EP0109958A2 - Dispositif pour mesurer le contenu d'oxygène d'un échantillon - Google Patents

Dispositif pour mesurer le contenu d'oxygène d'un échantillon Download PDF

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Publication number
EP0109958A2
EP0109958A2 EP83890193A EP83890193A EP0109958A2 EP 0109958 A2 EP0109958 A2 EP 0109958A2 EP 83890193 A EP83890193 A EP 83890193A EP 83890193 A EP83890193 A EP 83890193A EP 0109958 A2 EP0109958 A2 EP 0109958A2
Authority
EP
European Patent Office
Prior art keywords
indicator
measuring device
polymer
sample
carrier
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP83890193A
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German (de)
English (en)
Other versions
EP0109958B1 (fr
EP0109958A3 (en
Inventor
Hermann Marsoner
Herbert Kroneis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Avl AG
Original Assignee
Avl AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avl AG filed Critical Avl AG
Publication of EP0109958A2 publication Critical patent/EP0109958A2/fr
Publication of EP0109958A3 publication Critical patent/EP0109958A3/de
Application granted granted Critical
Publication of EP0109958B1 publication Critical patent/EP0109958B1/fr
Expired legal-status Critical Current

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N21/643—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" non-biological material
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"

Definitions

  • the invention relates to a measuring device for determining the 0 2 content of a sample, with a 0 2 -depending fluorescent indicator which is embedded in a polymer carrier and with which the sample can be at least partially brought into contact, and an arrangement for measuring the fluorescent light emitted by the indicator after excitation.
  • Molecular oxygen is known to affect the fluorescence intensity of a wide range of organic substances, for example polycyclic aromatic hydrocarbons.
  • the molecular oxygen interacts with the molecule excited by the excitation light, takes energy from the molecule in the excited state and reduces the intensity of the emitted fluorescent light. It is also known to measure the partial pressure of the molecular oxygen via the detour of the fluorescence intensity of such an indicator substance.
  • the fluorescent substance must be dissolved in a solvent. The partial pressure of the oxygen contained in this solvent determines the level of fluorescence intensity.
  • a thin layer of the indicator solution is on a suitable carrier material which is translucent and a covering of the solution of the fluorescent substance is provided by an oxygen-permeable membrane.
  • An illumination and light measuring device is arranged on the carrier side of this arrangement.
  • the thin, oxygen-permeable membrane enables the oxygen partial pressure between the fluorescent layer and the adjacent medium outside the cover membrane to be quickly compensated.
  • the fluorescent layer takes on the oxygen partial pressure of the adjacent medium very quickly and then adjusts the intensity of its fluorescent light.
  • the object of the present invention is to design a measuring device of the type mentioned at the outset in such a way that the disadvantages mentioned of the known devices do not occur and that in particular a sufficiently large fluorescence quenching which can be evaluated by measurement technology occurs.
  • plasticizer-compatible, in particular linear, amorphous polymers as carrier material for the indicator, which also contain plasticizers in addition to the embedded indicator molecules.
  • Adequate fluorescence quenching of the indicator molecules contained in the polymer therefore occurs if the mixture of polymer and indicator contains further additional components, namely so-called plasticizers.
  • plasticizers are compounds that are added to a polymer to reduce brittleness or increase flexibility. They act like solvents penetrating the polymer, which reduce intermolecular cohesion.
  • a sufficiently high oxygen permeability of the membrane material is to be regarded as an essential requirement.
  • the oxygen sensitivity is determined by the fluorescence decay time of the indicator used and the oxygen permeability coefficient (P0 2 ) of the polymer material.
  • Fluorescence decay time 2 is the mean lifetime of the excited state of a fluorescent molecule.
  • the oxygen permeability coefficients of plasticizer-free polymers are too small (P0 2 ⁇ 35.10 10 -10 cm 2 s -1 cmHg -1 ) to be sensitive to oxygen sensitivity even when using indicators with high fluorescence decay to get times.
