EP0102832A2 - Appareil de trempage de capsules en gélatine durcie et méthode - Google Patents

Appareil de trempage de capsules en gélatine durcie et méthode Download PDF

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Publication number
EP0102832A2
EP0102832A2 EP83305054A EP83305054A EP0102832A2 EP 0102832 A2 EP0102832 A2 EP 0102832A2 EP 83305054 A EP83305054 A EP 83305054A EP 83305054 A EP83305054 A EP 83305054A EP 0102832 A2 EP0102832 A2 EP 0102832A2
Authority
EP
European Patent Office
Prior art keywords
bars
pins
gelatin
dipping
capsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP83305054A
Other languages
German (de)
English (en)
Other versions
EP0102832A3 (fr
Inventor
Leonard Mackie
Bela N. Lorincz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Catalent Pharma Solutions Inc
Original Assignee
Catalent Pharma Solutions Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Catalent Pharma Solutions Inc filed Critical Catalent Pharma Solutions Inc
Publication of EP0102832A2 publication Critical patent/EP0102832A2/fr
Publication of EP0102832A3 publication Critical patent/EP0102832A3/fr
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
    • A61J3/077—Manufacturing capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use

Definitions

  • This invention relates to an apparatus for producing hard shell gelatin capsules and to the method for manufacturing hard shell gelatin capsules, and it particularly relates to improvements in the apparatus and method, wherein the improvements are highly efficient in operation because of significantly improved production speeds as compared to well known prior art machines.
  • hard shell gelatin capsule which generally comprises two halves which are telescopically locked or secured together in various ways, such as by friction.
  • One type of locking hard shell gelatin capsule is shown, for example, in United States Patent No. 4,040,536. These hard shell gelatin capsules are filled, generally with a medicament in various forms, such as powdered form.
  • the techniques and apparatus that are employed to manufacture hard shell gelatin capsules generally involve well known and established techniques.
  • a container of a liquid gelatin is provided.
  • Pins are supported on a rigid support member and are inverted and dipped into the liquid gelatin.
  • the liquid gelatin coats a portion of each pin.
  • the gelatin coated pins are repositioned into an upright position and the gelatin that is formed on the pins is dried to a desired moisture content over a period of time by being conveyed through a drying chamber which has the temperature and humidity carefully controlled.
  • the formed gelatin capsule is stripped from the pin and then cut to the desired size.
  • the capsule halves are joined together and finally, ejected and packaged.
  • the empty, joined capsules are later again separted and filled, as with a drug in the selected form, by the drug manufacturer.
  • the art of manufacturing the hard shell gelatin capsules is quite a well established art. Typical of older prior art apparatus is shown, for example, in the Hubel Reissue Patent No. 10,437, the Taylor Patent No. 275,092, the Glover Patent No. 297,380, and the Taylor Patent No. 311,860. A more recent patent, the Weyers Patent No. 3,756,759 discloses an improvement in a dipping pan that contains gelatin liquid. The Padilla Patent No. 3,794,453 also shows a more modern apparatus, and discloses improvements in the apparatus for drying the gelatin on the capsule forming pins. Most manufacturing of hard shell gelatin capsules is performed today by equipment, known in the art, as a "Colton 950" machine.
  • the Colton 950 machine generally carries out the manufacture of hard shell capsules according to the techniques discussed above. Although these Colton 950 machines have proven to be quite, acceptable in the manufacture of the hard shell capsules, as with most production equipment, any significant increase in the production rate of the equipment would, generally, be considered highly desirable.
  • an improved apparatus and process for forming hard shell gelatin capsules the apparatus being of the type that includes a container for holding liquid gelatin, a plurality of separate and distinct rigid bars are provided for rigidly supporting a plurality of upright pins that are shaped and sized and have individual halves of the capsules formed thereon, means are provided for dipping a selected number of adjacent bars, with the pins thereon, into the liquid gelatin, means are provided for drying the gelatin on the pins supported by the bars, means are provided for stripping the dried capsules from the pins, and drive means are provided for operating the dipping means, the drying means, and the stripping means at a selected speed, when five of the bars are dipped into the liquid gelatin, the improvement in the apparatus and process includes means for dipping at least six of the pin support bars simultaneously into the liquid gelatin, wherein the drive means includes gear means for operating at least the stripping means at a speed which is at least 20 percent greater than the selected speed of the drive means when five of the pin support bars
  • the capsule making machine 10 is of the type commonly known to those in the art as a "Colton 950" hard shell gelatin capsule manufacturing machine.
  • a "Colton 950" hard shell gelatin capsule manufacturing machine Presently, there are known to be at least two principal manufacturers of the equipment, namely, Cherry-Burrell, of Cedar Rapids, Iowa, and R. & J. Engineering, of Kitchener, Ontario. Since the Colton 950 equipment is of known construction to those skilled in the art, a deailed discussion of the hard shell gelatin capsule manufacturing machine 10 will not be provided herein, although a general description will be provided to provide a full and complete understanding of our improvements in the machine 10.
