EP0185968A2 - Anal suppository and package therefor - Google Patents

Anal suppository and package therefor Download PDF

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Publication number
EP0185968A2
EP0185968A2 EP85115227A EP85115227A EP0185968A2 EP 0185968 A2 EP0185968 A2 EP 0185968A2 EP 85115227 A EP85115227 A EP 85115227A EP 85115227 A EP85115227 A EP 85115227A EP 0185968 A2 EP0185968 A2 EP 0185968A2
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EP
European Patent Office
Prior art keywords
suppository
head
suppositories
packaging
anus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP85115227A
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German (de)
French (fr)
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EP0185968A3 (en
EP0185968B1 (en
Inventor
Joachim Klädtke
Ewald Giesselmann
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UCB Pharma GmbH
Original Assignee
Schwarz Pharma AG
Schwarz GmbH
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Publication date
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Priority to AT85115227T priority Critical patent/ATE50142T1/en
Publication of EP0185968A2 publication Critical patent/EP0185968A2/en
Publication of EP0185968A3 publication Critical patent/EP0185968A3/en
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Publication of EP0185968B1 publication Critical patent/EP0185968B1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/08—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of suppositories or sticks
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/321—Both sheets being recessed
    • B65D75/323—Both sheets being recessed and forming several compartments
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/325—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil
    • B65D75/327—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet being recessed, and the other being a flat not- rigid sheet, e.g. puncturable or peelable foil and forming several compartments

Definitions

  • the present invention relates to an introduction to the rectum, i.e. suppository to be administered rectally, a so-called anal suppository, with improved properties in relation to its introduction into the rectum.
  • the invention further relates to an improved packaging for this.
  • Suppository base composition all counters and are used here, inter alia, cocoa butter, vegetable or animal fats, hydrogenated oils, mixtures of fats, waxes and spermaceti, resin-free ozokerite, paraffin wax, glycerol gelatin and glycerin soap gels or polyethylene oxides, fchengrundmassen p which are solid at room temperature are and soften at body temperature or liquefy and release as the active substances contained in them for absorption through the mucous membranes of the rectum (see Hager's Handbook of pharmaceutical practice, Volume VIIa 4.
  • suppositories are generally torpedo-like in shape today, with the head tapered to facilitate rectal insertion, and the suppository is a little thicker at the head than at the end of the suppository, ie tapering towards the end.
  • suppositories for rectal use generally have a weight of approx. 2 g for adults and approx. 1 g for children. Suppositories up to 2.5 g are often on the market.
  • suppositories for example with a weight of approx. 2.4 g with the dimensions of 30.5 mm in length, 9.6 mm in diameter at the end of the suppository and 11.7 mm at the widest point of the head with respect to the Tearability of suppository packaging problems.
  • the suppositories are now generally packaged on machines in strip-shaped packagings, with six suppositories lying side by side and separated from one another and the individual suppository packs being able to be separated by perforations between the suppositories.
  • the packaging is formed, for example, from plastic foils in thermoforming machines, each from two superimposed, partially welded foils, so that the shape of the suppository corresponds to the shape of the wells that are open at the lower end, the wells thus formed are filled with the suppository mass and finally also sealed at the lower end . Unsealed tabs are left at the head end. The user disconnects a suppository from the dressing means mounted perforations from, the packaging opened by unfolding of the tabs located on the head and removes the suppository at A the form usurr excen generally from the package falls out and is administered by hand.
  • the suppository according to the invention is characterized in that it has a thickened head and a constriction behind the head, from which the suppository, as usual, tapers towards the end.
  • the head of the Z is advantageous äpfchens spherical.
  • the head of the Z is äpfchens onion-shaped with the pointed end the onion to the front, ie the head is not round at its front end, but tapers slightly tapered.
  • the suppository according to the invention has lateral notches near the conically tapering end and shows the improved packaging at the corresponding point corresponding indentations which engage in these notches, so that the suppository does not need to be removed from the packaging for insertion but the package is opened by means of the sufficiently large tabs at the top end of the package, the package is unfolded, wherein the suppository is held by the indentations and corresponding Einbuchtun q en still in the package, and the suppositories by touching the packaging at the height of the conically tapered end can be inserted into the anus.
  • the suppository shape according to the invention can be reduced by reducing the previous suppository base mass by up to 20%, the suppository overall by approx. 10% and thus extending the parts of the packaging strip which are not connected to one another and which serve to grip when the packaging is opened, and thus lengthen them Grip strength for the consumer can be increased using the same packaging materials and machines.
  • Grip strength for the consumer can be increased using the same packaging materials and machines.
  • the avoidance of the need to pound the finaer contributes to the hygiene of the use of such suppositories.
  • the previous suppository casting machines can also continue to be used, with only the molds of the commonly used ones Forming and casting machines are to be changed.
  • suppositories according to the invention allows a reduction by about 10% of the previously required suppositories length and therefore a broadening of the grip tabs, is designed packaging for the erfindunqsqemäße suppositories so according to a Favor q th embodiment is that one of the two plates to the other flap shortened performed is, so that the other flap protrudes beyond the end of one flap and is expediently designed conspicuously, for example by a colored print, so that the consumer, even if he has poor eyesight due to age or other reasons, can quickly recognize this relief and can easily separate the two tabs, which are close together.
  • the head 1 is spherical, the constriction 2 is located behind the head, and from there the lower end 3 tapers out.
  • 2 to 4 show suppositories together with their usual packaging in the form of a strip 4, in which the suppositories 5 lie next to one another in the departments provided for this purpose. While the environment 6 around the suppository compartments are suitably sealed, the front ends 7 of the strips lie loosely on top of one another.
  • a packaging compartment is torn off along the perforation 9, starting at the notch 8, and the two packaging foils welded to one another can be separated using the loosely arranged tabs 7 and the packaging of the individual suppository can be opened.
  • the packaging flaps in the packaging for the usual torpedo-shaped suppositories are relatively narrow due to the shape and length of the torpedo-shaped suppositories and do not give sufficient grip when the package is torn open.
  • the suppository according to the invention with the spherical or onion-shaped head is shorter with the smaller suppository mass, so that the tabs 7, which are sealed after the suppository compartments have been sealed remain, are longer.
  • the length is such that the tabs can be of different lengths, so that one tab is surmounted by the other tab with its part 7a, which can be designed in a striking manner, for example by suitable coloring, so that people with worsened Au g enlicht the tabs easier separate from each other and can open so the sealed compartments suppository easier.
  • notches are provided on the conical taper shaft 3 near the rear end and in the likewise preferred embodiment of the packaging there are indentations 10, so that the suppository after tearing open the individual packaging for the individual suppository and bending the front parts apart with the the rear part can be held without the risk of the suppository falling out, and thus the suppository can be inserted into the anus in a hygienic manner without touching it.

