EG24168A - N-[5-iii5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases - Google Patents

N-[5-iii5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

Info

Publication number: EG24168A
Authority: EG; Egypt
Prior art keywords: iii5; oxazolyl; thiazolyl; thio; alkyl
Prior art date: 1999-12-15

Application number

EG20001523A

Other languages

English (en)

Inventor

Raj N Misra

Original Assignee

Bristol Myers Squibb Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-12-15

Filing date

2000-12-09

Publication date

2008-09-10

1999-12-15 Priority claimed from US09/464,511 external-priority patent/US6262096B1/en

2000-12-09 Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co

2008-09-10 Application granted granted Critical

2008-09-10 Publication of EG24168A publication Critical patent/EG24168A/xx

Links

108091007914 CDKs Proteins 0.000 title 1
102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title 1
125000000446 sulfanediyl group Chemical group *S* 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

EG20001523A 1999-12-15 2000-12-09 N-[5-iii5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases EG24168A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/464,511 US6262096B1 (en)	1997-11-12	1999-12-15	Aminothiazole inhibitors of cyclin dependent kinases
US61662700A	2000-07-26	2000-07-26

Publications (1)

Publication Number	Publication Date
EG24168A true EG24168A (en)	2008-09-10

Family

ID=27041008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG20001523A EG24168A (en)	1999-12-15	2000-12-09	N-[5-iii5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases

Country Status (29)

Country	Link
EP (1)	EP1240166B1 (cs)
JP (1)	JP2003516987A (cs)
KR (1)	KR100738132B1 (cs)
CN (1)	CN1433416A (cs)
AR (1)	AR026974A1 (cs)
AT (1)	ATE289306T1 (cs)
AU (1)	AU783719B2 (cs)
BR (1)	BR0016424A (cs)
CA (1)	CA2394552A1 (cs)
CO (1)	CO5261565A1 (cs)
CZ (1)	CZ20022015A3 (cs)
DE (1)	DE60018205T2 (cs)
DK (1)	DK1240166T3 (cs)
EG (1)	EG24168A (cs)
ES (1)	ES2236034T3 (cs)
HK (1)	HK1049661B (cs)
HU (1)	HUP0301032A3 (cs)
IL (2)	IL149755A0 (cs)
MX (1)	MXPA02005870A (cs)
MY (1)	MY125768A (cs)
NO (1)	NO323726B1 (cs)
NZ (1)	NZ519120A (cs)
PE (1)	PE20011026A1 (cs)
PL (1)	PL364921A1 (cs)
PT (1)	PT1240166E (cs)
RU (1)	RU2002119016A (cs)
TW (1)	TWI273103B (cs)
UY (1)	UY26481A1 (cs)
WO (1)	WO2001044242A1 (cs)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6262096B1 (en)	1997-11-12	2001-07-17	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) *	1998-10-21	2002-07-02	Bristol-Myers Squibb Company	Process for preparing azacycloalkanoylaminothiazoles
US6515004B1 (en)	1999-12-15	2003-02-04	Bristol-Myers Squibb Company	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases
US6392053B2 (en)	1999-12-15	2002-05-21	Bristol-Myers Squibb Company	Process for preparing arylacetylaminothiazoles
WO2002010162A1 (en) *	2000-07-26	2002-02-07	Bristol-Myers Squibb Company	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl] carboxamide inhibitors of cyclin dependent kinases
AU2001290912A1 (en)	2000-09-15	2002-03-26	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US7473691B2 (en)	2000-09-15	2009-01-06	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
US6660731B2 (en)	2000-09-15	2003-12-09	Vertex Pharmaceuticals Incorporated	Pyrazole compounds useful as protein kinase inhibitors
BR0116493A (pt)	2000-12-21	2003-09-30	Vertex Pharma	Compostos de pirazol úteis como inibidores de proteìna cinase
MY141867A (en)	2002-06-20	2010-07-16	Vertex Pharma	Substituted pyrimidines useful as protein kinase inhibitors
MXPA05001367A (es)	2002-08-02	2005-04-28	Vertex Pharma	Composiciones de pirazol utiles como inhibidores de gsk-3.
US7392929B1 (en)	2004-07-26	2008-07-01	Zephyros, Inc.	Weldable synthetic material
EP1845973B1 (en)	2005-01-21	2015-08-12	Astex Therapeutics Limited	Pharmaceutical compounds
DE102005008310A1 (de) *	2005-02-17	2006-08-24	Schering Ag	Verwendung von CDKII Inhibitoren zur Fertilitätskontrolle
JP5249770B2 (ja)	2005-11-03	2013-07-31	バーテックスファーマシューティカルズインコーポレイテッド	キナーゼインヒビターとして有用なアミノピリジン
US8883790B2 (en)	2006-10-12	2014-11-11	Astex Therapeutics Limited	Pharmaceutical combinations
US8916552B2 (en)	2006-10-12	2014-12-23	Astex Therapeutics Limited	Pharmaceutical combinations
US8236128B2 (en)	2006-10-26	2012-08-07	Zephyros, Inc.	Adhesive materials, adhesive parts formed therewith and their uses
US20100247552A1 (en) *	2006-11-10	2010-09-30	Massachusetts Institute Of Technology	Pak modulators
WO2010033045A1 (en) *	2008-09-16	2010-03-25	Igor Anatolievich Pomytkin	Compositions and methods for prevention or treatment of beta amyloid deposition
EP2937345B1 (en)	2009-12-29	2018-03-21	Dana-Farber Cancer Institute, Inc.	Type ii raf kinase inhibitors
US10870651B2 (en)	2014-12-23	2020-12-22	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh)	2015-03-27	2021-08-03	达纳-法伯癌症研究所股份有限公司	细胞周期蛋白依赖性激酶的抑制剂
WO2017044858A2 (en)	2015-09-09	2017-03-16	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinases
EP3810132A4 (en)	2018-06-25	2022-06-22	Dana-Farber Cancer Institute, Inc.	TAIRE FAMILY KINASE INHIBITORS AND RELATED USES