  • hydrophilic polymers from the group: cellulose acetate, cellulose acetate butyrate, cellulose nitrate or ethyl cellulose are used as carrier material and plasticizers from the group: glycol, glycerol or pentaverythritol, or that hydrophobic polymers from the group: polyvinyl chloride , Polystyrene, polyvinyl acetate, polyvinyl butyral, polyvinyl chloride acetate, polyethylene, polypropylene, polyurethane, polyester, natural rubber, isoprene rubber, chloroprene rubber or butyl rubber, as carrier material and plasticizer from the group: high-boiling esters - such as triaryl phosphates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialkyl phthalates, dialky
  • Inner softening means a chemical modification of the polymer or copolymerization with proportions of other monomers.
  • plasticizer to the polymer; - To what extent depends on the type and amount of plasticizer. As expected, higher amounts of plasticizer lead to higher permeabilities. Which type of plasticizer can advantageously be used depends on the viscosity of the plasticizer. Plasticizer substances with a lower viscosity lead to higher permeabilities.
  • polycyclic, homocyclic or heterocyclic aromatic molecules preferably polycyclic aromatic hydrocarbons with fluorescence decay times Z 0 greater than 5 ns, are used as indicators, which gives particularly good results with regard to the signal yield.
  • optical sensors must be calibrated with calibration media of known gas concentration. If the task now is to measure the oxygen partial pressure in liquids and, furthermore, it cannot be assumed that the calibration medium has the same optical properties as the sample, optical effects are to be expected at the interface between the membrane and the sample, which the measured fluorescence signal in disturbing way. This takes place above all in that the reflection conditions at the interface between the membrane and the sample depend in each case on the optical properties of the sample medium and thus the back reflection of the excitation and fluorescent light in the sensor membrane depends on the optical properties of the sample medium. In order to avoid this undesirable side effect, it is necessary to give the interface between the membrane and the sample medium defined optical properties.
  • a further possibility for producing the optical independence from the sample medium is given by the incorporation of pigments, such as iron oxide particles, into the indicator-containing polymer membrane.
  • pigments such as iron oxide particles
  • These particles can advantageously be directed into a region of the indicator membrane near the surface by the action of external force fields during the hardening process of the membrane (examples of force fields: gravitational field, electric field, magnetic field).
  • a further possibility for producing the optical independence from the sample medium is given according to the invention in that a thin mesh, in particular made of metal or plastic, is co-polymerized on the side of the polymer carrier facing the sample.
  • the materials used for this are e.g. Screen printing nets proved to be suitable.
  • the measures described provide a layered sensor, as shown in the figure.
  • the bottom layer 1 which faces an illumination and light measuring device (not shown here) and is shone through by the excitation light (hv), serves as a solid support (for example glass).
  • the middle layer 2 is the polymer layer which contains the fluorescent indicator substance in molecular distribution in such a way that a fluorescence signal (hv ') dependent on the oxygen content of the sample material adjacent to the sensor can be measured.
  • the optical insulation layer 3 facing the sample material lies above the layer 2.
  • the layers 2 and 3 consist of a polymer material which is well permeable to oxygen. The two layers mentioned are homogeneously bonded to one another by polymerization.
  • the carrier layer 1 could possibly be dispensed with if either no mechanical stability is required or the remaining two layers are clamped in a suitable holder.
  • the lighting and light measuring device is located directly adjacent to the layer 2.
  • the sensor element After the tetrahydrofuran solvent has evaporated, the sensor element is ready for use.
  • the sensor element After the tetrahydrofuran solvent has evaporated, the sensor element is ready for use.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP83890193A 1982-11-22 1983-10-28 Dispositif pour mesurer le contenu d'oxygène d'un échantillon Expired EP0109958B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT4248/82 1982-11-22
AT0424882A AT379688B (de) 1982-11-22 1982-11-22 Sensorelement zur bestimmung des o2-gehaltes einer probe

Publications (3)

Publication Number Publication Date
EP0109958A2 true EP0109958A2 (fr) 1984-05-30
EP0109958A3 EP0109958A3 (en) 1985-11-21
EP0109958B1 EP0109958B1 (fr) 1988-03-02

Family

ID=3561568

Family Applications (1)

Application Number Title Priority Date Filing Date
EP83890193A Expired EP0109958B1 (fr) 1982-11-22 1983-10-28 Dispositif pour mesurer le contenu d'oxygène d'un échantillon

