EP0000332A3 - Benzophenone-anti-oxime, Diazepin-N-oxyde deren Herstellung und deren Verwendung als Heilmittel und als Zwischenprodukte in der Herstellung von Diazepinen - Google Patents

Benzophenone-anti-oxime, Diazepin-N-oxyde deren Herstellung und deren Verwendung als Heilmittel und als Zwischenprodukte in der Herstellung von Diazepinen Download PDF

Info

Publication number: EP0000332A3
Authority: EP; European Patent Office
Prior art keywords: preparation; diazepin; intermediates; oxides; diazepines
Prior art date: 1977-06-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

EP78100164A

Other languages

English (en)

French (fr)

Other versions

EP0000332A2 (de

Inventor

William Joseph Middleton

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

EIDP Inc

Original Assignee

EI Du Pont de Nemours and Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-06-16

Filing date

1978-06-15

Publication date

1979-05-30

1978-06-15 Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co

1979-01-24 Publication of EP0000332A2 publication Critical patent/EP0000332A2/de

1979-05-30 Publication of EP0000332A3 publication Critical patent/EP0000332A3/de

Status Withdrawn legal-status Critical Current

Links

238000002360 preparation method Methods 0.000 title abstract 4
239000000543 intermediate Substances 0.000 title abstract 2
RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 title 1
239000012965 benzophenone Substances 0.000 title 1
150000004908 diazepines Chemical class 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1
229940035363 muscle relaxants Drugs 0.000 abstract 2
239000003158 myorelaxant agent Substances 0.000 abstract 2
239000000932 sedative agent Substances 0.000 abstract 2
229940125723 sedative agent Drugs 0.000 abstract 2
239000003204 tranquilizing agent Substances 0.000 abstract 2
230000002936 tranquilizing effect Effects 0.000 abstract 2
PZOZHMBWLDUJCP-UHFFFAOYSA-N 3-fluoro-1H-1,2-benzodiazepine Chemical class FC1=NNC2=C(C=C1)C=CC=C2 PZOZHMBWLDUJCP-UHFFFAOYSA-N 0.000 abstract 1
SZISTGVKBCMSGQ-UHFFFAOYSA-N [N+]=1(NC=CC=CC=1)[O-] Chemical class [N+]=1(NC=CC=CC=1)[O-] SZISTGVKBCMSGQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
- C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
- C07D239/76—N-oxides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/24—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Oil, Petroleum & Natural Gas (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Anesthesiology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EP78100164A 1977-06-16 1978-06-15 Benzophenone-anti-oxime, Diazepin-N-oxyde deren Herstellung und deren Verwendung als Heilmittel und als Zwischenprodukte in der Herstellung von Diazepinen Withdrawn EP0000332A3 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/807,075 US4182760A (en)	1977-06-16	1977-06-16	Benzophenone anti-oximes, diazepin-N-oxides, and their use as pharmaceutical agents and as intermediates for pharmaceutical agents
US807075		1985-12-09

Publications (2)

Publication Number	Publication Date
EP0000332A2 EP0000332A2 (de)	1979-01-24
EP0000332A3 true EP0000332A3 (de)	1979-05-30

Family

ID=25195504

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EP78100164A Withdrawn EP0000332A3 (de)	1977-06-16	1978-06-15	Benzophenone-anti-oxime, Diazepin-N-oxyde deren Herstellung und deren Verwendung als Heilmittel und als Zwischenprodukte in der Herstellung von Diazepinen

Country Status (4)