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  • Chemical & Material Sciences (AREA)
  • Composite Materials (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • External Artificial Organs (AREA)
  • Packages (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Wirkstoff in üblicher Menge enthaltendes Analzäpfchen üblicher Zäpfchengrundmassen, das aufgrund seiner Gestaltung, nämlich mit seinem verdickten Kopf und einer Einschnürung hinter dem Kopf eine sichere Einführung in den Anus ermöglicht, ohne das Gefahr besteht, daß der Schließmuskel des Anus das Zäpfchen hinausdrängt, und für die Einführung kein Nachschieben mit dem Finger notwendig ist, obwohl die besondere Zäpfchenform eine Verringerung der Zäpfchengrundmasse um ca. 20 % und eine Verkürzung des Zäpfchens um ca. 10% ermöglicht. Die Erfindung betrifft weiterhin eine verbesserte Verpackung für derartige Analzäpfchen.The present invention relates to an active substance containing conventional suppositories of conventional suppository base masses, which due to its design, namely with its thickened head and a constriction behind the head, enables a safe introduction into the anus without the risk that the sphincter of the anus can cause the suppository pushed out, and no pushing with the finger is necessary for the introduction, although the special suppository shape allows a reduction of the suppository base mass by approx. 20% and a shortening of the suppository by approx. 10%. The invention further relates to an improved packaging for such anal suppositories.

Description

Die vorliegende Erfindung betrifft ein zur Einführung in den Mastdarm, d.h. rektal zu verabreichendes Zäpfchen, ein sogenanntes Analzäpfchen, mit in bezuc auf seine Einführung in den Mastdarm verbesserten Eigenschaften. Die Erfindung betrifft weiter eine verbesserte Verpackunc hierfür.The present invention relates to an introduction to the rectum, i.e. suppository to be administered rectally, a so-called anal suppository, with improved properties in relation to its introduction into the rectum. The invention further relates to an improved packaging for this.

