EE03827B1 - Meetod transkriptaasi pöördinhibiitori kristallimiseks antilahusti kasutamisega - Google Patents

Meetod transkriptaasi pöördinhibiitori kristallimiseks antilahusti kasutamisega

Info

Publication number
EE03827B1
EE03827B1 EEP199900341A EEP9900341A EE03827B1 EE 03827 B1 EE03827 B1 EE 03827B1 EE P199900341 A EEP199900341 A EE P199900341A EE P9900341 A EEP9900341 A EE P9900341A EE 03827 B1 EE03827 B1 EE 03827B1
Authority
EE
Estonia
Prior art keywords
solvent
crystallizing
transcriptase
inhibitor
rotary
Prior art date
Application number
EEP199900341A
Other languages
English (en)
Estonian (et)
Inventor
Clarke William
S. Crocker Louis
L. Kukura Ii Joseph
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27451618&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EE03827(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB9706046.1A external-priority patent/GB9706046D0/en
Priority claimed from GBGB9709348.8A external-priority patent/GB9709348D0/en
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of EE9900341A publication Critical patent/EE9900341A/xx
Publication of EE03827B1 publication Critical patent/EE03827B1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
EEP199900341A 1997-02-05 1998-02-02 Meetod transkriptaasi pöördinhibiitori kristallimiseks antilahusti kasutamisega EE03827B1 (et)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3738597P 1997-02-05 1997-02-05
GBGB9706046.1A GB9706046D0 (en) 1997-03-24 1997-03-24 Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
US4280797P 1997-04-08 1997-04-08
GBGB9709348.8A GB9709348D0 (en) 1997-05-07 1997-05-07 Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
PCT/US1998/001999 WO1998033782A1 (fr) 1997-02-05 1998-02-02 Procede de cristallisation d'un inhibiteur de transcriptase inverse utilisant un antisolvant

Publications (2)

Publication Number Publication Date
EE9900341A EE9900341A (et) 2000-02-15
EE03827B1 true EE03827B1 (et) 2002-08-15

Family

ID=27451618

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP199900341A EE03827B1 (et) 1997-02-05 1998-02-02 Meetod transkriptaasi pöördinhibiitori kristallimiseks antilahusti kasutamisega

Country Status (18)