Country Status (5)

Country Link
US (1) US4587101A (fr)
EP (1) EP0109958B1 (fr)
JP (1) JPS59108957A (fr)
AT (1) AT379688B (fr)
DE (1) DE3375826D1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0135745A3 (en) * 1983-08-12 1986-04-30 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Solid membrane for an indicator cavity
EP0128497A3 (en) * 1983-06-09 1986-07-02 Wolfgang Prof. Dr.Dr. Barnikol Luminescent layers for use in devices for the determination of oxygen concentration in gases or the like, by measurement of the luminescence quenching
US4703182A (en) * 1984-09-17 1987-10-27 AVL Gesellschaft fur Verbrennungskraftmaschinen und Messtechnik m.b.H. Prof.Dr.Dr.h.c. Hans List Arrangement for fluorescence-optical measurement of concentrations of substances contained in a sample
EP0190830A3 (fr) * 1985-02-04 1988-04-27 Gould Inc. Senseur à fibre optique unique pour mesurer la pression partielle d'oxygène
EP0190829A3 (fr) * 1985-02-07 1988-04-27 Gould Inc. Senseur optique pour mesurer la pression partielle d'oxygène
DE3817732A1 (de) * 1987-05-27 1988-12-08 Avl Ag Verfahren zur kontinuierlichen, quantitativen bestimmung von schwefeldioxid und anordnung zur durchfuehrung des verfahrens
AU582947B2 (en) * 1986-02-13 1989-04-13 Howmedica Inc. Fluorescent polymers
DE3900191A1 (de) * 1989-01-05 1990-07-12 Barnikol Wolfgang Messvorrichtung zur bestimmung des sauerstoffpartialdruckes, des sauerstoffgehaltes und des sauerstoff-flusses in biologischen systemen
DE3923950A1 (de) * 1989-07-19 1991-01-31 Biotechnolog Forschung Gmbh Faseroptische sensoranordnung zur bestimmung eines analyts, insbesondere von glucose
US5039490A (en) * 1986-04-23 1991-08-13 Avl Ag Sensor element for determination of concentration of substances
DE19831770A1 (de) * 1998-07-15 2000-02-03 Inst Chemo Biosensorik Sensormembran zur Bestimmung von chemischen Stoffkonzentrationen und Verfahren zu deren Herstellung
DE10149734A1 (de) * 2001-10-09 2003-04-24 Bosch Gmbh Robert Gassensor
DE102004033303A1 (de) * 2004-04-16 2005-11-03 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung zur Bestimmung und/oder Überwachung eines in einem fluiden Prozessmedium enthaltenen Analyten
WO2008095960A1 (fr) * 2007-02-08 2008-08-14 Dsm Ip Assets B.V. Capteur de gaz
DE102018116345A1 (de) 2018-07-05 2020-01-09 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und Verfahren zum Aufbringen einer Sensormembran