Die Verabreichungsform des Zäpfchens ist ein weitverbreitetes Mittel,in der Zäpfchengrundmasse verteilte Wirkstoffe rektal zu verabreichen, sei es zur lokalen Behandlung im Mastdarm, sei es, weil eine orale oder parenterale Verabreichung des Wirkstoffes nicht möglich oder nicht gewünscht ist. Als Zäpfchengrundmasse werden dabei u.a. Kakaobutter, pflanzliche oder tierische Fette, hydrierte Öle, Mischungen aus Fetten, Wachs und Walrat, harzfreies Ozokerit, Hartparaffin, Glycerin-Gelatine und Glycerin-Seifen-Gele oder Polyethylenoxide verwendet, alles Zäpfchengrundmassen, die bei Zimmertemperatur fest sind und bei Körpertemperatur erweichen oder sich verflüssigen und so die in ihnen enthaltenen Wirkstoffe zur Absorption durch die Schleimhäute des Mastdarms freigeben (vgl. Hagers Handbuch der pharmazeutischen Praxis, Band VIIa, 4. Aufl., Springer Verlag, 1971, S. 644; F. Gstirner, Einführung in die Verfahrenstechnik der Arzneiformung, 5. Aufl. (1973), Wissenschaftl. Verlagsgesellschaft mbH, Stuttgart, S. 149-151; Der Apotheker-Praktikant, 8. Aufl. (1967), Wissenschaftl. Verlagsgesellschaft mbH, Stuttgart, S. 189-191). Diese Zäpfchen haben heute im allgemeinen torpedoähnliche Form, wobei der Kopf konisch zugespitzt ist, um die rektale Einführung zu erleichtern, und das Zäpfchen am Kopf etwas dicker als am Zäpfchenende ist, d.h. zum Ende hin schwach konisch zuläuft. Gemäß DAB8-BRD haben Suppositorien zur rektalen Anwendung im allgemeinen ein Gewicht von ca. 2 g für Erwachsene und von ca. 1 g für Kinder. Im Handel sind häufig Zäpfchen bis 2,5 g.The form of administration of the suppository is a widespread means of administering active ingredients distributed in the suppository base rectally, be it for local treatment in the rectum, either because oral or parenteral administration of the active ingredient is not possible or is not desired. Suppository base composition all counters and are used here, inter alia, cocoa butter, vegetable or animal fats, hydrogenated oils, mixtures of fats, waxes and spermaceti, resin-free ozokerite, paraffin wax, glycerol gelatin and glycerin soap gels or polyethylene oxides, fchengrundmassen p which are solid at room temperature are and soften at body temperature or liquefy and release as the active substances contained in them for absorption through the mucous membranes of the rectum (see Hager's Handbook of pharmaceutical practice, Volume VIIa 4. A ufl, Springer Verlag, 1971, p 644th. F. Gstirner, Introduction to Process Engineering in Pharmaceutical Forming, 5th ed. (1973), Wissenschaftl. Verlagsgesellschaft mbH, Stuttgart, pp. 149-151; Der Apotheker-Praktikant, 8th ed. (1967), Wissenschaftl. Verlagsgesellschaft mbH, Stuttgart, pp. 189-191). These suppositories are generally torpedo-like in shape today, with the head tapered to facilitate rectal insertion, and the suppository is a little thicker at the head than at the end of the suppository, ie tapering towards the end. According to DAB8-BRD, suppositories for rectal use generally have a weight of approx. 2 g for adults and approx. 1 g for children. Suppositories up to 2.5 g are often on the market.

Diese bisherigen Analzäpfchen haben den Nachteil, daß sie, wenn sie nicht genügend weit rektal eingeführt und sogar mit dem Finger - in unhygienischer Weise - nachgestoßen werden, aufgrund der Gleitfähigkeit der üblichen Zäpfchengrundmasse und dem Bestreben des Anusschließmuskels den Anus geschlossen zu halten, häufig wieder ausgestoßen werden.These previous anal suppositories have the disadvantage that, if they are not inserted far enough rectally and even pushed in with the finger - in an unsanitary way - due to the lubricity of the usual suppository base and the endeavor of the anus sphincter to keep the anus closed, often be expelled again.

