EE200000032A - Asendatud 6-fenüülfenantridiinid - Google Patents
Asendatud 6-fenüülfenantridiinidInfo
- Publication number
- EE200000032A EE200000032A EEP200000032A EEP200000032A EE200000032A EE 200000032 A EE200000032 A EE 200000032A EE P200000032 A EEP200000032 A EE P200000032A EE P200000032 A EEP200000032 A EE P200000032A EE 200000032 A EE200000032 A EE 200000032A
- Authority
- EE
- Estonia
- Prior art keywords
- pct
- compounds
- phenylphenanthridines
- substituted
- sec
- Prior art date
Links
- XXWONCALJGBUFK-UHFFFAOYSA-N 6-phenylphenanthridine Chemical class C1=CC=CC=C1C1=NC2=CC=CC=C2C2=CC=CC=C12 XXWONCALJGBUFK-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 229940082638 cardiac stimulant phosphodiesterase inhibitors Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002571 phosphodiesterase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Otolaryngology (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112793 | 1997-07-25 | ||
| PCT/EP1998/004478 WO1999005113A1 (en) | 1997-07-25 | 1998-07-18 | Substituted 6-phenylphenanthridines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EE200000032A true EE200000032A (et) | 2000-10-16 |
| EE04189B1 EE04189B1 (et) | 2003-12-15 |
Family
ID=8227117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200000032A EE04189B1 (et) | 1997-07-25 | 1998-07-18 | Asendatud 6-fenüülfenantridiinid |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6121279A (et) |
| EP (1) | EP1000035B1 (et) |
| JP (1) | JP2001510827A (et) |
| AT (1) | ATE228507T1 (et) |
| AU (1) | AU756349B2 (et) |
| CA (1) | CA2297911C (et) |
| CZ (1) | CZ296064B6 (et) |
| DE (1) | DE69809754T2 (et) |
| DK (1) | DK1000035T3 (et) |
| EE (1) | EE04189B1 (et) |
| ES (1) | ES2189235T3 (et) |
| HU (1) | HUP0003311A3 (et) |
| IL (1) | IL133825A (et) |
| PL (1) | PL191094B1 (et) |
| PT (1) | PT1000035E (et) |
| WO (1) | WO1999005113A1 (et) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1147088B1 (en) | 1999-01-15 | 2006-01-04 | ALTANA Pharma AG | 6-arylphenanthridines with pde-iv inhibiting activity |
| WO2000042017A1 (en) * | 1999-01-15 | 2000-07-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridine-n-oxides with pde-iv inhibiting activity |
| DE60024581T2 (de) * | 1999-01-15 | 2006-08-10 | Altana Pharma Ag | 6-phenylphenanthridine mit pde-iv hemmender wirkung |
| DE60033918D1 (de) | 1999-01-15 | 2007-04-26 | Altana Pharma Ag | Polysubstituted 6-phenylphenanthridines mit pde-iv hemmender wirkung |
| US6495550B2 (en) * | 1999-08-04 | 2002-12-17 | Icagen, Inc. | Pyridine-substituted benzanilides as potassium ion channel openers |
| JP2003506387A (ja) | 1999-08-04 | 2003-02-18 | アイカゲン インコーポレイテッド | カリウムチャンネルオープナーとしてのベンズアニリド |
| CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
| EP1250325B1 (en) * | 2000-01-11 | 2008-05-07 | Nycomed GmbH | Phenanthridine-n-oxides |
| ATE288430T1 (de) | 2000-07-14 | 2005-02-15 | Altana Pharma Ag | 6-heteroarylphenanthridine |
| AU2001281965A1 (en) * | 2000-07-14 | 2002-01-30 | Byk Gulden Lomberg Chemische Fabrik G.M.B.H. | Novel 6-phenylphenanthridines |
| ES2337887T3 (es) * | 2001-12-20 | 2010-04-30 | Merck Serono Sa | Derivados de pirrolidina en calidad de moduladores de prostaglandina. |
| PL374014A1 (en) * | 2002-08-17 | 2005-09-19 | Altana Pharma Ag | Novel phenanthridines having pde 3/4 inhibiting properties |
