1 (id)
EP (1)	EP0834507B1 (id)
JP (1)	JP4127882B2 (id)
KR (1)	KR100478846B1 (id)
CN (1)	CN1083438C (id)
AP (1)	AP914A (id)
AR (1)	AR008864A1 (id)
AT (1)	ATE267179T1 (id)
AU (1)	AU740809B2 (id)
BR (1)	BR9704937A (id)
CA (1)	CA2216486A1 (id)
CZ (1)	CZ297333B6 (id)
DE (1)	DE69729153T2 (id)
DK (1)	DK0834507T3 (id)
EE (1)	EE03826B1 (id)
ES (1)	ES2221679T3 (id)
HR (1)	HRP970526B1 (id)
HU (1)	HU225270B1 (id)
ID (1)	ID19599A (id)
IL (1)	IL121849A (id)
MY (1)	MY123803A (id)
NO (1)	NO311614B1 (id)
NZ (1)	NZ328854A (id)
OA (1)	OA10620A (id)
PL (1)	PL190155B1 (id)
PT (1)	PT834507E (id)
RU (1)	RU2186774C2 (id)
SG (1)	SG53075A1 (id)
SI (1)	SI0834507T1 (id)
SK (1)	SK285241B6 (id)
TR (1)	TR199701070A2 (id)
TW (1)	TW411335B (id)
ZA (1)	ZA978766B (id)

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NO311614B1 (no)	1996-10-01	2001-12-17	Janssen Pharmaceutica Nv	Substituerte diamino-1,3,5-triazinderivater
HRP20080359B1 (hr)	1998-11-10	2016-01-01	Janssen Pharmaceutica N.V.	PIRIMIDINI KOJI INHIBIRAJU REPLIKACIJU HIV-a
AU764472B2 (en) *	1998-11-10	2003-08-21	Janssen Pharmaceutica N.V.	2,4-disubstituted triazine derivatives
DE19945982A1 (de)	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
CA2384188C (en) *	1999-09-24	2008-06-17	Janssen Pharmaceutica N.V.	Antiviral compositions
US6906067B2 (en)	1999-12-28	2005-06-14	Bristol-Myers Squibb Company	N-heterocyclic inhibitors of TNF-α expression
CA2394727A1 (en) *	1999-12-28	2001-07-05	Pharmacopeia, Inc.	Pyrimidine and triazine kinase inhibitors
WO2001085700A2 (en)	2000-05-08	2001-11-15	Janssen Pharmaceutica N.V.	Hiv replication inhibiting pyrimidines and triazines
JP4969010B2 (ja)	2000-05-08	2012-07-04	ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ	Ｈｉｖ複製阻害性ピリミジンのプロドラッグ
US7067148B2 (en)	2001-02-15	2006-06-27	King Pharmaceutical Research & Development, Inc.	Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
CA2451125A1 (en) *	2001-06-26	2003-01-09	Bristol-Myers Squibb Company	N-heterocyclic inhibitors of tnf-alpha expression
US6958211B2 (en)	2001-08-08	2005-10-25	Tibotech Bvba	Methods of assessing HIV integrase inhibitor therapy
US7101569B2 (en)	2001-08-14	2006-09-05	Franz G Andrew	Methods of administering levothyroxine pharmaceutical compositions
CA2463821A1 (en)	2001-11-01	2003-05-08	Janssen Pharmaceutica N.V.	Amide derivatives as glycogen synthase kinase 3-beta inhibitors
MXPA04004178A (es)	2001-11-01	2004-09-06	Janssen Pharmaceutica Nv	Heteroarilaminas como inhibidores de glucogeno cintasa cinasa 3beta.
US7476741B2 (en) *	2002-05-16	2009-01-13	Cytovia, Inc.	Substituted 4H-chromens, 2H-chromenes, chromans and analogs as activators of caspases and inducers of apoptosis and the use thereof
AU2003230411A1 (en)	2002-05-16	2003-12-02	Cytovia, Inc.	Substituted 4-aryl-4h-pyrrolo(2,3-h)chromenes and analogs as activators of caspases and inducers of apoptosis and the use thereof
AU2002350719A1 (en)	2002-11-29	2004-06-23	Janssen Pharmaceutica N.V.	Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
AP2005003365A0 (en)	2003-02-07	2005-09-30	Janssen Pharmaceutica Nv	Hiv inhibiting 1, 2, 4-triazines.
