EG25993A - Heteroaromatic quinoline compounds and their use as pde10 inhibitors - Google Patents

Heteroaromatic quinoline compounds and their use as pde10 inhibitors

Info

Publication number: EG25993A
Authority: EG; Egypt
Prior art keywords: quinoline compounds; pde10 inhibitors; heteroaromatic quinoline; heteroaromatic; pde10
Prior art date: 2005-01-07

Application number

Other languages

English (en)

Inventor

Patrick Robert Verhoest

Christopher John Helal

Dennis Jay Hoover

John Michael Humphrey

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-01-07

Filing date

2007-07-02

Publication date

2012-11-28

2007-07-02 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2012-11-28 Application granted granted Critical

2012-11-28 Publication of EG25993A publication Critical patent/EG25993A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Addiction (AREA)
Epidemiology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Heart & Thoracic Surgery (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Child & Adolescent Psychology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Pregnancy & Childbirth (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

EGNA2007000687 2005-01-07 2007-07-02 Heteroaromatic quinoline compounds and their use as pde10 inhibitors EG25993A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US64205805P	2005-01-07	2005-01-07
PCT/IB2005/003937 WO2006072828A2 (fr)	2005-01-07	2005-12-22	Composes de quinoline heteroaromatiques

Publications (1)

Publication Number	Publication Date
EG25993A true EG25993A (en)	2012-11-28

Family

ID=36589327

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EGNA2007000687 EG25993A (en)	2005-01-07	2007-07-02	Heteroaromatic quinoline compounds and their use as pde10 inhibitors

Country Status (43)

Country	Link
US (2)	US7429665B2 (fr)
EP (1)	EP1841757B1 (fr)
JP (1)	JP4302762B2 (fr)
KR (1)	KR100896380B1 (fr)
CN (2)	CN101098866A (fr)
AP (1)	AP2362A (fr)
AR (1)	AR052863A1 (fr)
AT (1)	ATE472543T1 (fr)
AU (1)	AU2005323794B2 (fr)
BR (1)	BRPI0518508A2 (fr)
CA (1)	CA2592986C (fr)
CR (1)	CR9180A (fr)
CU (1)	CU23780B7 (fr)
CY (1)	CY1110746T1 (fr)
DE (1)	DE602005022115D1 (fr)
DK (1)	DK1841757T3 (fr)
EA (1)	EA012211B1 (fr)
EG (1)	EG25993A (fr)
ES (1)	ES2346674T3 (fr)
GE (1)	GEP20094623B (fr)
GT (1)	GT200600002A (fr)
HN (1)	HN2006000668A (fr)
HR (1)	HRP20100461T1 (fr)
IL (1)	IL183851A (fr)
MA (1)	MA29140B1 (fr)
ME (1)	ME01142B (fr)
MX (1)	MX2007008287A (fr)
MY (1)	MY142052A (fr)
NL (1)	NL1030863C2 (fr)
NO (1)	NO340476B1 (fr)
NZ (1)	NZ555737A (fr)
PE (1)	PE20060873A1 (fr)
PL (1)	PL1841757T3 (fr)
PT (1)	PT1841757E (fr)
RS (1)	RS51385B (fr)
SI (1)	SI1841757T1 (fr)
SV (1)	SV2008002365A (fr)
TN (1)	TNSN07258A1 (fr)
TW (1)	TWI312682B (fr)
UA (1)	UA86283C2 (fr)
UY (1)	UY29324A1 (fr)
WO (1)	WO2006072828A2 (fr)
ZA (1)	ZA200705427B (fr)

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Also Published As

Publication number	Publication date
MX2007008287A (es)	2007-09-07
IL183851A0 (en)	2007-10-31
CY1110746T1 (el)	2015-06-10
WO2006072828A2 (fr)	2006-07-13
DK1841757T3 (da)	2010-09-13
IL183851A (en)	2012-03-29
AU2005323794A1 (en)	2006-07-13
EA012211B1 (ru)	2009-08-28
PT1841757E (pt)	2010-08-31
AR052863A1 (es)	2007-04-11
US20060154931A1 (en)	2006-07-13
GT200600002A (es)	2006-08-01
CA2592986A1 (fr)	2006-07-13
HK1167263A1 (zh)	2012-11-23
ZA200705427B (en)	2008-09-25
EA200701252A1 (ru)	2007-12-28
CN102491969A (zh)	2012-06-13
AU2005323794B2 (en)	2012-07-19
KR100896380B1 (ko)	2009-05-08
NZ555737A (en)	2010-01-29
JP2008526825A (ja)	2008-07-24
CR9180A (es)	2007-07-04
HRP20100461T1 (hr)	2010-11-30
JP4302762B2 (ja)	2009-07-29
UA86283C2 (uk)	2009-04-10
CU23780B7 (es)	2012-02-15
DE602005022115D1 (de)	2010-08-12
EP1841757A2 (fr)	2007-10-10
AP2007004043A0 (en)	2007-06-30
NO20072918L (no)	2007-07-05
MY142052A (en)	2010-08-30
ES2346674T3 (es)	2010-10-19
BRPI0518508A2 (pt)	2008-11-25
PL1841757T3 (pl)	2010-10-29
NL1030863C2 (nl)	2006-12-28
WO2006072828A3 (fr)	2006-11-09
PE20060873A1 (es)	2006-09-04
AP2362A (en)	2012-02-08
UY29324A1 (es)	2006-08-31
ATE472543T1 (de)	2010-07-15
KR20070091005A (ko)	2007-09-06
HN2006000668A (es)	2010-09-17
RS51385B (sr)	2011-02-28
NO340476B1 (no)	2017-05-02
TW200637555A (en)	2006-11-01
TNSN07258A1 (fr)	2008-12-31
CN102491969B (zh)	2015-08-19
SV2008002365A (es)	2008-02-08
US7429665B2 (en)	2008-09-30
TWI312682B (en)	2009-08-01
SI1841757T1 (sl)	2010-09-30
EP1841757B1 (fr)	2010-06-30
CU20070156A7 (es)	2009-03-16
GEP20094623B (en)	2009-02-25
CN101098866A (zh)	2008-01-02
US7825254B2 (en)	2010-11-02
NL1030863A1 (nl)	2006-07-10
CA2592986C (fr)	2011-02-15
US20080214607A1 (en)	2008-09-04
ME01142B (me)	2013-03-20
MA29140B1 (fr)	2008-01-02

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