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3001669A1 (de) * 1980-01-18 1981-08-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Anordnung zur optischen messung von physikalischen groessen und stoffkonzentrationen
US5354825A (en) * 1985-04-08 1994-10-11 Klainer Stanley M Surface-bound fluorescent polymers and related methods of synthesis and use
US4689309A (en) * 1985-09-30 1987-08-25 Miles Laboratories, Inc. Test device, method of manufacturing same and method of determining a component in a sample
US5006314A (en) * 1986-04-18 1991-04-09 Minnesota Mining And Manufacturing Company Sensor and method for sensing the concentration of a component in a medium
US4849172A (en) * 1986-04-18 1989-07-18 Minnesota Mining And Manufacturing Company Optical sensor
US4760250A (en) * 1986-09-29 1988-07-26 Spectramed, Inc. Optoelectronics system for measuring environmental properties having plural feedback detectors
US5120510A (en) * 1986-10-10 1992-06-09 Minnesota Mining And Manufacturing Company Sensor and method for sensing the concentration of a component in a medium
US5462052A (en) * 1987-01-30 1995-10-31 Minnesota Mining And Manufacturing Co. Apparatus and method for use in measuring a compositional parameter of blood
US4925544A (en) * 1987-05-15 1990-05-15 National Research Development Corporation Electrochemical sensor with solid phase electrolyte
AT388248B (de) * 1987-07-20 1989-05-26 Avl Verbrennungskraft Messtech Deckschicht, vorzugsweise zur probenseitigen anbringung an optischen ionensensoren
US4974929A (en) * 1987-09-22 1990-12-04 Baxter International, Inc. Fiber optical probe connector for physiologic measurement devices
EP0312293A3 (fr) * 1987-10-16 1990-03-14 O.C.T. Optical Chemical Technologies Limited Dispositif capteur pour analyse
US5173432A (en) * 1987-12-14 1992-12-22 The Dow Chemical Company Apparatus and method for measuring the concentration or partial pressure of oxygen
AT393326B (de) * 1988-08-02 1991-09-25 Avl Verbrennungskraft Messtech Indikatorsubstanz fuer eine messvorrichtung zur optischen bestimmung interessierender parameter einer probe und messverfahren dafuer
AT390517B (de) * 1988-08-04 1990-05-25 Avl Verbrennungskraft Messtech Optischer sensor und verfahren zu dessen herstellung
US5047350A (en) * 1989-01-19 1991-09-10 Eastman Kodak Company Material and method for oxygen sensing
US5175016A (en) * 1990-03-20 1992-12-29 Minnesota Mining And Manufacturing Company Method for making gas sensing element
DE4016030A1 (de) * 1990-05-18 1991-11-21 Heraeus Quarzglas Verfahren zum werkzeugfreien umformen eines hohlkoerpers
WO1992005441A1 (fr) * 1990-09-17 1992-04-02 Baxter International Inc. Capteur d'oxygene dans les tissus insensible a l'eau
EP0507154B1 (fr) * 1991-03-21 1996-05-08 Willi Möller AG Procédé pour la détermination des alcools et utilisation d'un appareil pour la détermination des alcools
AU1915892A (en) * 1991-05-08 1992-12-21 Baxter Diagnostics Inc. Method and apparatus to detect bacterial contamination of transfusable blood
US5267532A (en) * 1992-05-05 1993-12-07 Anitox Corporation pH-indicating material and cat litter containing same
AT399402B (de) * 1992-07-09 1995-05-26 Avl Verbrennungskraft Messtech Sensormembran eines optischen sensors zur bestimmung eines physikalischen oder chemischen parameters einer probe
AT400907B (de) * 1992-07-24 1996-04-25 Avl Verbrennungskraft Messtech Sensormembran eines optischen sensors
US5326531A (en) * 1992-12-11 1994-07-05 Puritan-Bennett Corporation CO2 sensor using a hydrophilic polyurethane matrix and process for manufacturing
US5863460A (en) * 1996-04-01 1999-01-26 Chiron Diagnostics Corporation Oxygen sensing membranes and methods of making same
US5662067A (en) * 1996-04-29 1997-09-02 Cherokee Sun Corporation Insect repelling cat litter
US6325978B1 (en) 1998-08-04 2001-12-04 Ntc Technology Inc. Oxygen monitoring and apparatus
US20070225612A1 (en) * 1996-07-15 2007-09-27 Mace Leslie E Metabolic measurements system including a multiple function airway adapter
US6815211B1 (en) 1998-08-04 2004-11-09 Ntc Technology Oxygen monitoring methods and apparatus (I)
