EE200000059A - Tetrahüdro-gamma-karboliinid - Google Patents

Tetrahüdro-gamma-karboliinid

Info

Publication number: EE200000059A
Authority: EE; Estonia
Prior art keywords: optionally substituted; 6alkyl; aryl; carbolines; tetrahydro
Prior art date: 1997-09-08

Application number

EEP200000059A

Other languages

English (en)

Inventor

Edmond Josephine Kennis Ludo

Carolus Mertens Josephus

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-09-08

Filing date

1998-09-01

Publication date

2000-10-16

1998-09-01 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2000-10-16 Publication of EE200000059A publication Critical patent/EE200000059A/et

2005-06-15 Publication of EE04496B1 publication Critical patent/EE04496B1/et

Links

125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
125000003118 aryl group Chemical group 0.000 abstract 2
102000040125 5-hydroxytryptamine receptor family Human genes 0.000 abstract 1
108091032151 5-hydroxytryptamine receptor family Proteins 0.000 abstract 1
125000000815 N-oxide group Chemical group 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
150000002431 hydrogen Chemical class 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

EEP200000059A 1997-09-08 1998-09-01 Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid EE04496B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97202761A EP0905136A1 (en)	1997-09-08	1997-09-08	Tetrahydro gamma-carbolines
PCT/EP1998/005710 WO1999012926A1 (en)	1997-09-08	1998-09-01	Tetrahydro gamma-carbolines

Publications (2)

Publication Number	Publication Date
EE200000059A true EE200000059A (et)	2000-10-16
EE04496B1 EE04496B1 (et)	2005-06-15

Family

ID=8228715

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000059A EE04496B1 (et)	1997-09-08	1998-09-01	Tetrahüdro-gamma-karboliinid, nende valmistamine ja kasutamine ravimina ning neid sisaldavad kompositsioonid

Country Status (27)

Country	Link
US (2)	US6303614B1 (et)
EP (2)	EP0905136A1 (et)
JP (1)	JP2001515899A (et)
KR (1)	KR100603896B1 (et)
CN (1)	CN1110496C (et)
AT (1)	ATE243209T1 (et)
AU (1)	AU752410B2 (et)
BR (1)	BR9811769A (et)
CA (1)	CA2301807A1 (et)
CZ (1)	CZ297220B6 (et)
DE (1)	DE69815700T2 (et)
EE (1)	EE04496B1 (et)
ES (1)	ES2202902T3 (et)
HR (1)	HRP20000108A2 (et)
HU (1)	HUP0003577A3 (et)
ID (1)	ID23954A (et)
IL (1)	IL134894A (et)
MY (1)	MY129176A (et)
NO (1)	NO315236B1 (et)
NZ (1)	NZ503096A (et)
PL (1)	PL191863B1 (et)
RU (1)	RU2208614C2 (et)
SK (1)	SK285594B6 (et)
TR (1)	TR200000616T2 (et)
TW (1)	TW531539B (et)
WO (1)	WO1999012926A1 (et)
ZA (1)	ZA988161B (et)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE602004019118D1 (de) *	2003-09-17	2009-03-05	Janssen Pharmaceutica Nv	Kondensierte heterocyclische verbindungen als modulatoren des serotoninrezeptors
CN1882590B (zh) *	2003-09-17	2014-03-05	詹森药业有限公司	作为血清素受体调节剂的稠合杂环化合物
EP1944306A1 (en) *	2003-09-17	2008-07-16	Janssen Pharmaceutica, N.V.	Fused heterocyclic compounds as serotonin receptor modulators
AU2005233456A1 (en) *	2004-04-12	2005-10-27	Taisho Pharmaceutical Co., Ltd.	Cyclic amine compound
CN101120002A (zh)	2005-02-17	2008-02-06	惠氏公司	环烷基稠合的吲哚、苯并噻吩、苯并呋喃和茚衍生物
FR2885905A1 (fr) *	2005-05-23	2006-11-24	Trophos Sa	Nouveaux composes chimiques et leurs utilisations comme medicament
WO2007009485A1 (en) *	2005-07-22	2007-01-25	Pharma C S.A.	Substituted 8-phenoxy-y-carboline derivatives with 5ht1 activity
JP2009515949A (ja) *	2005-11-15	2009-04-16	アストラゼネカ・アクチエボラーグ	新規な２−アミノピリミジノン誘導体およびそれらの使用
US8584921B2 (en) *	2006-10-06	2013-11-19	Covidien Lp	Surgical instrument with articulating tool assembly
US20090221627A1 (en) *	2007-09-20	2009-09-03	Alexey Aksinenko	Fluoro-containing derivatives of hydrogenated pyrido[4,3-b]indoles with neuroprotective and cognition enhancing properties, process for preparing, and use
JP2011507835A (ja)	2007-12-21	2011-03-10	アンドレイ・アレクサンドロビッチ・イワシェンコ	α−アドレナリン受容体、ドーパミン、ヒスタミン、イミダゾリン及びセロトニン受容体のリガンド並びにその使用
RU2374245C1 (ru)	2008-08-22	2009-11-27	Андрей Александрович Иващенко	Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
CN105399674B (zh)	2015-12-31	2017-02-15	青岛清原化合物有限公司	吡唑类化合物或其盐、制备方法、除草剂组合物及用途
CN106631941B (zh) *	2016-12-30	2018-09-28	青岛瀚生生物科技股份有限公司	一种2-甲基-3氯苯基甲硫醚的制备方法
GB201704325D0 (en)	2017-03-17	2017-05-03	Argonaut Therapeutics Ltd	Compounds
CN110698474B (zh) *	2019-11-14	2021-11-02	福州大学	一种α位取代四氢-γ-咔啉类化合物及其制备方法和应用
KR102894755B1 (ko) *	2020-10-09	2025-12-02	슈징 바이오파마 컴퍼니 리미티드	헤테로사이클로로 치환된 융합 γ-카르볼린 유도체, 이의 제조 방법, 중간체 및 용도

