EP0080134A1 - Handbetätigter Wascher für Mehrlochplatten - Google Patents

Handbetätigter Wascher für Mehrlochplatten Download PDF

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Publication number
EP0080134A1
EP0080134A1 EP82110470A EP82110470A EP0080134A1 EP 0080134 A1 EP0080134 A1 EP 0080134A1 EP 82110470 A EP82110470 A EP 82110470A EP 82110470 A EP82110470 A EP 82110470A EP 0080134 A1 EP0080134 A1 EP 0080134A1
Authority
EP
European Patent Office
Prior art keywords
liquid supply
channel
suction
block
washer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP82110470A
Other languages
English (en)
French (fr)
Other versions
EP0080134B1 (de
Inventor
Jorgen Cappelen
Borge Nielsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nunc AS
Original Assignee
Nunc AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8138846&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EP0080134(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nunc AS filed Critical Nunc AS
Priority to AT82110470T priority Critical patent/ATE20196T1/de
Publication of EP0080134A1 publication Critical patent/EP0080134A1/de
Application granted granted Critical
Publication of EP0080134B1 publication Critical patent/EP0080134B1/de
Expired legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B3/00—Cleaning by methods involving the use or presence of liquid or steam
    • B08B3/02—Cleaning by the force of jets or sprays
    • A—HUMAN NECESSITIES
    • A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
    • A47L—DOMESTIC WASHING OR CLEANING; SUCTION CLEANERS IN GENERAL
    • A47L17/00—Apparatus or implements used in manual washing or cleaning of crockery, table-ware, cooking-ware or the like
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L13/00—Cleaning or rinsing apparatus
    • B01L13/02—Cleaning or rinsing apparatus for receptacle or instruments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates

Definitions

  • This invention relates to a manually operable washer for washing the wells of multi well plates with a liquid.
  • the washer of the invention being characterized in that it comprises a manifold comprising a liquid supply channel and a suction channel, said liquid supply channel being connected with a single row of parallel liquid supply pipes and the suction channel being connected with a similar number of suction pipes, each suction pipe being located parallel with and adjacent to a liquid supply pipe, that the liquid supply channel via a valve is connected with means for connecting said liquid supply channel with a source for washing liquid and that the suction channel is connected with means for connecting the suction channel with a source of vacuum.
  • washing liquid may be supplied to the liquid supply pipes and from these pipes it flows into the wells to be washed.
  • the washer In the initial phase of a washing procedure the washer is preferably held at such a distance above the wells that the free ends of the suction pipes are located at the level of the upper edges of the wells so as to prevent excessive amounts of washing liquid from flowing from one well into an adjacent well.
  • the valve When the wells have been filled, the valve is dosed so as to stop the supply of liquid and the apparatus of the invention is moved downwardly to a position in which the lower ends of the suction pipes are located a short distance above the bottoms of the wells. During this movement liquid is continuously sucked out of the wells and the wells ordinarily are empty when the above mentioned lower position has been reached. The apparatus is then raised to the starting position and the washing operation may be repeated e.g. 2-3 times.
  • the ends of the suction pipes which pipes preferably are made from stainless steel, are preferably located at a longer distance from the manifold than the ends of the liquid supply pipes so as to allow the ends of the suction pipes to be moved down to the bottoms of wells having round bottoms without risking contact between the ends of the liquid supply pipes and the rounded bottom parts of said wells.
  • the manifold preferably is a block, e.g. of a plastics material, in which a bore forms a liquid supply channel which is located parallel to another bore forming the suction channel.
  • the liquid supply pipes e.g. thin pipes of stainless steel, are preferably mounted in the lower part of distributor channels in the form of bores extending from the top surface through the liquid supply channel to the bottom surface of the manifold block, the upper ends of said distributor channels being closed by removable closure means.
  • the closure means are preferably screws, such as Umbraco @ screws, having an external thread corresponding to an internal thread in the upper ends of said distributor channels.
  • a distributor channel can readily be cleaned in case a liquid supply pipe is blocked during use.
  • the screw in the upper end of the distributor channel is merely removed and a wire or a similar thin member is introduced into the distributor channel and the blocked liquid supply pipe.
  • liquid supply pipes may vary within broad ranges but when the washer of the invention is to be used in connection with multi well plates of the above mentioned type, 8 or 12 pipes are preferably employed.
  • the washer of the invention preferably comprises at least one and preferably two spacers provided at the underside of the manifold block. These spacers may consist of a fixed cylindrical core and an interchangeable bushing mounted on said core.
  • An O-ring is preferably provided on the cylindrical cylinder surface of the core in order to maintain the bushing thereon in a fixed position.
  • the valve controlling the liquid supply to the liquid supply channel is preferably a spring activated valve which in its position of rest prevents washing liquid from flowing into the liquid supply channel and which can be opened by a slight finger pressure.
  • the valve is preferably mounted in a further bore in the manifold block and is maintained in said bore by a bottom screw which is screwed into said bore.
  • the means for connecting the liquid supply channel with the source of washing liquid and the means for connecting the suction channel with a source of vacuum are preferably pipe stubs made from a plastics material and inserted into bores in the manifold block.
  • a further important advantage of the apparatus of the invention is that in case the liquid supply channel or a liquid supply pipe is blocked, it can be cleaned simply by connecting the pipe stub communicating with the liquid supply channel with the source of vacuum.
  • a suitable source of vacuum is a water jet pump.
  • the washer illustrated in the drawings comprises a manifold in the form of a block 1 comprising two internal longitudinally extending channels, viz. a liquid supply channel 2 and a suction channel 3.
  • the liquid supply channel 2 is at one end connected with a bore 4 having provided therein a valve which will be described below.
  • the opposite end of the liquid supply channel 2 is closed by a screw 5 having an external thread corresponding to an internal thread in said channel.
  • the block 1 comprises 8 channels 6 extending from the top surface of the block 1 through the channel 2 and to the bottom surface of the block and perpendicular to the channel 2.
  • each channel 6 located above the channel 2 comprises an internal thread, and a screw 8 having an external thread is screwed into said portion 7.
  • a liquid supply pipe 9 extending some distance out from the block 1 is inserted in the lower portion of each channel 6.
  • a channel 13 connects the bore 4 with the exterior side of the block 1 and a pipe stub 14 is inserted in said channel 13.
  • Another channel 15 connects one end of the suction channel 3 with the exterior side of the block 1, and a pipe stub 16 is inserted in the channel 15.
  • the opposite end of the suction channel is closed by a screw 17 having an external thread corresponding to the internal thread of said channel.
  • the block 1 further comprises 8 channels extending perpendicularly from the suction channel 3 and each having inserted therein a suction pipe 18 extending a few millimetres longer out from the block 1 than the corresponding liquid supply pipes 9.
  • valve body 19 having a lower portion 20 of a greater diametre than the upper portion 21.
  • zone between the upper portion 21 and the lower portion 20 of the valve body it comprises a zone 22 of reduced diametre.
  • An annular groove in which an O-ring 23 is mounted is provided on the exterior surface of the upper portion 21 of the valve body.
  • the underside of the valve body is hollow and the upper end of a coil spring 24 is inserted in said hollow portion.
  • the lower end of the coil spring 24 rests on a bottom screw 25 which is screwed into the lower portion of the bore 4 and which is sealed to the block 1 by means of an O-ring 26.
  • the lower portion of the bore 4 has a greater diametre than its uppor portion and the lower portion of the valve body 19 cannot move upwardly through the bore 4.
  • the block 1 is sealed relative to the lower portion 19 of the valve body by means of an O-ring 27 which is provided in the transition zone between the upper and the lower portion of the bore 4.

Landscapes

  • Health & Medical Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Electrical Discharge Machining, Electrochemical Machining, And Combined Machining (AREA)
  • Washing And Drying Of Tableware (AREA)
  • Laminated Bodies (AREA)
  • Bolts, Nuts, And Washers (AREA)
  • Electric Stoves And Ranges (AREA)
  • Baking, Grill, Roasting (AREA)
  • Cleaning By Liquid Or Steam (AREA)
  • Paper (AREA)
  • Water Treatment By Sorption (AREA)
  • Telephone Function (AREA)
EP82110470A 1981-11-13 1982-11-12 Handbetätigter Wascher für Mehrlochplatten Expired EP0080134B1 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT82110470T ATE20196T1 (de) 1981-11-13 1982-11-12 Handbetaetigter wascher fuer mehrlochplatten.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK503381A DK147254B (da) 1981-11-13 1981-11-13 Manuelt betjeneligt skylleapparat til skylning af broende i en mikrotestplade
DK5033/81 1981-11-13

