EP0225565B1 - Capsule divisible - Google Patents

Capsule divisible Download PDF

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Publication number
EP0225565B1
EP0225565B1 EP86116604A EP86116604A EP0225565B1 EP 0225565 B1 EP0225565 B1 EP 0225565B1 EP 86116604 A EP86116604 A EP 86116604A EP 86116604 A EP86116604 A EP 86116604A EP 0225565 B1 EP0225565 B1 EP 0225565B1
Authority
EP
European Patent Office
Prior art keywords
capsule
capsules
divisible
die
cylindrical casing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
EP86116604A
Other languages
German (de)
English (en)
Other versions
EP0225565A2 (fr
EP0225565A3 (en
Inventor
Bernhard Dr. Freund
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Boehringer Ingelheim GmbH
Original Assignee
Boehringer Ingelheim International GmbH
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Boehringer Ingelheim GmbH filed Critical Boehringer Ingelheim International GmbH
Priority to AT86116604T priority Critical patent/ATE63215T1/de
Publication of EP0225565A2 publication Critical patent/EP0225565A2/fr
Publication of EP0225565A3 publication Critical patent/EP0225565A3/de
Application granted granted Critical
Publication of EP0225565B1 publication Critical patent/EP0225565B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
    • A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules

Definitions

  • the invention relates to a divisible capsule and to processes for its production.
  • Hard gelatin capsules are preferably used for the dosage of solidifying, highly viscous, powdered, granulated and, in special cases, also tablet-shaped pharmaceutical preparations.
  • divisible forms for more flexible dosing are known in other galenical preparations, e.g. Divisible tablets, divisible soft gelatin capsules, the development of an inexpensively manufactured divisible hard gelatin capsule failed due to the special characteristics of this galenic form.
  • the utility model DE-U-8 120 453 describes a soft gelatin capsule in which two partial capsules are connected to one another via a central web made of capsule material.
  • the teaching disclosed relates to soft gelatin capsules, which are generally not suitable for powder preparations.
  • a divisible capsule which consists of two elongated partial capsules, each with a semicircular cross section, which, after filling, are combined with a medicament to form a capsule of the usual shape.
  • the special feature of the divisible hard gelatin capsule described is the specially shaped partial capsule of conventional length, but with a semicircular cross-section, the area of which is slightly smaller than half the circular cross-sectional area of the fully assembled capsule.
  • a particular advantage of the divisible capsule according to the invention is that the partial capsule is available, for example, under the trade name "Suprokapsel". Elaborate special shapes of the partial capsules are not necessary.
  • the partial capsules can thus be filled and sealed using the standardized, commercially available filling machines.
  • the individual subcapsules can be made of different materials in a separable capsule.
  • the time at which the active ingredient is released can be influenced by a suitable selection of the composition of these materials.
  • Corresponding materials are known from the prior art. This is of particular interest if the active substances in combination preparations are to be released in a predeterminable sequence. By dividing the capsule, an individual adjustment of the dosage to the patient is also possible. Appropriate coloring of the capsules almost eliminates the risk of confusion by the patient.
  • Drug combinations that react chemically with each other i.e. are incompatible can be filled separately in a simple manner and then combined to form a capsule with two partial capsules.

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Cosmetics (AREA)

Claims (9)

  1. Capsule divisible pour préparations pharmaceutiques figeables, fortement visqueuses, pulvérulentes et/ou granulées, caractérisée par le fait qu'elle se compose d'au moins deux capsules partielles longilignes (2) de section transversale circulaire ou elliptique transversalement par rapport à 1'axe longitudinal , les capsules partielles comprenant, d'une manière connue par elle-même, une partie inférieure (3) et une partie supérieure (4) emboîtée sur cette dernière, et
    1.1. étant disposées le long d'un axe longitudinal commun et
    a) étant reliées, par leurs faces extrêmes (5), au moyen d'un adhésif pharmaceutiquement neutre,
    ou
    b) présentant une enveloppe commune (6), qui entoure intégralement ou partiellement les capsules partielles (2),

    ou
    1.2. étant disposées parallèlement l'une à l'autre et étant reliées, par les parties latérales, au moyen d'un adhésif pharmaceutiquement neutre.
  2. Capsule divisible selon la revendication 1, caractérisée par le fait que les capsules partiel les (2) sont entourées par une capsule extérieure (6a) , pouvant être éventuellement refermée.
  3. Capsule divisible selon la revendication 1, caractérisée par le fait que les capsules partielles (2) sont entourées par une enveloppe cylindrique (6b, c, d) en un matériau pharmaceutiquement neutre, l'enveloppe cylindrique pouvant renfermer des dispositifs (8), comme par exemple une perforation, un fil ou un ruban arrachable, en vue d améliorer la séparation de 1a capsule.
  4. Capsule divisible selon la revendication 3, caractérisée par le fait que l'enveloppe cylindrique (6d) consiste en un matériau thermorétracté, pharmaceutiquement neutre.
  5. Procédé de fabrication d'une capsule divisible selon la revendication 2, caractérisé par le fait que les capsules partielles (2) sont placées dans la partie inférieure de la capsule extérieure (6a), après quoi cette dernière est obturée par la partie supérieure associée.
  6. Procédé de fabrication d'une capsule divisible selon la revendication 3, caractérisé par le fait que les capsules partielles (2) sont reliées par emboîtement à leurs faces extrêmes, par 1'intermédiaire d'une enveloppe cylindrique (6b).
  7. Procédé de fabrication d'une capsule divisible selon la revendication 3, caractérisé par le fait que les capsules partielles (2) sont reliées par emboîtement à leurs faces extrêmes, par l'intermédiaire d'une enveloppe cylindrique (6c) et avec adjonction d'un adhésif, l' enveloppe (6c) renfermant des dispositifs (8) destinés à la séparation ultérieure.
  8. Procédé de fabrication d'une capsule divisible selon la revendication 4, caractérisé par le fait que les capsules partielles sont placèes sur une feuille thermorétractible, ladite feuille étant soudée pour former un tube, étant ensuite thermorétractée, munie de dispositifs destinés à améliorer la séparation, puis éventuellement subdivisée en des quantités fragmentaires comprenant deux ou plusieurs capsules partielles.
  9. Procédé de fabrication d'une capsule divisible selon la revendication 1, caractérisé par le fait que les capsules partielles sont reliées par leurs faces extrêmes, le long d'un axe longitudinal commun, au moyen d'un adhésif pharmaceutiquement neutre.
EP86116604A 1985-12-06 1986-11-28 Capsule divisible Expired - Lifetime EP0225565B1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT86116604T ATE63215T1 (de) 1985-12-06 1986-11-28 Teilbare kapsel.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853543154 DE3543154A1 (de) 1985-12-06 1985-12-06 Teilbare kapsel
DE3543154 1985-12-06

