EE200000357A - Meetod 16ß-arüüloksü-4-asasteroidide valmistamiseks ning vaheühendid - Google Patents

Meetod 16ß-arüüloksü-4-asasteroidide valmistamiseks ning vaheühendid

Info

Publication number
EE200000357A
EE200000357A EEP200000357A EEP200000357A EE200000357A EE 200000357 A EE200000357 A EE 200000357A EE P200000357 A EEP200000357 A EE P200000357A EE P200000357 A EEP200000357 A EE P200000357A EE 200000357 A EE200000357 A EE 200000357A
Authority
EE
Estonia
Prior art keywords
azasteroids
aryloxy
intermediates
preparation
Prior art date
Application number
EEP200000357A
Other languages
English (en)
Estonian (et)
Inventor
R. Humphrey Guy
A. Miller Ross
Li Wenjie
Original Assignee
Merck & Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.
Publication of EE200000357A publication Critical patent/EE200000357A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/205—Saturated compounds having only one carboxyl group and containing keto groups containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
EEP200000357A 1997-12-23 1998-12-18 Meetod 16ß-arüüloksü-4-asasteroidide valmistamiseks ning vaheühendid EE200000357A (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6853697P 1997-12-23 1997-12-23
PCT/US1998/027136 WO1999032507A2 (en) 1997-12-23 1998-12-18 Intermediates and process for the synthesis of 17-unsubstituted 16.beta.-aryloxy 4-azasteroids

Publications (1)

Publication Number Publication Date
EE200000357A true EE200000357A (et) 2001-12-17

Family

ID=22083194

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000357A EE200000357A (et) 1997-12-23 1998-12-18 Meetod 16ß-arüüloksü-4-asasteroidide valmistamiseks ning vaheühendid

Country Status (10)

Country Link
US (1) US6187925B1 (is)
EP (1) EP1042356A2 (is)
AR (1) AR014944A1 (is)
AU (1) AU2306799A (is)
EA (1) EA002333B1 (is)
EE (1) EE200000357A (is)
IS (1) IS5507A (is)
TR (1) TR200001969T2 (is)
TW (1) TW548276B (is)
WO (1) WO1999032507A2 (is)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR016257A1 (es) * 1998-05-14 2001-06-20 Merck & Co Inc Proceso para la sintesis estereoselectiva de ariloxi-4-aza-5alfa-androstan-3-onas, 16 alfa y 16 beta-sustituidas e insustituidas, e intermediariosobtenidos en dicho proceso.
NO20031736D0 (no) * 2003-04-15 2003-04-15 Amersham Health As Forbindelser

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB813845A (en) 1955-08-01 1959-05-27 Lasdon Foundation Inc Improvements in cyclopentanophenanthrene compounds
US2759952A (en) 1955-08-01 1956-08-21 Lasdon Foundation Inc Cyclopentano-phenanthrene compounds
US4377584A (en) 1978-04-13 1983-03-22 Merck & Co., Inc. 4-Aza-17β-substituted-5α-androstan-3-one-reductase inhibitors
US4760071A (en) 1984-02-27 1988-07-26 Merck & Co., Inc. 17β-N-monosubstituted carbamoyl-4-aza-5α-androst-1-en-3-ones which are active as testosterone 5α-reductase inhibitors
JP2863786B2 (ja) 1989-05-30 1999-03-03 ファルマシア・アンド・アップジョン・カンパニー ３，５―セコアンドロスト―５―オン―３，１７β―二酸の酸化調製方法
US5021575A (en) 1989-11-13 1991-06-04 Merck & Co., Inc. Method for introducing a 1,2 double bond into azasteroids
US5091534A (en) 1990-08-27 1992-02-25 Merck & Co., Inc. Trialkylsilyl trifluoromethanesulfonate mediated α-methylenic carbon functionalization of 4-AZA-5α-androstan-3-one steroids
US5120847A (en) 1990-08-27 1992-06-09 Merck & Co., Inc. Process for iodinating or brominating the α-methylenic carbon of a secondary amide
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5237064A (en) 1992-05-20 1993-08-17 Merck & Co., Inc. Process for producing 7β-substituted-aza-5αandrostan-3-ones
BR9407866A (pt) * 1993-10-21 1996-10-29 Merck & Co Inc Composto processos para inibiçao de 5 -redufase ou isoenzimas da mesma paratratamento de condiçoes de acne vulgar alopécia androgènica hirsutismo feminino hiperplasia prostática benigna prostatite e para o tratamento e/ou prevençao do cancer da próstata para interrupçao e reversao de alopécia androgènica e promoçao do crescimento de cabelo em um mamifero e para inibiçao de conversao biossintética da testosterona para di-hidro- testosterona em um mamifero e composiçao farmacèutica
CN1152316A (zh) 1994-05-19 1997-06-18 麦克公司 具有烯丙基的甾族化合物的氧化
US5470976A (en) 1994-09-07 1995-11-28 Merck & Co., Inc. Process for the stereoselective reduction of steroid enelactams
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
JP2000505444A (ja) 1996-02-14 2000-05-09 ヘキスト・マリオン・ルセル・インコーポレイテツド テストステロン５α―レダクターゼおよびＣ▲下１７―２０▼リアーゼの活性阻害剤としての１７β―シクロプロピル（アミノ／オキシ）４―アザステロイド

