EP0140367A3 - Procédé pour la préparation de 6-désoxy-6-méthylène-naloxone et 6-désoxy-6-méthylène-naltréxone - Google Patents

Procédé pour la préparation de 6-désoxy-6-méthylène-naloxone et 6-désoxy-6-méthylène-naltréxone Download PDF

Info

Publication number
EP0140367A3
EP0140367A3 EP84113052A EP84113052A EP0140367A3 EP 0140367 A3 EP0140367 A3 EP 0140367A3 EP 84113052 A EP84113052 A EP 84113052A EP 84113052 A EP84113052 A EP 84113052A EP 0140367 A3 EP0140367 A3 EP 0140367A3
Authority
EP
European Patent Office
Prior art keywords
desoxy
methylenenaltrexone
making
methylenenaloxone
improved process
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP84113052A
Other languages
German (de)
English (en)
Other versions
EP0140367A2 (fr
Inventor
Peter C. Meltzer
Jotham W. Coe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ivax Research Holdings Inc
Original Assignee
Ivax Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Laboratories Inc filed Critical Ivax Laboratories Inc
Publication of EP0140367A2 publication Critical patent/EP0140367A2/fr
Publication of EP0140367A3 publication Critical patent/EP0140367A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP84113052A 1983-11-01 1984-10-30 Procédé pour la préparation de 6-désoxy-6-méthylène-naloxone et 6-désoxy-6-méthylène-naltréxone Withdrawn EP0140367A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/547,676 US4535157A (en) 1983-11-01 1983-11-01 Process for making 6-desoxy-6-methylenenaloxone and 6-desoxy-6-methylenenaltrexone
US547676 1983-11-01

Publications (2)

Publication Number Publication Date
EP0140367A2 EP0140367A2 (fr) 1985-05-08
EP0140367A3 true EP0140367A3 (fr) 1988-07-20

Family

ID=24185669

Family Applications (1)

Application Number Title Priority Date Filing Date
EP84113052A Withdrawn EP0140367A3 (fr) 1983-11-01 1984-10-30 Procédé pour la préparation de 6-désoxy-6-méthylène-naloxone et 6-désoxy-6-méthylène-naltréxone

Country Status (3)

