EE9900543A - Sulphate salt of HIV protease inhibitor with improved oral absorption and bioavailability - Google Patents

Sulphate salt of HIV protease inhibitor with improved oral absorption and bioavailability

Info

Publication number: EE9900543A
Authority: EE; Estonia
Prior art keywords: bioavailability; protease inhibitor; hiv protease; oral absorption; sulphate salt
Prior art date: 1997-05-29

Application number

EEP199900543A

Other languages

Estonian (et)

Inventor

Askin David

Scott Hoerrner R.

M. Purick Robert

Reider Paul

J. Varsolona Richard

P. Volante Ralph

Original Assignee

Merck & Co., Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-29

Filing date

1998-05-26

Publication date

2000-06-15

1997-07-07 Priority claimed from GBGB9714320.0A external-priority patent/GB9714320D0/en

1998-05-26 Application filed by Merck & Co., Inc. filed Critical Merck & Co., Inc.

2000-06-15 Publication of EE9900543A publication Critical patent/EE9900543A/en

Links

229940122440 HIV protease inhibitor Drugs 0.000 title 1
238000010521 absorption reaction Methods 0.000 title 1
239000004030 hiv protease inhibitor Substances 0.000 title 1
150000003467 sulfuric acid derivatives Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Virology (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

EEP199900543A 1997-05-29 1998-05-26 Sulphate salt of HIV protease inhibitor with improved oral absorption and bioavailability EE9900543A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US4795097P	1997-05-29	1997-05-29
GBGB9714320.0A GB9714320D0 (en)	1997-07-07	1997-07-07	Hiv protease inhibitor
PCT/US1998/010633 WO1998054178A1 (en)	1997-05-29	1998-05-26	Sulfate salt of an hiv protease inhibitor having an improved oral absorption and bioavailability

Publications (1)

Publication Number	Publication Date
EE9900543A true EE9900543A (en)	2000-06-15

Family

ID=26311845

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP199900543A EE9900543A (en)	1997-05-29	1998-05-26	Sulphate salt of HIV protease inhibitor with improved oral absorption and bioavailability

Country Status (22)

Country	Link
EP (1)	EP0986554A1 (en)
JP (1)	JP3267632B2 (en)
KR (1)	KR20010013042A (en)
CN (1)	CN1257497A (en)
AU (1)	AU730245B2 (en)
BG (1)	BG103923A (en)
BR (1)	BR9809498A (en)
CA (1)	CA2291086A1 (en)
EA (1)	EA199901095A1 (en)
EE (1)	EE9900543A (en)
HR (1)	HRP980283A2 (en)
HU (1)	HUP0004621A3 (en)
ID (1)	ID23858A (en)
IL (1)	IL132779A0 (en)
IS (1)	IS5240A (en)
NO (1)	NO995822L (en)
PE (1)	PE75099A1 (en)
PL (1)	PL336847A1 (en)
SK (1)	SK163299A3 (en)
TR (1)	TR199902816T2 (en)
TW (1)	TW438799B (en)
WO (1)	WO1998054178A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2295068T3 (en) *	1999-11-24	2008-04-16	MERCK & CO., INC.	GAMMA-HIDROXI-2- (FLUOROALQUILAMINOCARBONIL) -1-PIPERAZINPENTANAMIDS AS INHIBITORS OF HIV PROTEASE.
US20020082421A1 (en) *	2000-09-14	2002-06-27	Abdel-Magid Ahmed F.	Novel solid salt forms of N-[2-[4-[2-(1- methylethoxy)phenyl]-1-piperazinyl]-2-oxo-1piperidineacetamide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2174921T3 (en) *	1993-12-15	2002-11-16	Merck & Co Inc	HIV PROTEASE INHIBITORS.

1998
- 1998-05-20 TW TW087107834A patent/TW438799B/en active
- 1998-05-26 KR KR1019997011018A patent/KR20010013042A/en not_active Withdrawn
- 1998-05-26 IL IL13277998A patent/IL132779A0/en unknown
- 1998-05-26 SK SK1632-99A patent/SK163299A3/en unknown
- 1998-05-26 EE EEP199900543A patent/EE9900543A/en unknown
- 1998-05-26 EP EP98923741A patent/EP0986554A1/en not_active Withdrawn
- 1998-05-26 CN CN98805372A patent/CN1257497A/en active Pending
- 1998-05-26 BR BR9809498-0A patent/BR9809498A/en not_active Application Discontinuation
- 1998-05-26 WO PCT/US1998/010633 patent/WO1998054178A1/en not_active Ceased
- 1998-05-26 ID IDW991462A patent/ID23858A/en unknown
- 1998-05-26 EA EA199901095A patent/EA199901095A1/en unknown
- 1998-05-26 JP JP50079999A patent/JP3267632B2/en not_active Expired - Fee Related
- 1998-05-26 CA CA002291086A patent/CA2291086A1/en not_active Abandoned
- 1998-05-26 TR TR1999/02816T patent/TR199902816T2/en unknown
- 1998-05-26 AU AU75959/98A patent/AU730245B2/en not_active Ceased
- 1998-05-26 HU HU0004621A patent/HUP0004621A3/en unknown
- 1998-05-26 PL PL98336847A patent/PL336847A1/en unknown
- 1998-05-28 PE PE1998000432A patent/PE75099A1/en not_active Application Discontinuation
- 1998-05-28 HR HR9714320.0A patent/HRP980283A2/en not_active Application Discontinuation
1999
- 1999-11-09 IS IS5240A patent/IS5240A/en unknown
- 1999-11-24 BG BG103923A patent/BG103923A/en unknown
- 1999-11-26 NO NO995822A patent/NO995822L/en not_active Application Discontinuation

Also Published As

Publication number	Publication date
IL132779A0 (en)	2001-03-19
WO1998054178A1 (en)	1998-12-03
SK163299A3 (en)	2000-07-11
JP3267632B2 (en)	2002-03-18
AU7595998A (en)	1998-12-30
CN1257497A (en)	2000-06-21
EA199901095A1 (en)	2000-08-28
EP0986554A1 (en)	2000-03-22
TR199902816T2 (en)	2000-02-21
ID23858A (en)	2000-05-25
HUP0004621A2 (en)	2002-03-28
CA2291086A1 (en)	1998-12-03
AU730245B2 (en)	2001-03-01
BR9809498A (en)	2000-06-20
HUP0004621A3 (en)	2002-04-29
NO995822D0 (en)	1999-11-26
TW438799B (en)	2001-06-07
PL336847A1 (en)	2000-07-17
PE75099A1 (en)	1999-08-11
KR20010013042A (en)	2001-02-26
HRP980283A2 (en)	1999-08-31
JP2000513747A (en)	2000-10-17
BG103923A (en)	2000-06-30
NO995822L (en)	2000-01-28
IS5240A (en)	1999-11-09

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