CL2004000303A1 (es) *	2003-02-20	2005-04-08	Tibotec Pharm Ltd	Compuestos derivados de pirimidinas y triazinas; proceso de preparacion; composicion farmaceutica; y su uso para inhibir la replicacion del vih.
WO2005003103A2 (en) *	2003-06-30	2005-01-13	Astrazeneca Ab	2, 4, 6-tri-substituted 6-membered heterocycles and their use in the treatment of neurodegenerative diseases
ES2442857T3 (es)	2004-08-10	2014-02-13	Janssen Pharmaceutica Nv	Derivados de 1,2,4-triazin-6-ona inhibidores de VIH
WO2006024175A1 (en) *	2004-09-03	2006-03-09	Prometic Biosciences Inc.	2,4,6-TRIAMINO-S-TRIAZINE-BASED COMPOUNDS WHICH BIND TO THE TAIL (Fc) PORTION OF IMMUNOGLOBULINS AND THEIR USE
CN101031550B (zh)	2004-09-30	2015-05-27	泰博特克药品有限公司	抑制hiv的5-碳环-或杂环取代的嘧啶类
RU2405778C2 (ru)	2004-09-30	2010-12-10	Тиботек Фармасьютикалз Лтд.	5-гетероциклилпиримидины, ингибирующие вич
ATE542802T1 (de)	2004-09-30	2012-02-15	Tibotec Pharm Ltd	Hiv-inhibierende 5-substituierte pyrimidine
AU2005298637B8 (en)	2004-10-29	2012-12-06	Janssen Sciences Ireland Uc	HIV inhibiting bicyclic pyrimidine derivatives
JP5118029B2 (ja)	2005-06-14	2013-01-16	タイゲンバイオテクノロジーカンパニー，リミテッド	ピリミジン化合物
US8193206B2 (en)	2005-06-14	2012-06-05	Taigen Biotechnology Co., Ltd.	Pyrimidine compounds
WO2007113254A1 (en)	2006-03-30	2007-10-11	Tibotec Pharmaceuticals Ltd.	Hiv inhibiting 5-amido substituted pyrimidines
EP2114902B1 (en) *	2006-12-29	2014-09-17	Janssen R&D Ireland	Hiv inhibiting 5,6-substituted pyrimidines
JP5185283B2 (ja)	2006-12-29	2013-04-17	テイボテク・フアーマシユーチカルズ	Ｈｉｖ阻害６−置換ピリミジン
JP5450381B2 (ja)	2007-04-30	2014-03-26	プロメティック・バイオサイエンスィズ・インコーポレーテッド	化合物、そのような化合物を含有する組成物、及びそのような化合物を用いるがん及び自己免疫疾患の治療法
AU2008355098B2 (en) *	2008-04-21	2012-11-15	Gpcr Therapeutics, Inc	Heterocyclic compounds
WO2010056847A2 (en)	2008-11-13	2010-05-20	Taigen Biotechnology Co., Ltd.	Lyophilization formulation
US9058223B2 (en) *	2011-04-22	2015-06-16	Microsoft Technology Licensing Llc	Parallel entropy encoding on GPU
EP2912024B1 (en) *	2012-10-24	2016-07-20	Basf Se	Herbicidal azines
CN106458937A (zh) *	2014-04-11	2017-02-22	巴斯夫欧洲公司	作为除草剂的二氨基三嗪衍生物
WO2016059647A2 (en) *	2014-10-13	2016-04-21	SHRI CHHATRAPTI SHIVAJI COLLEGE Maharashtra, India)	Triaminotriazine picolinonitrile derivatives as potent reverse transcriptase inhibitor of hiv-1
CN105837525B (zh) *	2016-03-25	2019-05-28	浙江工业大学	2,4-二胺-1,3,5-三嗪类化合物及其制备方法与应用

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NO311614B1 (no) *	1996-10-01	2001-12-17	Janssen Pharmaceutica Nv	Substituerte diamino-1,3,5-triazinderivater

1997
- 1997-09-22 NO NO19974368A patent/NO311614B1/no unknown
- 1997-09-23 SG SG1997003520A patent/SG53075A1/en unknown
- 1997-09-23 CZ CZ0299397A patent/CZ297333B6/cs not_active IP Right Cessation
- 1997-09-24 DE DE69729153T patent/DE69729153T2/de not_active Expired - Fee Related
- 1997-09-24 PT PT97202917T patent/PT834507E/pt unknown
- 1997-09-24 ES ES97202917T patent/ES2221679T3/es not_active Expired - Lifetime
- 1997-09-24 AT AT97202917T patent/ATE267179T1/de not_active IP Right Cessation
- 1997-09-24 DK DK97202917T patent/DK0834507T3/da active
