EE9600186A - Neurokiniini (tahhüülkiniini) antagonistid - Google Patents

Neurokiniini (tahhüülkiniini) antagonistid

Info

Publication number: EE9600186A
Authority: EE; Estonia
Prior art keywords: tachylquinine; neurokinin; antagonists
Prior art date: 1994-05-07

Application number

EE9600186A

Other languages

English (en)

Estonian (et)

Inventor

Schnorrenberg Gerd

Esser Franz

Dollinger Horst

Jung Birgit

Speck Georg

Buerger Erich

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-05-07

Filing date

1995-05-04

Publication date

1997-08-15

1994-12-22 Priority claimed from DE4445939A external-priority patent/DE4445939A1/de

1995-05-04 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1997-08-15 Publication of EE9600186A publication Critical patent/EE9600186A/xx

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EE9600186A 1994-05-07 1995-05-04 Neurokiniini (tahhüülkiniini) antagonistid EE9600186A (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE4416255		1994-05-07
DE4445939A DE4445939A1 (de)	1994-05-07	1994-12-22	Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen (II)
PCT/EP1995/001691 WO1995030687A1 (de)	1994-05-07	1995-05-04	Neurokinin (tachykinin)-antagonisten

Publications (1)

Publication Number	Publication Date
EE9600186A true EE9600186A (et)	1997-08-15

Family

ID=25936418

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EE9600186A EE9600186A (et)	1994-05-07	1995-05-04	Neurokiniini (tahhüülkiniini) antagonistid

Country Status (20)

Country	Link
US (2)	US5712273A (no)
EP (1)	EP0804463A1 (no)
JP (1)	JPH09512806A (no)
CN (1)	CN1147260A (no)
AU (1)	AU690275B2 (no)
BG (1)	BG100946A (no)
CA (1)	CA2189764A1 (no)
CZ (1)	CZ325496A3 (no)
EE (1)	EE9600186A (no)
FI (1)	FI964473A0 (no)
HR (1)	HRP950276A2 (no)
HU (1)	HUT75708A (no)
IL (1)	IL113625A0 (no)
MX (1)	MX9605128A (no)
NO (1)	NO964700D0 (no)
NZ (1)	NZ285750A (no)
PL (1)	PL317127A1 (no)
RO (1)	RO115355B1 (no)
SK (1)	SK142696A3 (no)
WO (1)	WO1995030687A1 (no)