Publications (3)

Publication Number Publication Date
EP0225565A2 EP0225565A2 (fr) 1987-06-16
EP0225565A3 EP0225565A3 (en) 1988-06-15
EP0225565B1 true EP0225565B1 (fr) 1991-05-08

Family

ID=6287800

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86116604A Expired - Lifetime EP0225565B1 (fr) 1985-12-06 1986-11-28 Capsule divisible

Country Status (6)

Country Link
EP (1) EP0225565B1 (fr)
JP (1) JPS62133960A (fr)
AT (1) ATE63215T1 (fr)
DE (2) DE3543154A1 (fr)
ES (1) ES2021579B3 (fr)
GR (1) GR3001923T3 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274345B1 (fr) * 1986-11-13 1991-08-07 Warner-Lambert Company Capsule divisible

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3727894A1 (de) * 1987-08-21 1989-03-02 Stephan Dieter Kapsel fuer pharmazeutisch wirksame inhaltsstoffe einer droge
ES2150017T3 (es) * 1994-12-16 2000-11-16 Warner Lambert Co Proceso de encapsulacion de comprimidos en una capsula y formas de dosificacion solidas obtenidas por este proceso.
US6245350B1 (en) 1994-12-16 2001-06-12 Warner-Lambert Company Process for encapsulation of caplets in a capsule and solid dosage forms obtainable by such process
JP2005528383A (ja) * 2002-04-10 2005-09-22 ミラー，フレッド，エイチ． 多重相・複数コンパートメントカプセルシステム
BRPI0518125A (pt) * 2004-11-19 2008-10-28 Smithkline Beecham Corp produto farmacêutico
PL1954249T3 (pl) 2005-11-18 2015-12-31 Glaxo Group Ltd Urządzenie i sposób zespalania produktów farmaceutycznych oraz podobnych do farmaceutycznych
DE102006031441B4 (de) * 2006-07-05 2011-12-29 Hans Matt Orales Creatin-Supplement, sowie Verfahren zur Herstellung desselben
DE102008006197B4 (de) * 2008-01-26 2020-06-04 Man Energy Solutions Se Kraftstoffversorgungsanlage einer Brennkraftmaschine
FR2962647B1 (fr) * 2010-07-19 2013-05-24 Duo Ge Dispositif et installation d'assemblage d'au moins deux capsules medicamenteuses par collage
NZ760633A (en) 2017-07-10 2025-11-28 Gel Cap Tech Llc Dual release dosage form capsule and methods, devices and systems for making same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1815902A (en) * 1927-07-16 1931-07-28 Nat Aniline & Chem Co Inc Device for administering medicaments
FR1454013A (fr) * 1965-08-18 1966-07-22 Pluripharm Mode de présentation de deux médicaments associés
DE2719156A1 (de) * 1977-04-29 1978-11-02 Rainer Dr Med Liedtke Zwei-kammer arzneikapsel
DE8120453U1 (de) * 1981-07-13 1982-02-04 Alsitan-Gesellschaft Wilh. E. Ronneburg & Co, 8000 München Kapsel fuer arzneimittel
US4478658A (en) * 1982-12-20 1984-10-23 Warner-Lambert Company Method for sealing non-enteric capsules
DE3340262A1 (de) * 1983-11-08 1985-05-23 Sanol Schwarz GmbH, 4019 Monheim Teilbare hartgelatine-kapsel und verfahren zu ihrer herstellung
DE8503747U1 (de) * 1985-02-11 1985-05-09 Klinge Pharma GmbH, 8000 München Doppel-Kapsel zur Aufnahme von Medikamenten

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0274345B1 (fr) * 1986-11-13 1991-08-07 Warner-Lambert Company Capsule divisible

Also Published As

Publication number Publication date
EP0225565A2 (fr) 1987-06-16
DE3679156D1 (de) 1991-06-13
EP0225565A3 (en) 1988-06-15
ATE63215T1 (de) 1991-05-15
DE3543154A1 (de) 1987-06-11
GR3001923T3 (en) 1992-11-23
ES2021579B3 (es) 1991-11-16
JPS62133960A (ja) 1987-06-17
DE3543154C2 (fr) 1988-04-14

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