EG20726A - Process for preparing of galanthamine derivatives as acetylchol inc-sterase inhibitors - Google Patents

Process for preparing of galanthamine derivatives as acetylchol inc-sterase inhibitors

Info

Publication number: EG20726A
Authority: EG; Egypt
Prior art keywords: acetylchol; preparing; compounds; galanthamine derivatives; sterase
Prior art date: 1993-10-15

Application number

EG64694A

Other languages

English (en)

Inventor

Raymond W Kosley Jr

Original Assignee

Hoechst Marion Roussel Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-15

Filing date

1994-10-15

Publication date

1999-12-29

1994-10-15 Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc

1999-12-29 Application granted granted Critical

1999-12-29 Publication of EG20726A publication Critical patent/EG20726A/xx

Links

ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical class O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 4
230000006949 cholinergic function Effects 0.000 abstract 1
230000003247 decreasing effect Effects 0.000 abstract 1
230000007074 memory dysfunction Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

EG64694A 1993-10-15 1994-10-15 Process for preparing of galanthamine derivatives as acetylchol inc-sterase inhibitors EG20726A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/137,444 US6316439B1 (en)	1993-10-15	1993-10-15	Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (1)

Publication Number	Publication Date
EG20726A true EG20726A (en)	1999-12-29

Family

ID=22477461

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG64694A EG20726A (en)	1993-10-15	1994-10-15	Process for preparing of galanthamine derivatives as acetylchol inc-sterase inhibitors

Country Status (23)

Country	Link
US (1)	US6316439B1 (pl)
EP (1)	EP0649846B1 (pl)
JP (1)	JP2664343B2 (pl)
KR (1)	KR100227957B1 (pl)
CN (1)	CN1039910C (pl)
AT (1)	ATE211474T1 (pl)
AU (1)	AU696170B2 (pl)
CA (1)	CA2118172C (pl)
CZ (1)	CZ283731B6 (pl)
DE (1)	DE69429570T2 (pl)
DK (1)	DK0649846T3 (pl)
EG (1)	EG20726A (pl)
ES (1)	ES2170759T3 (pl)
FI (1)	FI108722B (pl)
IL (1)	IL111275A (pl)
NO (1)	NO307464B1 (pl)
NZ (1)	NZ264682A (pl)
PL (1)	PL177549B1 (pl)
PT (1)	PT649846E (pl)
RO (1)	RO114134B1 (pl)
RU (1)	RU2109743C1 (pl)
TW (1)	TW289754B (pl)
ZA (1)	ZA948061B (pl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT403803B (de)	1996-04-19	1998-05-25	Sanochemia Ltd	Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
EP2311463A1 (en) *	1999-12-10	2011-04-20	Bonnie M. Davis	Analogs of galanthamine and lycoramine as modulators of nicotinic receptors
CN101100472A (zh) *	2001-04-30	2008-01-09	美国拜尔公司	4-氨基-5,6-取代的噻吩并[2,3-d]嘧啶化合物及其应用
US20030162770A1 (en) *	2002-02-22	2003-08-28	Davis Bonnie M.	Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
US20040254146A1 (en) *	2002-05-21	2004-12-16	Nastech Pharmaceutical Company Inc.	Carboxylate salts of galantamine and their pharmaceutical use
US20050143350A1 (en) *	2003-11-19	2005-06-30	Seed John C.	Combination drug therapy to treat obesity
WO2005065661A2 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Immediate, controlled and sustained release formulations of galanthamine
WO2005065662A1 (en) *	2003-12-31	2005-07-21	Actavis Group Hf	Solid dosage formulations of galantamine
JPWO2006004201A1 (ja) *	2004-07-01	2008-04-24	エーザイ・アール・アンド・ディー・マネジメント株式会社	神経再生促進剤
WO2006071274A2 (en) *	2004-12-23	2006-07-06	Voyager Pharmaceutical Corporation	Leuprolide acetate and acetylcholinesterase inhibitors or nmda receptor antagonists for the treatment of alzheimer’s disease
WO2006124584A2 (en) *	2005-05-13	2006-11-23	Alza Corporation	Multilayer drug delivery system with barrier against reservoir material flow
US20080188510A1 (en) *	2005-05-23	2008-08-07	Eisai R & D Management Co., Ltd.	Novel methods using zonisamide
US20090253654A1 (en)	2005-09-22	2009-10-08	Galantos Pharma Gmbh	Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
WO2007035941A2 (en) *	2005-09-23	2007-03-29	Alza Corporation	Transdermal galantamine delivery system
CN102007129B (zh)	2008-04-14	2014-05-07	神经动力生命科学公司	用作治疗人类脑疾病的前药的雪花胺衍生物
EP2456434A1 (en) *	2009-07-23	2012-05-30	Shire LLC	Galantamine amino acid and peptide prodrugs and uses thereof
US11219627B2 (en) *	2014-05-16	2022-01-11	Synaptec Development Llc	Clearance of amyloid beta
EP4029867A1 (en)	2021-01-13	2022-07-20	Alpha Cognition Inc.	Solid forms of galantamine benzoate gluconate
US12551491B1 (en) *	2025-07-23	2026-02-17	Alpha Cognition Inc.	Dosage regimens for benzgalantamine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL122665B1 (en)	1978-11-21	1982-08-31	Edinen Zentar Chim	Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en)	1986-01-15	1987-05-05	Bonnie Davis	Method of treating Alzheimer's disease
US6150354A (en) *	1987-01-15	2000-11-21	Bonnie Davis	Compounds for the treatment of Alzheimer's disease
JP2755403B2 (ja) *	1987-05-04	1998-05-20	デイービス、ボニー	アルツハイマー病の治療のための化合物
NL8800350A (nl)	1988-02-12	1989-09-01	Stichting Biomedical Research	Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
EP0584185B1 (en)	1991-05-14	1999-08-11	Ernir Snorrason	Treatment of fatigue syndrome with cholinesterase inhibitors
US5231093A (en) *	1991-10-01	1993-07-27	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5153193A (en)	1991-10-01	1992-10-06	Hoechst-Roussel Pharmaceuticals Incorporated	Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