Dazu besteht bei den bisherigen Zäpfchen z.B. mit einem Gewicht von ca. 2,4 g mit den Maßen von 30,5 mm Länge, 9,6 mm im Durchmesser am Ende des Zäpfchens und 11,7 mm an der breitesten Stelle des Kopfes bezüglich der Aufreißbarkeit der Zäpfchenverpackung Probleme. Die Zäpfchen werden heute im allgemeinen auf Automaten in streifenförmigen Verpackungen verpackt, wobei sechs Zäpfchen nebeneinander und getrennt voneinander versiegelt zu liegen kommen und die einzelnen Zäpfchenverpackungen durch Perforationen zwischen den Zäpfchen abgetrennt werden können. Die Verpackungen werden z.B. aus Kunststofffolien in Tiefziehautomaten geformt, jeweils aus zwei übereinanderliegenden, teilweise verschweißten Folien so, daß der Form des Zäpfchens entsprechende, am unteren Ende offene Näpfe entstehen, die so gebildeten Näpfe mit der Zäpfchenmasse gefüllt und schließlich am unteren Ende ebenfalls versiegelt werden. Am Kopfende sind dabei nichtversiegelte Laschen belassen. Der Benutzer trennt ein Zäpfchen aus dem Verband mittels angebrachter Perforationen ab, öffnet die Verpackung durch Auseinanderfalten der am Kopf befindlichen Laschen und entnimmt das Zäpfchen, das bei Auseinanderreißen der Form im allgemeinen aus der Verpackung herausfällt und mit der Hand verabreicht wird. Die Probleme entstehen, weil zum Entpacken eines Zäpfchens die am Kopfende der Zäpfchenverpackung vorgesehenen Aufreißlaschen in ihrer Länge zum problemlosen Aufreißen bei der oben angegebenen Länge der Zäpfchen zu schmal verbleiben. Um hier an der Verpackung für das Aufreißen eine optimale Lösung zu bringen unter Beibehaltung der formatgebundenen Teile der bestehenden Abfüllautomaten, wäre es erforderlich, das Zäpfchen kürzer und damit zur Erhaltung der Zäpfchenmasse dicker zu gestalten. Gegen eine Verbreiterung des breiteren Teils des Kopfes der bisherigen torpedoähnlichen Zäpfchen spricht jedoch, daß dann der Steg in der heute üblichen streifenförmigen Verpackung zwischen zwei Zäpfchen zu schmal wird, um beim Abreißen der Einzelverpackung für eines der Zäpfchen die Verpackung des danebenliegenden Zäpfchens sicher und haltbar geschlossen zu halten. Abgesehen hiervon spricht dagegen, daß sich gekürzte Zäpfchen von torpedoähnlicher Form aber noch schlechter rektal einführen lassen als Zäpfchen der genannten Länge, da der Schließmuskel des Anus bei seiner fortlaufenden Schließfunktion dazu neigt, das Zäpfchen nach außen zu drücken und man, wie bei diesem Umstand bekannt, das Zäpfchen umso tiefer einschieben muß, je kürzer es ist.For this there is in the previous suppositories, for example with a weight of approx. 2.4 g with the dimensions of 30.5 mm in length, 9.6 mm in diameter at the end of the suppository and 11.7 mm at the widest point of the head with respect to the Tearability of suppository packaging problems. The suppositories are now generally packaged on machines in strip-shaped packagings, with six suppositories lying side by side and separated from one another and the individual suppository packs being able to be separated by perforations between the suppositories. The packaging is formed, for example, from plastic foils in thermoforming machines, each from two superimposed, partially welded foils, so that the shape of the suppository corresponds to the shape of the wells that are open at the lower end, the wells thus formed are filled with the suppository mass and finally also sealed at the lower end . Unsealed tabs are left at the head end. The user disconnects a suppository from the dressing means mounted perforations from, the packaging opened by unfolding of the tabs located on the head and removes the suppository at A the form useinanderreißen generally from the package falls out and is administered by hand. The problems arise because unpacking a suppository on the head end of the packaging suppositories provided A ufreißlaschen remain too narrow in its length for easy tearing at the above length of the suppositories. In order to bring an optimal solution to the packaging for tearing open while maintaining the format-bound parts of the existing filling machines, it would be necessary to make the suppository shorter and thus thicker to maintain the suppository mass. Against a widening of the wider part of the head of the previous torpedo-like suppositories, however, is that the bridge in the strip-shaped packaging that is common today between two suppositories is too narrow to securely and durably close the packaging of the adjacent suppository when one of the suppositories is torn off to keep. Apart from this, there is an argument against the fact that shortened suppositories of torpedo-like shape are even more difficult to insert rectally than suppositories of the stated length, since the sphincter of the anus tends to push the suppository outwards during its continuous closing function and, as is known in this circumstance , the suppository has to slide in the deeper the shorter it is.

Es ist Aufgabe der vorliegenden Erfindung, ein Analzäpfchen zu schaffen, das leichter und sicherer in den Anus eingeführt werden kann. Es ist weiterhin Aufgabe der vorliegenden Erfindung, dabei für ein solches Zäpfchen eine solche Verpackung zu schaffen, die leicht geöffnet werden kann und es erlaubt, das Zäpfchen zu verabreichen, ohne daß es dabei angefaßt werden muß.It is an object of the present invention to provide an anal suppository that can be inserted into the anus more easily and safely. It is a further object of the present invention to provide such a package for such a suppository that can be opened easily and allows the suppository to be administered without having to be touched.

