EP0216901A4 - Immunogenes antigen-träger-proteinkonjugat zur verwendung in impfstoffen gegen malaria. - Google Patents

Immunogenes antigen-träger-proteinkonjugat zur verwendung in impfstoffen gegen malaria.

Info

Publication number
EP0216901A4
EP0216901A4 EP19860902613 EP86902613A EP0216901A4 EP 0216901 A4 EP0216901 A4 EP 0216901A4 EP 19860902613 EP19860902613 EP 19860902613 EP 86902613 A EP86902613 A EP 86902613A EP 0216901 A4 EP0216901 A4 EP 0216901A4
Authority
EP
European Patent Office
Prior art keywords
antigen
protein conjugate
immunogenic protein
malaria vaccine
carrier immunogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP19860902613
Other languages
English (en)
French (fr)
Other versions
EP0216901A1 (de
Inventor
Victor N Nussenzweig
Fidel P Zavala
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
Original Assignee
New York University NYU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New York University NYU filed Critical New York University NYU
Publication of EP0216901A1 publication Critical patent/EP0216901A1/de
Publication of EP0216901A4 publication Critical patent/EP0216901A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/44—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from protozoa
    • C07K14/445—Plasmodium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
EP19860902613 1985-03-28 1986-03-27 Immunogenes antigen-träger-proteinkonjugat zur verwendung in impfstoffen gegen malaria. Withdrawn EP0216901A4 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US716960 1976-08-23
US71696085A 1985-03-28 1985-03-28

Publications (2)

Publication Number Publication Date
EP0216901A1 EP0216901A1 (de) 1987-04-08
EP0216901A4 true EP0216901A4 (de) 1989-10-04

Family

ID=24880143

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19860902613 Withdrawn EP0216901A4 (de) 1985-03-28 1986-03-27 Immunogenes antigen-träger-proteinkonjugat zur verwendung in impfstoffen gegen malaria.

Country Status (9)

Country Link
EP (1) EP0216901A4 (de)
JP (1) JPS62502340A (de)
AU (1) AU5695686A (de)
ES (1) ES8800273A1 (de)
IE (1) IE860846L (de)
IL (1) IL78292A0 (de)
PT (1) PT82282B (de)
WO (1) WO1986005790A1 (de)
ZA (1) ZA862376B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA855232B (en) * 1984-07-23 1986-02-26 Univ New York Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein
IT1187710B (it) * 1985-07-25 1987-12-23 Eniricerche Spa Composizione peptidica utile per la preparazione di vaccini per la malaria e di kit diagnostici per la determinazione di affezioni malariche
US5225530A (en) * 1986-07-16 1993-07-06 Eniricerche S.P.A. Polypeptide useful for the preparation of antimalarial vaccines and of diagnostic kits for the detection of malarial affections
IT1196501B (it) * 1986-07-16 1988-11-16 Eniricerche Spa Polipeptide utile per la preparazione di vaccini per la malaria e di kits diagnostici per la determinazione di affezioni malariche
CA1329124C (en) * 1987-02-02 1994-05-03 Jerald C. Sadoff Conjugate malaria vaccine
IT1223301B (it) * 1987-09-11 1990-09-19 Eniricerche Spa Polipeptidi sequenziali immunologicamente attivi
IT1233419B (it) * 1987-12-11 1992-03-31 Eniricerche Spa Peptidi sintetici immunologicamente attivi utili per la preparazione di un vaccino antimalaria
IT8820888A0 (it) * 1988-06-08 1988-06-08 Eniricerche Spa Peptidi di sintesi immunologicamente attivi per lapreparazione di vaccini antimalarici.
IT1226728B (it) * 1988-08-05 1991-02-05 Eniricerche Spa Coniugato peptidico immunologicamente attivo utile come vaccino antimalaria e metodo di immunizzazione impiegante lo stesso
CA2006700A1 (en) * 1989-01-17 1990-07-17 Antonello Pessi Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
IT1237764B (it) * 1989-11-10 1993-06-17 Eniricerche Spa Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
GB9616351D0 (en) * 1996-08-02 1996-09-11 Smithkline Beecham Biolog Vaccine composition
GB9808932D0 (en) 1998-04-27 1998-06-24 Chiron Spa Polyepitope carrier protein

