EE04497B1 - Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine - Google Patents

Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine

Info

Publication number: EE04497B1
Authority: EE; Estonia
Prior art keywords: preparation; therapeutic use; pyridopyranoazepine; derivatives; pyridopyranoazepine derivatives
Prior art date: 1999-03-05

Application number

EEP200100470A

Other languages

English (en)

Estonian (et)

Inventor

Galli Fr�d�ric

Jegham Samir

Lochead Alistair

Samson Axelle

Original Assignee

Sanofi-Synthlabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-05

Filing date

2000-03-01

Publication date

2005-06-15

2000-03-01 Application filed by Sanofi-Synthlabo filed Critical Sanofi-Synthlabo

2002-12-16 Publication of EE200100470A publication Critical patent/EE200100470A/xx

2005-06-15 Publication of EE04497B1 publication Critical patent/EE04497B1/xx

Links

CJNWEJQNKRUGOX-UHFFFAOYSA-N pyrido[1,2]pyrano[3,5-b]azepine Chemical class C1=CC=NC2=CC3=NC=CC=C3OC2=C1 CJNWEJQNKRUGOX-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EEP200100470A 1999-03-05 2000-03-01 Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine EE04497B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9902784A FR2790474B1 (fr)	1999-03-05	1999-03-05	Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique
PCT/FR2000/000502 WO2000053608A1 (fr)	1999-03-05	2000-03-01	Derives de pyridopyranoazepines, leur preparation et leur application en therapeutique

Publications (2)

Publication Number	Publication Date
EE200100470A EE200100470A (et)	2002-12-16
EE04497B1 true EE04497B1 (et)	2005-06-15

Family

ID=9542888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200100470A EE04497B1 (et)	1999-03-05	2000-03-01	Püridopüranoasepiini derivaadid, nende valmistamine ja terapeutiline kasutamine

Country Status (37)