Country Link
EP (1) EP0975609B1 (fr)
JP (6) JP3418626B2 (fr)
KR (1) KR100573192B1 (fr)
CN (2) CN1073991C (fr)
AT (1) ATE486065T1 (fr)
AU (1) AU738545C (fr)
CA (1) CA2279198C (fr)
CZ (2) CZ297535B6 (fr)
DE (1) DE69841972D1 (fr)
EA (1) EA001805B1 (fr)
EE (1) EE03827B1 (fr)
HU (1) HU229087B1 (fr)
IL (1) IL130715A (fr)
NO (1) NO320128B1 (fr)
NZ (1) NZ336510A (fr)
PL (1) PL197740B1 (fr)
SK (1) SK284935B6 (fr)
WO (1) WO1998033782A1 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU229087B1 (en) * 1997-02-05 2013-07-29 Merck Sharp & Dohme Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
AR011731A1 (es) * 1997-05-16 2000-08-30 Merck & Co Inc Un proceso de reaccion de adicion enantioselectiva eficiente utilizando un reactivo de organozinc.
US20010014352A1 (en) 1998-05-27 2001-08-16 Udit Batra Compressed tablet formulation
HRP990182A2 (en) * 1998-06-11 2000-02-29 Du Pont Pharm Co Crystalline efavirenz
GB9828721D0 (en) * 1998-12-24 1999-02-17 Glaxo Group Ltd Novel apparatus and process
WO2006018853A2 (fr) 2004-08-19 2006-02-23 Hetero Drugs Limited Nouveaux polymorphes d'efavirenz
WO2008108630A1 (fr) * 2007-03-02 2008-09-12 Ultimorphix Technologies B.V. Formes polymorphes de l'efavirenz
US8318930B2 (en) * 2007-12-24 2012-11-27 Matrix Laboratories Limited Process for preparing polymorphic forms of (S)-6-chloro-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
US8383811B2 (en) 2008-12-22 2013-02-26 Hetero Research Foundation Process for preparing efavirenz polymorph
DE102009041443A1 (de) 2009-09-16 2011-03-31 Archimica Gmbh Salze des 6-Chlor-4-(cyclopropylethinyl)-1,4-dihydro-4-(trifluormethyl)-2H-3,1-benzoxazin-2-ons und deren Synthese, Aufreinigung und Anwendung als Vorstufen für Efavirenz
EP2471783A1 (fr) 2010-12-23 2012-07-04 Esteve Química, S.A. Nouvelle forme polymorphe de l'éfavirenz
CN103508973B (zh) * 2012-06-25 2016-04-27 上海迪赛诺药业有限公司 制备依非韦伦i型结晶的方法
CN105037175B (zh) * 2014-07-18 2017-02-22 盐城迪赛诺制药有限公司 一种用于提高依非韦伦中间体光学纯度的方法
US11524964B2 (en) 2015-10-16 2022-12-13 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11773106B2 (en) 2015-10-16 2023-10-03 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US10550126B2 (en) 2015-10-16 2020-02-04 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11512092B2 (en) 2015-10-16 2022-11-29 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US12365689B2 (en) 2015-10-16 2025-07-22 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
US11365198B2 (en) 2015-10-16 2022-06-21 Abbvie Inc. Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof
SG10201913990RA (en) 2015-10-16 2020-03-30 Abbvie Inc PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF
CN114195761B (zh) * 2021-12-23 2023-04-14 浙江普洛家园药业有限公司 一种高纯度西他沙星3/2水合物的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1282405C (fr) * 1984-05-21 1991-04-02 Michael R. Violante Methode pour produire des particules dimensionnellement uniformes a partir des composes organiques insolubles dans l'eau
US5665720A (en) * 1992-08-07 1997-09-09 Merck & Co., Inc. Benzoxazinones as inhibitors of HIV reverse transcriptase
IL106507A (en) * 1992-08-07 1997-11-20 Merck & Co Inc Pharmaceutical compositions containing benzoxazinones and some novel compounds of this type
WO1995020389A1 (fr) * 1994-01-28 1995-08-03 Merck & Co., Inc. Benzoxazinones en tant qu'inhibiteurs de transcriptase inverse du vih
US5663467A (en) * 1995-01-23 1997-09-02 Merck & Co., Inc. Synthesis of cyclopropylacetylene
US5633405A (en) * 1995-05-25 1997-05-27 Merck & Co., Inc. Asymmetric synthesis of (-)-6-chloro-4-cyclopropyl-ethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxanzin-2-one
HU229087B1 (en) * 1997-02-05 2013-07-29 Merck Sharp & Dohme Process for the crystallization of a reverse transcriptase inhibitor using an anti-solvent
AU6876898A (en) * 1997-04-07 1998-10-30 Du Pont Pharmaceuticals Company Asymmetric synthesis of benzoxazinones via new intermediates

Also Published As

Publication number Publication date
CA2279198C (fr) 2009-04-14
JP2013139484A (ja) 2013-07-18
CN1073991C (zh) 2001-10-31
CN1385425A (zh) 2002-12-18
JP6126172B2 (ja) 2017-05-10
NZ336510A (en) 2001-04-27
JP2015205914A (ja) 2015-11-19
JP3418626B2 (ja) 2003-06-23
CZ304186B6 (cs) 2013-12-11
CA2279198A1 (fr) 1998-08-06
IL130715A (en) 2003-07-31
HU229087B1 (en) 2013-07-29
NO993779D0 (no) 1999-08-04
EA001805B1 (ru) 2001-08-27
ATE486065T1 (de) 2010-11-15
EP0975609A1 (fr) 2000-02-02
EA199900720A1 (ru) 2000-04-24
WO1998033782A1 (fr) 1998-08-06
PL197740B1 (pl) 2008-04-30
CZ297535B6 (cs) 2007-01-03
PL334478A1 (en) 2000-02-28
CN1191242C (zh) 2005-03-02
JP5295190B2 (ja) 2013-09-18
DE69841972D1 (de) 2010-12-09
JP2000507972A (ja) 2000-06-27
NO320128B1 (no) 2005-10-31
EP0975609A4 (fr) 2001-02-21
JP2003040874A (ja) 2003-02-13
CZ276599A3 (cs) 2000-02-16
NO993779L (no) 1999-10-05
SK284935B6 (sk) 2006-02-02
EE9900341A (et) 2000-02-15
HUP0001313A3 (en) 2002-12-28
HUP0001313A2 (hu) 2000-10-28
AU738545B2 (en) 2001-09-20
KR100573192B1 (ko) 2006-04-24
AU738545C (en) 2004-06-17
JP2017061575A (ja) 2017-03-30
CN1246113A (zh) 2000-03-01
JP2011006472A (ja) 2011-01-13
KR20000070735A (ko) 2000-11-25
AU6263298A (en) 1998-08-25
IL130715A0 (en) 2000-06-01
EP0975609B1 (fr) 2010-10-27
SK105599A3 (en) 2000-05-16

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