Country Link
US (1) US4535157A (fr)
EP (1) EP0140367A3 (fr)
JP (1) JPS60112792A (fr)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE84717T1 (de) * 1985-09-06 1993-02-15 Baker Cummins Pharma Verwendung von 6-methylen-6-desoxy-nus850906
US4722928A (en) * 1985-12-02 1988-02-02 E. I. Du Pont De Nemours And Company N-oxide prodrug derivatives of 3-hydroxy morphinans and partial morphinans having improved oral bioavailability, pharmaceutical compositions, and processes
US5922705A (en) * 1996-04-12 1999-07-13 Intensive Narcotic Detoxification Centers Of America, Llc Rapid narcotic detoxification
US5783583A (en) * 1996-04-12 1998-07-21 Simon; David Lew 17-(cyclopropylmethyl)-4,5alpha-epoxy-6-methylenemorphinan-3,14-diol, hydrochloride salt for the purpose of rapid narcotic detoxification
US5919760A (en) * 1996-04-12 1999-07-06 Intensive Narcotic Detoxification Centers Of America, Llc Method for treating acute and severe diarrhea
US6271240B1 (en) 1996-05-06 2001-08-07 David Lew Simon Methods for improved regulation of endogenous dopamine in prolonged treatment of opioid addicted individuals
CN1050130C (zh) * 1997-07-04 2000-03-08 卢正堂 纳洛酮酸脂和纳屈酮酸脂及系列物和制备方法
PT2561860T (pt) * 2002-05-31 2018-05-08 Titan Pharmaceuticals Inc Dispositivo polimérico implantável para a libertação prolongada de buprenorfina
US7285665B2 (en) * 2002-11-08 2007-10-23 Mallinckrodt Inc. Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
US7323565B2 (en) * 2002-11-11 2008-01-29 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7321038B2 (en) * 2002-11-11 2008-01-22 Mallinckrodt Inc. Method for the catalytic production of hydrocodone and hydromorphone
US7399858B2 (en) * 2002-11-11 2008-07-15 Mallinckrodt Inc. Method for the catalytic production of hydrocodone, hydromorphone, and derivatives thereof
SI1610791T1 (sl) * 2003-03-31 2011-05-31 Titan Pharmaceuticals Inc Implantibilna polimerna naprava za zadržano sproščanje dopaminskega agonista
US20060069086A1 (en) * 2004-09-23 2006-03-30 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
US20080045610A1 (en) * 2004-09-23 2008-02-21 Alexander Michalow Methods for regulating neurotransmitter systems by inducing counteradaptations
EP2099764B1 (fr) * 2006-09-20 2011-07-27 Mallinckrodt Inc. Préparation de morphinan-6-ones substitués et leurs sels et intermédiaires
US9040726B2 (en) * 2007-03-06 2015-05-26 Mallinckrodt Llc Process for the preparation of quaternary N-alkyl morphinan alkaloid salts
JP5875748B2 (ja) * 2007-03-06 2016-03-02 マリンクロッド エルエルシー 第４級ｎ−アルキルモルフィナンアルカロイド塩の調製のための方法
EP2896614B1 (fr) * 2008-05-27 2017-07-12 Mallinckrodt LLC Procédés et composés pour la préparation de normorphinanes
WO2010028004A2 (fr) 2008-09-03 2010-03-11 Mallinckrodt Inc. Berbines substituées et leurs procédés de synthèse
UA102128C2 (en) 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate
EA019331B1 (ru) * 2009-05-25 2014-02-28 Х. Лундбекк А/С Получение налмефена гидрохлорида из налтрексона
CA2936749C (fr) 2010-06-11 2019-07-09 Rhodes Technologies Procedes catalyses par metal de transition pour la preparation de composes de n-allyle et utilisation de ceux-ci
AU2011325563B2 (en) 2010-11-05 2015-08-20 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN103012416B (zh) * 2011-09-28 2015-07-01 辽宁海思科制药有限公司 一种盐酸纳美芬的制备方法
TWI560170B (en) 2011-12-06 2016-12-01 Lundbeck & Co As H Process for recovery of nalmefene hydrochloride
CN102584840A (zh) * 2011-12-28 2012-07-18 南京优科生物医药有限公司 一种制备纳美芬化合物的方法
US20140155608A1 (en) 2012-05-03 2014-06-05 H. Lundbeck A/S Method for the manufacturing of naltrexone
US20140005217A1 (en) 2012-06-27 2014-01-02 H. Lundbeck A/S Nalmefene for reduction of alcohol consumption in specific target populations
CN103204859B (zh) * 2013-04-25 2015-12-02 四川海思科制药有限公司 一种盐酸纳美芬化合物及其制备方法
CA2946698A1 (fr) 2014-04-22 2015-10-29 Otsuka Pharmaceutical Co., Ltd. Association de brexpiprazole et de nalmefene et son utilisation pour traiter les troubles lies a certaines substances
CN104513251A (zh) * 2014-11-28 2015-04-15 安徽悦康凯悦制药有限公司 一种盐酸纳美芬的制备方法
RU2712232C1 (ru) * 2018-10-05 2020-01-27 Федеральное государственное унитарное предприятие "Научно-исследовательский институт гигиены, профпатологии и экологии человека" Федерального медико-биологического агентства Улучшенный способ получения налмефена из налтрексона
US10927121B1 (en) 2019-12-20 2021-02-23 Southwest Research Institute Technologies for removing residual solvent from nalmefene hydrochloride and producing crystalline nalmefene hydrochloride monohydrate, monosolvate, or crystalline nalmefene hydrochloride dihydrate
WO2022165040A1 (fr) 2021-01-28 2022-08-04 Rhodes Technologies Procédé de cristallisation de chlorhydrate de nalmefène
CN117986261B (zh) * 2024-04-02 2024-06-18 成都瑞尔医药科技有限公司 一种盐酸纳美芬母液的回收套用方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2257715A1 (de) * 1971-11-26 1973-05-30 Jack Dr Fishman 6-methylen-6-desoxydihydromorphinund codeinderivate

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4322426A (en) * 1980-04-28 1982-03-30 E. I. Du Pont De Nemours And Company 17-Substituted-6-desoxy-7,8-dihydro-6α-methylnoroxymorphone narcotic antagonists

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2257715A1 (de) * 1971-11-26 1973-05-30 Jack Dr Fishman 6-methylen-6-desoxydihydromorphinund codeinderivate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF MEDICINAL CHEMISTRY, vol. 18, no. 3, 1975, pages 259-262; E.F. HAHN et al: "Narcotic Autagonists. 4. Carbon-6 Derivatives of N-Substituted Noroxymorphones as Narcotic Antagonists" *
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 79, 1957, pages 5730-5734; M.S. CHADHA et al.: "The Preparation of Some 6-Methylated Dihydrodesoxymorphines" *

Also Published As

Publication number Publication date
JPH0432831B2 (fr) 1992-06-01
EP0140367A2 (fr) 1985-05-08
US4535157A (en) 1985-08-13
JPS60112792A (ja) 1985-06-19

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Owner name: KEY PHARMACEUTICALS, INC.

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Owner name: IVAX LABORATORIES, INC.

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Effective date: 19890121

RIN1 Information on inventor provided before grant (corrected)

Inventor name: MELTZER, PETER C.

Inventor name: COE, JOTHAM W.