| US7423046B2 (en) * | 2002-08-29 | 2008-09-09 | Nycomed Gmbh | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| AU2003255493B8 (en) | 2002-08-29 | 2009-03-26 | Takeda Gmbh | 2-hydroxy-6-phenylphenanthridines as PDE-4 inhibitors |
| US6894061B2 (en) * | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| EA200501548A1 (ru) | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
| US20060189641A1 (en) * | 2003-07-31 | 2006-08-24 | Beate Schmidt | Novel 6-phenlyphenanthridines |
| WO2005012252A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenantridines |
| WO2005077906A1 (en) * | 2004-02-18 | 2005-08-25 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| SG182194A1 (en) | 2004-03-03 | 2012-07-30 | Nycomed Gmbh | Novel hydroxy-6-heteroarylphenanthridines and their use as pde4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| BRPI0508361A (pt) * | 2004-03-09 | 2007-11-20 | Altana Pharma Ag | hidróxi-6-fenilfenantridinas substituìdas por isoamido |
| US20080161339A1 (en) * | 2004-03-10 | 2008-07-03 | Altana Pharma Ag | Novel Thio-Containing Hydroxy-6-Phenylphenanthridines and their Use as Pde4 Inhibitors |
| BRPI0508471A8 (pt) * | 2004-03-10 | 2019-01-15 | Altana Pharma Ag | compostos de hidróxi-6-fenilfenantidinas substituídas por difluoroetóxi, composição farmacêutica e uso para a produção dos mesmos |
| NZ549254A (en) * | 2004-03-10 | 2010-06-25 | Nycomed Gmbh | Amido-substituted hydroxy-6-phenylphenanthridines and their use as PDE4 inhibitors |
| SI1856093T1 (sl) | 2005-03-02 | 2010-03-31 | Nycomed Gmbh | Hidrokloridna sol R aR bR dimetoksipiridin il etoksi metoksi a b heksahidrofenantridin ola |
| WO2006095009A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| JP5187616B2 (ja) | 2007-07-31 | 2013-04-24 | 住友化学株式会社 | β−ニトロスチレン化合物の製造方法 |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| EP2804603A1 (en) | 2012-01-10 | 2014-11-26 | President and Fellows of Harvard College | Beta-cell replication promoting compounds and methods of their use |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309545A (en) * | 1980-07-28 | 1982-01-05 | Pfizer Inc. | Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof |
| BR9707233A (pt) * | 1996-01-31 | 1999-07-20 | Byk Gulden Lomberg Chem Fab | Fenantridinas |
| EP0889886B1 (de) * | 1996-03-26 | 2002-09-18 | ALTANA Pharma AG | Neue in 6-position substituierte phenanthridine |
| GB9606425D0 (en) * | 1996-03-27 | 1996-06-05 | Binding Site Ltd | Improvements in and relating to the production of antibodies and test kits incorporating antibodies |
-
1998
- 1998-07-18 ES ES98943742T patent/ES2189235T3/es not_active Expired - Lifetime
- 1998-07-18 AT AT98943742T patent/ATE228507T1/de not_active IP Right Cessation
- 1998-07-18 CA CA002297911A patent/CA2297911C/en not_active Expired - Fee Related
- 1998-07-18 PL PL338452A patent/PL191094B1/pl not_active IP Right Cessation
- 1998-07-18 EP EP98943742A patent/EP1000035B1/en not_active Expired - Lifetime
- 1998-07-18 WO PCT/EP1998/004478 patent/WO1999005113A1/en not_active Ceased
- 1998-07-18 HU HU0003311A patent/HUP0003311A3/hu unknown
- 1998-07-18 CZ CZ20000281A patent/CZ296064B6/cs not_active IP Right Cessation
- 1998-07-18 DE DE69809754T patent/DE69809754T2/de not_active Expired - Fee Related
- 1998-07-18 US US09/462,508 patent/US6121279A/en not_active Expired - Fee Related