Also Published As

Publication number Publication date
WO1999032507A2 (en) 1999-07-01
US6187925B1 (en) 2001-02-13
TW548276B (en) 2003-08-21
WO1999032507A3 (en) 1999-09-10
EA200000705A1 (ru) 2000-12-25
EP1042356A2 (en) 2000-10-11
AR014944A1 (es) 2001-04-11
EA002333B1 (ru) 2002-04-25
TR200001969T2 (tr) 2000-12-21
AU2306799A (en) 1999-07-12
IS5507A (is) 2000-05-23

Similar Documents

Publication Publication Date Title
NO990756D0 (no) FremgangsmÕte for fremstilling av mellomprodukter for florfenikol
HUP0004388A3 (en) Process for the preparation of oxazolidinones, intermediates and preparation thereof
IL113850A0 (en) Process and intermediates for the preparation of 3-aryluracils
NO991382D0 (no) Mellomprodukter og fremgangsmÕte for fremstilling av olanzapin
TR199701051A3 (tr) 2' -Fluoro-5-metil- -l-arabino-furanosilüridin hazirlanma prosesi
HUP0003958A3 (en) Process for preparation of 4-aryl-piperidines and intermediates
HUP0004855A3 (en) Method for the synthesis of quinoline derivatives and intermediates
HUP9600320A3 (en) Process and new intermediates for the preparation of triazolinon-derivatives
CY2005003I2 (el) Mεθοδοι και ενδιαμεσα χρησιμα για κατασκευη αντιφολικων
HUP0104278A3 (en) Novel process for the preparation of 7-azaindolyl-3-carboxylic acid and 7-azaindol and their intermediates
DE69922440D1 (de) Verfahren und Zwischenprodukte zur Herstellung von 2,3-Pyridindicarboxylatderivaten
NO996432D0 (no) Fremgangsmåte for fremstilling av 4-substituert-1H-indol-3- glykosamider
HU228274B1 (en) Intermediates for the preparation of 2-imidazoline-5-ones
EE200000357A (et) Meetod 16ß-arüüloksü-4-asasteroidide valmistamiseks ning vaheühendid
DE69804920D1 (de) Verfahren zur Herstellung von Furopyridin-Derivaten und Zwischenprodukten
EE200100333A (et) Meetod 2-halo-3-nitro-4-aminopüridiini valmistamiseks ja selleks vajalike vaheühendite saamine
DE69819093D1 (de) Apparat zur Herstellung von Metalbändern
DE59510416D1 (de) Verfahren zur Herstellung von Chlormethylpyridin Derivaten und Acylaminomethylpyridine als Zwischenprodukte
NO990185L (no) FremgangsmÕte for fremstilling av naftypyridoner og mellomprodukter
AU4708697A (en) Process for the preparation of eberconazol and intermediates thereof
EE9900404A (et) Arüülaminotriasolopüridiinide valmistamise meetod
NO20003077L (no) FremgangsmÕte for fremstilling av klorbenzooksazolen
DE69510390D1 (de) Verfahren zur Herstellung von Allylchinon-Derivaten und Zwischenprodukte
FI971378A7 (fi) Menetelmiä ja välituotteita 3-aminobentso(b)-atsepinonien valmistusta varten
NO982975D0 (no) FremgangsmÕte for fremstilling av fosfatbundne keramer