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DE59309867D1 (de) *	1992-09-03	1999-12-16	Boehringer Ingelheim Pharma	Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen
DE19541283A1 (de)	1995-11-06	1997-05-07	Boehringer Ingelheim Kg	Neue Aminosäurederivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE19623950A1 (de) *	1996-06-15	1997-12-18	Boehringer Ingelheim Kg	Pharmazeutische Zubereitung in Form von Liposomen
US6329342B1 (en)	1997-08-19	2001-12-11	Eli Lilly And Company	Treatment of congestive heart failure with growth hormone secretagogues
US6639076B1 (en)	1998-08-18	2003-10-28	Eli Lilly And Company	Growth hormone secretagogues
GB9819860D0 (en)	1998-09-12	1998-11-04	Zeneca Ltd	Chemical compounds
WO2000048623A1 (en)	1999-02-18	2000-08-24	Kaken Pharmaceutical Co., Ltd.	Novel amide derivatives as growth hormone secretagogues
US6828331B1 (en)	1999-02-19	2004-12-07	Eli Lilly And Company	Growth hormone secretagogues
WO2001032625A1 (en)	1999-11-03	2001-05-10	Du Pont Pharmaceuticals Company	Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine and serotonin
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
JP2003514022A (ja)	1999-11-18	2003-04-15	アンテックスファーマ・インコーポレーテッド	置換された１−ベンズアゼピンとその誘導体
JP5132864B2 (ja)	2000-07-11	2013-01-30	アルバニーモレキュラーリサーチ，インコーポレイテッド	４−フェニル置換テトラヒドロイソキノリンおよびその使用方法
US7125840B2 (en) *	2001-10-09	2006-10-24	Eli Lilly And Company	Substituted dipeptides as growth hormone secretagogues
US20060167268A1 (en) *	2002-04-09	2006-07-27	Eli Lilly And Company, Patent Division,	Growth hormone secretagogues
WO2003087069A2 (en) *	2002-04-09	2003-10-23	Eli Lilly And Company	Dipeptidic growth hormone secretagogues
AU2005274927B2 (en)	2004-07-15	2011-11-03	Albany Molecular Research, Inc.	Aryl-and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
US7238560B2 (en) *	2004-07-23	2007-07-03	Cree, Inc.	Methods of fabricating nitride-based transistors with a cap layer and a recessed gate
US8362075B2 (en)	2005-05-17	2013-01-29	Merck Sharp & Dohme Corp.	Cyclohexyl sulphones for treatment of cancer
KR101594898B1 (ko)	2005-07-15	2016-02-18	알바니 몰레큘라 리써치, 인크.	아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
KR20080048502A (ko)	2005-09-29	2008-06-02	머크 앤드 캄파니 인코포레이티드	멜라노코르틴-4 수용체 조절제로서의 아실화스피로피페리딘 유도체
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US8173629B2 (en)	2006-09-22	2012-05-08	Merck Sharp & Dohme Corp.	Method of treatment using fatty acid synthesis inhibitors
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
EA016079B1 (ru)	2007-01-10	2012-01-30	Институто Ди Ричерке Ди Биолоджиа Молеколаре П. Анджелетти Спа	Амидзамещенные индазолы в качестве ингибиторов поли(adp-рибоза)полимеразы (parp)
JP5319518B2 (ja)	2007-04-02	2013-10-16	Ｍｓｄ株式会社	インドールジオン誘導体
AU2008269154B2 (en)	2007-06-27	2014-06-12	Merck Sharp & Dohme Llc	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
CN102014631A (zh)	2008-03-03	2011-04-13	泰格尔医药科技公司	酪氨酸激酶抑制剂
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
WO2010132487A1 (en)	2009-05-12	2010-11-18	Bristol-Myers Squibb Company	CRYSTALLINE FORMS OF (S)-7-([1,2,4]TRIAZOLO[1,5-a]PYRIDIN-6-YL)-4-(3,4-DICHLOROHPHENYL)-1,2,3,4-TETRAHYDROISOQUINOLINE AND USE THEREOF
CN102458123A (zh)	2009-05-12	2012-05-16	阿尔巴尼分子研究公司	芳基、杂芳基和杂环取代的四氢异喹啉及其用途
US8802696B2 (en)	2009-05-12	2014-08-12	Albany Molecular Research, Inc.	7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoqu inoli and use thereof
JP5099731B1 (ja)	2009-10-14	2012-12-19	メルク・シャープ・アンド・ドーム・コーポレーション	ｐ５３活性を増大する置換ピペリジン及びその使用
EP2584903B1 (en)	2010-06-24	2018-10-24	Merck Sharp & Dohme Corp.	Novel heterocyclic compounds as erk inhibitors
AU2011285909B2 (en)	2010-08-02	2016-11-10	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
EP2606134B1 (en)	2010-08-17	2019-04-10	Sirna Therapeutics, Inc.	RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
EP3766975A1 (en)	2010-10-29	2021-01-20	Sirna Therapeutics, Inc.	Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
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EP2699567A1 (en)	2011-04-21	2014-02-26	Merck Sharp & Dohme Corp.	Insulin-like growth factor-1 receptor inhibitors
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP3358013B1 (en)	2012-05-02	2020-06-24	Sirna Therapeutics, Inc.	Short interfering nucleic acid (sina) compositions
KR20150060724A (ko)	2012-09-28	2015-06-03	머크 샤프 앤드 돔 코포레이션	Erk 억제제인 신규 화합물
DK2925888T3 (en)	2012-11-28	2017-12-18	Merck Sharp & Dohme	COMPOSITIONS AND METHODS OF CANCER TREATMENT
EP2935263B1 (en)	2012-12-20	2018-12-05	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as hdm2 inhibitors
US9540377B2 (en)	2013-01-30	2017-01-10	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as HDM2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
SG10201913587WA (en)	2016-02-05	2020-02-27	Denali Therapeutics Inc	Inhibitors of receptor-interacting protein kinase 1
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DK3552017T3 (da)	2016-12-09	2022-05-16	Denali Therapeutics Inc	Forbindelser, der er anvendelige som ripk1-inhibitorer
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8929070D0 (en) *	1989-12-22	1990-02-28	Fujisawa Pharmaceutical Co	Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
GB9023116D0 (en) *	1990-10-24	1990-12-05	Fujisawa Pharmaceutical Co	Peptide compounds,processes for preparation thereof and pharmaceutical composition comprising the same
DE59309867D1 (de) *	1992-09-03	1999-12-16	Boehringer Ingelheim Pharma	Neue aminosäurederivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zusammensetzungen

