EP0227799A1 - Isothiocyanate allylique et utilisation dudit compose destine a empecher la chute des cheveux - Google Patents
Isothiocyanate allylique et utilisation dudit compose destine a empecher la chute des cheveuxInfo
- Publication number
- EP0227799A1 EP0227799A1 EP86904525A EP86904525A EP0227799A1 EP 0227799 A1 EP0227799 A1 EP 0227799A1 EP 86904525 A EP86904525 A EP 86904525A EP 86904525 A EP86904525 A EP 86904525A EP 0227799 A1 EP0227799 A1 EP 0227799A1
- Authority
- EP
- European Patent Office
- Prior art keywords
- allyl isothiocyanate
- composition
- hair loss
- weight
- aitc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- ZOJBYZNEUISWFT-UHFFFAOYSA-N allyl isothiocyanate Chemical compound C=CCN=C=S ZOJBYZNEUISWFT-UHFFFAOYSA-N 0.000 title claims abstract description 52
- 235000016720 allyl isothiocyanate Nutrition 0.000 title claims abstract description 26
- 201000004384 Alopecia Diseases 0.000 title claims abstract description 14
- 230000003676 hair loss Effects 0.000 title claims abstract description 14
- 208000024963 hair loss Diseases 0.000 title claims abstract description 14
- 239000000203 mixture Substances 0.000 claims description 26
- 210000004761 scalp Anatomy 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 230000000699 topical effect Effects 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 230000005764 inhibitory process Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- 239000006071 cream Substances 0.000 description 2
- 230000003808 decrease of hair loss Effects 0.000 description 2
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- 235000019489 Almond oil Nutrition 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Natural products CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 239000004264 Petrolatum Substances 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- HFEHLDPGIKPNKL-UHFFFAOYSA-N allyl iodide Chemical compound ICC=C HFEHLDPGIKPNKL-UHFFFAOYSA-N 0.000 description 1
- 239000008168 almond oil Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Natural products OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
- 229960002216 methylparaben Drugs 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N n-propyl alcohol Natural products CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- -1 or other inert Substances 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229940066842 petrolatum Drugs 0.000 description 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
- 229940116357 potassium thiocyanate Drugs 0.000 description 1
- XTUSEBKMEQERQV-UHFFFAOYSA-N propan-2-ol;hydrate Chemical compound O.CC(C)O XTUSEBKMEQERQV-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
- 229960003415 propylparaben Drugs 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940099259 vaseline Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/26—Cyanate or isocyanate esters; Thiocyanate or isothiocyanate esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
Definitions
- This application is concerned with pharmaceutical compositions allyl isothiocyanate (AITC) , and the use of such compositions of AITC itself to inhibit hair loss from the human scalp.
- AITC allyl isothiocyanate
- Allyl isothiocyanate is a known compound. It may be prepared by reaction between allyl iodide and potassium thiocyanate as described by Duliere J. Pharm. Belg. 2 j _ 981 (1920).
- AITC topical application of AITC to the human scalp, preferably in a pharmaceutically acceptable carrier will assist in the prevention of hair loss.
- the AITC may be applied, generally by massage, in any of a variety of compositions including liquids, and viscous bases such as creams, lotions, emollients, and other compositions generally employed for topical application.
- Useful compositions will contain from about 0.01% to 5%, preferably 0.1% to 2% by weight based on the total weight of the composition of the active ingredient.
- shampoos may be considered as pharmaceutical compositions.
- AITC may be used in dilute solution in water, but because of its low solubility in this carrier it will be generally employed in liquid compositions which are mixtures of water and a water miscible alkanol such as methyl, ethyl, propyl or isopropyl alcohol.
- AITC may be compounded with vaseline, petrolatum, hydrocarbon waxes, vegetable oils such as safflower, almond or peanut oil, or other inert, pharmaceutically acceptable carriers.
- the compositions may contain other active ingredients such as antiseptics, germicides or anti-dandruff compounds.
- a liquid composition useful for inhibiting hair, loss is prepared by dissolving 0.5 ml. or AITC in 100 ml. of 70% ethanol-water.
- An ointment composition of the invention is prepared by thoroughly mixing the following ingredients:
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Birds (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
Isothiocyanate allylique destiné à empêcher la chute des cheveux chez l'homme.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74696585A | 1985-06-20 | 1985-06-20 | |
| US746965 | 1985-06-20 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP0227799A1 true EP0227799A1 (fr) | 1987-07-08 |
| EP0227799A4 EP0227799A4 (fr) | 1987-10-05 |
Family
ID=25003099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP19860904525 Withdrawn EP0227799A4 (fr) | 1985-06-20 | 1986-06-16 | Isothiocyanate allylique et utilisation dudit compose destine a empecher la chute des cheveux. |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP0227799A4 (fr) |
| JP (1) | JPS63500520A (fr) |
| WO (1) | WO1986007536A1 (fr) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2826261B1 (fr) * | 2001-06-26 | 2005-03-25 | Lmd | Composition a usage topique comprenant un produit cytotoxique et son utilisation dans le traitement de l'alopeche |
| CN101897691B (zh) * | 2009-05-31 | 2013-06-05 | 无锡杰西医药科技有限公司 | 异硫氰酸酯类化合物在促进毛发生长中的应用 |
| EP3745873A4 (fr) * | 2018-02-02 | 2021-10-27 | Commonwealth Scientific and Industrial Research Organisation | Protection d'un agent bioactif et/ou d'un précurseur de celui-ci |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB473769A (en) * | 1936-05-08 | 1937-10-20 | Hans Haag | Process for the production of a preparation for the destruction of vermin |
| GB2088714A (en) * | 1980-11-26 | 1982-06-16 | Marinello Rosolino | Pharmaceutical compositions containing allyl isothiocyanate |
| US4440783A (en) * | 1983-02-24 | 1984-04-03 | Bernard Weiss | Composition for repelling animals from garbage and the like |
-
1986
- 1986-06-16 WO PCT/US1986/001305 patent/WO1986007536A1/fr not_active Ceased
- 1986-06-16 JP JP61503712A patent/JPS63500520A/ja active Pending
- 1986-06-16 EP EP19860904525 patent/EP0227799A4/fr not_active Withdrawn
Non-Patent Citations (2)
| Title |
|---|
| No relevant documents have been disclosed. * |
| See also references of WO8607536A1 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO1986007536A1 (fr) | 1986-12-31 |
| EP0227799A4 (fr) | 1987-10-05 |
| JPS63500520A (ja) | 1988-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE CH DE FR GB IT LI LU NL SE |
|
| 17P | Request for examination filed |
Effective date: 19870821 |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 19871005 |
|
| 17Q | First examination report despatched |
Effective date: 19890712 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
| 18D | Application deemed to be withdrawn |
Effective date: 19900504 |
|
| RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: DARKO, LASZLO, L. |