EG16492A - Method of preparing of 6,7 - dihydro - 5,8 - dimethyl -9- fluro -1- oxo -1h,5h - benzo (ij) quinolizine -2- carboxylic acid and derivatives - Google Patents

Method of preparing of 6,7 - dihydro - 5,8 - dimethyl -9- fluro -1- oxo -1h,5h - benzo (ij) quinolizine -2- carboxylic acid and derivatives

Info

Publication number
EG16492A
EG16492A EG70383A EG70383A EG16492A EG 16492 A EG16492 A EG 16492A EG 70383 A EG70383 A EG 70383A EG 70383 A EG70383 A EG 70383A EG 16492 A EG16492 A EG 16492A
Authority
EG
Egypt
Prior art keywords
quinolizine
benzo
dihydro
oxo
dimethyl
Prior art date
Application number
EG70383A
Other languages
English (en)
Inventor
Richard M Stern
Original Assignee
Riker Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riker Laboratories Inc filed Critical Riker Laboratories Inc
Application granted granted Critical
Publication of EG16492A publication Critical patent/EG16492A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
EG70383A 1982-11-12 1983-11-12 Method of preparing of 6,7 - dihydro - 5,8 - dimethyl -9- fluro -1- oxo -1h,5h - benzo (ij) quinolizine -2- carboxylic acid and derivatives EG16492A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/441,245 US4472405A (en) 1982-11-12 1982-11-12 Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives

Publications (1)

Publication Number Publication Date
EG16492A true EG16492A (en) 1994-11-30

Family

ID=23752110

Family Applications (1)

Application Number Title Priority Date Filing Date
EG70383A EG16492A (en) 1982-11-12 1983-11-12 Method of preparing of 6,7 - dihydro - 5,8 - dimethyl -9- fluro -1- oxo -1h,5h - benzo (ij) quinolizine -2- carboxylic acid and derivatives

Country Status (22)

Country Link
US (1) US4472405A (de)
EP (1) EP0109284B1 (de)
JP (1) JPH0826017B2 (de)
KR (1) KR890000864B1 (de)
AT (1) ATE39926T1 (de)
AU (1) AU568319B2 (de)
CA (2) CA1254568A (de)
CS (1) CS390391A3 (de)
DE (1) DE3378912D1 (de)
EG (1) EG16492A (de)
ES (1) ES8504727A1 (de)
FI (1) FI73213C (de)
GR (1) GR79402B (de)
IE (1) IE56232B1 (de)
IL (1) IL70198A (de)
IN (1) IN161391B (de)
MX (1) MX7314E (de)
NO (1) NO160782C (de)
NZ (1) NZ206233A (de)
OA (1) OA07586A (de)
PT (1) PT77649B (de)
ZA (1) ZA838436B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3519926A1 (de) * 1985-06-04 1986-12-04 Bayer Ag Indolinderivate, verfahren zu ihrer herstellung und diese indolinderivate enthaltende kosmetische lichtschutzmittel
US4898945A (en) * 1986-01-22 1990-02-06 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolizine-2-carboxylic acid
CA1302413C (en) * 1986-01-22 1992-06-02 Bruce E. Williams Process for 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo- 1h,5h-benzo[ij]quinolizine-2-carboxylic acid
GB9827865D0 (en) * 1998-12-18 1999-02-10 Woodcock Fiona Medicament
DE10312346A1 (de) * 2003-03-20 2004-09-30 Bayer Healthcare Ag Kontrolliertes Freisetzungssystem
DE10351448A1 (de) 2003-11-04 2005-06-09 Bayer Healthcare Ag Geschmackstoffhaltige Arzneimittelformulierungen mit verbesserten pharmazeutischen Eigenschaften
DE102005055385A1 (de) * 2004-12-09 2006-06-14 Bayer Healthcare Ag Arzneimittel zur hygienischen Applikation im Ohr
DE102006010642A1 (de) * 2006-03-08 2007-09-27 Bayer Healthcare Aktiengesellschaft Arzneimittelformulierungen, enthaltend Fluorchinolone
DE102006010643A1 (de) 2006-03-08 2007-09-13 Bayer Healthcare Aktiengesellschaft Arzneimittel enthaltend Fluorchinolone
DE102007026550A1 (de) * 2007-06-08 2008-12-11 Bayer Healthcare Ag Extrudate mit verbesserter Geschmacksmaskierung
DE102007055341A1 (de) * 2007-11-19 2009-05-20 Bayer Animal Health Gmbh Stabilisierung öliger Suspensionen enthaltend hydrophobe Kieselsäuren
JP2013539772A (ja) 2010-10-12 2013-10-28 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 非澱粉を基にしたソフトチュアブル
AU2013361760B2 (en) 2012-12-19 2018-07-05 Elanco Animal Health Gmbh Tablets with improved acceptance and good storage stability
MD4291C1 (ro) * 2013-12-27 2015-02-28 Государственный Медицинский И Фармацевтический Университет "Nicolae Testemitanu" Республики Молдова Preparat medicamentos pentru tratamentul otitelor
CA3141337A1 (en) 2019-05-24 2020-12-03 Piedmont Animal Health Inc. Long-acting injectable formulations and use thereof
WO2021046305A1 (en) * 2019-09-06 2021-03-11 Bayer Healthcare Llc Palatable granular veterinary compositions
CN121930226B (zh) * 2026-03-31 2026-07-21 潍坊市海欣药业有限公司 一种盐酸黄连素的制备工艺