  • the capsule making machine 10 is elongated, and generally includes two halves or production lines, generally 12. Since each line 12 of the machine 10 is basically a mirror image of the other, it is considered necessary to describe only one of the lines 12. Each line 12 is supported on an elongated machine .frame, generally 14. A dipping pan 16 is supported at one end of the frame 14 and contains the liquid gelatin, generally 18, as seen in FIGURE 3, which forms the hard shell capsule halves 20 provided on the machine 10.
  • One typical hard shell capsule half 20 is shown in side view in FIGURE 3A and a fully assembled capsule is shown in FIGURE 3B with two halves 20 joined together.
  • a plurality of rigid support bars 22 are provided for supporting a plurality of pins 24 having rounded ends thereon.
  • the support bars are elongated in the same direction as the machine 10.
  • One aspect of the present invention involves improvements in the support bars 22 so as to increase the machine's rate of producing capsule halves 20.
  • the pins 24 are sized and shaped to form individual capsule halves 20 thereon by having gelatin 18 being coated thereon, after the pins 24 are dipped into the liquid gelatin 18 contained within the dipping pan 16.
  • a capsule half 20 is shown in dotted view on each of the pins 24 following dipping into the gelatin liquid 18.
  • the pins 24, as shown, are dipped when in an inverted position.
  • an elevator mechanism generally 26, repositions the support bars 22 and pins 24 during elevation thereon and with the liquid gelatin 18 coated thereon, into an upright position.
  • the bars 22 are then raised or elevated into position for conveying by a conveyor mechanism, generally 28.
  • the conveyer mechansim 28 includes an upper section 30, during which the support bars 22 are moved away from the dipping mechanism 39, and a lower section 32, during which the support bars 22 are carried back towards the forward part of the machine.
  • the conveyor mechanism 28 is quite elongated and is shown partially broken away.
  • the conveyor mechanism 28 transports the bars 22 with the pins 24 through a drying chamber, generally 33, for drying the gelatin on the pins to the desired moisture content while also hardening the capsule halves 20 on the pins 24.
  • the temperature and humidity conditions in the chamber 33 are carefully controlled.
  • the time for transportation of the bars 24 through the chamber 33 is carefully controlled.
  • the conveyor 28 carries the bars to a pusher mechanism 34, at the forward section of the machine, after the capsule halves have reached the desired degree of hardening.
  • the pusher mechanism 34 moves the support bars 22 into a stripping and cutting area, generally 36, also of known design. In this area, the gelatin capsule halves 20 are removed from the pins 24 and are also cut or trimmed to the desired length. The capsule halves 20 are then joined together to form the capsule illustrated in FIGURE 3B. The joined capsules are then ejected. As indicated previously, the joined capsules, are later separated and filled, generally with a powdered material.
  • the machine 10 is of known construction, that is, of the Colton 950 type.
  • the pins 24 are dipped into the dipping pan 16 in the inverted position with five of the support bars 22 in side-by-side relationship.
  • only five pin bars have been simultaneously dipped.
  • production rates for the machine 10 may be increased by at least twenty percent by increasing the number of support bars being dipped into the liquid gelatin from five, which was the only known practice in the prior art, to at least six in number.
  • Our improvement namely, a six bar dipping system is illustrated in FIGURE 3.
  • FIGURE 3 In the Colton 950 type of machine, it has been found that by narrowing the support bar enables there to be at least six bars mounted in the available space for dipping the pins 24 into the liquid container supported on the machine 10. Commonly, thirty pins 24 are provided on a single bar.
  • production increases from one hundred fifty to one hundred eighty capsules per dip, or a twenty percent increase in the production rate.
  • the drive system, generally 37, used in the machine 10 includes various drive motors and the like shown in FIGURES 1 and 2.
  • a gearing arrangement generally 38, as seen in FIGURE 4, is provided to gear down the speed of the dipping mechanism 39 relative to the speeded up production operations of the machine 10.
  • a gear reduction box, generally 40, as seen in FIGURE 5 uses a gear arrangement for gearing down the speed of the drying mechanism 28 relative to the speeded up operations of the machine 10.
  • production rate on a Colton 950 machine can be increased by twenty percent, while, at the same time gearing mechanism 38 and 40 are provided so as to maintain the machine speed for the dipping and drying times at a lower machine speed relative to other, increased machine speed rates which are twenty percent greater than a five bar dipping machine, of the type used in the prior art.
  • additional bars such as seven bars 22 or eights bars 22 may be used. These additional pin bars 22 would proportionally further increase the production rate of the equipment 10.
  • Each of the separate and distinct support bars is narrowed in width so that the desired number of bars, such as six, seven, or eight may be dipped into the dipping pan which has only an available width, such as about 4-3/3 inches, but requires no change from the prior art.
  • the present invention results.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Manufacturing & Machinery (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Formation And Processing Of Food Products (AREA)
EP83305054A 1982-09-02 1983-09-01 Appareil de trempage de capsules en gélatine durcie et méthode Withdrawn EP0102832A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41446282A 1982-09-02 1982-09-02
US414462 1982-09-02