1993
- 1993-10-15 US US08/137,444 patent/US6316439B1/en not_active Expired - Lifetime
1994
- 1994-10-10 AT AT94115961T patent/ATE211474T1/de active
- 1994-10-10 DE DE69429570T patent/DE69429570T2/de not_active Expired - Lifetime
- 1994-10-10 EP EP94115961A patent/EP0649846B1/en not_active Expired - Lifetime
- 1994-10-10 DK DK94115961T patent/DK0649846T3/da active
- 1994-10-10 ES ES94115961T patent/ES2170759T3/es not_active Expired - Lifetime
- 1994-10-10 PT PT94115961T patent/PT649846E/pt unknown
- 1994-10-13 NZ NZ264682A patent/NZ264682A/en not_active IP Right Cessation
- 1994-10-13 RU RU94036745A patent/RU2109743C1/ru active
- 1994-10-13 IL IL11127594A patent/IL111275A/xx not_active IP Right Cessation
- 1994-10-13 FI FI944823A patent/FI108722B/fi not_active IP Right Cessation
- 1994-10-14 KR KR1019940026305A patent/KR100227957B1/ko not_active Expired - Lifetime
- 1994-10-14 TW TW083109527A patent/TW289754B/zh not_active IP Right Cessation
- 1994-10-14 ZA ZA948061A patent/ZA948061B/xx unknown
- 1994-10-14 CA CA002118172A patent/CA2118172C/en not_active Expired - Lifetime
- 1994-10-14 NO NO943895A patent/NO307464B1/no not_active IP Right Cessation
- 1994-10-14 CN CN94117062A patent/CN1039910C/zh not_active Expired - Lifetime
- 1994-10-14 CZ CZ942545A patent/CZ283731B6/cs not_active IP Right Cessation
- 1994-10-14 PL PL94305457A patent/PL177549B1/pl unknown
- 1994-10-14 RO RO94-01670A patent/RO114134B1/ro unknown
- 1994-10-14 AU AU75813/94A patent/AU696170B2/en not_active Expired
- 1994-10-15 EG EG64694A patent/EG20726A/xx active
- 1994-10-17 JP JP6250777A patent/JP2664343B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT649846E (pt)	2002-06-28
EP0649846A1 (en)	1995-04-26
CZ283731B6 (cs)	1998-06-17
IL111275A (en)	2003-01-12
DK0649846T3 (da)	2002-04-15
IL111275A0 (en)	1994-12-29
AU696170B2 (en)	1998-09-03
ATE211474T1 (de)	2002-01-15
PL177549B1 (pl)	1999-12-31
RO114134B1 (ro)	1999-01-29
FI944823L (fi)	1995-04-16
NO943895L (no)	1995-04-18
DE69429570T2 (de)	2002-08-29
NO943895D0 (no)	1994-10-14
KR100227957B1 (ko)	1999-11-01
EP0649846B1 (en)	2002-01-02
FI108722B (fi)	2002-03-15
ZA948061B (en)	1995-06-06
CA2118172A1 (en)	1995-04-16
JPH07188239A (ja)	1995-07-25
CN1039910C (zh)	1998-09-23
FI944823A0 (fi)	1994-10-13
NO307464B1 (no)	2000-04-10
CA2118172C (en)	2000-01-04
DE69429570D1 (de)	2002-02-07
RU94036745A (ru)	1996-12-10
CN1108657A (zh)	1995-09-20
AU7581394A (en)	1995-05-04
US6316439B1 (en)	2001-11-13
KR950011445A (ko)	1995-05-15
RU2109743C1 (ru)	1998-04-27
ES2170759T3 (es)	2002-08-16
TW289754B (pl)	1996-11-01
CZ254594A3 (en)	1995-07-12
NZ264682A (en)	1995-07-26
JP2664343B2 (ja)	1997-10-15
PL305457A1 (en)	1995-04-18

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PL305457A1 (en)	1995-04-18	Galantamine derivatives, method of obtaining them and their application as drugs
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