US7335164B2 (en) 1996-07-15 2008-02-26 Ntc Technology, Inc. Multiple function airway adapter
AT405767B (de) * 1997-09-17 1999-11-25 Hawa Gerhard Dr Verfahren zur herstellung eines optischen sensors sowie schichtstruktur zur verwendung in analytischen prozessen
AT409306B (de) * 1997-10-03 2002-07-25 Hoffmann La Roche Optisch chemischer sensor
US6306347B1 (en) 1998-01-21 2001-10-23 Bayer Corporation Optical sensor and method of operation
US6190612B1 (en) 1998-01-21 2001-02-20 Bayer Corporation Oxygen sensing membranes and methods of making same
US6254831B1 (en) 1998-01-21 2001-07-03 Bayer Corporation Optical sensors with reflective materials
US6752964B1 (en) 1998-06-23 2004-06-22 California Institute Of Technology Polymer/plasticizer based sensors
AU4707699A (en) * 1998-06-23 2000-01-10 California Institute Of Technology Polymer/plasticizer based sensors
US6107083A (en) * 1998-08-21 2000-08-22 Bayer Corporation Optical oxidative enzyme-based sensors
US6207110B1 (en) 1998-08-21 2001-03-27 Bayer Corporation Metallic overcoating as a light attenuating layer for optical sensors
WO2002092783A2 (fr) * 2001-05-15 2002-11-21 Children's Medical Center Corporation Procedes et appareil d'application de forces micromecaniques sur des tissus
GB0224986D0 (en) 2002-10-28 2002-12-04 Smith & Nephew Apparatus
WO2004079349A1 (fr) * 2003-03-07 2004-09-16 Luxcel Biosciences Limited Sonde sensible a l'oxygene
GB0325126D0 (en) 2003-10-28 2003-12-03 Smith & Nephew Apparatus with heat
GB0325130D0 (en) * 2003-10-28 2003-12-03 Smith & Nephew Apparatus with scaffold
US11298453B2 (en) 2003-10-28 2022-04-12 Smith & Nephew Plc Apparatus and method for wound cleansing with actives
US10058642B2 (en) 2004-04-05 2018-08-28 Bluesky Medical Group Incorporated Reduced pressure treatment system
US8062272B2 (en) 2004-05-21 2011-11-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US7909805B2 (en) 2004-04-05 2011-03-22 Bluesky Medical Group Incorporated Flexible reduced pressure treatment appliance
US10413644B2 (en) 2004-04-27 2019-09-17 Smith & Nephew Plc Wound treatment apparatus and method
GB0409446D0 (en) 2004-04-28 2004-06-02 Smith & Nephew Apparatus
US8529548B2 (en) 2004-04-27 2013-09-10 Smith & Nephew Plc Wound treatment apparatus and method
US7753894B2 (en) 2004-04-27 2010-07-13 Smith & Nephew Plc Wound cleansing apparatus with stress
DE102006025470B4 (de) * 2006-05-30 2018-08-02 Airbus Defence and Space GmbH Fluoreszenzsensor zur Detektion von Gaszusammensetzungen
WO2007143209A2 (fr) * 2006-06-02 2007-12-13 University Of Virginia Patent Foundation Polymères de dicétonate luminescents
DK2155248T3 (en) 2007-04-12 2015-09-14 Brigham & Womens Hospital Targeting abcb5 for cancer therapy
EP2152196A1 (fr) * 2007-05-01 2010-02-17 The Brigham and Women's Hospital, Inc. Dispositif de cicatrisation de plaie
US10010658B2 (en) 2013-05-10 2018-07-03 Smith & Nephew Plc Fluidic connector for irrigation and aspiration of wounds
CN110749581B (zh) * 2019-09-19 2024-03-26 北京华科仪科技股份有限公司 一种荧光溶解氧传感器膜片及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2907882A (en) * 1957-05-03 1959-10-06 Du Pont Fluorescent screens
DE2117290A1 (de) * 1970-04-13 1971-10-28 Trw Inc Verfahren und Vorrichtung zum schnellen und kontinuierlichen Messen von Sauerstoff in einem Gasstrom
JPS5123172B1 (fr) * 1971-04-22 1976-07-15
CH575639A5 (en) * 1973-04-14 1976-05-14 Fluckiger & Cie Autoluminescent device prodn - by encapsulating luminescent body in mould with reflective surfaces
DE2508637C3 (de) * 1975-02-28 1979-11-22 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen Anordnung zur optischen Messung von Blutgasen
JPS5254771A (en) * 1975-10-31 1977-05-04 Asahi Dow Ltd Method of manufacturing polylayer films
JPS586699B2 (ja) * 1978-10-06 1983-02-05 出光興産株式会社 セツコウ成形体
IT7920190A0 (it) * 1979-02-14 1979-02-14 Ellesse Int Spa Composizione ad effetto fosforescente.
DE3001669A1 (de) * 1980-01-18 1981-08-06 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Anordnung zur optischen messung von physikalischen groessen und stoffkonzentrationen
DE8031841U1 (de) * 1980-11-29 1981-05-21 Hoechst Ag, 6000 Frankfurt Optischer informationstraeger aus flexibler kunststoffolie