- 1998-07-18 IL IL13382598A patent/IL133825A/en not_active IP Right Cessation
- 1998-07-18 PT PT98943742T patent/PT1000035E/pt unknown
- 1998-07-18 AU AU91546/98A patent/AU756349B2/en not_active Ceased
- 1998-07-18 EE EEP200000032A patent/EE04189B1/et not_active IP Right Cessation
- 1998-07-18 DK DK98943742T patent/DK1000035T3/da active
- 1998-07-18 JP JP2000504112A patent/JP2001510827A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0003311A2 (en) | 2001-03-28 |
| DE69809754D1 (en) | 2003-01-09 |
| AU756349B2 (en) | 2003-01-09 |
| WO1999005113A1 (en) | 1999-02-04 |
| CZ296064B6 (cs) | 2006-01-11 |
| ES2189235T3 (es) | 2003-07-01 |
| CA2297911A1 (en) | 1999-02-04 |
| PT1000035E (pt) | 2003-04-30 |
| PL191094B1 (pl) | 2006-03-31 |
| ATE228507T1 (de) | 2002-12-15 |
| EE04189B1 (et) | 2003-12-15 |
| PL338452A1 (en) | 2000-11-06 |
| DK1000035T3 (da) | 2003-03-17 |
| CZ2000281A3 (cs) | 2000-08-16 |
| EP1000035A1 (en) | 2000-05-17 |
| EP1000035B1 (en) | 2002-11-27 |
| IL133825A (en) | 2005-12-18 |
| AU9154698A (en) | 1999-02-16 |
| IL133825A0 (en) | 2001-04-30 |
| JP2001510827A (ja) | 2001-08-07 |
| HUP0003311A3 (en) | 2002-10-28 |
| DE69809754T2 (de) | 2003-09-18 |
| CA2297911C (en) | 2007-09-04 |
| US6121279A (en) | 2000-09-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1000035T3 (da) | Substituerede 6-phenylphenanthridiner | |
| DK0889886T3 (da) | Hidtil ukendte, i 6-stilling substituerede phenanthridiner | |
| EE200000033A (et) | Uudsed tetrasoolderivaadid | |
| DE69622031D1 (de) | INDOLDERIVATE ALS cGMP-PDE INHIBITOREN | |
| TR200103186T2 (tr) | MEK enzimlerinin inhibitörleri olarak kinolin türevleri | |
| BR0007527A (pt) | Fenilfenantridinas com atividade inibitória depde-iv | |
| BR9707233A (pt) | Fenantridinas | |
| AU2002319814A1 (en) | Substituted 1h-dihydropyrazoles, their preparation and use | |
| DK1070056T3 (da) | Phthalazinon-PDE III/IV-inhibitorer | |
| DE69924292D1 (de) | Pyrazol verbindungen und ihre verwendung | |
| ES2249309T3 (es) | Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de csbp/p39 kinasa. | |
| BG100069A (bg) | Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им | |
| PT920426E (pt) | Novos derivados de tiazole com efeito inibidor de fosfodiesterase | |
| AP2001002188A0 (en) | 5HT1 antagonists for antidepressant therapy. | |
| AR020563A1 (es) | Compuestos (poli)tia-alquinoicos y sus derivados, composiciones que los incluyen y su utilizacion | |
| DE60202669D1 (de) | 6-phenylbenzonaphthyidine | |
| TR199903159T2 (xx) | Yeni �-Amino ve �-Azido karbonik asit t�revleri. | |
| DE59809344D1 (de) | Disubstituierte biphenyloxazoline | |
| ZA955052B (en) | Pyrrolidine derivatives their preparation and compositions containing them | |
| IL139317A0 (en) | Benzimdazole and benzoxazole derivatives and pharmaceutical compositions contining the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| KB4A | Valid patent at the end of a year |
Effective date: 20031231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20041231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20051231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20061231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20071231 |
|
| KB4A | Valid patent at the end of a year |
Effective date: 20081231 |
|
| MM4A | Lapsed by not paying the annual fees |
Effective date: 20090718 |