EE200000239A - Uued metüleenbisfosfoonhappe derivaadid - Google Patents

Uued metüleenbisfosfoonhappe derivaadid

Info

Publication number: EE200000239A
Authority: EE; Estonia
Prior art keywords: acid derivatives; methylenebisphosphonic acid; novel methylenebisphosphonic; novel; derivatives
Prior art date: 1997-10-20

Application number

EEP200000239A

Other languages

English (en)

Inventor

Pohjala Esko

Veps�l�inen Jouko

Nupponen Heikki

K�hk�nen Jouni

Laur�n Leena

Hannuniemi Ritva

J�rvinen Tomi

Ahlmark Marko

Original Assignee

Leiras Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-20

Filing date

1998-10-20

Publication date

2001-08-15

1998-10-20 Application filed by Leiras Oy filed Critical Leiras Oy

2001-08-15 Publication of EE200000239A publication Critical patent/EE200000239A/et

2003-06-16 Publication of EE04061B1 publication Critical patent/EE04061B1/et

Links

MBKDYNNUVRNNRF-UHFFFAOYSA-N medronic acid Chemical class OP(O)(=O)CP(O)(O)=O MBKDYNNUVRNNRF-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/409—Compounds containing the structure P(=X)-X-acyl, P(=X) -X-heteroatom, P(=X)-X-CN (X = O, S, Se)
- C07F9/4093—Compounds containing the structure P(=X)-X-C(=X)- (X = O, S, Se)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Physical Education & Sports Medicine (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Rheumatology (AREA)
Animal Behavior & Ethology (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

EEP200000239A 1997-10-20 1998-10-20 Metüleenbisfosfoonhappe derivaadid EE04061B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FI974001A FI104901B (fi)	1997-10-20	1997-10-20	Uudet metyleenibisfosfonihappojohdannaiset
PCT/FI1998/000814 WO1999020634A1 (en)	1997-10-20	1998-10-20	Novel methylenebisphosphonic acid derivatives

Publications (2)

Publication Number	Publication Date
EE200000239A true EE200000239A (et)	2001-08-15
EE04061B1 EE04061B1 (et)	2003-06-16

Family

ID=8549759

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000239A EE04061B1 (et)	1997-10-20	1998-10-20	Metüleenbisfosfoonhappe derivaadid

Country Status (19)

Country	Link
US (1)	US6326363B1 (et)
EP (1)	EP1032578A1 (et)
JP (1)	JP2001520232A (et)
KR (1)	KR20010031269A (et)
CN (1)	CN1147497C (et)
AU (1)	AU740355B2 (et)
BG (1)	BG104452A (et)
BR (1)	BR9813102A (et)
CA (1)	CA2306080A1 (et)
EE (1)	EE04061B1 (et)
FI (1)	FI104901B (et)
HU (1)	HUP0004386A3 (et)
IL (1)	IL135639A0 (et)
NO (1)	NO20002006L (et)
NZ (1)	NZ504390A (et)
PL (1)	PL340055A1 (et)
RU (1)	RU2205833C2 (et)
TR (1)	TR200001055T2 (et)
WO (1)	WO1999020634A1 (et)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NO313180B1 (no) *	2000-07-04	2002-08-26	Anticancer Therapeutic Inv Sa	Bensökende alfapartikkel emitterende radiofarmasöytika
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
WO2008024169A1 (en) *	2006-07-21	2008-02-28	Glsynthesis, Inc.	Reactive pyrophosphoric and bisphosphonic acid derivatives and methods of their use
EP2364086B1 (en)	2008-11-20	2016-09-14	Glsynthesis Inc.	Novel antithrombotic diadenosine tetraphosphates and related analogs
CN107011380A (zh) *	2016-01-28	2017-08-04	臧伟	一种二膦酸衍生物及含二膦酸衍生物的组合物治疗骨折的应用
DE102024124931A1 (de) *	2024-08-30	2026-03-05	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein	Verwendung von N,N-disubstituierten Phosphorylcarbamaten und Verfahren zu deren Herstellung