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA728444B (en) * 1971-12-30 1973-10-31 Riker Laboratories Inc Substituted benzo(ij)quinolizine-2-carboxylic acids and derivatives thereof
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
JPS5630964A (en) * 1979-08-22 1981-03-28 Kyorin Pharmaceut Co Ltd Novel substituted quinolinecarboxylic acid and its preparation
JPS5655388A (en) 1979-10-11 1981-05-15 Otsuka Pharmaceut Co Ltd Benzo ij quinolidine-2-carboxylic acid derivative, and its preparation
US4301289A (en) * 1980-02-19 1981-11-17 Minnesota Mining And Manufacturing Company Process for 6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法

Also Published As

Publication number Publication date
IE56232B1 (en) 1991-05-22
KR840006659A (ko) 1984-12-01
PT77649A (en) 1983-12-01
US4472405A (en) 1984-09-18
AU2118183A (en) 1984-05-17
MX7314E (es) 1988-05-11
NO834093L (no) 1984-05-14
EP0109284B1 (de) 1989-01-11
ES527163A0 (es) 1985-05-01
ES8504727A1 (es) 1985-05-01
NO160782B (no) 1989-02-20
FI834147A0 (fi) 1983-11-11
AU568319B2 (en) 1987-12-24
NZ206233A (en) 1986-10-08
IL70198A0 (en) 1984-02-29
FI73213C (fi) 1987-09-10
FI834147L (fi) 1984-05-13
PT77649B (en) 1986-03-19
CA1280755C (en) 1991-02-26
ZA838436B (en) 1985-06-26
CS390391A3 (en) 1992-09-16
IE832639L (en) 1984-05-12
JPS59112969A (ja) 1984-06-29
KR890000864B1 (ko) 1989-04-11
DE3378912D1 (de) 1989-02-16
EP0109284A1 (de) 1984-05-23
NO160782C (no) 1989-05-31
JPH0826017B2 (ja) 1996-03-13
CA1254568A (en) 1989-05-23
GR79402B (de) 1984-10-22
ATE39926T1 (de) 1989-01-15
IL70198A (en) 1988-11-15
OA07586A (fr) 1985-03-31
IN161391B (de) 1987-11-28
FI73213B (fi) 1987-05-29

Similar Documents

Publication Publication Date Title
AU568319B2 (en) Benzo(ij)quinolizines and antimicrobial compositions
HUT45520A (en) Process for producing new quinoline derivatives and pharmaceutics comprising these compounds as active ingredient
IE782070L (en) Azabicyclo (3.2.0) hept-2-ene carboxylic acid derivatives
PT80773A (en) Process for the preparation of substituted benzoate ester prodrug derivatives of 3-hydroxymorfinans intermediates thereto and of pharmaceutical compositions containing the same
ES8702405A1 (es) Procedimiento para la obtencion de acidos benzo(ij) quinolizina-2-carboxilicos y sus derivados
DK159778A (da) Forbindelsesstik til flade traadkabler
NO301372B1 (no) Fremgangsmåte for fremstilling av et farmasöytisk tålbart salt av klavulansyre
IT8048062A0 (it) Derivati di acidi mercaptoacildii dropirazol carbossilici dotati di attivita' ipotensiva e procedimento per la loro preparazione
NO175369C (no) Analogifremgangsmåte for fremstilling av den terapeutisk aktive forbindelse (S)-7-(3-amino-1,4-dihydro-4-okso-1,8-naftyridin-3-karboksylsyre, en in vivo lett spaltbar lavere alkylester eller et farmasöytisk akseptabelt salt
JPS57108066A (en) 4-substituted-2-oxoazetidine derivative and its preparation
EP0207497A3 (de) Chinoloncarbonsäurederivat und Verfahren zu seiner Herstellung
SE8301687L (sv) 8-cyano-6,7-dihydro-5-metyl-1-oxo-1h-,5h-benso(ij)kinolizin-2-karboxylsyror och forfarande for framstellning derav
YU104986A (en) Process for obtaining penem derivatives
DE3560363D1 (en) Process for the preparation of carbamic acid esters derivatives
DK550183A (da) 6,7-dihydro-5,8-dimethyl-9-fluor-1-oxo-1h,5h-benzo/ij/-quinolizin-2-carboxylsyre, fremgangsmaade til fremstilling deraf og mellemprodukter til brug ved udoevelse af fremgangsmaaden
GB2102812B (en) Therapeutically active compounds from species of rubia synthetic derivatives thereof, methods for the production thereof and pharmaceutical compositions comprising the same
IT1101667B (it) Esteri 3-fenossi-alfa-vinil-benzilici di acidi vinil-ciclopropan-carbossilici, procedimento per la loro preparatione e loro impiego per combattere organismi nocivi
JPS57146775A (en) 1,8-naphthyridine derivative and its salt
PH20548A (en) Novel penem compounds,pharmaceutical compositions containing them and method of using said compounds
JPS57183737A (en) Use of phenylaliphatic carboxylic acid derivative as drug
JPS5772981A (en) 1,8-naphthyridine derivative and its salt
GB9018360D0 (en) Process for the preparation of quinoline carboxylic acid derivatives
HUT60736A (en) Process for producing derivatives of 3-l-(5-thioxo-l-prolyl)-thiazolidine-4-carboxylic acid and pharmaceutical compositions comprising same as active ingredient
PL245813A1 (en) Process for preparing 6-alpha-methoxy-6-beta(2-/methylphenoxycarbonyl/-2-/thienyl-3/-acetamido)-penicillanic acid
LV5479A3 (lv) Hinolina atvasinajumu vai to farmaceitiski pienemamu esteru vai farmaceitiski pienemamu skabes aditivo salu iegusanas metode