EE200200344A - Novel modulators of dopamine neurotransmission - Google Patents

Novel modulators of dopamine neurotransmission

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Publication number
EE200200344A
EE200200344A EEP200200344A EEP200200344A EE200200344A EE 200200344 A EE200200344 A EE 200200344A EE P200200344 A EEP200200344 A EE P200200344A EE P200200344 A EEP200200344 A EE P200200344A EE 200200344 A EE200200344 A EE 200200344A
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EE
Estonia
Prior art keywords
alkyl
oso
phenyl
disclosed
dopamine neurotransmission
Prior art date
Application number
EEP200200344A
Other languages
Estonian (et)
Inventor
Andersson Bengt (Surnud)
Sonesson Clas
Waters Susanna
Waters Nicholas
Tedroff Joakim
Original Assignee
A. Carlsson Research Ab
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Publication date
Application filed by A. Carlsson Research Ab filed Critical A. Carlsson Research Ab
Priority to EEP200900004A priority Critical patent/EE200900004A/en
Publication of EE200200344A publication Critical patent/EE200200344A/en
Publication of EE05135B1 publication Critical patent/EE05135B1/en

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Abstract

New 3-substituted 4-(phenyl-N-alkyl)-piperazine and 4-(phenyl-N-alkyl)-piperidine compounds of Formula 1: wherein X N, CH, or C, however X may only be C when the compound comprises a double bond at the dotted line; R 1 is OSO 2 CF 3 , OSO 2 CH 3 , SOR 3 , SO 2 R 3 , COR 3 , NO 2 , or CONHR 3 and when X is CH or C R 1 may also be CF 3 , CN, F, Cl, Br, or I; R 2 is a C 1 -C 4 alkyl, an allyl, CH 2 SCH 3 , CH 2 CH 2 OCH 3 , CH 2 CH 2 CH 2 F, CH 2 CF 3 , 3,3,3-trifluoropropyl, 4,4,4-trifluorobutyl, or -(CH 2 )-R 4 ; R 3 is a C 1 -C 3 alkyl, CF 3 , or N(R 2 ) 2 ; R 4 is a C 3 -C 6 cycloalkyl, 2-tetrahydrofurane or 3-tetra-hydrofurane, as well as pharmaceutically acceptable salts thereof are disclosed. €ƒ€ƒ€ƒAlso pharmaceutical compositions comprising the above compounds and methods wherein the above compounds are used for treatment of disorders in the central nervous system are disclosed.
EEP200200344A 1999-12-22 2000-12-22 Modulators of Dopamine Neurotransmission, their Use and Pharmaceutical Compositions Containing Them EE05135B1 (en)

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