Das erfindungsgemäße Zäpfchen ist dadurch gekennzeichnet, daß es einen verdickten Kopf und hinter dem Kopf eine Einschnürung aufweist, von der das Zäpfchen wie üblich konisch zum Ende ausläuft. Vorteilhaft ist der Kopf des Zäpfchens kugelförmig ausgebildet. Bei einer weiteren, besonders vorteilhaften Ausführungsform ist der Kopf des Zäpfchens zwiebelförmig ausgebildet mit dem spitzeren Ende der Zwiebel nach vorn, d.h. der Kopf ist an seinem vorderen Ende nicht rund, sondern läuft etwas zugespitzt schwach konisch aus. In einer weiteren vorteilhaften Ausführungsform weist das erfindungsgemäße Zäpfchen nahe dem konisch auslaufenden Ende seitliche Einkerbungen auf und zeigt die verbesserte Verpackung an der entsprechenden Stelle entsprechende Einbuchtungen auf, die in diese Einkerbungen eingreifen, so daß das Zäpfchen zum Einführen nicht aus der Verpackung herausgenommen zu werden braucht, sondern die Verpackung mittels der genügend großen Laschen am Kopfende der Verpackung geöffnet, die Verpackung auseinandergefaltet wird, wobei das Zäpfchen durch die Einkerbungen und entsprechenden Einbuchtunqen noch in der Verpackung gehalten wird, und das Zäpfchen unter Anfassen der Verpackung auf der Höhe des konisch zulaufenden Endes in den Anus eingeführt werden kann.The suppository according to the invention is characterized in that it has a thickened head and a constriction behind the head, from which the suppository, as usual, tapers towards the end. The head of the Z is advantageous äpfchens spherical. In a further, particularly advantageous embodiment, the head of the Z is äpfchens onion-shaped with the pointed end the onion to the front, ie the head is not round at its front end, but tapers slightly tapered. In a further advantageous embodiment, the suppository according to the invention has lateral notches near the conically tapering end and shows the improved packaging at the corresponding point corresponding indentations which engage in these notches, so that the suppository does not need to be removed from the packaging for insertion but the package is opened by means of the sufficiently large tabs at the top end of the package, the package is unfolded, wherein the suppository is held by the indentations and corresponding Einbuchtun q en still in the package, and the suppositories by touching the packaging at the height of the conically tapered end can be inserted into the anus.

Durch die erfindungsgemäße Zäpfchenform kann unter Verminderung der bisherigen Zäpfchengrundmasse um bis zu 20 %,das Zäpfchen insgesamt um ca. 10 % verkürzt werden und so aie am Kopfende befindlichen, nicht miteinander verbundenen, dem Anfassen beim Öffnen der VerpacKung dienenden Teile des Verpackungsstreifens verlängert und dadurch die Greiffestigkeit für den Verbraucher erhöht werden unter Verwendung der gleichen Verpackungsmaterialien und -maschinen. Überraschenderweise ist zum sicheren Einführen des Zäpfchens in den Anus trotz der Verkürzung um ca. 10 % ein Nachschieben mit dem Finger nicht notwendig, sondern greift der Schließmuskel des Anus das Zäpfchen sicher, ohne daß es Gefahr läuft, daß der dem Verschließen des Anus dienende Schließmuskel das Zäpfchen wieder nach außen drängt. Die Vermeidung der Notwendigkeit eines Nachstoßens mit dem Finaer trägt zur Hygiene der Anwendung derartiqer Zäpchen bei. Auch können die bisherigen Zäpfchengießmaschinen weiter verwendet werden, wobei nur die Formwerkzeuge der üblicherweise verwendeten Form- und Gießautomaten zu verändern sind.The suppository shape according to the invention can be reduced by reducing the previous suppository base mass by up to 20%, the suppository overall by approx. 10% and thus extending the parts of the packaging strip which are not connected to one another and which serve to grip when the packaging is opened, and thus lengthen them Grip strength for the consumer can be increased using the same packaging materials and machines. Surprisingly for safe insertion of the Cou p fchens into the anus, despite the reduction by about 10% a subsequent pushing with your finger not necessary, but the sphincter of the anus takes the uvula safely without it risks that the closing of the anus serving sphincter pushes the suppository outwards again. The avoidance of the need to pound the finaer contributes to the hygiene of the use of such suppositories. The previous suppository casting machines can also continue to be used, with only the molds of the commonly used ones Forming and casting machines are to be changed.