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4447256A (en)	1977-07-20	1984-05-08	Nissan Chemical Industries, Ltd.	N-(Unsubstituted or substituted pyridyl)aminomethylene-diphosphonic acids, herbicidal compositions containing same, their use for herbicides, and process for preparing same
DE2758580A1 (de)	1977-12-29	1979-07-05	Hoechst Ag	Verfahren zur herstellung von phosphin- und phosphonsaeure-anhydriden
HU199151B (en)	1987-03-10	1990-01-29	Yamanouchi Pharma Co Ltd	Process for producing bis-phosphonic acid derivatives
US4933472A (en)	1988-04-08	1990-06-12	Yamanouchi Pharmaceutical Co., Ltd.	Substituted aminomethylenebis(phosphonic acid) derivatives
EP0356866A3 (en)	1988-08-29	1991-03-27	E.R. SQUIBB & SONS, INC.	Phosphorus-containing squalene synthetase inhibitors and method
FI83421C (fi) *	1989-06-21	1991-07-10	Huhtamaeki Oy	Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
DE69023844T2 (de) *	1989-09-06	1996-06-20	Merck & Co Inc	Acyloxymethylester der Bisphonsäuren als Knochenresorptions-Inhibitoren.
FI89364C (fi) *	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya, farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89365C (fi) *	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
FI89366C (fi) *	1990-12-20	1993-09-27	Leiras Oy	Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat
JP3141028B2 (ja)	1991-04-06	2001-03-05	アストラ・フアーマシユウテイカルズ・リミテツド	Ａｔｐ類似体
TW237386B (et)	1992-04-15	1995-01-01	Ciba Geigy
KR100315612B1 (ko) *	1993-02-10	2002-06-20	추후제출	N-알킬-2-치환아데노신트리포스페이트동족체
US5462932A (en)	1994-05-17	1995-10-31	Merck & Co., Inc.	Oral liquid alendronate formulations

1997
- 1997-10-20 FI FI974001A patent/FI104901B/fi not_active IP Right Cessation
1998
- 1998-10-20 NZ NZ504390A patent/NZ504390A/en unknown
- 1998-10-20 RU RU2000112534/04A patent/RU2205833C2/ru not_active IP Right Cessation
- 1998-10-20 EE EEP200000239A patent/EE04061B1/et not_active IP Right Cessation
- 1998-10-20 KR KR1020007004256A patent/KR20010031269A/ko not_active Ceased
- 1998-10-20 CN CNB988103710A patent/CN1147497C/zh not_active Expired - Fee Related
- 1998-10-20 HU HU0004386A patent/HUP0004386A3/hu unknown
- 1998-10-20 AU AU95437/98A patent/AU740355B2/en not_active Ceased
- 1998-10-20 CA CA002306080A patent/CA2306080A1/en not_active Abandoned
- 1998-10-20 WO PCT/FI1998/000814 patent/WO1999020634A1/en not_active Ceased
- 1998-10-20 PL PL98340055A patent/PL340055A1/xx unknown
- 1998-10-20 BR BR9813102-8A patent/BR9813102A/pt not_active IP Right Cessation
- 1998-10-20 TR TR2000/01055T patent/TR200001055T2/xx unknown
- 1998-10-20 IL IL13563998A patent/IL135639A0/xx unknown
- 1998-10-20 JP JP2000516975A patent/JP2001520232A/ja not_active Withdrawn
- 1998-10-20 US US09/529,826 patent/US6326363B1/en not_active Expired - Lifetime
- 1998-10-20 EP EP98949022A patent/EP1032578A1/en not_active Withdrawn
2000
- 2000-04-17 NO NO20002006A patent/NO20002006L/no not_active Application Discontinuation
- 2000-05-17 BG BG104452A patent/BG104452A/xx unknown

Also Published As

Publication number	Publication date
AU9543798A (en)	1999-05-10
FI104901B (fi)	2000-04-28
WO1999020634A1 (en)	1999-04-29
BG104452A (en)	2000-12-29
RU2205833C2 (ru)	2003-06-10
TR200001055T2 (tr)	2000-09-21
CN1147497C (zh)	2004-04-28
IL135639A0 (en)	2001-05-20
NO20002006L (no)	2000-06-15
NO20002006D0 (no)	2000-04-17
US6326363B1 (en)	2001-12-04
HUP0004386A3 (en)	2002-08-28
FI974001L (fi)	1999-04-21
NZ504390A (en)	2001-10-26
HUP0004386A2 (hu)	2001-04-28
JP2001520232A (ja)	2001-10-30
KR20010031269A (ko)	2001-04-16
BR9813102A (pt)	2000-08-22
CA2306080A1 (en)	1999-04-29
CN1276793A (zh)	2000-12-13
PL340055A1 (en)	2001-01-15
EP1032578A1 (en)	2000-09-06
EE04061B1 (et)	2003-06-16
FI974001A0 (fi)	1997-10-20
AU740355B2 (en)	2001-11-01

Legal Events

Date	Code	Title	Description
2004-02-16	KB4A	Valid patent at the end of a year	Effective date: 20031231
2005-02-15	KB4A	Valid patent at the end of a year	Effective date: 20041231
2005-06-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20041020

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