EG23776A - New pseudopolymorphic forms of 2-(2,4)-bis(4-fluorophenyl) methyl-1-piperazinyl ethoxy acetic acid dihydrochloride - Google Patents

New pseudopolymorphic forms of 2-(2,4)-bis(4-fluorophenyl) methyl-1-piperazinyl ethoxy acetic acid dihydrochloride

Info

Publication number
EG23776A
EG23776A EG147698A EG147698A EG23776A EG 23776 A EG23776 A EG 23776A EG 147698 A EG147698 A EG 147698A EG 147698 A EG147698 A EG 147698A EG 23776 A EG23776 A EG 23776A
Authority
EG
Egypt
Prior art keywords
fluorophenyl
bis
methyl
acetic acid
acid dihydrochloride
Prior art date
Application number
EG147698A
Other languages
English (en)
Inventor
Monique Berwear
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Application granted granted Critical
Publication of EG23776A publication Critical patent/EG23776A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Otolaryngology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
EG147698A 1997-11-26 1998-11-25 New pseudopolymorphic forms of 2-(2,4)-bis(4-fluorophenyl) methyl-1-piperazinyl ethoxy acetic acid dihydrochloride EG23776A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97870193A EP0919550A1 (en) 1997-11-26 1997-11-26 Pseudopolymorphic forms of 2-2-4-bis(4-fluorophenyl)methyl-1-piperazinyl-ethoxy acetic acid dihydrochloride

Publications (1)

Publication Number Publication Date
EG23776A true EG23776A (en) 2007-08-08

Family

ID=8231072

Family Applications (1)

Application Number Title Priority Date Filing Date
EG147698A EG23776A (en) 1997-11-26 1998-11-25 New pseudopolymorphic forms of 2-(2,4)-bis(4-fluorophenyl) methyl-1-piperazinyl ethoxy acetic acid dihydrochloride

Country Status (39)

Country Link
US (2) US6262057B1 (sr)
EP (2) EP0919550A1 (sr)
JP (2) JP3996348B2 (sr)
KR (1) KR100557711B1 (sr)
CN (1) CN100406448C (sr)
AR (1) AR017676A1 (sr)
AT (1) ATE203237T1 (sr)
AU (1) AU735819B2 (sr)
BG (1) BG64155B1 (sr)
BR (1) BR9815405A (sr)
CA (1) CA2310318C (sr)
CO (1) CO4980892A1 (sr)
CZ (1) CZ295972B6 (sr)
DE (1) DE69801163T2 (sr)
DK (1) DK1034171T3 (sr)
EG (1) EG23776A (sr)
ES (1) ES2161552T3 (sr)
GC (1) GC0000094A (sr)
GR (1) GR3036702T3 (sr)
HU (1) HUP0100343A3 (sr)
ID (1) ID24964A (sr)
IL (1) IL135544A (sr)
MA (1) MA26569A1 (sr)
MY (1) MY119653A (sr)
NO (1) NO314692B1 (sr)
NZ (1) NZ504461A (sr)
PE (1) PE134899A1 (sr)
PL (1) PL190871B1 (sr)
PT (1) PT1034171E (sr)
RS (1) RS49904B (sr)
RU (1) RU2182575C2 (sr)
SI (1) SI20325A (sr)
SK (1) SK283237B6 (sr)
TN (1) TNSN98214A1 (sr)
TR (1) TR200001505T2 (sr)
TW (1) TWI225053B (sr)
UA (1) UA54568C2 (sr)
WO (1) WO1999028310A1 (sr)
ZA (1) ZA9810780B (sr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002221854A1 (en) * 2000-12-15 2002-06-24 U C B, S.A. Use of cetirizine or efletirizine for preventing urticaria
WO2003009849A1 (en) * 2001-07-26 2003-02-06 Ucb, S.A. Process for the preparation of 2-(2-(4-(bis(4-fluorophenyl)methyl)-piperazin-1-yl)ethoxy)acetic acid derivatives or corresponding salt forms thereof and intermediates therefor
WO2004000263A1 (en) 2002-06-25 2003-12-31 Acrux Dds Pty Ltd Transdermal delivery rate control using amorphous pharmaceutical compositions
US20050181032A1 (en) * 2002-06-25 2005-08-18 Acrux Dds Pty Ltd. Metastable pharmaceutical compositions
WO2004105760A1 (en) * 2003-05-28 2004-12-09 Ucb Farchim, S.A. Use of efletirizine for treating persistent allergic rhinitis
WO2006050909A1 (en) * 2004-11-10 2006-05-18 Ucb Farchim Sa Novel forms of efletirizine dihydrochloride, processes for making them and pharmaceutical compositions including them
WO2008155777A2 (en) * 2007-06-18 2008-12-24 Cadila Healthcare Limited Process for preparing efletrizine
KR101006760B1 (ko) * 2008-07-17 2011-01-11 주식회사 진영테크 모터 순간 정전 복원 장치