Country	Link
US (1)	US4182760A (de)
EP (1)	EP0000332A3 (de)
JP (1)	JPS545956A (de)
IT (1)	IT1098339B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4472435A (en) *	1980-07-31	1984-09-18	Hoffman-La Roche Inc.	Benzophenone derivatives useful in treating heart failure
US4374067A (en) *	1981-12-23	1983-02-15	Hoechst-Roussel Pharmaceuticals, Inc.	Intermediates for the preparation of 4-phenyl-1,3-benzodiazepins and methods for preparing the intermediates
US4461728A (en) *	1981-12-23	1984-07-24	Hoechst Roussel Pharmaceuticals Inc.	Preparation of 4-phenyl-1,3-benzodiazepins
JP2020023441A (ja) *	2016-11-02	2020-02-13	国立大学法人九州大学	Ｅｇｆｒ阻害及び腫瘍治療に有用な新規化合物
RU2687556C1 (ru) *	2018-12-24	2019-05-15	Акционерное общество "Федеральный научно-производственный центр "Алтай"	Способ получения 7-хлор-1,3-дигидро-1-метил-5-фенил-2Н-1,4-бензодиазепин-2-она

Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE656226A (de) *	1963-11-27	1965-05-25
US3398139A (en) *	1964-04-10	1968-08-20	Hoffmann La Roche	Process for preparing 2-amino-benzodiazepines
DE2460360A1 (de) *	1974-12-20	1976-06-24	Merck Patent Gmbh	3-fluorbenzodiazepine und verfahren zu ihrer herstellung
FR2318643A1 (fr) *	1975-07-21	1977-02-18	Du Pont	Nouvelles benzodiazepines, leur preparation et compositions pharmaceutiques les contenant
DE2542251A1 (de) *	1975-09-23	1977-03-31	Merck Patent Gmbh	3-fluorbenzodiazepine und verfahren zu ihrer herstellung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3453279A (en) *	1963-11-27	1969-07-01	Hoffmann La Roche	2-dihalo lower alkyl-4-phenyl-quinazoline 3-oxide
US3453326A (en) *	1963-11-27	1969-07-01	Hoffmann La Roche	2'-benzoyl-2,2-dihaloacetanilide oxime

1977
- 1977-06-16 US US05/807,075 patent/US4182760A/en not_active Expired - Lifetime
1978
- 1978-06-15 IT IT24616/78A patent/IT1098339B/it active
- 1978-06-15 EP EP78100164A patent/EP0000332A3/de not_active Withdrawn
- 1978-06-16 JP JP7368178A patent/JPS545956A/ja active Pending

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE656226A (de) *	1963-11-27	1965-05-25
US3398139A (en) *	1964-04-10	1968-08-20	Hoffmann La Roche	Process for preparing 2-amino-benzodiazepines
DE2460360A1 (de) *	1974-12-20	1976-06-24	Merck Patent Gmbh	3-fluorbenzodiazepine und verfahren zu ihrer herstellung
FR2318643A1 (fr) *	1975-07-21	1977-02-18	Du Pont	Nouvelles benzodiazepines, leur preparation et compositions pharmaceutiques les contenant
DE2542251A1 (de) *	1975-09-23	1977-03-31	Merck Patent Gmbh	3-fluorbenzodiazepine und verfahren zu ihrer herstellung

Also Published As

Publication number	Publication date
US4182760A (en)	1980-01-08
JPS545956A (en)	1979-01-17
IT7824616A0 (it)	1978-06-15
EP0000332A2 (de)	1979-01-24
IT1098339B (it)	1985-09-07

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Legal Events

Date	Code	Title	Description
1978-11-28	PUAI	Public reference made under article 153(3) epc to a published international application that has entered the european phase	Free format text: ORIGINAL CODE: 0009012
1979-01-24	AK	Designated contracting states	Designated state(s): BE CH DE FR GB LU NL SE
1979-03-27	PUAL	Search report despatched	Free format text: ORIGINAL CODE: 0009013
1979-05-30	AK	Designated contracting states	Designated state(s): BE CH DE FR GB LU NL SE
1980-01-23	17P	Request for examination filed
1981-05-04	STAA	Information on the status of an ep patent application or granted ep patent	Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN
1981-07-08	18W	Application withdrawn	Withdrawal date: 19810424
2007-08-08	RIN1	Information on inventor provided before grant (corrected)	Inventor name: MIDDLETON, WILLIAM JOSEPH