Die Möglichkeit der breiteren Gestaltung der dem Anfassen beim Öffnen der Verpackung dienenden Teile des Verpackungsstreifens ermöglicht eine weitere Maßnahme zur Vereinfachung des Öffnens aer Verpackung für den Verbraucher. Bei der bisherigen Zäpfchenlänge und der damit notwendigen schmalen Ausgestaltung der Anfaßlaschen mußten diese gleichlang ausgeführt werden. Der Verbraucher übersah häufig die Anfaßlaschen und hatte entsprechende Schwieriqkeiten bei der Anwendung des Zäpfchens. Nachdem das erfindungsgemäße Zäpfchen eine Verkürzung um ca. 10 % der bisher notwendigen Zäpfchenlänge und damit eine Verbreiterung der Anfaßlaschen ermöglicht, ist gemäß einer bevorzuqten Ausführungsform die Verpackung für das erfindunqsqemäße Zäpfchen so gestaltet, daß eine der beiden Laschen gegenüber der anderen Lasche verkürzt ausgeführt ist, so daß die andere Lasche über das Ende der einen Lasche hinausragt und zweckmäßigerweise auffällig gestaltet ist, z.B. durch einen farbigen Aufdruck, so daß der Verbraucher, auch wenn er infolge Alters- oder aus anderen Gründen verschlechtertes Augenlicht hat, schnell diese Erleichterung erkennen kann und die beiden eng übereinanderliegenden Laschen leicht trennen kann.The possibility of a wider configuration of the parts of the packaging strip which serve to grasp when the packaging is opened enables a further measure to simplify the opening of the packaging for the consumer. With the previous suppository length and the necessary narrow design of the handle tabs, they had to be of the same length. The consumer often overlooked the grip tabs and had appropriate Schwieri q speeds when using the suppository. After suppositories according to the invention allows a reduction by about 10% of the previously required suppositories length and therefore a broadening of the grip tabs, is designed packaging for the erfindunqsqemäße suppositories so according to a Favor q th embodiment is that one of the two plates to the other flap shortened performed is, so that the other flap protrudes beyond the end of one flap and is expediently designed conspicuously, for example by a colored print, so that the consumer, even if he has poor eyesight due to age or other reasons, can quickly recognize this relief and can easily separate the two tabs, which are close together.

Die beiliegende Zeichnung dient der weiteren Erläuterung der vorliegenden Erfindung.The accompanying drawing serves to further explain the present invention.

  • Fig. 1 stellt das erfindungsgemäße Zäpfchen mit Kugelkopf im Längsschnitt dar.Fig. 1 shows the suppository according to the invention with a spherical head in longitudinal section.
  • Fig. 2 zeigt einen Verpackungsstreifen mit 6 Zäpfchen der bisherigen Form mit den bei dieser Verpackung una Zäpfchenform üblichen Maßen.Fig. 2 shows a packaging strip with 6 suppositories of the previous shape with the usual dimensions in this packaging una suppository shape.
  • Fig. 3 zeigt einen solchen Verpackungsstreifen mit der gleichen Zahl der erfindungsqemäßen Zäpfchen mit kugelförmigem Kopf mit den hierfür bei deser Verpackung und Zäpfchenform notwendigen Maßen.Fig. 3 shows such a packaging strip with the same number of suppositories according to the invention with a spherical head with the dimensions necessary for this in their packaging and suppository shape.
  • Fig. 4 zeigt eine weitere bevorzugte Ausführungsform der erfindungsqemäßen Zäpfchen, bei der der kugelförmige Kopf zur Spitze des Zäpfchens hin schwach konisch ausläuft, d.h. der Kopf des Zäpfchens zwiebelförmig ausgebildet ist. Dabei zeigt diese Figur auch eine besonders bevorzugte Ausführungsform der erfindungsgemäßen Verpackung für das erfindungsgemäße Analzäpfchen.Fig. 4 shows a further preferred embodiment of the suppository according to the invention, in which the spherical head tapers slightly conically towards the tip of the suppository, i.e. the head of the suppository is onion-shaped. This figure also shows a particularly preferred embodiment of the packaging according to the invention for the anal suppository according to the invention.