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
EP0166410A2 (de) * 1984-06-26 1986-01-02 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Immunologisch aktive Peptide, geeignet zur Einführung von Immunisierung gegen Malaria und deren Kodierung von Genen
WO1986000911A1 (en) * 1984-07-23 1986-02-13 New York University Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5344613A (en) * 1976-09-30 1978-04-21 Eisai Co Ltd Tumor vaccine containing lectin/tumor cell-complex

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
EP0166410A2 (de) * 1984-06-26 1986-01-02 THE UNITED STATES OF AMERICA as represented by the Secretary United States Department of Commerce Immunologisch aktive Peptide, geeignet zur Einführung von Immunisierung gegen Malaria und deren Kodierung von Genen
WO1986000911A1 (en) * 1984-07-23 1986-02-13 New York University Protective peptide antigen corresponding to plasmodium falciparum circumsporozoite protein

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
CELL, vol. 37, July 1984, pages 767-778, MIT; A. WILSON et al.: "The structure of an antigenic determinant in a protein" *
CHEMICAL ABSTRACTS, vol. 104, no. 3, 20th January 1986, page 18, abstract no. 14545j, Columbus, Ohio, US; E.R. CLOUGH et al.: "Production of antisporozoite antibodies in absence of response to carrier by coupling an MDP derivative to a malaria peptide-tetanus toxoid conjugate", & BIOCHEM. BIOPHYS. RES. COMMUN. 1985, 131(1), 70-6 *
EXP. MED., vol. 153, June 1983, pages 1947-1957, The Rockefeller University Press; F. ZAVALA et al.: "Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes" *
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, vol. 5, 1982, pages 391-400, Elsevier Biomedical Press; M. GOMAN et al.: "The establishment of genomic DNA libraries for the human malaria parasite plasmodium falciparum and identification of individual clones by hybridisation" *
SCIENCE, vol. 225, 10th August 1984, pages 593-599; J.B. DAME et al.: "Structure of the gene encoding the immunodominant surface antigen on the sporozoite of the human malaria parasite plasmodium falciparum" *
SCIENCE, vol. 225, 10th August 1984, pages 628-629; V. ENEA et al.: "DNA cloning of plasmodium falciparum circumsporozoite gene: amino acid sequence of repetitive epitope" *
SCIENCE, vol. 228, 21st June 1985, pages 1436-1440; F. ZAVALA et al.: "Rationale for development of a synthetic vaccine against plasmodium falciparum malaria" *
SCIENCE, vol. 228, 24th May 1985, pages 996-999, Washington, US; R. BALLOU: "Immunogenicity of synthetic peptides from circumsporozoite protein of plasmodium falciparum" *
See also references of WO8605790A1 *

Also Published As

Publication number Publication date
PT82282A (en) 1986-04-01
EP0216901A1 (de) 1987-04-08
ES553425A0 (es) 1987-11-01
WO1986005790A1 (en) 1986-10-09
AU5695686A (en) 1986-10-23
ES8800273A1 (es) 1987-11-01
PT82282B (pt) 1988-02-17
IE860846L (en) 1986-09-28
ZA862376B (en) 1986-11-26
IL78292A0 (en) 1986-07-31
JPS62502340A (ja) 1987-09-10

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Legal Events

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PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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Designated state(s): AT BE CH DE FR GB IT LI LU NL SE

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Effective date: 19870403

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DET De: translation of patent claims
A4 Supplementary search report drawn up and despatched

Effective date: 19891004

17Q First examination report despatched

Effective date: 19910809

STAA Information on the status of an ep patent application or granted ep patent

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18D Application deemed to be withdrawn

Effective date: 19920422

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZAVALA, FIDEL, P.

Inventor name: NUSSENZWEIG, VICTOR, N.