EP0201732A2 - Bêta-2-mimétiques du type des 4-amoniphényléthanolamines pour la prévention des ulcères stomacaux - Google Patents

Bêta-2-mimétiques du type des 4-amoniphényléthanolamines pour la prévention des ulcères stomacaux Download PDF

Info

Publication number
EP0201732A2
EP0201732A2 EP86104951A EP86104951A EP0201732A2 EP 0201732 A2 EP0201732 A2 EP 0201732A2 EP 86104951 A EP86104951 A EP 86104951A EP 86104951 A EP86104951 A EP 86104951A EP 0201732 A2 EP0201732 A2 EP 0201732A2
Authority
EP
European Patent Office
Prior art keywords
prevention
peptic ulcers
treatment
tert
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP86104951A
Other languages
German (de)
English (en)
Other versions
EP0201732A3 (fr
Inventor
Ernst Dr. Salamon
Alberto Dr. Briganti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica GmbH filed Critical Boehringer Ingelheim Vetmedica GmbH
Publication of EP0201732A2 publication Critical patent/EP0201732A2/fr
Publication of EP0201732A3 publication Critical patent/EP0201732A3/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

Definitions

  • the above compound according to the invention is administered orally and to the feed to the fattening animal, in particular calves, in a daily dose of 1 to 10 mcg / kg body weight, but preferably of 1.5 to 5 mcg / kg body weight.
  • the compound 1- (4-amino-3,5, -dichforphenyl) -2-tertbutyfamina-ethanol hydrochloride was administered in a daily dose of 2 mcg / kg body weight, divided into 2 doses, which was added to the feed, 32 at the beginning The treatment continued to give calves approximately 70 days old and approximately 100 kg in weight compared to a control group of the same size.
  • the substance administered is well tolerated. This has, for example, an LD 50 on the mouse of 176 mg / kg po. Furthermore, there were no side effects when applying this substance, for example, there were no significant differences between the two groups in the haematological examination and the enzymes SGOT, CPK, LDH and GLDH, which was carried out on a sample basis.
  • the application according to the invention of a compound of the above general formula I thus increases the tolerance of the calf's stomach to the age and size of the animals inadequate or unphysiological feed composition in an unforeseeable manner. It thus avoids the previously unavoidable losses in the intensive fattening of white meat cats of all related cattle breeds (in particular the brown cattle, Fleckvieh, Charolais, black and white, red and angled breeds), which over a period of approx. 5 months up to a weight of approx 250 kg are fattened by mortality due to ulcers and poor daily weight gain due to peptic abomasal ulcers.
  • composition of milk exchange feed is Composition of milk exchange feed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feed For Specific Animals (AREA)
  • Fodder In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP86104951A 1985-04-24 1986-04-10 Bêta-2-mimétiques du type des 4-amoniphényléthanolamines pour la prévention des ulcères stomacaux Withdrawn EP0201732A3 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3514725 1985-04-24
DE19853514725 DE3514725A1 (de) 1985-04-24 1985-04-24 Ss(pfeil abwaerts)2(pfeil abwaerts)-mimetica vom typ der 4-amino-phenylaethanolamine zur verhinderung von peptischen magen-geschwueren

Publications (2)

Publication Number Publication Date
EP0201732A2 true EP0201732A2 (fr) 1986-11-20
EP0201732A3 EP0201732A3 (fr) 1989-08-02

Family

ID=6268944

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86104951A Withdrawn EP0201732A3 (fr) 1985-04-24 1986-04-10 Bêta-2-mimétiques du type des 4-amoniphényléthanolamines pour la prévention des ulcères stomacaux

Country Status (8)

Country Link
EP (1) EP0201732A3 (fr)
JP (1) JPS61251621A (fr)
AU (1) AU585602B2 (fr)
DE (1) DE3514725A1 (fr)
DK (1) DK186386A (fr)
IL (1) IL78579A (fr)
NZ (1) NZ215926A (fr)
ZA (1) ZA863025B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201714734D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714736D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201714745D0 (en) 2017-09-13 2017-10-25 Atrogi Ab New compounds and uses
GB201903832D0 (en) 2019-03-20 2019-05-01 Atrogi Ab New compounds and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2838923A1 (de) * 1978-09-07 1980-04-03 Thomae Gmbh Dr K Verwendung von phenylaethanolaminen als antiphlogistica
IL60530A (en) * 1979-08-16 1984-10-31 American Cyanamid Co Animal feed compositions useful as growth promotors and for reduction of fat in animals,comprising phenylethanolamine derivatives and certain such novel compounds
DE3104850A1 (de) * 1981-02-11 1982-08-26 Dr. Karl Thomae Gmbh, 7950 Biberach "neuer futterzusatz zur verbesserung des wachstums"
AU8612082A (en) * 1982-07-16 1984-01-19 Thomae, Karl G.M.B.H. Phenylethanolamines and use thereof as animal growth promotors

Also Published As

Publication number Publication date
ZA863025B (en) 1987-12-30
DK186386D0 (da) 1986-04-23
AU5658686A (en) 1986-11-06
JPS61251621A (ja) 1986-11-08
AU585602B2 (en) 1989-06-22
IL78579A (en) 1989-03-31
DK186386A (da) 1986-10-25
IL78579A0 (en) 1986-08-31
EP0201732A3 (fr) 1989-08-02
NZ215926A (en) 1988-10-28
DE3514725A1 (de) 1986-10-30

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Inventor name: SALAMON, ERNST, DR.

Inventor name: BRIGANTI, ALBERTO, DR.