Bei dem erfindungsgemäßen Zäpfchen gemäß Fiq. 1 ist der Kopf 1 kugelförmig ausgebildet, befindet sich hinter dem Kopf die Einschnürung 2 und läuft von dort das untere Ende 3 konisch aus. Die Fig. 2 bis 4 zeigen Zäpfchen zusammen mit ihrer heute üblichen, in Form eines Streifens 4 ausgebildeten Verpackung, bei dem die Zäpfchen 5 nebeneinander in den hierfür vorgesehenen Abteilungen liegen. Während die Umgebung 6 um die Zäpfchenabteilungen herum in geeigneter Weise versiegelt sind, liegen die vorderen Enden 7 der Streifen lose aufeinander. Beim Gebrauch eines Zäpfchens wird ein Verpackungsabteil entlang der Perforation 9, beginnend an der Kerbe 8, abgerissen und können die beiden aufeinandergeschweißten Verpackungsfolien mit Hilfe der lose aufeinanderliegenden Laschen 7 auseinandergetrennt und so die Verpackung des einzelnen Zäpfchens geöffnet werden. Die Verpackungslaschen bei der Verpackung für die üblichen torpedoförmigen Zäpfchen sind afugrund der Form und Länge des torpedoförmiqen Zäpfchens relativ schmal und geben nicht genügend Griff beim Aufreißen der Verpackung. Das erfindungsgemäße Zäpfchen mit dem kugel- oder zwiebelförmigen Kopf ist jedoch bei der geringeren Zäpfchenmasse kürzer, so daß die Laschen 7, die nach Versiegelung der Zäpfchenabteile verbleiben, länger sind. Die Länge ist dabei so, daß die Laschen unterschiedlich lang ausqeführt werden können, so daß die eine Lasche von der anderen Lasche mit ihrem Teil 7a überragt wird, die auqenfällig, z.B. durch geeignete Färbung, gestaltet werden kann, so daß auch Personen mit verschlechtertem Augenlicht erleichtert die Laschen voneinandertrennen und so die versiegelten Zäpfchenabteile leichter öffnen können. In einer besonders bevorzugten Ausführungsform sind am konisch zulaufenden Zäpfchenschaft 3 nahe dem hinteren Ende Einkerbungen und sind in der ebenfalls bevorzugten Ausführungsform der Verpackung entsprechenae Einbuchtungen 10 vorgesehen, so daß das Zäpfchen nach Aufreißen der einzelnen Verpackung für das einzelne Zäpfchen und Auseinanderbiegen der vorderen Teile mit dem hinteren Teil gehalten werden kann, ohne Gefahr des Herausfallens des Zäpfchens, und so das Zäpfchen, ohne es selbst anzufassen, auf hygienische Weise in den Anus eingeführt werden kann.In the suppository according to Fiq. 1, the head 1 is spherical, the constriction 2 is located behind the head, and from there the lower end 3 tapers out. 2 to 4 show suppositories together with their usual packaging in the form of a strip 4, in which the suppositories 5 lie next to one another in the departments provided for this purpose. While the environment 6 around the suppository compartments are suitably sealed, the front ends 7 of the strips lie loosely on top of one another. When a suppository is used, a packaging compartment is torn off along the perforation 9, starting at the notch 8, and the two packaging foils welded to one another can be separated using the loosely arranged tabs 7 and the packaging of the individual suppository can be opened. The packaging flaps in the packaging for the usual torpedo-shaped suppositories are relatively narrow due to the shape and length of the torpedo-shaped suppositories and do not give sufficient grip when the package is torn open. However, the suppository according to the invention with the spherical or onion-shaped head is shorter with the smaller suppository mass, so that the tabs 7, which are sealed after the suppository compartments have been sealed remain, are longer. The length is such that the tabs can be of different lengths, so that one tab is surmounted by the other tab with its part 7a, which can be designed in a striking manner, for example by suitable coloring, so that people with worsened Au g enlicht the tabs easier separate from each other and can open so the sealed compartments suppository easier. In a particularly preferred embodiment, notches are provided on the conical taper shaft 3 near the rear end and in the likewise preferred embodiment of the packaging there are indentations 10, so that the suppository after tearing open the individual packaging for the individual suppository and bending the front parts apart with the the rear part can be held without the risk of the suppository falling out, and thus the suppository can be inserted into the anus in a hygienic manner without touching it.