1995
- 1995-05-04 PL PL95317127A patent/PL317127A1/xx unknown
- 1995-05-04 EE EE9600186A patent/EE9600186A/xx unknown
- 1995-05-04 JP JP7528677A patent/JPH09512806A/ja not_active Ceased
- 1995-05-04 FI FI964473A patent/FI964473A0/fi unknown
- 1995-05-04 SK SK1426-96A patent/SK142696A3/sk unknown
- 1995-05-04 RO RO96-02085A patent/RO115355B1/ro unknown
- 1995-05-04 NZ NZ285750A patent/NZ285750A/en unknown
- 1995-05-04 MX MX9605128A patent/MX9605128A/es unknown
- 1995-05-04 CZ CZ963254A patent/CZ325496A3/cs unknown
- 1995-05-04 EP EP95919392A patent/EP0804463A1/de not_active Withdrawn
- 1995-05-04 WO PCT/EP1995/001691 patent/WO1995030687A1/de not_active Ceased
- 1995-05-04 CN CN95192859A patent/CN1147260A/zh active Pending
- 1995-05-04 AU AU25249/95A patent/AU690275B2/en not_active Ceased
- 1995-05-04 CA CA002189764A patent/CA2189764A1/en not_active Abandoned
- 1995-05-04 HU HU9603082A patent/HUT75708A/hu unknown
- 1995-05-04 US US08/434,613 patent/US5712273A/en not_active Expired - Fee Related
- 1995-05-05 HR HRP4445939.4A patent/HRP950276A2/hr not_active Application Discontinuation
- 1995-05-05 IL IL11362595A patent/IL113625A0/xx unknown
- 1995-06-07 US US08/475,278 patent/US5700827A/en not_active Expired - Fee Related
1996
- 1996-10-29 BG BG100946A patent/BG100946A/xx unknown
- 1996-11-06 NO NO964700A patent/NO964700D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JPH09512806A (ja)	1997-12-22
NO964700L (no)	1996-11-06
US5700827A (en)	1997-12-23
NO964700D0 (no)	1996-11-06
HUT75708A (en)	1997-05-28
HU9603082D0 (en)	1997-01-28
NZ285750A (en)	1998-08-26
US5712273A (en)	1998-01-27
BG100946A (bg)	1997-07-31
IL113625A0 (en)	1995-08-31
MX9605128A (es)	1997-08-30
FI964473L (fi)	1996-11-07
AU2524995A (en)	1995-11-29
SK142696A3 (en)	1997-06-04
PL317127A1 (en)	1997-03-17
FI964473A7 (fi)	1996-11-07
AU690275B2 (en)	1998-04-23
RO115355B1 (ro)	2000-01-28
HRP950276A2 (en)	1997-04-30
FI964473A0 (fi)	1996-11-07
WO1995030687A1 (de)	1995-11-16
EP0804463A1 (de)	1997-11-05
CN1147260A (zh)	1997-04-09
CZ325496A3 (en)	1997-09-17
CA2189764A1 (en)	1995-11-16

Publication	Publication Date	Title
FI971685A7 (fi)	1997-08-13	Takykiniini-antagonisteja
FI946140L (fi)	1995-06-30	Diatsabisyklisiä neurokiniiniantagonisteja
FI954008A7 (fi)	1996-02-27	Substituoituja bifenyyli-isoksatsolisulfoniamideja
FI951908L (fi)	1995-10-26	Substituoituja pyridyylipyratsoleja
FI970523A7 (fi)	1997-02-07	(Atsetidin-1-yylialkyyli)laktaamit takykiniiniantagonisteina
FI955927A7 (fi)	1996-06-15	Substituoidut 1H-imidatsolit
FI972194L (fi)	1997-05-22	Uusia bentsyylipyrimidiinejä
FI953303A0 (fi)	1995-07-04	Uusi fytaasi
DE69534718D1 (de)	2006-02-02	Substituierte 9-alkyladenine
FI960516L (fi)	1996-08-07	Substituoituja bifenyylisulfonamidiendoteliiniantagonisteja
FI942119A0 (fi)	1994-05-06	Anordning i en gasblandare
TR199501132A2 (tr)	1996-06-21	Nörokinin karsitlari (antagonistleri).
DE59507222D1 (de)	1999-12-16	Substituierte 1,2,3,4-tetrahydro-5-nitro-pyrimidine
FI953710L (fi)	1996-02-05	Uusia pyrrolokarbatsoleja
BR9509559A (pt)	1997-09-16	Azolilulsolfonilfeniluracilas substituídas
ID26508A (id)	2001-01-11	Oksim-oksim tersubstitusi sebagai antagonis-antagonis neurokinin
FI1516U1 (fi)	1994-09-20	Foerpackning foer i stapel anordnade smaoark
IS4320A (is)	1996-01-17	Ný súbstitúeruð bensimidasól
FI962961A0 (fi)	1996-07-24	Telebetalningssystem i realtid
KR970702876A (ko)	1997-06-10	뉴로키닌 길항제(Neurokinine (tachykinine) antagonists)
DE59510274D1 (de)	2002-08-14	Substituierte biphenyloxazoline
FI972558A0 (fi)	1997-06-16	Uusi reseptori
KR950027351U (ko)	1995-10-18	반목 항타장치
DK0964867T3 (da)	2005-06-27	Tachykininantagonister
KR960009044U (ko)	1996-03-16	기타 안치대