- 1997-09-24 SI SI9730663T patent/SI0834507T1/xx unknown
- 1997-09-24 EP EP97202917A patent/EP0834507B1/en not_active Expired - Lifetime
- 1997-09-25 CA CA002216486A patent/CA2216486A1/en not_active Abandoned
- 1997-09-26 NZ NZ328854A patent/NZ328854A/xx unknown
- 1997-09-26 EE EE9700253A patent/EE03826B1/xx not_active IP Right Cessation
- 1997-09-26 AU AU39266/97A patent/AU740809B2/en not_active Ceased
- 1997-09-26 US US08/938,602 patent/US6380194B1/en not_active Expired - Fee Related
- 1997-09-29 SK SK1319-97A patent/SK285241B6/sk unknown
- 1997-09-29 AP APAP/P/1997/001109A patent/AP914A/en active
- 1997-09-29 ID IDP973312A patent/ID19599A/id unknown
- 1997-09-29 JP JP27938797A patent/JP4127882B2/ja not_active Expired - Fee Related
- 1997-09-29 KR KR1019970049662A patent/KR100478846B1/ko not_active Expired - Fee Related
- 1997-09-29 MY MYPI97004540A patent/MY123803A/en unknown
- 1997-09-29 IL IL12184997A patent/IL121849A/xx not_active IP Right Cessation
- 1997-09-30 HU HU9701596A patent/HU225270B1/hu not_active IP Right Cessation
- 1997-09-30 TW TW086114172A patent/TW411335B/zh not_active IP Right Cessation
- 1997-09-30 RU RU97116200/04A patent/RU2186774C2/ru not_active IP Right Cessation
- 1997-09-30 CN CN97121454A patent/CN1083438C/zh not_active Expired - Fee Related
- 1997-09-30 AR ARP970104503A patent/AR008864A1/es active IP Right Grant
- 1997-09-30 BR BR9704937-9A patent/BR9704937A/pt not_active Application Discontinuation
- 1997-09-30 PL PL97322369A patent/PL190155B1/pl not_active IP Right Cessation
- 1997-09-30 TR TR97/01070A patent/TR199701070A2/xx unknown
- 1997-09-30 HR HR970526A patent/HRP970526B1/xx not_active IP Right Cessation
- 1997-09-30 ZA ZA978766A patent/ZA978766B/xx unknown
- 1997-10-01 OA OA70094A patent/OA10620A/en unknown
2001
- 2001-11-15 US US10/002,456 patent/US6858609B2/en not_active Expired - Fee Related
2003
- 2003-03-26 US US10/397,760 patent/US6962916B2/en not_active Expired - Fee Related
2005
- 2005-08-12 US US11/203,325 patent/US7449575B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE267179T1 (de)	2004-06-15
JPH10114759A (ja)	1998-05-06
CA2216486A1 (en)	1998-04-01
NO311614B1 (no)	2001-12-17
BR9704937A (pt)	2000-06-06
US7449575B2 (en)	2008-11-11
HRP970526A2 (en)	1998-10-31
HUP9701596A2 (hu)	1999-06-28
HK1009676A1 (en)	1999-06-04
AP914A (en)	2000-12-18
AR008864A1 (es)	2000-02-23
US20030199473A1 (en)	2003-10-23
IL121849A (en)	2001-08-26
RU2186774C2 (ru)	2002-08-10
PL322369A1 (en)	1998-04-14
ID19599A (id)	1998-07-23
ES2221679T3 (es)	2005-01-01
CN1180698A (zh)	1998-05-06
SK285241B6 (sk)	2006-09-07
AU740809B2 (en)	2001-11-15
JP4127882B2 (ja)	2008-07-30
US20020147181A1 (en)	2002-10-10
AP9701109A0 (en)	1997-10-31
HU225270B1 (en)	2006-08-28
HRP970526B1 (en)	2002-10-31
ZA978766B (en)	1999-03-30
KR19980032428A (ko)	1998-07-25
US6962916B2 (en)	2005-11-08
NO974368D0 (no)	1997-09-22
EP0834507A1 (en)	1998-04-08
SI0834507T1 (en)	2004-10-31
AU3926697A (en)	1998-04-09
NZ328854A (en)	2000-10-27
CZ297333B6 (cs)	2006-11-15
CN1083438C (zh)	2002-04-24
NO974368L (no)	1998-04-02
MX9707511A (es)	1998-06-30
US6858609B2 (en)	2005-02-22