Claims (6)

1. Wirkstoff in üblicher Menge enthaltendes Analzäpfchen üblicher Zäpfchengrundmassen, dadurch gekennzeichnet, daß das Zäpfchen einen verdickten Kopf und hinter dem Kopf eine Einschnürung aufweist, von der das Zäpfchen wie üblich konisch zum Ende ausläuft.1. Anal suppository containing the usual amount of conventional suppository base, characterized in that the suppository has a thickened head and a constriction behind the head, from which the suppository, as usual, tapers towards the end. 2. Analzäpfchen gemäß Anspruch 1, dadurch gekennzeichnet, daß der Kopf des Zäpfchens kugelförmige ausgebildet ist.2. suppository according to claim 1, characterized in that the head of the suppository is spherical. 3. Analzäpfchen gemäß Anspruch 2, dadurch gekennzeichnet, daß der kugelförmige Kopf zur Spitze des Zäpfchens hin schwach konisch ausläuft.3. suppository according to claim 2, characterized in that the spherical head tapers towards the tip of the suppository weakly conical. 4. Analzäpfchen gemäß Ansprüchen 1 bis 3, dadurch gekennzeichnet, daß im konisch zum Ende auslaufenden Teil nahe dem Ende des Zäpfchens Einkerbungen vorgesehen sind.4. suppository according to claims 1 to 3, characterized in that notches are provided in the conically tapering part near the end of the suppository. 5. Verpackung für Analzäpfchen gemäß Ansprüchen 1 bis 4, bestehend aus zwei der Form des Analzäpfchens ausgeformten Streifen aus geeignetem Kunststoff, die rund um das Zäpfchen versiegelt sind und am Kopf zwei lose aufeinanderliegenae Laschen aufweisen, dadurch gekennzeichnet, daß die Laschen verschieden lang ausgestaltet sind.5. Packaging for suppositories according to Claims 1 to 4, consisting of two strips of suitable plastic shaped into the shape of the suppository, which are sealed around the suppository and have two loosely lying tabs on the head, characterized in that the tabs are of different lengths . 6. Verpackung für Analzäpfchen gemäß Anspruch 4, dadurch gekennzeichnet, daß sie in dem Teil zum Zäpfchenende hin der Einkerbung im Zäpfchen entsprechenae Ausbuchtungen aufweisen.6. Packaging for suppositories according to claim 4, characterized in that they in the part towards the end of the suppository bulges corresponding to the notch in the suppository.
EP85115227A 1984-12-13 1985-11-30 Anal suppository and package therefor Expired - Lifetime EP0185968B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT85115227T ATE50142T1 (en) 1984-12-13 1985-11-30 ANAL SUPPLEMENTS AND PACKAGING THEREOF.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3445394 1984-12-13
DE19843445394 DE3445394A1 (en) 1984-12-13 1984-12-13 ANALZAFEFCHEN AND PACKING HERE

Publications (3)

Publication Number Publication Date
EP0185968A2 true EP0185968A2 (en) 1986-07-02
EP0185968A3 EP0185968A3 (en) 1986-12-17
EP0185968B1 EP0185968B1 (en) 1990-02-07

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ID=6252621

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Application Number Title Priority Date Filing Date
EP85115227A Expired - Lifetime EP0185968B1 (en) 1984-12-13 1985-11-30 Anal suppository and package therefor

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EP (1) EP0185968B1 (en)
AT (1) ATE50142T1 (en)
DE (2) DE3445394A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020051050A1 (en) * 2018-09-04 2020-03-12 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods
US10813963B2 (en) 2018-09-04 2020-10-27 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods
WO2021177938A1 (en) * 2020-03-02 2021-09-10 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10246003B4 (en) * 2002-10-02 2005-06-30 Anliker, Markus, Dr.med. Suppository

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3126887A (en) * 1964-03-31 gordon
GB252363A (en) * 1925-05-22 1927-01-27 Belge Des Produits Rationnels Improvements in suppositories and means for the insertion of the same
US3039246A (en) * 1959-08-06 1962-06-19 Ivers Lee Co Suppository package and method of making it
DE3220249A1 (en) * 1981-10-26 1983-05-05 Tadashi Ikeda Osaka Yagi Introduction aid for suppositories

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020051050A1 (en) * 2018-09-04 2020-03-12 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods
US10695301B2 (en) 2018-09-04 2020-06-30 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods
US10813963B2 (en) 2018-09-04 2020-10-27 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods
WO2021177938A1 (en) * 2020-03-02 2021-09-10 Babak Ghalili Veterinary cannabinoid and menthol compositions and methods

Also Published As

Publication number Publication date
DE3575858D1 (en) 1990-03-15
ATE50142T1 (en) 1990-02-15
EP0185968A3 (en) 1986-12-17
DE3445394A1 (en) 1986-06-19
EP0185968B1 (en) 1990-02-07

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