Publications (2)

Publication Number Publication Date
EP0102832A2 true EP0102832A2 (fr) 1984-03-14
EP0102832A3 EP0102832A3 (fr) 1984-09-05

Family

ID=23641552

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83305054A Withdrawn EP0102832A3 (fr) 1982-09-02 1983-09-01 Appareil de trempage de capsules en gélatine durcie et méthode

Country Status (4)

Country Link
EP (1) EP0102832A3 (fr)
KR (1) KR840006124A (fr)
CA (1) CA1151823A (fr)
WO (1) WO1984000919A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0781540A3 (fr) * 1991-05-31 1997-07-16 Gs Technologies, Inc. Procédé et dispositif de production de capsules pharmaceutiques et cellulose avec sèchage de capsule
US5750157A (en) * 1991-05-31 1998-05-12 Gs Technologies, Inc. Apparatus for the manufacture of pharmaceutical cellulose capsules
CN104586634A (zh) * 2015-01-16 2015-05-06 浙江大之医药胶囊有限公司 全自动胶囊生产线的蘸胶装置
CN104606054A (zh) * 2015-01-16 2015-05-13 浙江大之医药胶囊有限公司 一种全自动胶囊生产线的蘸胶装置
CN105560064A (zh) * 2016-03-22 2016-05-11 浙江睿码科技有限公司 一种采用热凝胶性能材料硬空心胶囊的制造生产线
WO2016157206A1 (fr) * 2015-03-28 2016-10-06 Goldie Anand Machine de fabrication de capsules de gélatine dure
CN107550737A (zh) * 2017-08-25 2018-01-09 贵州盛茂白芨开发有限公司 一种白芨多糖胶囊的制作方法
WO2020183005A1 (fr) 2019-03-14 2020-09-17 Universität Greifswald Forme posologique pharmaceutique destinée à être appliquée sur des muqueuses et ses procédés de production
WO2022243524A1 (fr) 2021-05-21 2022-11-24 Esocap Ag Dispositif de capsule avec une ouverture formée par une partie de paroi de l'une des deux enveloppes de demi-capsule
WO2022243516A1 (fr) 2021-05-21 2022-11-24 Esocap Ag Dispositif de capsule ayant une ouverture formée par un chevauchement de deux enveloppes de demi-capsule