EP0834507B1 (en)	2004-05-19
OA10620A (en)	2002-09-03
MY123803A (en)	2006-06-30
PL190155B1 (pl)	2005-11-30
EE9700253A (et)	1998-04-15
KR100478846B1 (ko)	2006-06-13
PT834507E (pt)	2004-10-29
US6380194B1 (en)	2002-04-30
HUP9701596A3 (en)	2000-04-28
SG53075A1 (en)	1998-09-28
DE69729153D1 (de)	2004-06-24
DK0834507T3 (da)	2004-09-06
SK131997A3 (en)	1999-06-11
TW411335B (en)	2000-11-11
TR199701070A2 (xx)	1998-04-21
CZ299397A3 (cs)	1998-11-11
DE69729153T2 (de)	2005-01-27
HU9701596D0 (en)	1997-11-28
US20060189614A1 (en)	2006-08-24
IL121849A0 (en)	1998-02-22

Legal Events

Date	Code	Title	Description
2003-02-17	KB4A	Valid patent at the end of a year	Effective date: 20021231
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20070926

Publication	Publication Date	Title
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FI973148A7 (fi)	1997-09-29	Substituoituja heterosyklisiä yhdisteitä, menetelmä niiden valmistamis eksi ja niitä sisältäviä farmaseuttisia koostumuksia
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EE200100252A (et)	2002-10-15	Pürimidiinderivaadid, nende valmistamismeetod ja kasutamine, farmatseutiline kompositsioon ja sellevalmistamismeetod, kombinatsioon ning saadus
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CZ346595A3 (en)	1996-08-14	Substituted derivatives of 4-phenylthiazoles, process of their preparation and pharmaceutical compositions containing thereof
FI963440A7 (fi)	1996-09-03	Uudet aminohappojohdannaiset, näiden valmistusmenetelmä ja näitä yhdis teitä sisältävät farmaseuttiset seokset
FI953308A7 (fi)	1996-01-07	Uudet bentsopyraaniyhdisteet, menetelmä niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
EE200200331A (et)	2003-06-16	Hargnenud ahelaga asendatud 3-amino-1-fenüül-1H-[1,2,4]triasooli aminoderivaadid, nende valmistamismeetod ja neid sisaldavad farmatseutilised kompositsioonid
HUP9601680A3 (en)	1998-08-28	Benzisothiazolyl-substituted aminomethyl-chromanes, pharmaceutical compositions containing the same, process for their preparation and use of the compounds
EE03773B1 (et)	2002-06-17	Kondenseeritud imidasoolderivaadid, nende kasutamine ravimina, neid sisaldav farmatseutiline kompositsioon, meetod selle valmistamiseks ning seda sisaldav kombineeritud preparaat
HUP9801879A3 (en)	1999-07-28	Pyridazinone-derivatives as endothelin-receptor antagonists, use thereof, pharmaceutical compositions containing these compounds and process for the preparation of the compounds and the compositions
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FI951091L (fi)	1995-09-12	Uudet alkyyliaminoindaaniyhdisteet, menetelmät niiden valmistamiseksi ja niitä sisältävät farmaseuttiset koostumukset
HUP9601712A3 (en)	1999-03-29	Substituted benzothiazine derivatives, intermediates of them, process for their preparation and pharmaceutical compositions containing the same
HUP9602324A3 (en)	1998-10-28	Piperidinyl-methyl-oxazolidinon derivatives, pharmaceutical compositions containing the same, process for the preparation of the compounds and use of them
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