EE9800230A - Difenüülstilbeenid kui COX-2 inhibiitorite eelravimid - Google Patents
Difenüülstilbeenid kui COX-2 inhibiitorite eelravimidInfo
- Publication number
- EE9800230A EE9800230A EE9800230A EE9800230A EE9800230A EE 9800230 A EE9800230 A EE 9800230A EE 9800230 A EE9800230 A EE 9800230A EE 9800230 A EE9800230 A EE 9800230A EE 9800230 A EE9800230 A EE 9800230A
- Authority
- EE
- Estonia
- Prior art keywords
- diphenylstilbenes
- cox
- prodrugs
- inhibitors
- cyclooxygenase
- Prior art date
Links
- 229940111134 coxibs Drugs 0.000 title 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- JLZUZNKTTIRERF-UHFFFAOYSA-N tetraphenylethylene Chemical class C1=CC=CC=C1C(C=1C=CC=CC=1)=C(C=1C=CC=CC=1)C1=CC=CC=C1 JLZUZNKTTIRERF-UHFFFAOYSA-N 0.000 title 1
- 102000010907 Cyclooxygenase 2 Human genes 0.000 abstract 2
- 108010037462 Cyclooxygenase 2 Proteins 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000001404 mediated effect Effects 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/24—Sulfones; Sulfoxides having sulfone or sulfoxide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Polyesters Or Polycarbonates (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1095096P | 1996-02-01 | 1996-02-01 | |
| GBGB9605647.8A GB9605647D0 (en) | 1996-03-18 | 1996-03-18 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
| PCT/CA1997/000063 WO1997028120A1 (en) | 1996-02-01 | 1997-01-29 | Diphenyl stilbenes as prodrugs to cox-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9800230A true EE9800230A (et) | 1998-12-15 |
Family
ID=26308949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EE9800230A EE9800230A (et) | 1996-02-01 | 1997-01-29 | Difenüülstilbeenid kui COX-2 inhibiitorite eelravimid |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP0882015B1 (de) |
| JP (1) | JP3662936B2 (de) |
| KR (1) | KR19990082260A (de) |
| CN (1) | CN1214677A (de) |
| AT (1) | ATE198323T1 (de) |
| AU (1) | AU707199B2 (de) |
| CA (1) | CA2244134C (de) |
| CZ (1) | CZ241698A3 (de) |
| DE (1) | DE69703791T2 (de) |
| EA (1) | EA199800675A1 (de) |
| EE (1) | EE9800230A (de) |
| ES (1) | ES2152648T3 (de) |
| HU (1) | HUP9902119A3 (de) |
| IL (1) | IL125441A0 (de) |
| NO (1) | NO983511L (de) |
| NZ (1) | NZ326283A (de) |
| PL (1) | PL328225A1 (de) |
| SK (1) | SK102698A3 (de) |
| WO (1) | WO1997028120A1 (de) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635417B1 (en) | 1996-07-31 | 2003-10-21 | California Institute Of Technology | Complex formation between DSDNA and oligomer of cyclic heterocycles |
| US5998140A (en) * | 1996-07-31 | 1999-12-07 | The Scripps Research Institute | Complex formation between dsDNA and oligomer of cyclic heterocycles |
| JP2003523958A (ja) | 1999-12-23 | 2003-08-12 | ニトロメド インコーポレーテッド | ニトロソ化およびニトロシル化されたシクロオキシゲナーゼ−２の阻害剤、組成物ならびに使用法 |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| AU2003252515A1 (en) | 2002-07-26 | 2004-02-16 | Merck Frosst Canada And Co. | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| DE602004021238D1 (de) | 2003-03-05 | 2009-07-09 | Merck Frosst Company | Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2 |
| CA2554333A1 (en) | 2004-01-27 | 2005-08-04 | Merck Frosst Company | Nitric oxide releasing prodrugs of diaryl-2-(5h)-furanones as cyclooxygenase-2 inhibitors |