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH505116A (it) * 1966-11-21 1971-03-31 Crc Ricerca Chim Metodo per l'ottenimento di derivati della piperazina
SE409706B (sv) * 1976-05-21 1979-09-03 Astra Pharma Prod Forfarande for framstellning av n,n-dimetyl-3-(4-bromfenyl)-3-3(3-pyridyl)-allylamin dihydroklorid monohydrat
JPS57149282A (en) * 1981-02-06 1982-09-14 Ucb Sa 2-(4-(diphenylmethyl)-1-piperazinyl)acetic acid and their derivatives as medicine
NO155805C (no) * 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
GB8827390D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
GB8827391D0 (en) * 1988-11-23 1988-12-29 Ucb Sa Process for preparation of 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-pipera-zinyl)ethoxy)-acetic acid & its dihydrochloride
US5968551A (en) * 1991-12-24 1999-10-19 Purdue Pharma L.P. Orally administrable opioid formulations having extended duration of effect
TW401300B (en) * 1992-12-25 2000-08-11 Senju Pharma Co Antiallergic composition for ophthalmic or nasal use
US5625358A (en) * 1993-09-13 1997-04-29 Analog Devices, Inc. Digital phase-locked loop utilizing a high order sigma-delta modulator
BE1010094A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Nouveaux [2-(1-piperazinyl)ethoxy] methyle substitues.
BE1010095A3 (fr) * 1996-04-10 1997-12-02 Ucb Sa Procede de preparation de l'acide 2-[2-[4-[(4-chlorophenyl)phenylmethyl]-1-piperazinyl] ethoxy]-acetique et de ses sels.

Also Published As

Publication number Publication date
TR200001505T2 (tr) 2000-09-21
TWI225053B (en) 2004-12-11
PL190871B1 (pl) 2006-02-28
MY119653A (en) 2005-06-30
US6335331B2 (en) 2002-01-01
CA2310318A1 (en) 1999-06-10
CN1279676A (zh) 2001-01-10
BG104424A (en) 2001-01-31
DE69801163D1 (en) 2001-08-23
IL135544A (en) 2004-02-08
JP2001524548A (ja) 2001-12-04
KR100557711B1 (ko) 2006-03-07
SK283237B6 (sk) 2003-04-01
JP3996348B2 (ja) 2007-10-24
HUP0100343A2 (hu) 2001-07-30
SI20325A (sl) 2001-02-28
EP0919550A1 (en) 1999-06-02
NO314692B1 (no) 2003-05-05
PL340724A1 (en) 2001-02-26
AU735819B2 (en) 2001-07-19
AU1327799A (en) 1999-06-16
CN100406448C (zh) 2008-07-30
DK1034171T3 (da) 2001-11-05
NO20002631D0 (no) 2000-05-23
ATE203237T1 (de) 2001-08-15
AR017676A1 (es) 2001-09-12
BR9815405A (pt) 2000-10-10
US6262057B1 (en) 2001-07-17
YU31600A (sh) 2002-03-18
RS49904B (sr) 2008-08-07
SK5942000A3 (en) 2000-10-09
PT1034171E (pt) 2001-11-30
ID24964A (id) 2000-08-31
TNSN98214A1 (fr) 2005-03-15
PE134899A1 (es) 2000-01-11
EP1034171B1 (en) 2001-07-18
US20010021712A1 (en) 2001-09-13
IL135544A0 (en) 2001-05-20
ZA9810780B (en) 1999-05-31
DE69801163T2 (de) 2002-03-28
CO4980892A1 (es) 2000-11-27
JP2007224042A (ja) 2007-09-06
NO20002631L (no) 2000-05-23
RU2182575C2 (ru) 2002-05-20
GC0000094A (en) 2005-06-29
GR3036702T3 (en) 2001-12-31
CZ295972B6 (cs) 2005-12-14
NZ504461A (en) 2001-06-29
HUP0100343A3 (en) 2001-09-28
UA54568C2 (uk) 2003-03-17
CZ20001787A3 (cs) 2000-09-13
KR20010032420A (ko) 2001-04-16
ES2161552T3 (es) 2001-12-01
CA2310318C (en) 2003-10-21
MA26569A1 (fr) 2004-12-20
WO1999028310A1 (en) 1999-06-10
EP1034171A1 (en) 2000-09-13
BG64155B1 (bg) 2004-02-27

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