EE200000428A - VLA-4 antagonistid - Google Patents

VLA-4 antagonistid

Info

Publication number
EE200000428A
EE200000428A EEP200000428A EEP200000428A EE200000428A EE 200000428 A EE200000428 A EE 200000428A EE P200000428 A EEP200000428 A EE P200000428A EE P200000428 A EEP200000428 A EE P200000428A EE 200000428 A EE200000428 A EE 200000428A
Authority
EE
Estonia
Prior art keywords
vla
antagonists
Prior art date
Application number
EEP200000428A
Other languages
English (en)
Inventor
Wattanasin Sompong
Josef Von Matt Peter
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of EE200000428A publication Critical patent/EE200000428A/et

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EEP200000428A 1998-01-23 1999-01-21 VLA-4 antagonistid EE200000428A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1233698A 1998-01-23 1998-01-23
US11072398P 1998-12-03 1998-12-03
PCT/EP1999/000384 WO1999037605A1 (en) 1998-01-23 1999-01-21 Vla-4 antagonists

Publications (1)

Publication Number Publication Date
EE200000428A true EE200000428A (et) 2001-12-17

Family

ID=26683440

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000428A EE200000428A (et) 1998-01-23 1999-01-21 VLA-4 antagonistid

Country Status (13)

Country Link
EP (1) EP1049665A1 (et)
JP (1) JP4564654B2 (et)
KR (1) KR20010034317A (et)
CN (1) CN1294576A (et)
AU (1) AU746174B2 (et)
BR (1) BR9907733A (et)
CA (1) CA2318639A1 (et)
EE (1) EE200000428A (et)
HU (1) HUP0100336A3 (et)
ID (1) ID26665A (et)
IL (1) IL137329A0 (et)
NO (1) NO20003694L (et)
WO (1) WO1999037605A1 (et)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2623900A (en) * 1999-01-22 2000-08-07 American Home Products Corporation Compounds which inhibit leukocyte adhesion mediated by vla-4
US6492372B1 (en) 1999-01-22 2002-12-10 Elan Pharmaceuticals, Inc. Heteroaryl, heterocyclic and aryl compounds which inhibit leukocyte adhesion mediated by VLA-4
US6436904B1 (en) 1999-01-25 2002-08-20 Elan Pharmaceuticals, Inc. Compounds which inhibit leukocyte adhesion mediated by VLA-4
CA2361162A1 (en) 1999-03-01 2000-09-08 Elan Pharmaceuticals, Inc. Alpha-aminoacetic acid derivatives useful as alpha 4 beta 7-receptor antagonists
WO2001042192A2 (en) * 1999-12-07 2001-06-14 Novartis Ag Vla-4 integrin antagonists
EA004673B1 (ru) 1999-12-28 2004-06-24 Пфайзер Продактс Инк. Непептидильные ингибиторы vla-4-зависимого связывания клеток, применяемые при лечении воспалительных, аутоимунных и респираторных заболеваний
DE10019755A1 (de) * 2000-04-20 2001-11-08 Bayer Ag Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten
GB2367816A (en) * 2000-10-09 2002-04-17 Bayer Ag Urea- and thiourea-containing derivatives of beta-amino acids
GB2369357A (en) * 2000-10-09 2002-05-29 Bayer Ag Aliphatic, cyclic amino carboxylic acids as integrin antagonists
GB2377933A (en) 2001-07-06 2003-01-29 Bayer Ag Succinic acid derivatives useful as integrin antagonists
TWI281470B (en) 2002-05-24 2007-05-21 Elan Pharm Inc Heterocyclic compounds which inhibit leukocyte adhesion mediated by alpha4 integrins
TW200307671A (en) 2002-05-24 2003-12-16 Elan Pharm Inc Heteroaryl compounds which inhibit leukocyte adhesion mediated by α 4 integrins
TW200610754A (en) * 2004-06-14 2006-04-01 Daiichi Seiyaku Co Vla-4 inhibitor
GB0523576D0 (en) * 2005-11-18 2005-12-28 Theradeas Ltd Drug composition and its use in therapy
KR20080100271A (ko) 2006-02-27 2008-11-14 엘란 파마슈티칼스, 인크. Vla-4에 의해 매개되는 백혈구 부착을 억제하는 피리미디닐 술폰아미드 화합물
EP2510941A3 (en) 2007-02-20 2013-01-23 Merrimack Pharmaceuticals, Inc. Methods of treating multiple sclerosis by administration of alpha-fetoprotein in combination with an integrin antagonist
BRPI0911652A2 (pt) 2008-04-11 2015-08-04 Merrimack Pharmaceuticals Inc Ligantes de albumina sérica humana e seus conjugados

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306840B1 (en) * 1995-01-23 2001-10-23 Biogen, Inc. Cell adhesion inhibitors
BR9814376A (pt) * 1997-12-23 2000-10-10 Aventis Pharma Ltd Composto ou um pró-medicamento correspondente, ou um sal farmaceuticamente aceitável ou solvato de um tal composto ou um pró-medicamento deste, uso destes, composição farmacêutica, processo para o tratamento de um paciente humano ou animal não humano sofrendo de, ou sujeito a, condições que podem ser melhoradas pela admnistração de um inibidor da adesão celular mediada por &4ß1, e, resina

Also Published As

Publication number Publication date
NO20003694L (no) 2000-09-20
WO1999037605A1 (en) 1999-07-29
HUP0100336A2 (hu) 2001-07-30
ID26665A (id) 2001-01-25
KR20010034317A (ko) 2001-04-25
NO20003694D0 (no) 2000-07-19
EP1049665A1 (en) 2000-11-08
CA2318639A1 (en) 1999-07-29
JP4564654B2 (ja) 2010-10-20
JP2002501039A (ja) 2002-01-15
AU746174B2 (en) 2002-04-18
IL137329A0 (en) 2001-07-24
AU2829299A (en) 1999-08-09
HUP0100336A3 (en) 2002-11-28
CN1294576A (zh) 2001-05-09
BR9907733A (pt) 2000-10-17

Similar Documents

Publication Publication Date Title
ID29066A (id) Turunan fenilglisina
ID27423A (id) Turunan kuinolin
ATE341990T1 (de) Sigmidoskop
ID23234A (id) Turunan-turunan benzosulfona
NO20004520D0 (no) HÕrbehandlingsinnretning
DE59901560D1 (de) Retrograder tibianagel
NO994700D0 (no) Nödunnsetningsinnretning
ID27484A (id) Turunan adenosina
NO990113D0 (no) Flerskrog-fart°y
DE69933980D1 (de) Netzadressensverwaltung
DE59907306D1 (de) Fadenchangierung
ID27547A (id) Turunan kuinolin
ID23761A (id) Trisiklik tersubstitusi
EP1124578A4 (en) NEW IMMUNOADJUVANTS
NO994626D0 (no) Substituerte benzamider
NO20003694D0 (no) VLA-4 antagonister
DE59908968D1 (de) Benzoylpyridazine
DE59903966D1 (de) Exzenterzahnradgetriebe
ID23219A (id) Trisiklik tersubstitusi
DE59908057D1 (de) Underdruckhandhabungseinrichung
DE59901046D1 (de) Methylcyclotetradec-5-en-1-one
DE59808995D1 (de) Endomikroskopsystem
ID28356A (id) Turunam tiazola
FI980759A0 (fi) Taetningskonstruktion foer suglaodan i en sugvals
DE19842103B4 (de) Stanznietzuführung