Country	Link
US (2)	US6538003B1 (id)
EP (1)	EP1161434B1 (id)
JP (1)	JP4806123B2 (id)
KR (2)	KR100768355B1 (id)
CN (1)	CN1137894C (id)
AR (1)	AR022820A1 (id)
AT (1)	ATE231869T1 (id)
AU (1)	AU764625B2 (id)
BG (1)	BG65211B1 (id)
BR (1)	BR0008763A (id)
CA (1)	CA2372063C (id)
CO (1)	CO5160250A1 (id)
CZ (1)	CZ302259B6 (id)
DE (1)	DE60001307T2 (id)
DK (1)	DK1161434T3 (id)
EE (1)	EE04497B1 (id)
ES (1)	ES2191611T3 (id)
FR (1)	FR2790474B1 (id)
HK (1)	HK1040398B (id)
HR (1)	HRP20010655B1 (id)
HU (1)	HU228671B1 (id)
ID (1)	ID30116A (id)
IL (2)	IL145150A0 (id)
MX (1)	MXPA01008972A (id)
NO (1)	NO327119B1 (id)
NZ (1)	NZ513561A (id)
PE (1)	PE20001543A1 (id)
PL (1)	PL201683B1 (id)
RS (1)	RS49997B (id)
RU (1)	RU2238273C2 (id)
SK (1)	SK284339B6 (id)
TR (1)	TR200102403T2 (id)
TW (1)	TWI222975B (id)
UA (1)	UA61164C2 (id)
UY (1)	UY26048A1 (id)
WO (1)	WO2000053608A1 (id)
ZA (1)	ZA200106811B (id)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10164139A1 (de)	2001-12-27	2003-07-10	Bayer Ag	2-Heteroarylcarbonsäureamide
NZ537003A (en)	2002-07-18	2008-03-28	Cytos Biotechnology Ag	Hapten-carrier conjugates comprising virus like particles and uses thereof
CN102657651A (zh) *	2002-12-06	2012-09-12	范因斯坦医学研究院	用α 7受体结合胆碱能激动剂抑制炎症
US7238715B2 (en) *	2002-12-06	2007-07-03	The Feinstein Institute For Medical Research	Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
US8580842B2 (en) *	2003-09-30	2013-11-12	Abbott Gmbh & Co. Kg	Heteroaryl-substituted 1,3-dihydroindol-2-one derivatives and medicaments containing them
US8316104B2 (en)	2005-11-15	2012-11-20	California Institute Of Technology	Method and apparatus for collaborative system
US20080167286A1 (en)	2006-12-12	2008-07-10	Abbott Laboratories	Pharmaceutical compositions and their methods of use
US8486979B2 (en) *	2006-12-12	2013-07-16	Abbvie Inc.	1,2,4 oxadiazole compounds and methods of use thereof
UY30846A1 (es)	2006-12-30	2008-07-31	Abbott Gmbh & Amp	Derivados de oxindol sustituidos, medicamentos que los comprenden y uso de los mismos
US20080255203A1 (en) *	2007-04-12	2008-10-16	Abbott Laboratories	Heterocyclic compounds and their methods of use
US20090076059A1 (en) *	2007-09-19	2009-03-19	Protia, Llc	Deuterium-enriched dianicline
WO2010009775A1 (de) *	2007-12-07	2010-01-28	Abbott Gmbh & Co. Kg	Carbamat-substituierte oxindol-derivate und ihre verwendung zur behandlung von vasopressin-abhängigen erkrankungen
US8703775B2 (en) *	2007-12-07	2014-04-22	AbbVie Deutschland GmbH & Co. KG	Amidomethyl-substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
ES2455197T3 (es)	2007-12-07	2014-04-14	Abbvie Deutschland Gmbh & Co Kg	Derivados de oxindol 5,6-disustituidos y el uso de los mismos para la preparación de un medicamento para el tratamiento de enfermedades dependientes de vasopresina
NZ586651A (en) *	2007-12-07	2012-06-29	Abbott Gmbh & Co Kg	5-halogen-substituted oxindole derivatives and use thereof for treating vasopressine-dependent diseases
US8383657B2 (en) *	2007-12-21	2013-02-26	Abbott Laboratories	Thiazolylidine urea and amide derivatives and methods of use thereof
US20090221648A1 (en) *	2007-12-21	2009-09-03	Abbott Laboratories	Compositions for treatment of cognitive disorders
US9463190B2 (en) *	2008-03-31	2016-10-11	University Of South Florida	Methods of treating disease-induced ataxia and non-ataxic imbalance
CN105687190A (zh)	2008-11-19	2016-06-22	福拉姆医药股份有限公司	用(R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺及其可药用盐治疗认知障碍
TW201031664A (en)	2009-01-26	2010-09-01	Targacept Inc	Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
PE20120324A1 (es) *	2009-05-11	2012-04-17	Envivo Pharmaceuticals Inc	Combinacion que comprende (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida y donezepilo como moduladora de trastornos cognitivos
EP2435080A2 (en) *	2009-05-29	2012-04-04	Abbott Laboratories	Pharmaceutical compositions for the treatment of pain
KR20180101641A (ko)	2010-05-17	2018-09-12	포럼 파마슈티칼즈 인크.	(R)-7-클로로-N-(퀴누클리딘-3-일)벤조[b]티오펜-2-카르복사미드 히드로클로리드 모노히드레이트의 결정질 형태
EP3461481A1 (en)	2012-05-08	2019-04-03	Forum Pharmaceuticals Inc.	Methods of maintaining, treating or improving cognitive function
US9585867B2 (en)	2015-08-06	2017-03-07	Charles Everett Ankner	Cannabinod formulation for the sedation of a human or animal

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3008226B2 (ja) *	1991-01-16	2000-02-14	第一製薬株式会社	六環性化合物
GB9301660D0 (en) *	1993-01-28	1993-03-17	Smithkline Beecham Plc	Pharmaceuticals
JPH11512443A (ja) *	1995-09-22	1999-10-26	ノボノルディスクアクティーゼルスカブ	新規な置換アザ環式またはアザ二環式化合物
FR2761072B1 (fr) *	1997-03-20	1999-04-23	Synthelabo	Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique
ZA984637B (en) *	1997-05-30	1998-12-21	Neurosearch As	Spiro-quinuclidine derivatives their preparation and use
AR013184A1 (es) *	1997-07-18	2000-12-13	Astrazeneca Ab	Aminas heterociclicas espiroazobiciclicas, composicion farmaceutica, uso de dichas aminas para preparar medicamentos y metodo de tratamiento o profilaxis
SE9900100D0 (sv) *	1999-01-15	1999-01-15	Astra Ab	New compounds

