EE04224B1 - Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon - Google Patents

Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon

Info

Publication number
EE04224B1
EE04224B1 EE9800249A EE9800249A EE04224B1 EE 04224 B1 EE04224 B1 EE 04224B1 EE 9800249 A EE9800249 A EE 9800249A EE 9800249 A EE9800249 A EE 9800249A EE 04224 B1 EE04224 B1 EE 04224B1
Authority
EE
Estonia
Prior art keywords
contrast medium
ultrasonic contrast
microbubbles
dispersion
matrix
Prior art date
Application number
EE9800249A
Other languages
English (en)
Estonian (et)
Other versions
EE9800249A (et
Inventor
Undheim Br�nden Jorunn
Dugstad Harald
Klaveness Jo
Rongved P�l
Skurtveit Roald
Original Assignee
Nycomed Imaging As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603466.5A external-priority patent/GB9603466D0/en
Priority claimed from GBGB9611894.8A external-priority patent/GB9611894D0/en
Priority claimed from GBGB9625663.1A external-priority patent/GB9625663D0/en
Application filed by Nycomed Imaging As filed Critical Nycomed Imaging As
Publication of EE9800249A publication Critical patent/EE9800249A/xx
Publication of EE04224B1 publication Critical patent/EE04224B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasonic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasonic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/227—Liposomes, lipoprotein vesicles, e.g. LDL or HDL lipoproteins, micelles, e.g. phospholipidic or polymeric
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
EE9800249A 1996-02-19 1997-02-19 Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon EE04224B1 (et)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9603466.5A GB9603466D0 (en) 1996-02-19 1996-02-19 Improvements in or relating to contrast agents
GBGB9611894.8A GB9611894D0 (en) 1996-06-07 1996-06-07 Improvements in or relating to contrast agents
GBGB9625663.1A GB9625663D0 (en) 1996-12-11 1996-12-11 Improvements in or relating to contrast agents
PCT/GB1997/000459 WO1997029783A1 (en) 1996-02-19 1997-02-19 Improvements in or relating to contrast agents

Publications (2)

Publication Number Publication Date
EE9800249A EE9800249A (et) 1999-02-15
EE04224B1 true EE04224B1 (et) 2004-02-16

Family

ID=27268137

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800249A EE04224B1 (et) 1996-02-19 1997-02-19 Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon

Country Status (24)