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5945136A (en) * 1997-04-03 1999-08-31 Technophar Equipment & Service Limited Heating elevator for capsule making machine
US6000928A (en) * 1997-04-03 1999-12-14 Technophar Equipment & Service Limited Capsule making machine having improved pin bars and air flow characteristics
US20110316697A1 (en) * 2010-06-29 2011-12-29 General Electric Company System and method for monitoring an entity within an area
CN103690368B (zh) * 2013-12-19 2015-05-13 丹东金丸集团有限公司 胶囊生产线系统
CN105034223B (zh) * 2015-06-16 2016-10-12 安徽黄山胶囊股份有限公司 具有改进蘸胶机及模条导向机构的空心胶囊制备装置
CN112744562B (zh) * 2020-02-08 2022-08-26 新昌县宏海机械有限公司 一种胶板输送机构及胶囊生产设备

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1125619A (en) * 1911-07-19 1915-01-19 Sharp And Dohme Capsule-machine.
US1187777A (en) * 1915-08-10 1916-06-20 Ernest Parkinson Protection of lubricating-holes in machines.
US1787777A (en) * 1926-12-10 1931-01-06 Parke Davis & Co Capsule machine
US2869178A (en) * 1953-12-07 1959-01-20 Scherer Corp R P Machine for making hard-shell gelatine capsules
GB1054977A (fr) * 1964-01-20
US3794453A (en) * 1972-08-02 1974-02-26 S Padilla Capsule making apparatus
US3842242A (en) * 1974-02-01 1974-10-15 Dow Chemical Co Apparatus for heating capsule forming pins

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0781540A3 (fr) * 1991-05-31 1997-07-16 Gs Technologies, Inc. Procédé et dispositif de production de capsules pharmaceutiques et cellulose avec sèchage de capsule
US5750157A (en) * 1991-05-31 1998-05-12 Gs Technologies, Inc. Apparatus for the manufacture of pharmaceutical cellulose capsules
US5756036A (en) * 1991-05-31 1998-05-26 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US6337045B1 (en) 1991-05-31 2002-01-08 R. P. Scherer Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
CN104606054B (zh) * 2015-01-16 2019-02-01 浙江大之医药胶囊有限公司 一种全自动胶囊生产线的蘸胶装置
CN104606054A (zh) * 2015-01-16 2015-05-13 浙江大之医药胶囊有限公司 一种全自动胶囊生产线的蘸胶装置
CN104586634A (zh) * 2015-01-16 2015-05-06 浙江大之医药胶囊有限公司 全自动胶囊生产线的蘸胶装置
WO2016157206A1 (fr) * 2015-03-28 2016-10-06 Goldie Anand Machine de fabrication de capsules de gélatine dure
CN105560064A (zh) * 2016-03-22 2016-05-11 浙江睿码科技有限公司 一种采用热凝胶性能材料硬空心胶囊的制造生产线
CN107550737A (zh) * 2017-08-25 2018-01-09 贵州盛茂白芨开发有限公司 一种白芨多糖胶囊的制作方法
CN107550737B (zh) * 2017-08-25 2020-05-05 贵州盛茂白芨开发有限公司 一种白芨多糖胶囊的制作方法
WO2020183005A1 (fr) 2019-03-14 2020-09-17 Universität Greifswald Forme posologique pharmaceutique destinée à être appliquée sur des muqueuses et ses procédés de production
WO2022243524A1 (fr) 2021-05-21 2022-11-24 Esocap Ag Dispositif de capsule avec une ouverture formée par une partie de paroi de l'une des deux enveloppes de demi-capsule
WO2022243516A1 (fr) 2021-05-21 2022-11-24 Esocap Ag Dispositif de capsule ayant une ouverture formée par un chevauchement de deux enveloppes de demi-capsule
EP4473978A2 (fr) 2021-05-21 2024-12-11 EsoCap AG Dispositif de capsule avec une ouverture formée par chevauchement de deux coques de capsule halve

Also Published As

Publication number Publication date
WO1984000919A1 (fr) 1984-03-15
CA1151823A (fr) 1983-08-16
EP0102832A3 (fr) 1984-09-05
KR840006124A (ko) 1984-11-22

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Inventor name: MACKIE, LEONARD