1999
- 1999-03-05 FR FR9902784A patent/FR2790474B1/fr not_active Expired - Fee Related
2000
- 2000-01-03 UA UA2001085808A patent/UA61164C2/uk unknown
- 2000-03-01 AT AT00907746T patent/ATE231869T1/de active
- 2000-03-01 TR TR2001/02403T patent/TR200102403T2/xx unknown
- 2000-03-01 SK SK1242-2001A patent/SK284339B6/sk not_active IP Right Cessation
- 2000-03-01 DK DK00907746T patent/DK1161434T3/da active
- 2000-03-01 EP EP00907746A patent/EP1161434B1/fr not_active Expired - Lifetime
- 2000-03-01 CA CA2372063A patent/CA2372063C/en not_active Expired - Fee Related
- 2000-03-01 CN CNB008046662A patent/CN1137894C/zh not_active Expired - Fee Related
- 2000-03-01 ID IDW00200101796A patent/ID30116A/id unknown
- 2000-03-01 NZ NZ513561A patent/NZ513561A/xx not_active IP Right Cessation
- 2000-03-01 KR KR1020017011245A patent/KR100768355B1/ko not_active Expired - Fee Related
- 2000-03-01 MX MXPA01008972A patent/MXPA01008972A/es unknown
- 2000-03-01 PL PL352330A patent/PL201683B1/pl unknown
- 2000-03-01 KR KR1020077013746A patent/KR20070086359A/ko not_active Withdrawn
- 2000-03-01 CZ CZ20013102A patent/CZ302259B6/cs not_active IP Right Cessation
- 2000-03-01 JP JP2000604044A patent/JP4806123B2/ja not_active Expired - Fee Related
- 2000-03-01 ES ES00907746T patent/ES2191611T3/es not_active Expired - Lifetime
- 2000-03-01 HR HR960321A patent/HRP20010655B1/xx not_active IP Right Cessation
- 2000-03-01 RS YUP-596/01A patent/RS49997B/sr unknown
- 2000-03-01 AU AU29226/00A patent/AU764625B2/en not_active Ceased
- 2000-03-01 DE DE60001307T patent/DE60001307T2/de not_active Expired - Lifetime
- 2000-03-01 RU RU2001123126/04A patent/RU2238273C2/ru not_active IP Right Cessation
- 2000-03-01 US US09/913,679 patent/US6538003B1/en not_active Expired - Lifetime
- 2000-03-01 IL IL14515000A patent/IL145150A0/xx active IP Right Grant
- 2000-03-01 EE EEP200100470A patent/EE04497B1/xx not_active IP Right Cessation
- 2000-03-01 WO PCT/FR2000/000502 patent/WO2000053608A1/fr not_active Ceased
- 2000-03-01 BR BR0008763-7A patent/BR0008763A/pt not_active Application Discontinuation
- 2000-03-01 HU HU0201753A patent/HU228671B1/hu not_active IP Right Cessation
- 2000-03-01 HK HK02101759.7A patent/HK1040398B/zh not_active IP Right Cessation
- 2000-03-01 CO CO00014724A patent/CO5160250A1/es unknown
- 2000-03-03 AR ARP000100942A patent/AR022820A1/es active IP Right Grant
- 2000-03-03 UY UY26048A patent/UY26048A1/es not_active IP Right Cessation
- 2000-03-03 PE PE2000000187A patent/PE20001543A1/es not_active Application Discontinuation
- 2000-03-08 TW TW089103753A patent/TWI222975B/zh not_active IP Right Cessation
2001
- 2001-08-16 BG BG105828A patent/BG65211B1/bg unknown
- 2001-08-17 ZA ZA200106811A patent/ZA200106811B/en unknown
- 2001-08-28 IL IL145150A patent/IL145150A/en not_active IP Right Cessation
- 2001-09-03 NO NO20014270A patent/NO327119B1/no not_active IP Right Cessation
2003
- 2003-02-06 US US10/359,881 patent/US6908927B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FR2790474B1 (fr)	2001-04-06
KR20070086359A (ko)	2007-08-27
EE200100470A (et)	2002-12-16
ES2191611T3 (es)	2003-09-16
BG105828A (bg)	2002-03-29
ZA200106811B (en)	2002-08-19
HK1040398A1 (en)	2002-06-07
NO327119B1 (no)	2009-04-27
CN1137894C (zh)	2004-02-11
CA2372063A1 (en)	2000-09-14
NZ513561A (en)	2003-06-30
CO5160250A1 (es)	2002-05-30
NO20014270D0 (no)	2001-09-03
PL352330A1 (en)	2003-08-11
EP1161434B1 (fr)	2003-01-29
HK1040398B (zh)	2003-07-18
IL145150A0 (en)	2002-06-30
JP4806123B2 (ja)	2011-11-02
HRP20010655A2 (en)	2002-08-31
NO20014270L (no)	2001-11-05
CZ20013102A3 (cs)	2002-01-16
TR200102403T2 (tr)	2001-12-21
KR100768355B1 (ko)	2007-10-17
UA61164C2 (uk)	2003-11-17
AU764625B2 (en)	2003-08-28
CA2372063C (en)	2011-01-11
CZ302259B6 (cs)	2011-01-19
RS49997B (sr)	2008-09-29
MXPA01008972A (es)	2002-03-27
DE60001307D1 (de)	2003-03-06
KR20010102492A (ko)	2001-11-15
PL201683B1 (pl)	2009-04-30
ID30116A (id)	2001-11-08
AU2922600A (en)	2000-09-28
BG65211B1 (bg)	2007-07-31
JP2002539129A (ja)	2002-11-19
SK284339B6 (sk)	2005-02-04
WO2000053608A1 (fr)	2000-09-14
HRP20010655B1 (en)	2003-06-30
BR0008763A (pt)	2002-01-02
US6908927B2 (en)	2005-06-21
PE20001543A1 (es)	2001-03-18
DK1161434T3 (da)	2003-05-26
EP1161434A1 (fr)	2001-12-12
HUP0201753A2 (en)	2002-09-28
US6538003B1 (en)	2003-03-25
FR2790474A1 (fr)	2000-09-08
ATE231869T1 (de)	2003-02-15
HUP0201753A3 (en)	2004-12-28
HU228671B1 (en)	2013-05-28
YU59601A (sh)	2004-03-12
SK12422001A3 (sk)	2002-04-04
TWI222975B (en)	2004-11-01
CN1343208A (zh)	2002-04-03
DE60001307T2 (de)	2003-12-11
IL145150A (en)	2007-06-03
RU2238273C2 (ru)	2004-10-20
AR022820A1 (es)	2002-09-04
US20030187012A1 (en)	2003-10-02
UY26048A1 (es)	2000-09-29