Country Link
US (4) US6221337B1 (cs)
EP (2) EP1331013A3 (cs)
JP (1) JP4418033B2 (cs)
KR (1) KR100500334B1 (cs)
CN (1) CN1278740C (cs)
AP (1) AP890A (cs)
AT (1) ATE238072T1 (cs)
AU (1) AU726503B2 (cs)
BG (1) BG102758A (cs)
CA (1) CA2246779C (cs)
CZ (1) CZ293986B6 (cs)
DE (1) DE69721235T2 (cs)
EA (1) EA001135B1 (cs)
EE (1) EE04224B1 (cs)
ES (1) ES2197986T3 (cs)
HU (1) HU229090B1 (cs)
IL (1) IL125748A (cs)
NZ (1) NZ331509A (cs)
OA (1) OA10839A (cs)
PL (1) PL328406A1 (cs)
PT (1) PT881915E (cs)
SK (1) SK284200B6 (cs)
TR (1) TR199801613T2 (cs)
WO (1) WO1997029783A1 (cs)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA99001053A (es) 1996-08-02 2002-03-11 Nycomed Imaging As Mejoramientos en o que se relacionan con agentes de contraste.
AU784367B2 (en) * 1996-08-02 2006-03-16 Ge Healthcare As Improvements in or relating to contrast agents
WO1999007415A1 (en) * 1997-08-12 1999-02-18 Bracco Research S.A. Administrable compositions and methods for magnetic resonance imaging
GB9717476D0 (en) * 1997-08-18 1997-10-22 Nycomed Imaging As Process
GB9717588D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717589D0 (en) * 1997-08-19 1997-10-22 Nycomed Imaging As Improvements in or relating to contrast agents
GB9717542D0 (en) 1997-08-19 1997-10-22 Nycomed Imaging As Process
GB9726773D0 (en) 1997-12-18 1998-02-18 Nycomed Imaging As Improvements in or relating to ultrasonagraphy
DE69916822T2 (de) * 1998-04-28 2005-04-21 Amersham Health As Oslo Verbesserung von trennungsverfahren
GB9813568D0 (en) 1998-06-23 1998-08-19 Nycomed Imaging As Improvements in or relating to cardiac imaging
US6514209B1 (en) 1999-06-07 2003-02-04 Drexel University Method of enhancing ultrasonic techniques via measurement of ultraharmonic signals
US20030103960A1 (en) * 1999-12-22 2003-06-05 Pierre Philippart Sealant and bone generating product
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
NO20004795D0 (no) 2000-09-26 2000-09-26 Nycomed Imaging As Peptidbaserte forbindelser
KR100373712B1 (ko) * 2000-12-23 2003-02-25 사회복지법인삼성생명공익재단(삼성서울병원) 초음파 조영제 및 그의 제조방법
US6984373B2 (en) 2000-12-23 2006-01-10 Dyax Corp. Fibrin binding moieties useful as imaging agents
AU2002253454A1 (en) 2001-04-06 2002-10-21 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
EP1469886B8 (en) * 2002-02-01 2008-01-09 Shimoda Biotech (PTY) LTD Lyophilized pharmaceutical composition of propofol
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
EP1587944A4 (en) 2002-03-01 2007-03-21 Dyax Corp KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES
AU2003213730A1 (en) 2002-03-01 2003-09-16 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
NO20024755D0 (no) * 2002-10-03 2002-10-03 Amersham Health As Metode
KR101280760B1 (ko) 2002-11-29 2013-07-05 지이 헬스케어 에이에스 초음파 조영 물질
US20070128117A1 (en) * 2003-02-04 2007-06-07 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
WO2004069284A2 (en) 2003-02-04 2004-08-19 Bracco International B.V. Ultrasound contrast agents and process for the preparation thereof
EP2284180B1 (en) 2003-03-03 2015-09-09 Dyax Corp. Uses of peptides that specifically bind HGF receptor (cMET)
US20060222694A1 (en) * 2003-06-27 2006-10-05 Oh Choon K Stabilized topotecan liposomal composition and methods
US20050019379A1 (en) 2003-07-22 2005-01-27 Kimberly-Clark Worldwide, Inc. Wipe and methods for improving skin health
NO20035401D0 (no) * 2003-12-04 2003-12-04 Amersham Health As Metode
EP1696965B1 (en) * 2003-12-22 2014-12-10 Bracco Suisse SA Assembly of gas-filled microvesicle with active component for contrast imaging
JP5513708B2 (ja) 2003-12-22 2014-06-04 ブラッコ・シュイス・ソシエテ・アノニム 造影イメージング用の気体封入マイクロベシクル・アセンブリー
US7025726B2 (en) 2004-01-22 2006-04-11 The Regents Of The University Of Nebraska Detection of endothelial dysfunction by ultrasonic imaging
US9248204B2 (en) 2004-08-18 2016-02-02 Bracco Suisse S.A. Gas-filled microvesicles composition for contrast imaging
WO2006044996A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for automated boundary detection of body structures
WO2006044997A2 (en) * 2004-10-15 2006-04-27 The Trustees Of Columbia University In The City Of New York System and method for localized measurement and imaging of viscosity of tissues
CN100574811C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用微粒类助剂及其应用
CN100574809C (zh) * 2005-01-10 2009-12-30 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用氟碳乳剂类助剂及其应用
CN100427142C (zh) * 2005-01-10 2008-10-22 重庆海扶(Hifu)技术有限公司 一种高强度聚焦超声治疗用助剂及其筛选方法
US10687785B2 (en) 2005-05-12 2020-06-23 The Trustees Of Columbia Univeristy In The City Of New York System and method for electromechanical activation of arrhythmias
EP1937151A4 (en) * 2005-09-19 2011-07-06 Univ Columbia Systems and methods for opening of the blood-brain barrier of a subject using ultrasound
CN101374955B (zh) 2005-12-09 2013-03-27 布拉科瑞士有限公司 靶向载体-磷脂缀合物