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3410286C2 (de) *	1984-03-21	1986-01-23	Fresenius AG, 6380 Bad Homburg	Verfahren zur Trennung von Blut sowie Vorrichtung zur Durchführung des Verfahrens
US4672117A (en) *	1985-09-16	1987-06-09	American Home Products Corporation	Antipsychotic gamma-carbolines
US4636563A (en) *	1985-09-16	1987-01-13	American Home Products Corporation	Antipsychotic γ-carbolines
US4798896A (en) *	1988-01-19	1989-01-17	American Home Products Corporation	Antipsychotic gamma-carboline N-oxides
RU2067980C1 (ru) *	1992-06-30	1996-10-20	Глэксо Груп Лимитед	Производные лактама и фармацевтическая композиция, являющаяся антагонистом 5-окситраптамина /5-нт/ на 5- нт3 -рецепторах или их физиологически приемлемые соли и соловаты
ATE247114T1 (de) *	1994-09-12	2003-08-15	Lilly Co Eli	Serotonergische modulatoren

1997
- 1997-09-08 EP EP97202761A patent/EP0905136A1/en not_active Withdrawn
1998
- 1998-09-01 CN CN98808818A patent/CN1110496C/zh not_active Expired - Fee Related
- 1998-09-01 KR KR1020007000970A patent/KR100603896B1/ko not_active Expired - Fee Related
- 1998-09-01 RU RU2000109310/04A patent/RU2208614C2/ru not_active IP Right Cessation
- 1998-09-01 DE DE69815700T patent/DE69815700T2/de not_active Expired - Fee Related
- 1998-09-01 NZ NZ503096A patent/NZ503096A/en unknown
- 1998-09-01 JP JP2000510733A patent/JP2001515899A/ja not_active Withdrawn
- 1998-09-01 CZ CZ20000726A patent/CZ297220B6/cs not_active IP Right Cessation
- 1998-09-01 SK SK299-2000A patent/SK285594B6/sk unknown
- 1998-09-01 CA CA002301807A patent/CA2301807A1/en not_active Abandoned
- 1998-09-01 IL IL13489498A patent/IL134894A/xx not_active IP Right Cessation
- 1998-09-01 US US09/508,240 patent/US6303614B1/en not_active Expired - Fee Related
- 1998-09-01 TR TR2000/00616T patent/TR200000616T2/xx unknown
- 1998-09-01 EP EP98951365A patent/EP1015451B1/en not_active Expired - Lifetime
- 1998-09-01 HR HR20000108A patent/HRP20000108A2/xx not_active Application Discontinuation
- 1998-09-01 WO PCT/EP1998/005710 patent/WO1999012926A1/en not_active Ceased
- 1998-09-01 ID IDW20000432A patent/ID23954A/id unknown
- 1998-09-01 EE EEP200000059A patent/EE04496B1/et not_active IP Right Cessation
- 1998-09-01 BR BR9811769-6A patent/BR9811769A/pt not_active Application Discontinuation
- 1998-09-01 AU AU97421/98A patent/AU752410B2/en not_active Ceased
- 1998-09-01 PL PL339143A patent/PL191863B1/pl not_active IP Right Cessation
- 1998-09-01 AT AT98951365T patent/ATE243209T1/de not_active IP Right Cessation
- 1998-09-01 ES ES98951365T patent/ES2202902T3/es not_active Expired - Lifetime
- 1998-09-02 TW TW087114508A patent/TW531539B/zh not_active IP Right Cessation
- 1998-09-07 MY MYPI98004080A patent/MY129176A/en unknown
- 1998-09-07 ZA ZA9808161A patent/ZA988161B/xx unknown
- 1998-09-08 HU HU0003577A patent/HUP0003577A3/hu unknown
2000
- 2000-02-14 NO NO20000737A patent/NO315236B1/no unknown
2001
- 2001-08-15 US US09/930,005 patent/US6506768B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
RU2208614C2 (ru)	2003-07-20
JP2001515899A (ja)	2001-09-25
TR200000616T2 (tr)	2000-07-21
NO20000737L (no)	2000-05-08
NO315236B1 (no)	2003-08-04
AU9742198A (en)	1999-03-29
AU752410B2 (en)	2002-09-19
US6506768B2 (en)	2003-01-14
ZA988161B (en)	2000-03-22
EE04496B1 (et)	2005-06-15
PL339143A1 (en)	2000-12-04
BR9811769A (pt)	2000-08-29
DE69815700T2 (de)	2004-04-29
ID23954A (id)	2000-06-08
EP1015451A1 (en)	2000-07-05
EP0905136A1 (en)	1999-03-31
SK285594B6 (sk)	2007-04-05
US20020103209A1 (en)	2002-08-01
DE69815700D1 (en)	2003-07-24
IL134894A0 (en)	2001-05-20
KR100603896B1 (ko)	2006-07-25
ES2202902T3 (es)	2004-04-01
TW531539B (en)	2003-05-11
HUP0003577A2 (hu)	2001-09-28
IL134894A (en)	2005-03-20
US6303614B1 (en)	2001-10-16
CZ297220B6 (cs)	2006-10-11
MY129176A (en)	2007-03-30
CZ2000726A3 (cs)	2000-07-12
CN1269800A (zh)	2000-10-11
NZ503096A (en)	2001-11-30
HK1029107A1 (en)	2001-03-23
SK2992000A3 (en)	2001-03-12
CA2301807A1 (en)	1999-03-18
HRP20000108A2 (en)	2000-12-31
NO20000737D0 (no)	2000-02-14
PL191863B1 (pl)	2006-07-31
KR20010022391A (ko)	2001-03-15
EP1015451B1 (en)	2003-06-18
WO1999012926A1 (en)	1999-03-18
ATE243209T1 (de)	2003-07-15
HUP0003577A3 (en)	2003-05-28
CN1110496C (zh)	2003-06-04