| EP1711459A4 (de) | 2004-01-27 | 2008-01-02 | Merck Frosst Company | Stickstoffmonoxid freisetzende prodrugs von diaryl-2-(5h)-furanonen als inhibitoren von cyclooxygenase-2 |
| WO2006029436A1 (de) * | 2004-09-17 | 2006-03-23 | Universität Wien | Cox-ii-inhibitorverbindungen |
| IL305573A (en) | 2021-03-15 | 2023-10-01 | Saul Yedgar | HYALURONIC ACID-CONJUGATED DIPALMITOYL PHOSPHATIDYL ETHANOLAMINE IN COMBINATION WITH NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDs) FOR TREATING OR ALLEVIATING INFLAMMATORY DISEASES |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990012786A1 (en) * | 1989-04-24 | 1990-11-01 | Otsuka Pharmaceutical Factory, Inc. | 3-halogeno-2,3-diphenylacrylaldehyde derivative, method of production thereof and curing agent for hyperlipidemia |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5393790A (en) * | 1994-02-10 | 1995-02-28 | G.D. Searle & Co. | Substituted spiro compounds for the treatment of inflammation |
-
1997
- 1997-01-29 EE EE9800230A patent/EE9800230A/xx unknown
- 1997-01-29 EA EA199800675A patent/EA199800675A1/ru unknown
- 1997-01-29 JP JP52720397A patent/JP3662936B2/ja not_active Expired - Fee Related
- 1997-01-29 SK SK1026-98A patent/SK102698A3/sk unknown
- 1997-01-29 PL PL97328225A patent/PL328225A1/xx unknown
- 1997-01-29 IL IL12544197A patent/IL125441A0/xx unknown
- 1997-01-29 WO PCT/CA1997/000063 patent/WO1997028120A1/en not_active Ceased
- 1997-01-29 DE DE69703791T patent/DE69703791T2/de not_active Expired - Fee Related
- 1997-01-29 CZ CZ982416A patent/CZ241698A3/cs unknown
- 1997-01-29 NZ NZ326283A patent/NZ326283A/xx unknown
- 1997-01-29 EP EP97900915A patent/EP0882015B1/de not_active Expired - Lifetime
- 1997-01-29 KR KR1019980705989A patent/KR19990082260A/ko not_active Withdrawn
- 1997-01-29 ES ES97900915T patent/ES2152648T3/es not_active Expired - Lifetime
- 1997-01-29 HU HU9902119A patent/HUP9902119A3/hu unknown
- 1997-01-29 AU AU14346/97A patent/AU707199B2/en not_active Ceased
- 1997-01-29 AT AT97900915T patent/ATE198323T1/de not_active IP Right Cessation
- 1997-01-29 CN CN97193332A patent/CN1214677A/zh active Pending
- 1997-01-29 CA CA002244134A patent/CA2244134C/en not_active Expired - Fee Related
-
1998
- 1998-07-30 NO NO983511A patent/NO983511L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP3662936B2 (ja) | 2005-06-22 |
| NO983511L (no) | 1998-09-30 |
| EA199800675A1 (ru) | 1999-02-25 |
| MX9806213A (es) | 1998-12-31 |
| KR19990082260A (ko) | 1999-11-25 |
| NO983511D0 (no) | 1998-07-30 |
| NZ326283A (en) | 1998-12-23 |
| EP0882015B1 (de) | 2000-12-27 |
| CZ241698A3 (cs) | 1998-12-16 |
| CN1214677A (zh) | 1999-04-21 |
| SK102698A3 (en) | 1999-04-13 |
| ES2152648T3 (es) | 2001-02-01 |
| DE69703791T2 (de) | 2001-06-21 |
| DE69703791D1 (de) | 2001-02-01 |
| JP2000504332A (ja) | 2000-04-11 |
| AU707199B2 (en) | 1999-07-08 |
| CA2244134A1 (en) | 1997-08-07 |
| WO1997028120A1 (en) | 1997-08-07 |
| AU1434697A (en) | 1997-08-22 |
| PL328225A1 (en) | 1999-01-18 |
| IL125441A0 (en) | 1999-03-12 |
| HUP9902119A3 (en) | 2001-08-28 |
| CA2244134C (en) | 2005-04-26 |
| ATE198323T1 (de) | 2001-01-15 |
| EP0882015A1 (de) | 1998-12-09 |
| HUP9902119A2 (hu) | 2001-04-28 |
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