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6040321A (en) *	1997-11-12	2000-03-21	Bristol-Myers Squibb Company	Aminothiazole inhibitors of cyclin dependent kinases

2000
- 2000-11-16 MY MYPI20005385A patent/MY125768A/en unknown
- 2000-12-07 NZ NZ519120A patent/NZ519120A/en unknown
- 2000-12-07 AT AT00990204T patent/ATE289306T1/de not_active IP Right Cessation
- 2000-12-07 EP EP00990204A patent/EP1240166B1/en not_active Expired - Lifetime
- 2000-12-07 BR BR0016424-0A patent/BR0016424A/pt not_active Application Discontinuation
- 2000-12-07 MX MXPA02005870A patent/MXPA02005870A/es active IP Right Grant
- 2000-12-07 HU HU0301032A patent/HUP0301032A3/hu unknown
- 2000-12-07 CZ CZ20022015A patent/CZ20022015A3/cs unknown
- 2000-12-07 JP JP2001544732A patent/JP2003516987A/ja not_active Withdrawn
- 2000-12-07 CN CN00818900A patent/CN1433416A/zh active Pending
- 2000-12-07 KR KR1020027007615A patent/KR100738132B1/ko not_active Expired - Fee Related
- 2000-12-07 HK HK03100935.5A patent/HK1049661B/en not_active IP Right Cessation
- 2000-12-07 RU RU2002119016/04A patent/RU2002119016A/ru unknown
- 2000-12-07 CA CA002394552A patent/CA2394552A1/en not_active Abandoned
- 2000-12-07 DK DK00990204T patent/DK1240166T3/da active
- 2000-12-07 DE DE60018205T patent/DE60018205T2/de not_active Expired - Fee Related
- 2000-12-07 AU AU27264/01A patent/AU783719B2/en not_active Ceased
- 2000-12-07 IL IL14975500A patent/IL149755A0/xx unknown
- 2000-12-07 PL PL00364921A patent/PL364921A1/xx not_active Application Discontinuation
- 2000-12-07 PT PT00990204T patent/PT1240166E/pt unknown
- 2000-12-07 WO PCT/US2000/033501 patent/WO2001044242A1/en not_active Ceased
- 2000-12-07 ES ES00990204T patent/ES2236034T3/es not_active Expired - Lifetime
- 2000-12-09 EG EG20001523A patent/EG24168A/xx active
- 2000-12-14 UY UY26481A patent/UY26481A1/es not_active Application Discontinuation
- 2000-12-14 CO CO00095237A patent/CO5261565A1/es not_active Application Discontinuation
- 2000-12-14 TW TW089126788A patent/TWI273103B/zh not_active IP Right Cessation
- 2000-12-15 PE PE2000001347A patent/PE20011026A1/es not_active Application Discontinuation
- 2000-12-15 AR ARP000106680A patent/AR026974A1/es unknown
2002
- 2002-05-20 IL IL149755A patent/IL149755A/en active IP Right Grant
- 2002-06-13 NO NO20022817A patent/NO323726B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
NO20022817L (no)	2002-08-14
DK1240166T3 (da)	2005-06-20
CA2394552A1 (en)	2001-06-21
EP1240166A1 (en)	2002-09-18
PE20011026A1 (es)	2001-12-02
NZ519120A (en)	2004-03-26
PT1240166E (pt)	2005-07-29
MXPA02005870A (es)	2003-01-28
IL149755A (en)	2009-09-22
KR20020067546A (ko)	2002-08-22
AR026974A1 (es)	2003-03-05
ATE289306T1 (de)	2005-03-15
AU2726401A (en)	2001-06-25
EP1240166B1 (en)	2005-02-16
DE60018205D1 (en)	2005-03-24
WO2001044242A9 (en)	2001-11-08
RU2002119016A (ru)	2004-01-10
JP2003516987A (ja)	2003-05-20
NO20022817D0 (no)	2002-06-13
DE60018205T2 (de)	2006-02-16
UY26481A1 (es)	2001-07-31
HUP0301032A3 (en)	2009-03-30
WO2001044242A1 (en)	2001-06-21
KR100738132B1 (ko)	2007-07-10
ES2236034T3 (es)	2005-07-16
TWI273103B (en)	2007-02-11
HUP0301032A2 (hu)	2003-08-28
HK1049661A1 (en)	2003-05-23
PL364921A1 (en)	2004-12-27
CO5261565A1 (es)	2003-03-31
HK1049661B (en)	2005-10-07
IL149755A0 (en)	2002-12-01
BR0016424A (pt)	2002-08-20
AU783719B2 (en)	2005-12-01
NO323726B1 (no)	2007-07-02
CZ20022015A3 (cs)	2003-02-12
CN1433416A (zh)	2003-07-30
MY125768A (en)	2006-08-30