EP1797919A1 (en) 2005-12-16 2007-06-20 Bracco Research S.A. Liquid transfer device for medical dispensing containers
AR059193A1 (es) 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
JP5154554B2 (ja) 2006-08-01 2013-02-27 ボストン サイエンティフィック サイムド，インコーポレイテッド 非線形イメージングのためのパルスインバージョンシーケンス
US8150128B2 (en) * 2006-08-30 2012-04-03 The Trustees Of Columbia University In The City Of New York Systems and method for composite elastography and wave imaging
US9446156B2 (en) 2006-09-05 2016-09-20 Bracco Suisse S.A. Gas-filled microvesicles with polymer-modified lipids
EP2005970A1 (de) 2007-06-22 2008-12-24 Berlin Science Partners GmbH i.V. Bildgebende Diagnostik durch Kombination von Kontrastmitteln
WO2011035312A1 (en) 2009-09-21 2011-03-24 The Trustees Of Culumbia University In The City Of New York Systems and methods for opening of a tissue barrier
JP2010005512A (ja) * 2008-06-25 2010-01-14 Kao Corp 微細気泡前駆体組成物
GB0811856D0 (en) * 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
WO2010014977A1 (en) * 2008-08-01 2010-02-04 The Trustees Of Columbia University In The City Of New York Systems and methods for matching and imaging tissue characteristics
WO2010030819A1 (en) 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Systems and methods for opening a tissue
WO2010030779A1 (en) * 2008-09-10 2010-03-18 The Trustees Of Columbia University In The City Of New York Isolation of microbubbles of selected size range from polydisperse microbubbles
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
WO2011034892A2 (en) * 2009-09-15 2011-03-24 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for microbubbles
US9700640B2 (en) * 2009-09-21 2017-07-11 Drexel University Stabilized ultrasound contrast agent
US8834846B2 (en) 2010-05-06 2014-09-16 Bruker Biospin Corporation Fluorescent NIRF activatable probes for disease detection
EP2600771A1 (en) 2010-08-06 2013-06-12 The Trustees of Columbia University in the City of New York Medical imaging contrast devices, methods, and systems
WO2012136813A2 (en) 2011-04-07 2012-10-11 Universitetet I Oslo Agents for medical radar diagnosis
WO2012162664A1 (en) 2011-05-26 2012-11-29 The Trustees Of Columbia University In The City Of New York Systems and methods for opening of a tissue barrier in primates
MX374926B (es) 2012-04-30 2025-03-06 Ge Healthcare As Metodo para llenar un contenedor con una composicion espumable.
ES2571481T3 (es) 2012-06-26 2016-05-25 Ge Healthcare As Preparación de una composición que comprende microburbujas de gas
WO2014059170A1 (en) 2012-10-10 2014-04-17 The Trustees Of Columbia University In The City Of New York Systems and methods for mechanical mapping of cardiac rhythm
CN105026030B (zh) 2012-12-21 2017-04-12 博莱科瑞士股份有限公司 充气微泡
US9255907B2 (en) 2013-03-14 2016-02-09 Empire Technology Development Llc Identification of surgical smoke
CA2902209C (en) 2013-03-15 2025-02-04 The Regents Of The University Of California REDUCED TOXICITY PEPTIDES STIMULATING CHOLESTEROL OUTFLOW
US9247921B2 (en) 2013-06-07 2016-02-02 The Trustees Of Columbia University In The City Of New York Systems and methods of high frame rate streaming for treatment monitoring
US10322178B2 (en) 2013-08-09 2019-06-18 The Trustees Of Columbia University In The City Of New York Systems and methods for targeted drug delivery
US10028723B2 (en) 2013-09-03 2018-07-24 The Trustees Of Columbia University In The City Of New York Systems and methods for real-time, transcranial monitoring of blood-brain barrier opening
GB201405735D0 (en) * 2014-03-31 2014-05-14 Ge Healthcare As Ultrasound precursor preparation method
DK3233136T3 (da) 2014-12-18 2019-05-20 Bracco Suisse Sa Formulering med målrettede gasfyldte mikrovesikler
EP3308779B1 (en) * 2015-06-10 2019-08-07 Teikyo University Theranostic bubble preparation (tb), and method for using same
CN107233583B (zh) * 2016-03-29 2020-04-24 北京飞锐达医疗科技有限公司 一种具有超长持续时间的超声造影剂及其制备方法
GB201821049D0 (en) * 2018-12-21 2019-02-06 Ge Healthcare As Ultrasound contrast agent and methods for use therof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) * 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5445813A (en) * 1992-11-02 1995-08-29 Bracco International B.V. Stable microbubble suspensions as enhancement agents for ultrasound echography
IN172208B (cs) * 1990-04-02 1993-05-01 Sint Sa
DE4100470A1 (de) * 1991-01-09 1992-07-16 Byk Gulden Lomberg Chem Fab Echokontrastmittel
GB9106673D0 (en) * 1991-03-28 1991-05-15 Hafslund Nycomed As Improvements in or relating to contrast agents
DE4328642A1 (de) * 1993-08-26 1995-03-02 Byk Gulden Lomberg Chem Fab Ultraschallkontrastmittel
GB9511488D0 (en) * 1995-06-07 1995-08-02 Nycomed Imaging As Improvements in or relating to contrast agents
US5846517A (en) * 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator

Also Published As

Publication number Publication date
US20010010811A1 (en) 2001-08-02
AP9801319A0 (en) 1998-09-30
BG102758A (en) 1999-09-30
KR19990082669A (ko) 1999-11-25
US20030202942A1 (en) 2003-10-30
KR100500334B1 (ko) 2005-09-09
DE69721235D1 (de) 2003-05-28
CZ262598A3 (cs) 1999-05-12
EA001135B1 (ru) 2000-10-30
PL328406A1 (en) 1999-01-18
CN1213972A (zh) 1999-04-14
EP1331013A3 (en) 2004-03-24
ES2197986T3 (es) 2004-01-16
CA2246779A1 (en) 1997-08-21
EA199800745A1 (ru) 1999-02-25
OA10839A (en) 2001-08-13
CN1278740C (zh) 2006-10-11
HUP9900813A2 (hu) 1999-07-28
WO1997029783A1 (en) 1997-08-21
AP890A (en) 2000-11-13
EE9800249A (et) 1999-02-15
NZ331509A (en) 2000-04-28
SK112698A3 (en) 1999-04-13
JP4418033B2 (ja) 2010-02-17
JP2000511510A (ja) 2000-09-05
TR199801613T2 (xx) 1998-11-23
SK284200B6 (sk) 2004-10-05
EP0881915A1 (en) 1998-12-09
HK1014872A1 (en) 1999-10-08
EP0881915B1 (en) 2003-04-23
DE69721235T2 (de) 2004-02-05
IL125748A0 (en) 1999-04-11
ATE238072T1 (de) 2003-05-15
CZ293986B6 (cs) 2004-09-15
PT881915E (pt) 2003-09-30
US20050201942A1 (en) 2005-09-15
EP1331013A2 (en) 2003-07-30
AU1884797A (en) 1997-09-02
HU229090B1 (en) 2013-07-29
US6221337B1 (en) 2001-04-24
HUP9900813A3 (en) 1999-11-29
CA2246779C (en) 2008-04-29
AU726503B2 (en) 2000-11-09
IL125748A (en) 2002-05-23

Similar Documents

Publication Publication Date Title
EE9800249A (et) Gaasi mikromullide dispersioon ja selle lüofiliseeritud jääk, ultraheli kontrastaine ja selle valmistamismeetod, mikromulle eraldav maatriks ning ultraheli kontrastaine kompositsioon
ID19203A (id) Proses untuk mengisolasi komposisi protein dari sumber otot dan komposisi protein tersebut
CA2207608A1 (en) Isolation of nucleic acid
AU2500197A (en) Method, apparatus and kits for sequencing of nucleic acids using multiple dyes
ID16801A (id) Metode untuk dispersi semen dan komposisi semen
AU6883096A (en) Method of isolating cells
AU6380001A (en) Porous ferro- or ferrimagnetic glass particles for isolating molecules
AU4226900A (en) Apparatus for fast preparation and analysis of nucleic acids
AU2069597A (en) Methods of screening nucleic acids using mass spectrometry
AU2001277961A1 (en) Compositions comprising heat shock proteins or alpha(2)macroglobulin, antigenic molecules and saponins, and methods of use thereof
AU2002235994A1 (en) Method for producing proteins by fermentation of microorganisms from the thermus family, the protein mixture thus obtained and cosmetic compositions containing same
EE9800053A (et) Kõrge efektiivsusega segusti ja selle valmistamise meetod
EP1015470A4 (en) COMPOSITION AND METHOD FOR DELIVERING NUCLEIC ACIDS
AU4145699A (en) Modified gellan gum composition process for preparation of same and use thereof
CA2263713A1 (en) Lyophilization of cultured human cells to preserve rna and dna
WO1998001557A3 (en) Mammalian chemokine reagents
DE69931735T8 (de) Homokinetisches Kreuzgelenk und Verfahren zur seiner Herstellung
ID28612A (id) Metode pembuatan asam tereftalat dan asam isoftalat murni dari campuran xilena
AU1686395A (en) (deltex) proteins, nucleic acids, and antibodies, and related methods and compositions
AU1346300A (en) Method of using water-borne epoxies and urethanes in print bonding fluid and products made therefrom
WO1999025861A3 (fr) Vecteurs adenoviraux et methode de reduction des evenements de recombinaison homologue
WO2000042188A3 (en) Interleukin-17 related mammalian cytokines. polynucleotides encoding them. uses
AU3028797A (en) Process for separating mixtures of substances using capillary affinity gel electrophoresis
EP1757616A3 (en) Semaphorin receptors
ID18954A (id) Kopolimer, proses terhidrogenasi daripadanya, dan proses untuk memproduksinya

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20041231

MM4A Lapsed by not paying the annual fees

Effective date: 20050219