Legal Events

Date	Code	Title	Description
2005-02-15	HC1A	Change of owner name
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2009-02-16	KB4A	Valid patent at the end of a year	Effective date: 20081231
2011-02-15	KB4A	Valid patent at the end of a year	Effective date: 20101231
2015-11-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20150301

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TR200002120A3 (tr)	2001-06-21	Heteroaril-Ikameli Pirrol Türevleri, Bunlarin Hazirlanmasi ve Bunlarin Terapötik Kullanimlari
HUP0201810A3 (en)	2004-12-28	Sootepenseone and its derivatives, their preparation and use as medicament
EE200000018A (et)	2000-08-15	6-pürrolidiin-2-üülpüridiinid, nende valmistamine ja terapeutiline kasutamine
NO20001782D0 (no)	2000-04-06	3-amino-3-arylpropan-1-ol-derivater, deres fremstilling og anvendelse
EE9900560A (et)	2000-06-15	5-naftaleen-1-üül-1,3-dioksaani derivaadid, nende valmistamine ja terapeutiline kasutamine
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SI1161434T1 (en)	2003-06-30	Pyridopyranoazepine derivatives, preparation and therapeutic use
IT1312082B1 (it)	2002-04-04	Derivati morfinoidi, procedimento per la loro preparzione e loroimpiego terapeutico.