Legal Events

Date	Code	Title	Description
2006-02-15	KB4A	Valid patent at the end of a year	Effective date: 20051231
2007-02-15	KB4A	Valid patent at the end of a year	Effective date: 20061231
2008-02-15	KB4A	Valid patent at the end of a year	Effective date: 20071231
2008-06-16	MM4A	Lapsed by not paying the annual fees	Effective date: 20070901

Publication	Publication Date	Title
ID23954A (id)	2000-06-08	Tetrahidrogama-karbolin
YU96103A (sh)	2006-08-17	Novi derivati indola sa afinitetom za 5-ht6 receptor
DE3762618D1 (de)	1990-06-13	Amidderivate.
ATE104971T1 (de)	1994-05-15	2-aminopyrimidinon-derivate.
KR910002340A (ko)	1991-02-25	구아니딘 유도체, 그것의 제조 방법 및 그것을 함유하는 살충제 조성물
LU90410I2 (fr)	1999-08-31	Milnacipran (chlorhydrate)
DK1029853T3 (da)	2004-05-24	Heteroaromatiske bicykliske derivativer, der er egnede som anticancermidler
DE68914292D1 (de)	1994-05-11	Zusammensetzung zur Behandlung von ischämischen Störungen in Organen.
EP0604354A3 (en)	1995-02-08	Antidepressant and anti-Parkinson's disease compounds.
HUT57773A (en)	1991-12-30	Process for produicng n-(aminocarbonyl)-carbamates related to physostigmine, as well as pharmaceutical compositions comprising such compounds
EP0604355A3 (en)	1995-02-08	Alkyl substituted heterocyclic compounds.
DE69319939D1 (de)	1998-09-03	Aminobenzoesäure Derivate
DE69001004D1 (de)	1993-04-08	Zusammensetzung gegen leberkrankheiten.
IL99434A0 (en)	1992-08-18	3-(1h-indazol-3-yl)-4-pyridinamines,a process and intermediates for their preparation and pharmaceutical compositions containing them
RU95110868A (ru)	1996-12-27	Новые конденсированные производные тиазола, способ его получения и его фармацевтическая композиция
DE68923231D1 (de)	1995-08-03	Antihypertensive 3-Piperidinylindazol-Derivate.
BG105521A (en)	2001-12-29	Benzisoxazoles and phenons as alpha2-antagonists
ES533657A0 (es)	1985-10-01	Un procedimiento para la preparacion de nuevos derivados de pirrolo-(2,1-a)isoquilonina.
DE69828087D1 (de)	2005-01-13	Aminderivate
ES2141134T3 (es)	2000-03-16	Derivados de carbamoil pirrolidona para el tratamiento de la depresion y de los trastornos cerebrovasculares.
ID26809A (id)	2001-02-08	Senyawa-senyawa turunan sianoiminokuinoksalin
AP2002002707A0 (en)	2002-12-31	4, 5-Dihydro-Thiazo-2-Ylamine Derivatives and their Use as NO-Synthase Inhibitors.