Publication	Publication Date	Title
PL364890A1 (en)	2004-12-27	Aminothiazole inhibitors of cyclin dependent kinases
HUP0300974A3 (en)	2009-03-30	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]-carboxamide inhibitors of cyclin dependent kinases, pharmaceutical compositions containing them and their use
EG24028A (en)	2008-03-26	Aminothiazole inhibitors of cyclin dependent kinases
PL364921A1 (en)	2004-12-27	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
EG24409A (en)	2009-05-20	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
EP1087951A4 (en)	2002-08-14	CARBON SUBSTITUTED AMINOTHIAZOLE, CYCLINE DEPENDENT KINASE INHIBITORS
LT2000033A (en)	2001-06-25	4-aminothiazole derivatives as inhibitors of cyclin-dependent kinases
AU2002213485A1 (en)	2002-04-22	Inhibitors of protein kinases
PL351720A1 (en)	2003-06-02	Pyrrolotriazine inhibitors of kinases
GB9809869D0 (en)	1998-07-08	Inhibition of protein kinases
PL338991A1 (en)	2000-12-04	Substituted oxindole derivatives as inhibitors of thyrosine kinase protein and serine/threonine kinase protein
PL352282A1 (en)	2003-08-11	Derivatives of thiazoles and pharmaceutical compositions containing these derivatives
AU6111000A (en)	2001-02-13	Inhibitors of viral helcase
PL350911A1 (en)	2003-02-10	Inhibitors of impdh enzyme
AU2001229727A1 (en)	2001-10-25	3-aminopyrazole inhibitors of cyclin dependent kinases
AU2576501A (en)	2001-06-18	Protein kinase inhibitors
AU7788500A (en)	2001-05-08	Use of substance p antagonists for influencing the circadian timing system
AU3636201A (en)	2001-05-08	Antisense modulation of protein kinase c-theta expression
NO20012838L (no)	2001-08-08	Tiourea-inhibitorer for herpesvirus
HK1052930A (en)	2003-10-03	N-[5-[[[5-alkyl-2-oxazolyl]methyl]thio]-2-thiazolyl]carboxamide inhibitors of cyclin dependent kinases
AU4021700A (en)	2000-10-09	Methods of use of beta1-integrin inhibitors
AU2963100A (en)	2000-08-01	Use of (s)-triazines for treating apicomplexan parasitic infections
GB9813467D0 (en)	1998-08-19	Inhibition of protein kinases
GB9929309D0 (en)	2000-02-02	Semiochemical capable of effecting gene expression
HK1045839A (en)	2002-12-13	Indole-type derivatives as inhibitors of p38 kinase