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0128497A3 (en) * 1983-06-09 1986-07-02 Wolfgang Prof. Dr.Dr. Barnikol Luminescent layers for use in devices for the determination of oxygen concentration in gases or the like, by measurement of the luminescence quenching
EP0135745A3 (en) * 1983-08-12 1986-04-30 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Solid membrane for an indicator cavity
US4703182A (en) * 1984-09-17 1987-10-27 AVL Gesellschaft fur Verbrennungskraftmaschinen und Messtechnik m.b.H. Prof.Dr.Dr.h.c. Hans List Arrangement for fluorescence-optical measurement of concentrations of substances contained in a sample
EP0190830A3 (fr) * 1985-02-04 1988-04-27 Gould Inc. Senseur à fibre optique unique pour mesurer la pression partielle d'oxygène
EP0190829A3 (fr) * 1985-02-07 1988-04-27 Gould Inc. Senseur optique pour mesurer la pression partielle d'oxygène
AU582947B2 (en) * 1986-02-13 1989-04-13 Howmedica Inc. Fluorescent polymers
US5039490A (en) * 1986-04-23 1991-08-13 Avl Ag Sensor element for determination of concentration of substances
DE3817732A1 (de) * 1987-05-27 1988-12-08 Avl Ag Verfahren zur kontinuierlichen, quantitativen bestimmung von schwefeldioxid und anordnung zur durchfuehrung des verfahrens
DE3900191C2 (de) * 1989-01-05 1998-09-03 Barnikol Wolfgang Meßvorrichtung zur Bestimmung des Sauerstoffpartialdruckes, des Sauerstoffgehaltes und des Sauerstoff-Flusses in biologischen Systemen
DE3900191A1 (de) * 1989-01-05 1990-07-12 Barnikol Wolfgang Messvorrichtung zur bestimmung des sauerstoffpartialdruckes, des sauerstoffgehaltes und des sauerstoff-flusses in biologischen systemen
DE3923950A1 (de) * 1989-07-19 1991-01-31 Biotechnolog Forschung Gmbh Faseroptische sensoranordnung zur bestimmung eines analyts, insbesondere von glucose
DE19831770A1 (de) * 1998-07-15 2000-02-03 Inst Chemo Biosensorik Sensormembran zur Bestimmung von chemischen Stoffkonzentrationen und Verfahren zu deren Herstellung
DE19831770C2 (de) * 1998-07-15 2001-12-13 Inst Chemo Biosensorik Verfahren zur Herstellung einer Sensormembran
US6441055B1 (en) 1998-07-15 2002-08-27 Institut Fur Chemo-Und Biosensorik Munster E.V. Sensor membrane for determining oxygen concentrations and process for the preparation thereof
DE10149734A1 (de) * 2001-10-09 2003-04-24 Bosch Gmbh Robert Gassensor
DE10149734B4 (de) * 2001-10-09 2004-09-16 Robert Bosch Gmbh Gassensor und Verfahren zur Herstellung seiner Polymermatrix
DE102004033303A1 (de) * 2004-04-16 2005-11-03 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik mbH + Co. KG Vorrichtung zur Bestimmung und/oder Überwachung eines in einem fluiden Prozessmedium enthaltenen Analyten
WO2008095960A1 (fr) * 2007-02-08 2008-08-14 Dsm Ip Assets B.V. Capteur de gaz
DE102018116345A1 (de) 2018-07-05 2020-01-09 Endress+Hauser Conducta Gmbh+Co. Kg Sensormembran, Sensorkappe und Verfahren zum Aufbringen einer Sensormembran

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DE3375826D1 (en) 1988-04-07
ATA424882A (de) 1985-06-15
EP0109958B1 (fr) 1988-03-02
US4587101A (en) 1986-05-06
AT379688B (de) 1986-02-10
EP0109958A3 (en) 1985-11-21
JPH0532701B2 (fr) 1993-05-17
JPS59108957A (ja) 1984-06-23

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