EE9800322A - TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine - Google Patents

TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine

Info

Publication number
EE9800322A
EE9800322A EE9800322A EE9800322A EE9800322A EE 9800322 A EE9800322 A EE 9800322A EE 9800322 A EE9800322 A EE 9800322A EE 9800322 A EE9800322 A EE 9800322A EE 9800322 A EE9800322 A EE 9800322A
Authority
EE
Estonia
Prior art keywords
traf
modulators
preparation
tnf receptor
related factor
Prior art date
Application number
EE9800322A
Other languages
English (en)
Other versions
EE04783B1 (et
Inventor
Wallach David
Malinin Nikolai
Boldin Mark
Kovalenko Andrei
Mett Igor
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11780096A external-priority patent/IL117800A0/xx
Priority claimed from IL11913396A external-priority patent/IL119133A0/xx
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of EE9800322A publication Critical patent/EE9800322A/et
Publication of EE04783B1 publication Critical patent/EE04783B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
EE9800322A 1996-04-02 1997-04-01 TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine EE04783B1 (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL11780096A IL117800A0 (en) 1996-04-02 1996-04-02 Modulators of TNF receptor associated factor (TRAF) their preparation and use
IL11913396A IL119133A0 (en) 1996-08-26 1996-08-26 Modulators of TNF receptor associated factor (TRAF) their preparation and use
PCT/IL1997/000117 WO1997037016A1 (en) 1996-04-02 1997-04-01 Modulators of tnf receptor associated factor (traf), their preparation and use

Publications (2)

Publication Number Publication Date
EE9800322A true EE9800322A (et) 1999-04-15
EE04783B1 EE04783B1 (et) 2007-02-15

Family

ID=26323248

Family Applications (1)

Application Number Title Priority Date Filing Date
EE9800322A EE04783B1 (et) 1996-04-02 1997-04-01 TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine

Country Status (22)

Country Link
US (2) US7485456B1 (et)
EP (1) EP0894130B1 (et)
JP (1) JP4180114B2 (et)
CN (1) CN1197966C (et)
AT (1) ATE380866T1 (et)
AU (1) AU732793B2 (et)
BG (1) BG64755B1 (et)
BR (1) BR9708518A (et)
CA (1) CA2250085C (et)
CZ (3) CZ298866B6 (et)
DE (1) DE69738370T2 (et)
DK (1) DK0894130T3 (et)
EA (1) EA004309B1 (et)
EE (1) EE04783B1 (et)
ES (1) ES2294796T3 (et)
HU (1) HU226328B1 (et)
NO (1) NO327054B1 (et)
NZ (1) NZ331902A (et)
PT (1) PT894130E (et)
SK (3) SK287085B6 (et)
UA (1) UA71889C2 (et)
WO (1) WO1997037016A1 (et)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
WO1999024469A1 (en) * 1997-11-07 1999-05-20 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
AU2877899A (en) * 1998-02-27 1999-09-15 Regents Of The University Of California, The A novel inhibitor of the inflammatory response induced by tnfalpha and il-1
AU754434B2 (en) * 1998-05-06 2002-11-14 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Novel inhibitors of NF-kappaB activation
HUP0103797A2 (hu) * 1998-08-18 2003-10-28 Abbott Gmbh & Co. Kg TPL-2/COT kináz és alkalmazásai
IL131719A0 (en) * 1999-09-02 2001-03-19 Yeda Res & Dev Iren protein its preparation and use
GB9930616D0 (en) 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
KR20020069140A (ko) * 2001-02-21 2002-08-29 주식회사 코메드 종양 괴사 인자 수용체 관련 인자 6 억제 단백질
WO2003000280A2 (en) 2001-06-22 2003-01-03 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Abin-mediated hepatitis protection
CA2482718C (en) * 2002-04-18 2014-08-19 Yeda Research And Development Co. Ltd. Derivatives of the il-2 receptor gamma chain, their production and use
DK1678209T3 (da) * 2003-10-07 2011-06-27 Yeda Res & Dev Antistoffer mod nik, deres frembringelse samt anvendelse
IL158287A0 (en) * 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
JP5039383B2 (ja) * 2003-11-30 2012-10-03 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド 免疫モジュレーションのための方法および薬剤ならびに免疫モジュレーターの同定方法
IL173104A0 (en) * 2006-01-12 2006-06-11 Yeda Res & Dev Siva and ubiquintination
EP3629022A1 (en) 2008-07-25 2020-04-01 Richard W. Wagner Protein screening methods
GB201012420D0 (en) 2010-07-23 2010-09-08 Univ Erasmus Medical Ct Foetal heamoglobin inhibitor
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
CN105177032B (zh) * 2010-09-01 2019-05-10 山东新时代药业有限公司 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
MX2013010513A (es) 2011-03-16 2013-10-07 Hoffmann La Roche Compuestos de alcohol 6,5-heterociclil-propargilico y usos de los mismos.
MY180616A (en) 2011-06-30 2020-12-03 Genzyme Corp Inhibitors of t-cell activation
EP2734232B1 (en) 2011-07-19 2017-11-01 Philogen S.p.A. Sequential anti-ctla4 and targeted il-2 therapy
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
CN105986001B (zh) * 2015-02-12 2019-12-03 上海交通大学 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
JP7114460B2 (ja) 2015-06-26 2022-08-08 サノフィ・バイオテクノロジー モノクローナル抗ＩＬ－１ＲＡｃＰ抗体
MA55529A (fr) 2019-04-03 2022-02-09 Genzyme Corp Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
AU2023345467A1 (en) 2022-09-21 2025-05-08 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641876A (en) * 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
EP0841934A1 (en) * 1995-08-02 1998-05-20 Teresa J. Ingram Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome
AU6692996A (en) 1995-08-08 1997-03-05 Tularik Inc. Inhibitors of apoptosis
US5804412A (en) * 1996-04-01 1998-09-08 The Regents Of The University Of California Nucleic acids encoding sorting nexins and methods of using same
UA71889C2 (uk) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Модулятори зв'язаного з рецептором tnf фактора (traf), їх одержання та застосування
KR20000010805A (ko) 1996-05-08 2000-02-25 웨인 씨. 제쉬크 알킬 폴리글리코시드 에테르 카르복실레이트
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein

Also Published As

Publication number Publication date
NO327054B1 (no) 2009-04-14
BG64755B1 (bg) 2006-02-28
SK287889B6 (sk) 2012-03-02
UA71889C2 (uk) 2005-01-17
CZ299094B6 (cs) 2008-04-23
EP0894130A1 (en) 1999-02-03
CZ318398A3 (cs) 1999-05-12
HK1018910A1 (en) 2000-01-07
US20090291888A1 (en) 2009-11-26
DE69738370T2 (de) 2008-12-04
WO1997037016A1 (en) 1997-10-09
JP4180114B2 (ja) 2008-11-12
DK0894130T3 (da) 2008-01-07
ATE380866T1 (de) 2007-12-15
NZ331902A (en) 2000-02-28
ES2294796T3 (es) 2008-04-01
JP2000507826A (ja) 2000-06-27
CZ299682B6 (cs) 2008-10-15
HUP9902429A2 (hu) 1999-10-28
EA199800885A1 (ru) 1999-04-29
BR9708518A (pt) 1999-08-03
SK287890B6 (sk) 2012-03-02
AU2175597A (en) 1997-10-22
SK287085B6 (sk) 2009-11-05
US7485456B1 (en) 2009-02-03
NO984551L (no) 1998-11-24
CZ298866B6 (cs) 2008-02-27
HU226328B1 (en) 2008-09-29
EP0894130B1 (en) 2007-12-12
CA2250085A1 (en) 1997-10-09
AU732793B2 (en) 2001-05-03
NO984551D0 (no) 1998-09-29
EE04783B1 (et) 2007-02-15
BG102817A (en) 1999-05-31
CN1197966C (zh) 2005-04-20
DE69738370D1 (de) 2008-01-24
US8236507B2 (en) 2012-08-07
HUP9902429A3 (en) 2001-11-28
SK136198A3 (en) 1999-05-07
PT894130E (pt) 2008-01-14
EA004309B1 (ru) 2004-02-26
CA2250085C (en) 2009-10-20
CN1221449A (zh) 1999-06-30

Similar Documents

Publication Publication Date Title
EE9800322A (et) TNF retseptoriga seotud faktori (TRAF) modulaatorid, nende valmistamine ja kasutamine
DK0970213T3 (da) Dödsdomæneholdig receptor
DK0417563T3 (da) TNF-bindende proteiner
IL140938A (en) Dna sequences encoding polypeptides capable of binding to ldcam, polypeptides encoded by them, fusion proteins comprising the polypeptides and a process for the preparation of the polypeptides
DK0975754T3 (da) Osteoprotegerin bindende proteiner og receptorer
NO960767D0 (no) Protocadherinproteiner og deres anvendelse
ATE128184T1 (de) Expression des rekombinanten tumor-nekrosisfaktor-bindungsproteins i (tbp-i).
CY1108175T1 (el) ΠΟΛΥΠΕΠΤΙΔΙΟ DcR3, ΟΜΟΛΟΓΟ TNFR
IL193886A (en) Antibodies that bind to ldcam sequences
TW200716746A (en) Methods for identifying a compound modulating the binding between polypeptides
ATE342976T1 (de) Cytokinrezeptor-kette
WO2000066156A8 (en) Death domain containing receptor 5
NZ315514A (en) Tumour necrosis factor associated factor (traf) inhibitors including traf polypeptide, murine nucleotide sequence and associated assays
MY125980A (en) Highly purified cytokine activating factor and methods of use
WO2000024771A3 (en) Nucleic acids encoding osteoprotegerin-like proteins and methods of using same
ATE408687T1 (de) Semaphorin polypeptide
AR008064A1 (es) Una proteina ligante del factor de necrosis tumoral truncada de bajo peso molecular (tnf bp), un polinucleotido codificante de dicha proteina, un vector, una celula hospedante, metodos para producir dicha proteina, una composicion farmaceutica, metodo para tratar una enfermedad mediada por tnf bp y usos de dicha proteina.
MX9605531A (es) Modulador de receptores de la superfamilia de factor de necrosis tumoral/factor de crecimiento de nervio y receptores oligomericos solubles de la superfamilia de factor de necrosis tumoral/factor de crecimiento necrotico.

Legal Events

Date Code Title Description
KB4A Valid patent at the end of a year

Effective date: 20071231

KB4A Valid patent at the end of a year

Effective date: 20081231

KB4A Valid patent at the end of a year

Effective date: 20101231