Publications (2)

Publication Number Publication Date
EP0080134A1 true EP0080134A1 (de) 1983-06-01
EP0080134B1 EP0080134B1 (de) 1986-06-04

Family

ID=8138846

Family Applications (1)

Application Number Title Priority Date Filing Date
EP82110470A Expired EP0080134B1 (de) 1981-11-13 1982-11-12 Handbetätigter Wascher für Mehrlochplatten

Country Status (7)

Country Link
EP (1) EP0080134B1 (de)
JP (1) JPS5892486A (de)
AT (1) ATE20196T1 (de)
CA (1) CA1181319A (de)
DE (1) DE3271585D1 (de)
DK (1) DK147254B (de)
NO (1) NO151919B (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001616A1 (en) * 1985-09-16 1987-03-26 Flow Laboratories Limited Multi-cavity washing apparatus
US4879242A (en) * 1986-11-18 1989-11-07 Yasunobu Tsukioka Method of syringing reaction bead in examination of blood or the like and apparatus thereof
US5620894A (en) * 1995-06-16 1997-04-15 Glaxo Wellcome Inc. Apparatus for automated biological cell harvesting
EP3187855A4 (de) * 2014-08-29 2018-04-25 Hitachi High-Technologies Corporation Reaktionszelle für automatische analysevorrichtung, mit besagter reaktionszelle ausgestattete, automatische analysevorrichtung und analyseverfahren mit verwendung der besagten automatischen analysevorrichtung

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020015351A (ko) 1999-06-18 2002-02-27 고구치 유죠 로터리식 실린더장치

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351405A1 (fr) * 1976-05-13 1977-12-09 Secr Social Service Brit Procede et appareil de controle de la proprete d'une cuvette
FR2358206A1 (fr) * 1976-07-16 1978-02-10 Dynatech Worldmed Procede et dispositif pour le nettoyage de plaques de micro-test
DE3028746A1 (de) * 1980-07-29 1982-02-11 Guido 7919 Bellenberg Oberdorfer Steuer- und druckventil fuer eine hochdruck-reinigungsanlage
DE3029440A1 (de) * 1980-08-02 1982-02-18 Ernst 4030 Ratingen Fooke Vorrichtung zum waschen von festkoerpern

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2351405A1 (fr) * 1976-05-13 1977-12-09 Secr Social Service Brit Procede et appareil de controle de la proprete d'une cuvette
FR2358206A1 (fr) * 1976-07-16 1978-02-10 Dynatech Worldmed Procede et dispositif pour le nettoyage de plaques de micro-test
DE3028746A1 (de) * 1980-07-29 1982-02-11 Guido 7919 Bellenberg Oberdorfer Steuer- und druckventil fuer eine hochdruck-reinigungsanlage
DE3029440A1 (de) * 1980-08-02 1982-02-18 Ernst 4030 Ratingen Fooke Vorrichtung zum waschen von festkoerpern

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987001616A1 (en) * 1985-09-16 1987-03-26 Flow Laboratories Limited Multi-cavity washing apparatus
US4879242A (en) * 1986-11-18 1989-11-07 Yasunobu Tsukioka Method of syringing reaction bead in examination of blood or the like and apparatus thereof
US5620894A (en) * 1995-06-16 1997-04-15 Glaxo Wellcome Inc. Apparatus for automated biological cell harvesting
EP3187855A4 (de) * 2014-08-29 2018-04-25 Hitachi High-Technologies Corporation Reaktionszelle für automatische analysevorrichtung, mit besagter reaktionszelle ausgestattete, automatische analysevorrichtung und analyseverfahren mit verwendung der besagten automatischen analysevorrichtung

Also Published As

Publication number Publication date
DK147254B (da) 1984-05-28
DK503381A (da) 1983-05-14
EP0080134B1 (de) 1986-06-04
ATE20196T1 (de) 1986-06-15
DE3271585D1 (en) 1986-07-10
CA1181319A (en) 1985-01-22
NO822317L (no) 1983-05-16
NO151919B (no) 1985-03-25
JPS5892486A (ja) 1983-06-01

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