EP0245480A1 - Application transdermique de nicotine - Google Patents

Application transdermique de nicotine

Info

Publication number
EP0245480A1
EP0245480A1 EP86907172A EP86907172A EP0245480A1 EP 0245480 A1 EP0245480 A1 EP 0245480A1 EP 86907172 A EP86907172 A EP 86907172A EP 86907172 A EP86907172 A EP 86907172A EP 0245480 A1 EP0245480 A1 EP 0245480A1
Authority
EP
European Patent Office
Prior art keywords
tobacco
patch
nicotine
skin
nicotine patch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP86907172A
Other languages
German (de)
English (en)
Inventor
David I. Rosen
William E. Rosen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of EP0245480A1 publication Critical patent/EP0245480A1/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F47/00—Smokers' requisites not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof

Definitions

  • This invention relates to tobacco skin patches designed to reduce or eliminate the disadvantages associated with conventional smoking habits using combustible tobacco.
  • the field is patches used in the absorbtion of tobacco nicotine through the skin.
  • the amount of nicotine absorbed into the body generally does not build up to a harmful dose, but produces certain pleasurable effects, frequently leading to habitual use.
  • the relative mildness of a tobacco cigarette as compared to a pipe or cigar permits a user to draw the smoke from the burning cigarette directly into the lungs.
  • the nicotine vapors in the tobacco smoke are rapidly assim ⁇ ilated into the bloodstream of the user from the lungs, so that tobacco smoking provides a method by which a user may very quickly feel the effects of the nicotine.
  • Tobacco concentrates for example, have been processed into a tablet form which may be sucked or chewed in the mouth of the user, the nicotine being absorbed into the user's body through the lining of the mouth.
  • the tobacco in this method may be heated by various pyrophorous materials, which are mixed together with the tobacco. Such materials react with oxygen, alcohol, water, etc. and thereby produce sufficient heat to cause the tobacco to release vapors.
  • any by-products of the com ⁇ bustion reaction which occurs within the tobacco mix, will also tend to be inhaled through the device by the user.
  • the structure of such devices tend to be unduly complex, resulting in a relatively high manufacturing cost.
  • Various other smoking substitutes have been developed which include cigarette simulating devices containing various materials which approximate the taste and aroma of tobacco or release various other additional aromatic vapors which are intended to have a satisfying effect on the user when those vapors are inhaled.
  • synthetic materials simulating the taste and aroma of tobacco are micro-encapsulated within a cigarette device. The desired vapors are released by squeezing or crushing the device.
  • a tobacco nicotine product containing one or all sufficient quantity of finely powdered cigar, cigarette, chew snuff and leaf tobacco which can be mixed into a slurry and made into reconstituted tobacco sheet or made as a reconstituted tobacco sheet on a standard paper making machine (fortenier). Cut into size of any reasonable dimension.
  • Glycerin, alcohol or water separately or mixed are applied to skin and/or product then the patch of tobacco is placed on same area of skin.
  • Cover patch of tobacco with any plastic film or any product that holds in body heat. When body heat builds under plastic film, nicotine vapors are absorbed into the user's body, which give them the stimulation of tobacco without lighting up.
  • This invention can also be applied with fine ground tobaccos being added to creams, oil, alcohol, propylene glycol-glycerin, water, gelatin, gura gum, or a solid piece and applied to the skin wrapped or not wrapped or covered by any material; in any form or solid.
  • Any type of tobacco, cigar, cigarette, chew, leaf, and snuff can be added to product from 1% tobacco to 100% tobacco, in any form including leaf.
  • This Invention is used so a person wanting to stop smoking combustible tobacco can place a patch of uncombustible tobacco on the skin to get the sensation of nicotine from smoking without lighting up.
  • the tobacco patch is a simple method for nicotine replacement. It is medically acknowledged that the tar and gases such as carbon monoxide, oxides of nitrogen, and many other toxic com ⁇ bustion products are the principal culprits that cause s oking-related cancer, bronchitis and possibly heart disease. Simple nicotine replacement by other means would seem a logical and straightforward method to "kick the habit.” DESCRIPTION OF DRAWING:
  • Figure 1 shows my tobacco patch invention having a tobacco sheet patch (1), film (2) and glycerin, alcohol or water separately or mixed (3).
  • This invention is a patch having tobacco designed to be wrapped on to the skin and releasing tobacco nicotine through skin temperature.
  • the patch of tobacco is a sheet made from one or all of finely powdered cigar, cigarette, chew snuff and leaf tobacco.
  • a plastic film or any product which holds in body heat covers the tobacco patch when applied to the skin.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Manufacture Of Tobacco Products (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Une application transcutanée de nicotine est effectuée à l'aide d'une compresse munie d'une pellicule (2) contenant du tabac (1) servant de source de micotine. La compresse est conçue pour être appliquée sur la peau. L'application transcutanée de nicotine réduit l'envie de fumer.
EP86907172A 1985-11-14 1986-11-13 Application transdermique de nicotine Pending EP0245480A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79793885A 1985-11-14 1985-11-14
US797938 1985-11-14

Publications (1)

Publication Number Publication Date
EP0245480A1 true EP0245480A1 (fr) 1987-11-19

Family

ID=25172154

Family Applications (1)

Application Number Title Priority Date Filing Date
EP86907172A Pending EP0245480A1 (fr) 1985-11-14 1986-11-13 Application transdermique de nicotine

Country Status (3)

Country Link
EP (1) EP0245480A1 (fr)
AU (1) AU6630086A (fr)
WO (1) WO1987002870A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839174A (en) * 1987-10-05 1989-06-13 Pharmetrix Corporation Novel transdermal nicotine patch
US4781924A (en) 1987-11-09 1988-11-01 Alza Corporation Transdermal drug delivery device
US5004610A (en) * 1988-06-14 1991-04-02 Alza Corporation Subsaturated nicotine transdermal therapeutic system
US5077104A (en) * 1989-12-21 1991-12-31 Alza Corporation Nicotine packaging materials
US5508038A (en) * 1990-04-16 1996-04-16 Alza Corporation Polyisobutylene adhesives for transdermal devices
DE4416927C1 (de) * 1994-05-13 1995-08-31 Lohmann Therapie Syst Lts Vorrichtung zur Abgabe von Wirkstoffen aus Haftschmelzklebern, Verfahren zu ihrer Herstellung und ihre Verwendung
DE4433191A1 (de) * 1994-09-17 1996-03-21 Lohmann Therapie Syst Lts Selbstklebendes Pflaster zur Abgabe von Wirkstoff an die Umgebung eines Trägers
GB2446672A (en) * 2007-02-14 2008-08-20 Cotrex Llc Tobacco extraction methods and formulations

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA930668A (en) * 1969-04-01 1973-07-24 Zaffaroni Alejandro Bandage for administering drugs
GB8301659D0 (en) * 1983-01-21 1983-02-23 Leo Ab Smoking substitutes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8702870A1 *

Also Published As

Publication number Publication date
AU6630086A (en) 1987-06-02
WO1987002870A1 (fr) 1987-05-21

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Legal Events

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